Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H618_LEIBR

TriTrypDb:

LbrM.10.0390 , LBRM2903_100008700

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72

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Expansion

Sequence features

A4H618

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H618

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.479
CLV_C14_Caspase3-7	305	309	PF00656	0.531
CLV_MEL_PAP_1	428	434	PF00089	0.250
CLV_NRD_NRD_1	274	276	PF00675	0.341
CLV_NRD_NRD_1	50	52	PF00675	0.415
CLV_NRD_NRD_1	6	8	PF00675	0.421
CLV_PCSK_KEX2_1	135	137	PF00082	0.296
CLV_PCSK_KEX2_1	274	276	PF00082	0.298
CLV_PCSK_KEX2_1	297	299	PF00082	0.383
CLV_PCSK_KEX2_1	50	52	PF00082	0.448

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	45%	97%
A0A0N1HY49	Leptomonas seymouri	47%	100%
A0A0N1HZ06	Leptomonas seymouri	37%	100%
A0A0N1IHL1	Leptomonas seymouri	39%	96%
A0A0N1PAY4	Leptomonas seymouri	47%	78%
A0A0N1PB77	Leptomonas seymouri	33%	100%
A0A0N1PBZ2	Leptomonas seymouri	64%	100%
A0A0N1PCC1	Leptomonas seymouri	43%	100%
A0A0S4INN8	Bodo saltans	29%	100%
A0A381MBI0	Leishmania infantum	44%	100%

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