Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H616_LEIBR

TriTrypDb:

LbrM.10.0360 , LBRM2903_100008600

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H616

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H616

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.637
CLV_C14_Caspase3-7	261	265	PF00656	0.556
CLV_NRD_NRD_1	162	164	PF00675	0.550
CLV_NRD_NRD_1	292	294	PF00675	0.501
CLV_PCSK_FUR_1	458	462	PF00082	0.698
CLV_PCSK_KEX2_1	116	118	PF00082	0.354
CLV_PCSK_KEX2_1	162	164	PF00082	0.550
CLV_PCSK_KEX2_1	291	293	PF00082	0.491
CLV_PCSK_KEX2_1	34	36	PF00082	0.509
CLV_PCSK_KEX2_1	460	462	PF00082	0.741
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.354
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.509
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.801
CLV_PCSK_SKI1_1	116	120	PF00082	0.376
CLV_PCSK_SKI1_1	180	184	PF00082	0.656
CLV_PCSK_SKI1_1	225	229	PF00082	0.553
CLV_Separin_Metazoa	361	365	PF03568	0.477
DEG_APCC_DBOX_1	131	139	PF00400	0.540
DEG_SPOP_SBC_1	81	85	PF00917	0.399
DOC_CYCLIN_yCln2_LP_2	209	212	PF00134	0.321
DOC_MAPK_MEF2A_6	336	345	PF00069	0.529
DOC_MAPK_NFAT4_5	336	344	PF00069	0.388
DOC_PP2B_LxvP_1	209	212	PF13499	0.321
DOC_PP4_FxxP_1	90	93	PF00568	0.419
DOC_USP7_MATH_1	237	241	PF00917	0.548
DOC_USP7_MATH_1	265	269	PF00917	0.394
DOC_USP7_MATH_1	298	302	PF00917	0.613
DOC_USP7_MATH_1	382	386	PF00917	0.621
DOC_USP7_MATH_1	431	435	PF00917	0.681
DOC_USP7_MATH_1	75	79	PF00917	0.590
DOC_WW_Pin1_4	241	246	PF00397	0.618
DOC_WW_Pin1_4	313	318	PF00397	0.581
DOC_WW_Pin1_4	35	40	PF00397	0.525
DOC_WW_Pin1_4	376	381	PF00397	0.525
DOC_WW_Pin1_4	42	47	PF00397	0.480
DOC_WW_Pin1_4	435	440	PF00397	0.638
LIG_14-3-3_CanoR_1	205	212	PF00244	0.513
LIG_14-3-3_CanoR_1	364	374	PF00244	0.487
LIG_Actin_WH2_2	189	207	PF00022	0.485
LIG_Actin_WH2_2	356	373	PF00022	0.574
LIG_BRCT_BRCA1_1	86	90	PF00533	0.331
LIG_FHA_1	205	211	PF00498	0.531
LIG_FHA_1	213	219	PF00498	0.427
LIG_FHA_1	351	357	PF00498	0.534
LIG_FHA_1	36	42	PF00498	0.568
LIG_FHA_1	391	397	PF00498	0.417
LIG_FHA_1	464	470	PF00498	0.575
LIG_FHA_1	52	58	PF00498	0.343
LIG_FHA_1	81	87	PF00498	0.413
LIG_FHA_1	97	103	PF00498	0.557
LIG_FHA_2	259	265	PF00498	0.464
LIG_GBD_Chelix_1	331	339	PF00786	0.521
LIG_HP1_1	9	13	PF01393	0.338
LIG_LIR_Apic_2	87	93	PF02991	0.407
LIG_LIR_Gen_1	215	223	PF02991	0.403
LIG_LIR_Gen_1	277	288	PF02991	0.671
LIG_LIR_Nem_3	122	128	PF02991	0.348
LIG_LIR_Nem_3	215	220	PF02991	0.400
LIG_LIR_Nem_3	277	283	PF02991	0.511
LIG_SH2_STAP1	223	227	PF00017	0.516
LIG_SH2_STAT5	148	151	PF00017	0.365
LIG_SH2_STAT5	256	259	PF00017	0.461
LIG_SH3_3	245	251	PF00018	0.467
LIG_SH3_3	43	49	PF00018	0.533
LIG_SH3_3	448	454	PF00018	0.662
LIG_SUMO_SIM_anti_2	141	146	PF11976	0.291
LIG_SUMO_SIM_anti_2	359	365	PF11976	0.556
LIG_SUMO_SIM_anti_2	393	398	PF11976	0.383
LIG_SUMO_SIM_par_1	171	177	PF11976	0.518
LIG_SUMO_SIM_par_1	218	224	PF11976	0.377
LIG_SUMO_SIM_par_1	392	398	PF11976	0.491
LIG_SUMO_SIM_par_1	399	404	PF11976	0.423
LIG_SUMO_SIM_par_1	8	14	PF11976	0.410
LIG_TRAF2_1	267	270	PF00917	0.575
LIG_TRAF2_1	327	330	PF00917	0.555
MOD_CDK_SPK_2	435	440	PF00069	0.719
MOD_CK1_1	154	160	PF00069	0.727
MOD_CK1_1	174	180	PF00069	0.454
MOD_CK1_1	229	235	PF00069	0.550
MOD_CK1_1	258	264	PF00069	0.499
MOD_CK1_1	348	354	PF00069	0.663
MOD_CK1_1	376	382	PF00069	0.616
MOD_CK1_1	65	71	PF00069	0.562
MOD_CK2_1	264	270	PF00069	0.476
MOD_CK2_1	323	329	PF00069	0.397
MOD_GlcNHglycan	108	111	PF01048	0.490
MOD_GlcNHglycan	176	179	PF01048	0.581
MOD_GlcNHglycan	228	231	PF01048	0.614
MOD_GlcNHglycan	257	260	PF01048	0.345
MOD_GlcNHglycan	300	303	PF01048	0.764
MOD_GlcNHglycan	325	328	PF01048	0.388
MOD_GlcNHglycan	397	400	PF01048	0.530
MOD_GlcNHglycan	461	464	PF01048	0.729
MOD_GlcNHglycan	64	67	PF01048	0.621
MOD_GlcNHglycan	86	89	PF01048	0.449
MOD_GSK3_1	106	113	PF00069	0.488
MOD_GSK3_1	151	158	PF00069	0.525
MOD_GSK3_1	225	232	PF00069	0.642
MOD_GSK3_1	233	240	PF00069	0.492
MOD_GSK3_1	260	267	PF00069	0.525
MOD_GSK3_1	293	300	PF00069	0.609
MOD_GSK3_1	309	316	PF00069	0.710
MOD_GSK3_1	345	352	PF00069	0.535
MOD_GSK3_1	378	385	PF00069	0.563
MOD_GSK3_1	431	438	PF00069	0.738
MOD_GSK3_1	459	466	PF00069	0.711
MOD_GSK3_1	58	65	PF00069	0.484
MOD_GSK3_1	76	83	PF00069	0.495
MOD_LATS_1	410	416	PF00433	0.485
MOD_N-GLC_1	284	289	PF02516	0.545
MOD_N-GLC_1	323	328	PF02516	0.395
MOD_NEK2_1	203	208	PF00069	0.471
MOD_NEK2_1	255	260	PF00069	0.515
MOD_NEK2_1	331	336	PF00069	0.398
MOD_NEK2_1	345	350	PF00069	0.502
MOD_NEK2_1	362	367	PF00069	0.538
MOD_NEK2_1	421	426	PF00069	0.625
MOD_NEK2_1	432	437	PF00069	0.525
MOD_NEK2_1	51	56	PF00069	0.443
MOD_NEK2_1	58	63	PF00069	0.469
MOD_NEK2_2	3	8	PF00069	0.345
MOD_PIKK_1	29	35	PF00454	0.502
MOD_PIKK_1	76	82	PF00454	0.421
MOD_PKA_2	154	160	PF00069	0.727
MOD_PKA_2	204	210	PF00069	0.465
MOD_PKA_2	308	314	PF00069	0.621
MOD_PKA_2	452	458	PF00069	0.676
MOD_PKB_1	291	299	PF00069	0.515
MOD_Plk_1	110	116	PF00069	0.466
MOD_Plk_1	284	290	PF00069	0.490
MOD_Plk_1	346	352	PF00069	0.449
MOD_Plk_4	11	17	PF00069	0.359
MOD_Plk_4	110	116	PF00069	0.414
MOD_Plk_4	284	290	PF00069	0.558
MOD_ProDKin_1	241	247	PF00069	0.611
MOD_ProDKin_1	313	319	PF00069	0.577
MOD_ProDKin_1	35	41	PF00069	0.527
MOD_ProDKin_1	376	382	PF00069	0.529
MOD_ProDKin_1	42	48	PF00069	0.476
MOD_ProDKin_1	435	441	PF00069	0.639
MOD_SUMO_for_1	182	185	PF00179	0.642
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.444
TRG_ER_diArg_1	290	293	PF00400	0.482
TRG_NES_CRM1_1	395	406	PF08389	0.524
TRG_NLS_Bipartite_1	162	184	PF00514	0.515
TRG_NLS_MonoExtC_3	179	185	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC0	Leptomonas seymouri	34%	87%
A0A3Q8I7N0	Leishmania donovani	69%	100%
A4HUE3	Leishmania infantum	69%	100%
E9AN43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QHI3	Leishmania major	68%	100%