Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H618_LEIBR

TriTrypDb:

LbrM.10.0390 , LBRM2903_100008700

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4H618

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H618

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.479
CLV_C14_Caspase3-7	305	309	PF00656	0.531
CLV_MEL_PAP_1	428	434	PF00089	0.250
CLV_NRD_NRD_1	274	276	PF00675	0.341
CLV_NRD_NRD_1	50	52	PF00675	0.415
CLV_NRD_NRD_1	6	8	PF00675	0.421
CLV_PCSK_KEX2_1	135	137	PF00082	0.296
CLV_PCSK_KEX2_1	274	276	PF00082	0.298
CLV_PCSK_KEX2_1	297	299	PF00082	0.383
CLV_PCSK_KEX2_1	50	52	PF00082	0.448
CLV_PCSK_KEX2_1	509	511	PF00082	0.525
CLV_PCSK_KEX2_1	672	674	PF00082	0.504
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.296
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.383
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.525
CLV_PCSK_PC1ET2_1	672	674	PF00082	0.399
CLV_PCSK_SKI1_1	118	122	PF00082	0.357
CLV_PCSK_SKI1_1	426	430	PF00082	0.274
DEG_Nend_UBRbox_2	1	3	PF02207	0.592
DEG_SCF_FBW7_2	11	16	PF00400	0.606
DOC_CDC14_PxL_1	599	607	PF14671	0.335
DOC_CKS1_1	611	616	PF01111	0.436
DOC_CYCLIN_yCln2_LP_2	616	622	PF00134	0.375
DOC_MAPK_gen_1	135	141	PF00069	0.504
DOC_MAPK_gen_1	259	269	PF00069	0.552
DOC_MAPK_gen_1	274	282	PF00069	0.544
DOC_MAPK_gen_1	509	517	PF00069	0.327
DOC_MAPK_gen_1	627	636	PF00069	0.589
DOC_MAPK_MEF2A_6	229	236	PF00069	0.332
DOC_MAPK_MEF2A_6	509	517	PF00069	0.360
DOC_PP1_RVXF_1	485	491	PF00149	0.509
DOC_PP2B_LxvP_1	616	619	PF13499	0.361
DOC_PP2B_PxIxI_1	229	235	PF00149	0.288
DOC_USP7_MATH_1	158	162	PF00917	0.268
DOC_USP7_MATH_1	201	205	PF00917	0.328
DOC_USP7_MATH_1	3	7	PF00917	0.660
DOC_USP7_MATH_1	300	304	PF00917	0.563
DOC_USP7_MATH_1	44	48	PF00917	0.643
DOC_USP7_MATH_1	464	468	PF00917	0.387
DOC_USP7_MATH_1	482	486	PF00917	0.528
DOC_USP7_MATH_1	551	555	PF00917	0.489
DOC_USP7_MATH_1	664	668	PF00917	0.787
DOC_WW_Pin1_4	296	301	PF00397	0.591
DOC_WW_Pin1_4	431	436	PF00397	0.337
DOC_WW_Pin1_4	610	615	PF00397	0.419
DOC_WW_Pin1_4	9	14	PF00397	0.721
LIG_14-3-3_CanoR_1	106	113	PF00244	0.495
LIG_14-3-3_CanoR_1	259	269	PF00244	0.587
LIG_14-3-3_CanoR_1	431	435	PF00244	0.417
LIG_14-3-3_CanoR_1	487	491	PF00244	0.495
LIG_14-3-3_CanoR_1	642	646	PF00244	0.449
LIG_14-3-3_CanoR_1	7	13	PF00244	0.623
LIG_APCC_ABBA_1	52	57	PF00400	0.638
LIG_APCC_ABBAyCdc20_2	51	57	PF00400	0.506
LIG_BRCT_BRCA1_1	453	457	PF00533	0.321
LIG_CtBP_PxDLS_1	619	623	PF00389	0.189
LIG_EH1_1	489	497	PF00400	0.346
LIG_FHA_1	119	125	PF00498	0.572
LIG_FHA_1	355	361	PF00498	0.592
LIG_FHA_1	372	378	PF00498	0.355
LIG_FHA_1	387	393	PF00498	0.258
LIG_FHA_1	427	433	PF00498	0.417
LIG_FHA_1	458	464	PF00498	0.336
LIG_FHA_1	471	477	PF00498	0.400
LIG_FHA_1	487	493	PF00498	0.490
LIG_FHA_1	611	617	PF00498	0.422
LIG_FHA_2	271	277	PF00498	0.559
LIG_GBD_Chelix_1	386	394	PF00786	0.469
LIG_GBD_Chelix_1	468	476	PF00786	0.233
LIG_GBD_Chelix_1	491	499	PF00786	0.477
LIG_GBD_Chelix_1	529	537	PF00786	0.505
LIG_Integrin_RGD_1	673	675	PF01839	0.400
LIG_LIR_Apic_2	31	37	PF02991	0.617
LIG_LIR_Apic_2	338	344	PF02991	0.533
LIG_LIR_Apic_2	406	412	PF02991	0.406
LIG_LIR_Apic_2	443	447	PF02991	0.336
LIG_LIR_Apic_2	582	586	PF02991	0.306
LIG_LIR_Gen_1	126	133	PF02991	0.524
LIG_LIR_Gen_1	204	212	PF02991	0.501
LIG_LIR_Gen_1	456	465	PF02991	0.327
LIG_LIR_Gen_1	556	565	PF02991	0.515
LIG_LIR_Gen_1	87	97	PF02991	0.543
LIG_LIR_Nem_3	126	131	PF02991	0.498
LIG_LIR_Nem_3	134	140	PF02991	0.498
LIG_LIR_Nem_3	204	210	PF02991	0.297
LIG_LIR_Nem_3	244	250	PF02991	0.342
LIG_LIR_Nem_3	361	367	PF02991	0.502
LIG_LIR_Nem_3	406	411	PF02991	0.372
LIG_LIR_Nem_3	454	458	PF02991	0.300
LIG_LIR_Nem_3	566	571	PF02991	0.309
LIG_Pex14_2	171	175	PF04695	0.371
LIG_Pex14_2	453	457	PF04695	0.310
LIG_Pex14_2	477	481	PF04695	0.370
LIG_PTB_Apo_2	449	456	PF02174	0.375
LIG_PTB_Apo_2	475	482	PF02174	0.444
LIG_PTB_Phospho_1	449	455	PF10480	0.407
LIG_SH2_CRK	104	108	PF00017	0.516
LIG_SH2_CRK	138	142	PF00017	0.373
LIG_SH2_CRK	153	157	PF00017	0.327
LIG_SH2_CRK	188	192	PF00017	0.518
LIG_SH2_CRK	341	345	PF00017	0.619
LIG_SH2_CRK	369	373	PF00017	0.351
LIG_SH2_CRK	444	448	PF00017	0.329
LIG_SH2_CRK	458	462	PF00017	0.302
LIG_SH2_CRK	583	587	PF00017	0.329
LIG_SH2_GRB2like	440	443	PF00017	0.360
LIG_SH2_NCK_1	444	448	PF00017	0.320
LIG_SH2_NCK_1	458	462	PF00017	0.304
LIG_SH2_PTP2	34	37	PF00017	0.615
LIG_SH2_PTP2	514	517	PF00017	0.401
LIG_SH2_SRC	34	37	PF00017	0.621
LIG_SH2_SRC	440	443	PF00017	0.348
LIG_SH2_STAP1	133	137	PF00017	0.505
LIG_SH2_STAP1	188	192	PF00017	0.490
LIG_SH2_STAP1	369	373	PF00017	0.399
LIG_SH2_STAP1	86	90	PF00017	0.534
LIG_SH2_STAT5	133	136	PF00017	0.502
LIG_SH2_STAT5	248	251	PF00017	0.444
LIG_SH2_STAT5	268	271	PF00017	0.454
LIG_SH2_STAT5	34	37	PF00017	0.610
LIG_SH2_STAT5	423	426	PF00017	0.356
LIG_SH2_STAT5	440	443	PF00017	0.283
LIG_SH2_STAT5	514	517	PF00017	0.306
LIG_SH2_STAT5	523	526	PF00017	0.298
LIG_SH2_STAT5	74	77	PF00017	0.524
LIG_SH3_1	341	347	PF00018	0.587
LIG_SH3_3	341	347	PF00018	0.598
LIG_SH3_3	429	435	PF00018	0.362
LIG_SUMO_SIM_par_1	541	547	PF11976	0.334
LIG_TRFH_1	153	157	PF08558	0.367
LIG_TYR_ITIM	151	156	PF00017	0.383
LIG_UBA3_1	151	159	PF00899	0.359
LIG_UBA3_1	476	483	PF00899	0.396
LIG_Vh1_VBS_1	367	385	PF01044	0.413
LIG_WRC_WIRS_1	565	570	PF05994	0.222
MOD_CK1_1	108	114	PF00069	0.358
MOD_CK1_1	6	12	PF00069	0.655
MOD_CK2_1	270	276	PF00069	0.418
MOD_CK2_1	654	660	PF00069	0.588
MOD_CK2_1	664	670	PF00069	0.685
MOD_Cter_Amidation	295	298	PF01082	0.473
MOD_Cter_Amidation	670	673	PF01082	0.477
MOD_DYRK1A_RPxSP_1	431	435	PF00069	0.421
MOD_GlcNHglycan	160	164	PF01048	0.357
MOD_GlcNHglycan	236	239	PF01048	0.377
MOD_GlcNHglycan	283	286	PF01048	0.342
MOD_GlcNHglycan	29	33	PF01048	0.493
MOD_GlcNHglycan	369	372	PF01048	0.204
MOD_GSK3_1	211	218	PF00069	0.322
MOD_GSK3_1	230	237	PF00069	0.446
MOD_GSK3_1	296	303	PF00069	0.426
MOD_GSK3_1	354	361	PF00069	0.476
MOD_GSK3_1	367	374	PF00069	0.365
MOD_GSK3_1	38	45	PF00069	0.392
MOD_GSK3_1	426	433	PF00069	0.249
MOD_GSK3_1	453	460	PF00069	0.375
MOD_GSK3_1	482	489	PF00069	0.369
MOD_N-GLC_1	451	456	PF02516	0.360
MOD_N-GLC_2	610	612	PF02516	0.490
MOD_NEK2_1	113	118	PF00069	0.382
MOD_NEK2_1	131	136	PF00069	0.288
MOD_NEK2_1	139	144	PF00069	0.344
MOD_NEK2_1	171	176	PF00069	0.350
MOD_NEK2_1	211	216	PF00069	0.330
MOD_NEK2_1	270	275	PF00069	0.415
MOD_NEK2_1	315	320	PF00069	0.370
MOD_NEK2_1	367	372	PF00069	0.371
MOD_NEK2_1	386	391	PF00069	0.302
MOD_NEK2_1	42	47	PF00069	0.390
MOD_NEK2_1	453	458	PF00069	0.361
MOD_NEK2_1	490	495	PF00069	0.368
MOD_NEK2_2	230	235	PF00069	0.472
MOD_PIKK_1	181	187	PF00454	0.332
MOD_PIKK_1	84	90	PF00454	0.306
MOD_PK_1	106	112	PF00069	0.456
MOD_PKA_2	105	111	PF00069	0.382
MOD_PKA_2	430	436	PF00069	0.463
MOD_PKA_2	486	492	PF00069	0.355
MOD_PKA_2	551	557	PF00069	0.340
MOD_PKA_2	6	12	PF00069	0.506
MOD_PKA_2	641	647	PF00069	0.409
MOD_Plk_1	451	457	PF00069	0.379
MOD_Plk_4	201	207	PF00069	0.344
MOD_Plk_4	211	217	PF00069	0.336
MOD_Plk_4	38	44	PF00069	0.511
MOD_Plk_4	404	410	PF00069	0.396
MOD_Plk_4	453	459	PF00069	0.442
MOD_Plk_4	464	470	PF00069	0.326
MOD_Plk_4	486	492	PF00069	0.343
MOD_Plk_4	553	559	PF00069	0.376
MOD_ProDKin_1	296	302	PF00069	0.477
MOD_ProDKin_1	431	437	PF00069	0.337
MOD_ProDKin_1	610	616	PF00069	0.419
MOD_ProDKin_1	9	15	PF00069	0.658
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.386
TRG_DiLeu_BaLyEn_6	611	616	PF01217	0.326
TRG_ENDOCYTIC_2	104	107	PF00928	0.326
TRG_ENDOCYTIC_2	138	141	PF00928	0.351
TRG_ENDOCYTIC_2	153	156	PF00928	0.342
TRG_ENDOCYTIC_2	188	191	PF00928	0.343
TRG_ENDOCYTIC_2	369	372	PF00928	0.353
TRG_ENDOCYTIC_2	458	461	PF00928	0.357
TRG_ENDOCYTIC_2	514	517	PF00928	0.484
TRG_ENDOCYTIC_2	559	562	PF00928	0.346
TRG_ENDOCYTIC_2	90	93	PF00928	0.356
TRG_ER_diArg_1	277	280	PF00400	0.323
TRG_ER_diArg_1	49	51	PF00400	0.575
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	45%	97%
A0A0N1HY49	Leptomonas seymouri	47%	100%
A0A0N1HZ06	Leptomonas seymouri	37%	100%
A0A0N1IHL1	Leptomonas seymouri	39%	96%
A0A0N1PAY4	Leptomonas seymouri	47%	78%
A0A0N1PB77	Leptomonas seymouri	33%	100%
A0A0N1PBZ2	Leptomonas seymouri	64%	100%
A0A0N1PCC1	Leptomonas seymouri	43%	100%
A0A0S4INN8	Bodo saltans	29%	100%
A0A381MBI0	Leishmania infantum	44%	100%
A0A3Q8I8X7	Leishmania donovani	44%	100%
A0A3Q8IAZ0	Leishmania donovani	80%	98%
A0A3Q8IH50	Leishmania donovani	58%	95%
A0A3Q8IVN0	Leishmania donovani	37%	100%
A0A3R7M4J1	Trypanosoma rangeli	43%	100%
A0A3S5H5P4	Leishmania donovani	44%	100%
A0A3S5H5V2	Leishmania donovani	45%	100%
A0A3S5H6F6	Leishmania donovani	81%	98%
A0A3S5H763	Leishmania donovani	52%	100%
A0A3S7WR10	Leishmania donovani	44%	92%
A0A3S7WR14	Leishmania donovani	72%	100%
A0A3S7WR15	Leishmania donovani	68%	81%
A0A3S7WR24	Leishmania donovani	79%	97%
A4H4T8	Leishmania braziliensis	43%	100%
A4H5Y4	Leishmania braziliensis	45%	100%
A4H617	Leishmania braziliensis	96%	100%
A4H619	Leishmania braziliensis	97%	98%
A4H620	Leishmania braziliensis	58%	97%
A4H6C3	Leishmania braziliensis	44%	100%
A4HNH7	Leishmania braziliensis	36%	100%
A4HSS2	Leishmania infantum	44%	100%
A4HUE4	Leishmania infantum	44%	92%
A4HUE5	Leishmania infantum	68%	99%
A4HUE6	Leishmania infantum	72%	100%
A4HUE7	Leishmania infantum	80%	98%
A4HUE8	Leishmania infantum	79%	97%
A4HUF4	Leishmania infantum	80%	98%
A4HUF5	Leishmania infantum	57%	100%
A4HYA9	Leishmania infantum	52%	100%
A4IC33	Leishmania infantum	37%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	98%
E9AG72	Leishmania infantum	45%	100%
E9AI40	Leishmania braziliensis	83%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	92%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	96%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QDC4	Leishmania major	51%	100%
Q4QH81	Leishmania major	45%	100%
Q4QHH7	Leishmania major	57%	100%
Q4QHH8	Leishmania major	79%	100%
Q4QHH9	Leishmania major	78%	100%
Q4QHI0	Leishmania major	80%	100%
Q4QHI1	Leishmania major	73%	100%
Q4QHI2	Leishmania major	70%	100%
Q4QIU9	Leishmania major	44%	99%
Q4QJ48	Leishmania major	45%	100%
Q7KIP2	Leishmania major	36%	100%