Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4H619_LEIBR

TriTrypDb:

LbrM.10.0400 , LBRM2903_100008700

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4H619

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H619

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.479
CLV_C14_Caspase3-7	308	312	PF00656	0.531
CLV_MEL_PAP_1	431	437	PF00089	0.250
CLV_NRD_NRD_1	277	279	PF00675	0.341
CLV_NRD_NRD_1	53	55	PF00675	0.415
CLV_NRD_NRD_1	9	11	PF00675	0.419
CLV_PCSK_KEX2_1	138	140	PF00082	0.296
CLV_PCSK_KEX2_1	277	279	PF00082	0.298
CLV_PCSK_KEX2_1	300	302	PF00082	0.383
CLV_PCSK_KEX2_1	512	514	PF00082	0.525
CLV_PCSK_KEX2_1	53	55	PF00082	0.448
CLV_PCSK_KEX2_1	675	677	PF00082	0.520
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.296
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.383
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.525
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.415
CLV_PCSK_SKI1_1	121	125	PF00082	0.357
CLV_PCSK_SKI1_1	429	433	PF00082	0.274
DEG_Nend_Nbox_1	1	3	PF02207	0.598
DEG_SCF_FBW7_2	14	19	PF00400	0.606
DOC_CDC14_PxL_1	602	610	PF14671	0.335
DOC_CKS1_1	614	619	PF01111	0.436
DOC_CKS1_1	692	697	PF01111	0.614
DOC_CYCLIN_yCln2_LP_2	619	625	PF00134	0.375
DOC_MAPK_gen_1	138	144	PF00069	0.504
DOC_MAPK_gen_1	262	272	PF00069	0.552
DOC_MAPK_gen_1	277	285	PF00069	0.544
DOC_MAPK_gen_1	512	520	PF00069	0.327
DOC_MAPK_gen_1	630	639	PF00069	0.589
DOC_MAPK_MEF2A_6	232	239	PF00069	0.332
DOC_MAPK_MEF2A_6	512	520	PF00069	0.360
DOC_PP1_RVXF_1	488	494	PF00149	0.509
DOC_PP2B_LxvP_1	619	622	PF13499	0.361
DOC_PP2B_PxIxI_1	232	238	PF00149	0.288
DOC_USP7_MATH_1	161	165	PF00917	0.268
DOC_USP7_MATH_1	204	208	PF00917	0.328
DOC_USP7_MATH_1	303	307	PF00917	0.563
DOC_USP7_MATH_1	47	51	PF00917	0.645
DOC_USP7_MATH_1	485	489	PF00917	0.528
DOC_USP7_MATH_1	554	558	PF00917	0.489
DOC_USP7_MATH_1	6	10	PF00917	0.669
DOC_USP7_MATH_1	667	671	PF00917	0.796
DOC_WW_Pin1_4	12	17	PF00397	0.728
DOC_WW_Pin1_4	299	304	PF00397	0.591
DOC_WW_Pin1_4	434	439	PF00397	0.337
DOC_WW_Pin1_4	613	618	PF00397	0.419
DOC_WW_Pin1_4	691	696	PF00397	0.788
LIG_14-3-3_CanoR_1	10	16	PF00244	0.620
LIG_14-3-3_CanoR_1	109	116	PF00244	0.495
LIG_14-3-3_CanoR_1	262	272	PF00244	0.587
LIG_14-3-3_CanoR_1	434	438	PF00244	0.417
LIG_14-3-3_CanoR_1	490	494	PF00244	0.495
LIG_14-3-3_CanoR_1	570	579	PF00244	0.501
LIG_14-3-3_CanoR_1	645	649	PF00244	0.449
LIG_APCC_ABBA_1	55	60	PF00400	0.637
LIG_APCC_ABBAyCdc20_2	54	60	PF00400	0.505
LIG_BRCT_BRCA1_1	456	460	PF00533	0.321
LIG_CtBP_PxDLS_1	622	626	PF00389	0.189
LIG_EH1_1	492	500	PF00400	0.346
LIG_FHA_1	122	128	PF00498	0.572
LIG_FHA_1	358	364	PF00498	0.592
LIG_FHA_1	375	381	PF00498	0.355
LIG_FHA_1	390	396	PF00498	0.258
LIG_FHA_1	430	436	PF00498	0.417
LIG_FHA_1	467	473	PF00498	0.406
LIG_FHA_1	474	480	PF00498	0.400
LIG_FHA_1	490	496	PF00498	0.490
LIG_FHA_1	614	620	PF00498	0.422
LIG_FHA_2	274	280	PF00498	0.559
LIG_FHA_2	682	688	PF00498	0.620
LIG_GBD_Chelix_1	389	397	PF00786	0.469
LIG_GBD_Chelix_1	471	479	PF00786	0.233
LIG_GBD_Chelix_1	494	502	PF00786	0.477
LIG_GBD_Chelix_1	532	540	PF00786	0.505
LIG_Integrin_RGD_1	676	678	PF01839	0.418
LIG_LIR_Apic_2	34	40	PF02991	0.621
LIG_LIR_Apic_2	341	347	PF02991	0.533
LIG_LIR_Apic_2	409	415	PF02991	0.406
LIG_LIR_Apic_2	446	450	PF02991	0.336
LIG_LIR_Apic_2	585	589	PF02991	0.306
LIG_LIR_Gen_1	129	136	PF02991	0.524
LIG_LIR_Gen_1	207	215	PF02991	0.501
LIG_LIR_Gen_1	459	468	PF02991	0.327
LIG_LIR_Gen_1	559	569	PF02991	0.515
LIG_LIR_Gen_1	90	100	PF02991	0.543
LIG_LIR_Nem_3	129	134	PF02991	0.498
LIG_LIR_Nem_3	137	143	PF02991	0.498
LIG_LIR_Nem_3	207	213	PF02991	0.297
LIG_LIR_Nem_3	247	253	PF02991	0.342
LIG_LIR_Nem_3	364	370	PF02991	0.502
LIG_LIR_Nem_3	409	414	PF02991	0.372
LIG_LIR_Nem_3	457	461	PF02991	0.300
LIG_Pex14_2	174	178	PF04695	0.371
LIG_Pex14_2	456	460	PF04695	0.310
LIG_Pex14_2	480	484	PF04695	0.370
LIG_PTB_Apo_2	452	459	PF02174	0.375
LIG_PTB_Apo_2	478	485	PF02174	0.444
LIG_PTB_Phospho_1	452	458	PF10480	0.407
LIG_SH2_CRK	107	111	PF00017	0.516
LIG_SH2_CRK	141	145	PF00017	0.373
LIG_SH2_CRK	156	160	PF00017	0.327
LIG_SH2_CRK	191	195	PF00017	0.518
LIG_SH2_CRK	344	348	PF00017	0.619
LIG_SH2_CRK	372	376	PF00017	0.351
LIG_SH2_CRK	447	451	PF00017	0.329
LIG_SH2_CRK	461	465	PF00017	0.302
LIG_SH2_CRK	586	590	PF00017	0.329
LIG_SH2_GRB2like	443	446	PF00017	0.360
LIG_SH2_NCK_1	447	451	PF00017	0.320
LIG_SH2_NCK_1	461	465	PF00017	0.304
LIG_SH2_PTP2	37	40	PF00017	0.616
LIG_SH2_PTP2	517	520	PF00017	0.401
LIG_SH2_SRC	37	40	PF00017	0.622
LIG_SH2_SRC	443	446	PF00017	0.348
LIG_SH2_STAP1	136	140	PF00017	0.505
LIG_SH2_STAP1	191	195	PF00017	0.490
LIG_SH2_STAP1	372	376	PF00017	0.399
LIG_SH2_STAP1	562	566	PF00017	0.345
LIG_SH2_STAP1	89	93	PF00017	0.534
LIG_SH2_STAT5	136	139	PF00017	0.502
LIG_SH2_STAT5	251	254	PF00017	0.444
LIG_SH2_STAT5	271	274	PF00017	0.454
LIG_SH2_STAT5	37	40	PF00017	0.611
LIG_SH2_STAT5	426	429	PF00017	0.356
LIG_SH2_STAT5	443	446	PF00017	0.283
LIG_SH2_STAT5	517	520	PF00017	0.306
LIG_SH2_STAT5	526	529	PF00017	0.298
LIG_SH2_STAT5	77	80	PF00017	0.524
LIG_SH3_1	344	350	PF00018	0.587
LIG_SH3_3	344	350	PF00018	0.598
LIG_SH3_3	432	438	PF00018	0.362
LIG_SH3_3	689	695	PF00018	0.832
LIG_SUMO_SIM_par_1	545	550	PF11976	0.334
LIG_TRAF2_1	684	687	PF00917	0.617
LIG_TRFH_1	156	160	PF08558	0.367
LIG_TYR_ITIM	154	159	PF00017	0.383
LIG_UBA3_1	154	162	PF00899	0.359
LIG_UBA3_1	479	486	PF00899	0.396
LIG_Vh1_VBS_1	370	388	PF01044	0.413
LIG_Vh1_VBS_1	460	478	PF01044	0.392
MOD_CDK_SPxK_1	691	697	PF00069	0.754
MOD_CK1_1	111	117	PF00069	0.358
MOD_CK1_1	9	15	PF00069	0.671
MOD_CK2_1	273	279	PF00069	0.418
MOD_CK2_1	657	663	PF00069	0.597
MOD_CK2_1	667	673	PF00069	0.699
MOD_CK2_1	681	687	PF00069	0.837
MOD_Cter_Amidation	298	301	PF01082	0.473
MOD_Cter_Amidation	673	676	PF01082	0.493
MOD_DYRK1A_RPxSP_1	434	438	PF00069	0.421
MOD_GlcNHglycan	163	167	PF01048	0.357
MOD_GlcNHglycan	239	242	PF01048	0.377
MOD_GlcNHglycan	286	289	PF01048	0.342
MOD_GlcNHglycan	32	36	PF01048	0.502
MOD_GlcNHglycan	575	578	PF01048	0.397
MOD_GSK3_1	214	221	PF00069	0.322
MOD_GSK3_1	233	240	PF00069	0.446
MOD_GSK3_1	299	306	PF00069	0.426
MOD_GSK3_1	357	364	PF00069	0.476
MOD_GSK3_1	370	377	PF00069	0.365
MOD_GSK3_1	41	48	PF00069	0.397
MOD_GSK3_1	429	436	PF00069	0.249
MOD_GSK3_1	456	463	PF00069	0.375
MOD_GSK3_1	485	492	PF00069	0.369
MOD_GSK3_1	571	578	PF00069	0.380
MOD_N-GLC_1	454	459	PF02516	0.360
MOD_N-GLC_2	613	615	PF02516	0.490
MOD_NEK2_1	116	121	PF00069	0.382
MOD_NEK2_1	134	139	PF00069	0.288
MOD_NEK2_1	142	147	PF00069	0.344
MOD_NEK2_1	174	179	PF00069	0.350
MOD_NEK2_1	214	219	PF00069	0.330
MOD_NEK2_1	273	278	PF00069	0.415
MOD_NEK2_1	318	323	PF00069	0.370
MOD_NEK2_1	370	375	PF00069	0.371
MOD_NEK2_1	389	394	PF00069	0.302
MOD_NEK2_1	45	50	PF00069	0.393
MOD_NEK2_1	456	461	PF00069	0.361
MOD_NEK2_1	493	498	PF00069	0.368
MOD_NEK2_1	571	576	PF00069	0.359
MOD_NEK2_2	233	238	PF00069	0.472
MOD_PIKK_1	184	190	PF00454	0.332
MOD_PIKK_1	87	93	PF00454	0.306
MOD_PK_1	109	115	PF00069	0.456
MOD_PKA_2	108	114	PF00069	0.382
MOD_PKA_2	433	439	PF00069	0.463
MOD_PKA_2	489	495	PF00069	0.355
MOD_PKA_2	554	560	PF00069	0.340
MOD_PKA_2	572	578	PF00069	0.340
MOD_PKA_2	644	650	PF00069	0.409
MOD_PKA_2	9	15	PF00069	0.503
MOD_Plk_1	454	460	PF00069	0.379
MOD_Plk_1	686	692	PF00069	0.704
MOD_Plk_4	204	210	PF00069	0.344
MOD_Plk_4	214	220	PF00069	0.336
MOD_Plk_4	370	376	PF00069	0.357
MOD_Plk_4	407	413	PF00069	0.396
MOD_Plk_4	41	47	PF00069	0.513
MOD_Plk_4	456	462	PF00069	0.442
MOD_Plk_4	467	473	PF00069	0.326
MOD_Plk_4	489	495	PF00069	0.343
MOD_Plk_4	556	562	PF00069	0.376
MOD_ProDKin_1	12	18	PF00069	0.668
MOD_ProDKin_1	299	305	PF00069	0.477
MOD_ProDKin_1	434	440	PF00069	0.337
MOD_ProDKin_1	613	619	PF00069	0.419
MOD_ProDKin_1	691	697	PF00069	0.754
TRG_DiLeu_BaLyEn_6	603	608	PF01217	0.386
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.326
TRG_ENDOCYTIC_2	107	110	PF00928	0.326
TRG_ENDOCYTIC_2	141	144	PF00928	0.351
TRG_ENDOCYTIC_2	156	159	PF00928	0.342
TRG_ENDOCYTIC_2	191	194	PF00928	0.343
TRG_ENDOCYTIC_2	372	375	PF00928	0.353
TRG_ENDOCYTIC_2	461	464	PF00928	0.357
TRG_ENDOCYTIC_2	517	520	PF00928	0.484
TRG_ENDOCYTIC_2	562	565	PF00928	0.346
TRG_ENDOCYTIC_2	93	96	PF00928	0.356
TRG_ER_diArg_1	280	283	PF00400	0.323
TRG_ER_diArg_1	52	54	PF00400	0.576
TRG_ER_diArg_1	629	632	PF00400	0.352
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	46%	99%
A0A0N1HY49	Leptomonas seymouri	47%	100%
A0A0N1HZ06	Leptomonas seymouri	37%	100%
A0A0N1IHL1	Leptomonas seymouri	39%	98%
A0A0N1PAY4	Leptomonas seymouri	46%	79%
A0A0N1PB77	Leptomonas seymouri	34%	100%
A0A0N1PBZ2	Leptomonas seymouri	64%	100%
A0A0N1PCC1	Leptomonas seymouri	43%	100%
A0A0S4INN8	Bodo saltans	30%	100%
A0A381MBI0	Leishmania infantum	45%	100%
A0A3Q8I8X7	Leishmania donovani	45%	100%
A0A3Q8IAZ0	Leishmania donovani	80%	100%
A0A3Q8IH50	Leishmania donovani	58%	97%
A0A3Q8IVN0	Leishmania donovani	38%	100%
A0A3R7M4J1	Trypanosoma rangeli	43%	100%
A0A3S5H5P4	Leishmania donovani	45%	100%
A0A3S5H5V2	Leishmania donovani	44%	100%
A0A3S5H6F6	Leishmania donovani	81%	100%
A0A3S5H763	Leishmania donovani	53%	100%
A0A3S7WR10	Leishmania donovani	44%	94%
A0A3S7WR14	Leishmania donovani	74%	100%
A0A3S7WR15	Leishmania donovani	70%	82%
A0A3S7WR24	Leishmania donovani	81%	99%
A4H4T8	Leishmania braziliensis	43%	100%
A4H5Y4	Leishmania braziliensis	45%	100%
A4H617	Leishmania braziliensis	96%	100%
A4H618	Leishmania braziliensis	97%	100%
A4H620	Leishmania braziliensis	58%	99%
A4H6C3	Leishmania braziliensis	44%	100%
A4HNH7	Leishmania braziliensis	36%	100%
A4HSS2	Leishmania infantum	45%	100%
A4HUE4	Leishmania infantum	43%	94%
A4HUE5	Leishmania infantum	70%	100%
A4HUE6	Leishmania infantum	74%	100%
A4HUE7	Leishmania infantum	81%	100%
A4HUE8	Leishmania infantum	81%	99%
A4HUF4	Leishmania infantum	80%	100%
A4HUF5	Leishmania infantum	57%	100%
A4HYA9	Leishmania infantum	53%	100%
A4IC33	Leishmania infantum	38%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9AG72	Leishmania infantum	44%	100%
E9AI40	Leishmania braziliensis	83%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	94%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	98%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QDC4	Leishmania major	51%	100%
Q4QH81	Leishmania major	46%	100%
Q4QHH7	Leishmania major	57%	100%
Q4QHH8	Leishmania major	81%	100%
Q4QHH9	Leishmania major	80%	100%
Q4QHI0	Leishmania major	80%	100%
Q4QHI1	Leishmania major	75%	100%
Q4QHI2	Leishmania major	72%	100%
Q4QIU9	Leishmania major	43%	99%
Q4QJ48	Leishmania major	45%	100%
Q7KIP2	Leishmania major	36%	100%