Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 4, putative

Species:

Leishmania braziliensis

UniProt:

A4H613_LEIBR

TriTrypDb:

LbrM.10.0320 , LBRM2903_100008300

Length:

765

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H613

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H613

PDB structure(s): 6zpj_A , 6zpj_B

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.594
CLV_C14_Caspase3-7	393	397	PF00656	0.608
CLV_NRD_NRD_1	156	158	PF00675	0.790
CLV_NRD_NRD_1	193	195	PF00675	0.572
CLV_NRD_NRD_1	246	248	PF00675	0.558
CLV_NRD_NRD_1	411	413	PF00675	0.830
CLV_NRD_NRD_1	449	451	PF00675	0.715
CLV_NRD_NRD_1	452	454	PF00675	0.681
CLV_NRD_NRD_1	602	604	PF00675	0.500
CLV_NRD_NRD_1	82	84	PF00675	0.794
CLV_PCSK_FUR_1	450	454	PF00082	0.747
CLV_PCSK_KEX2_1	156	158	PF00082	0.725
CLV_PCSK_KEX2_1	193	195	PF00082	0.572
CLV_PCSK_KEX2_1	352	354	PF00082	0.720
CLV_PCSK_KEX2_1	391	393	PF00082	0.733
CLV_PCSK_KEX2_1	411	413	PF00082	0.830
CLV_PCSK_KEX2_1	451	453	PF00082	0.706
CLV_PCSK_KEX2_1	595	597	PF00082	0.566
CLV_PCSK_KEX2_1	602	604	PF00082	0.500
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.720
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.733
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.853
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.566
CLV_PCSK_PC7_1	387	393	PF00082	0.783
CLV_PCSK_PC7_1	447	453	PF00082	0.691
CLV_PCSK_SKI1_1	10	14	PF00082	0.630
CLV_PCSK_SKI1_1	172	176	PF00082	0.697
CLV_PCSK_SKI1_1	229	233	PF00082	0.546
CLV_PCSK_SKI1_1	257	261	PF00082	0.495
CLV_PCSK_SKI1_1	504	508	PF00082	0.745
CLV_PCSK_SKI1_1	603	607	PF00082	0.444
CLV_PCSK_SKI1_1	653	657	PF00082	0.485
CLV_PCSK_SKI1_1	702	706	PF00082	0.484
CLV_PCSK_SKI1_1	758	762	PF00082	0.512
CLV_Separin_Metazoa	7	11	PF03568	0.734
DEG_APCC_DBOX_1	712	720	PF00400	0.486
DEG_APCC_KENBOX_2	287	291	PF00400	0.677
DEG_Nend_UBRbox_3	1	3	PF02207	0.523
DEG_SCF_FBW7_1	455	461	PF00400	0.721
DEG_SCF_FBW7_1	492	497	PF00400	0.721
DEG_SPOP_SBC_1	639	643	PF00917	0.546
DOC_CKS1_1	165	170	PF01111	0.686
DOC_CKS1_1	426	431	PF01111	0.801
DOC_CKS1_1	455	460	PF01111	0.726
DOC_CYCLIN_RxL_1	254	262	PF00134	0.557
DOC_CYCLIN_RxL_1	699	708	PF00134	0.602
DOC_MAPK_gen_1	699	707	PF00069	0.596
DOC_PP4_FxxP_1	694	697	PF00568	0.497
DOC_USP7_MATH_1	135	139	PF00917	0.698
DOC_USP7_MATH_1	278	282	PF00917	0.517
DOC_USP7_MATH_1	331	335	PF00917	0.776
DOC_USP7_MATH_1	37	41	PF00917	0.585
DOC_USP7_MATH_1	390	394	PF00917	0.628
DOC_USP7_MATH_1	471	475	PF00917	0.762
DOC_USP7_MATH_1	494	498	PF00917	0.714
DOC_USP7_MATH_1	502	506	PF00917	0.697
DOC_USP7_MATH_1	514	518	PF00917	0.627
DOC_USP7_MATH_1	630	634	PF00917	0.684
DOC_USP7_MATH_1	729	733	PF00917	0.636
DOC_USP7_MATH_1	91	95	PF00917	0.620
DOC_USP7_MATH_1	98	102	PF00917	0.603
DOC_USP7_MATH_2	168	174	PF00917	0.565
DOC_WW_Pin1_4	131	136	PF00397	0.727
DOC_WW_Pin1_4	159	164	PF00397	0.688
DOC_WW_Pin1_4	419	424	PF00397	0.691
DOC_WW_Pin1_4	425	430	PF00397	0.673
DOC_WW_Pin1_4	451	456	PF00397	0.732
DOC_WW_Pin1_4	488	493	PF00397	0.728
DOC_WW_Pin1_4	508	513	PF00397	0.740
DOC_WW_Pin1_4	585	590	PF00397	0.639
DOC_WW_Pin1_4	648	653	PF00397	0.537
DOC_WW_Pin1_4	666	671	PF00397	0.458
DOC_WW_Pin1_4	94	99	PF00397	0.583
LIG_14-3-3_CanoR_1	10	19	PF00244	0.622
LIG_14-3-3_CanoR_1	119	123	PF00244	0.829
LIG_14-3-3_CanoR_1	172	177	PF00244	0.650
LIG_14-3-3_CanoR_1	238	242	PF00244	0.477
LIG_14-3-3_CanoR_1	325	330	PF00244	0.754
LIG_14-3-3_CanoR_1	340	347	PF00244	0.709
LIG_14-3-3_CanoR_1	379	389	PF00244	0.778
LIG_14-3-3_CanoR_1	392	400	PF00244	0.666
LIG_14-3-3_CanoR_1	504	514	PF00244	0.636
LIG_14-3-3_CanoR_1	596	601	PF00244	0.416
LIG_14-3-3_CanoR_1	616	624	PF00244	0.544
LIG_14-3-3_CanoR_1	702	708	PF00244	0.494
LIG_14-3-3_CanoR_1	758	765	PF00244	0.498
LIG_14-3-3_CanoR_1	76	85	PF00244	0.636
LIG_Actin_WH2_2	743	760	PF00022	0.515
LIG_Clathr_ClatBox_1	231	235	PF01394	0.404
LIG_Clathr_ClatBox_1	704	708	PF01394	0.501
LIG_FHA_1	139	145	PF00498	0.656
LIG_FHA_1	204	210	PF00498	0.620
LIG_FHA_1	426	432	PF00498	0.686
LIG_FHA_1	435	441	PF00498	0.785
LIG_FHA_1	455	461	PF00498	0.600
LIG_FHA_1	482	488	PF00498	0.723
LIG_FHA_1	575	581	PF00498	0.713
LIG_FHA_1	641	647	PF00498	0.536
LIG_FHA_2	165	171	PF00498	0.766
LIG_FHA_2	173	179	PF00498	0.703
LIG_FHA_2	223	229	PF00498	0.414
LIG_FHA_2	362	368	PF00498	0.563
LIG_FHA_2	37	43	PF00498	0.588
LIG_FHA_2	415	421	PF00498	0.819
LIG_FHA_2	459	465	PF00498	0.705
LIG_FHA_2	49	55	PF00498	0.744
LIG_FHA_2	749	755	PF00498	0.492
LIG_LIR_Gen_1	240	245	PF02991	0.471
LIG_LIR_LC3C_4	365	370	PF02991	0.560
LIG_LIR_Nem_3	240	244	PF02991	0.470
LIG_NRBOX	24	30	PF00104	0.466
LIG_NRBOX	255	261	PF00104	0.648
LIG_PDZ_Class_3	760	765	PF00595	0.669
LIG_SH2_CRK	241	245	PF00017	0.545
LIG_SH2_SRC	373	376	PF00017	0.753
LIG_SH2_STAP1	272	276	PF00017	0.549
LIG_SH2_STAP1	347	351	PF00017	0.604
LIG_SH2_STAT3	674	677	PF00017	0.579
LIG_SH2_STAT3	759	762	PF00017	0.614
LIG_SH2_STAT5	425	428	PF00017	0.812
LIG_SH2_STAT5	672	675	PF00017	0.460
LIG_SH3_1	145	151	PF00018	0.573
LIG_SH3_1	452	458	PF00018	0.735
LIG_SH3_2	591	596	PF14604	0.628
LIG_SH3_3	145	151	PF00018	0.573
LIG_SH3_3	171	177	PF00018	0.544
LIG_SH3_3	452	458	PF00018	0.735
LIG_SH3_3	524	530	PF00018	0.773
LIG_SH3_3	588	594	PF00018	0.657
LIG_SH3_3	704	710	PF00018	0.609
LIG_SUMO_SIM_anti_2	364	371	PF11976	0.559
LIG_SUMO_SIM_anti_2	746	752	PF11976	0.506
LIG_SUMO_SIM_par_1	703	708	PF11976	0.492
LIG_SUMO_SIM_par_1	746	752	PF11976	0.506
LIG_UBA3_1	605	610	PF00899	0.630
LIG_WW_3	62	66	PF00397	0.724
MOD_CDK_SPK_2	451	456	PF00069	0.743
MOD_CDK_SPK_2	648	653	PF00069	0.537
MOD_CK1_1	101	107	PF00069	0.677
MOD_CK1_1	109	115	PF00069	0.638
MOD_CK1_1	138	144	PF00069	0.781
MOD_CK1_1	342	348	PF00069	0.742
MOD_CK1_1	505	511	PF00069	0.591
MOD_CK1_1	575	581	PF00069	0.681
MOD_CK1_1	641	647	PF00069	0.549
MOD_CK1_1	676	682	PF00069	0.493
MOD_CK1_1	738	744	PF00069	0.498
MOD_CK1_1	94	100	PF00069	0.765
MOD_CK2_1	164	170	PF00069	0.725
MOD_CK2_1	309	315	PF00069	0.546
MOD_CK2_1	414	420	PF00069	0.723
MOD_CK2_1	43	49	PF00069	0.595
MOD_Cter_Amidation	409	412	PF01082	0.831
MOD_DYRK1A_RPxSP_1	587	591	PF00069	0.675
MOD_GlcNHglycan	267	270	PF01048	0.520
MOD_GlcNHglycan	348	351	PF01048	0.687
MOD_GlcNHglycan	447	450	PF01048	0.821
MOD_GlcNHglycan	473	476	PF01048	0.577
MOD_GlcNHglycan	516	519	PF01048	0.713
MOD_GlcNHglycan	574	577	PF01048	0.686
MOD_GlcNHglycan	581	584	PF01048	0.657
MOD_GlcNHglycan	618	621	PF01048	0.614
MOD_GlcNHglycan	65	68	PF01048	0.601
MOD_GlcNHglycan	662	665	PF01048	0.500
MOD_GlcNHglycan	678	681	PF01048	0.380
MOD_GlcNHglycan	729	732	PF01048	0.632
MOD_GlcNHglycan	737	740	PF01048	0.660
MOD_GlcNHglycan	751	754	PF01048	0.321
MOD_GlcNHglycan	93	96	PF01048	0.856
MOD_GlcNHglycan	98	101	PF01048	0.713
MOD_GSK3_1	131	138	PF00069	0.706
MOD_GSK3_1	159	166	PF00069	0.754
MOD_GSK3_1	274	281	PF00069	0.514
MOD_GSK3_1	338	345	PF00069	0.594
MOD_GSK3_1	37	44	PF00069	0.589
MOD_GSK3_1	390	397	PF00069	0.730
MOD_GSK3_1	414	421	PF00069	0.700
MOD_GSK3_1	441	448	PF00069	0.753
MOD_GSK3_1	454	461	PF00069	0.817
MOD_GSK3_1	490	497	PF00069	0.672
MOD_GSK3_1	498	505	PF00069	0.662
MOD_GSK3_1	531	538	PF00069	0.705
MOD_GSK3_1	570	577	PF00069	0.686
MOD_GSK3_1	579	586	PF00069	0.755
MOD_GSK3_1	735	742	PF00069	0.711
MOD_GSK3_1	94	101	PF00069	0.703
MOD_N-GLC_2	314	316	PF02516	0.552
MOD_NEK2_1	139	144	PF00069	0.854
MOD_NEK2_1	181	186	PF00069	0.563
MOD_NEK2_1	202	207	PF00069	0.519
MOD_NEK2_1	237	242	PF00069	0.506
MOD_NEK2_1	259	264	PF00069	0.541
MOD_NEK2_1	265	270	PF00069	0.527
MOD_NEK2_1	439	444	PF00069	0.620
MOD_NEK2_1	466	471	PF00069	0.787
MOD_NEK2_1	506	511	PF00069	0.745
MOD_NEK2_1	604	609	PF00069	0.514
MOD_NEK2_2	297	302	PF00069	0.542
MOD_NEK2_2	483	488	PF00069	0.739
MOD_PIKK_1	101	107	PF00454	0.831
MOD_PIKK_1	203	209	PF00454	0.551
MOD_PIKK_1	278	284	PF00454	0.536
MOD_PIKK_1	381	387	PF00454	0.593
MOD_PIKK_1	441	447	PF00454	0.729
MOD_PIKK_1	531	537	PF00454	0.756
MOD_PIKK_1	546	552	PF00454	0.539
MOD_PIKK_1	673	679	PF00454	0.587
MOD_PIKK_1	758	764	PF00454	0.641
MOD_PK_1	325	331	PF00069	0.564
MOD_PKA_1	391	397	PF00069	0.717
MOD_PKA_1	595	601	PF00069	0.418
MOD_PKA_2	118	124	PF00069	0.826
MOD_PKA_2	237	243	PF00069	0.590
MOD_PKA_2	324	330	PF00069	0.760
MOD_PKA_2	339	345	PF00069	0.710
MOD_PKA_2	391	397	PF00069	0.704
MOD_PKA_2	595	601	PF00069	0.418
MOD_Plk_1	502	508	PF00069	0.844
MOD_Plk_2-3	361	367	PF00069	0.563
MOD_Plk_4	106	112	PF00069	0.816
MOD_Plk_4	332	338	PF00069	0.764
MOD_ProDKin_1	131	137	PF00069	0.723
MOD_ProDKin_1	159	165	PF00069	0.689
MOD_ProDKin_1	419	425	PF00069	0.693
MOD_ProDKin_1	451	457	PF00069	0.730
MOD_ProDKin_1	488	494	PF00069	0.725
MOD_ProDKin_1	508	514	PF00069	0.738
MOD_ProDKin_1	585	591	PF00069	0.639
MOD_ProDKin_1	648	654	PF00069	0.531
MOD_ProDKin_1	666	672	PF00069	0.455
MOD_ProDKin_1	94	100	PF00069	0.582
MOD_SUMO_for_1	270	273	PF00179	0.611
MOD_SUMO_for_1	351	354	PF00179	0.599
MOD_SUMO_for_1	487	490	PF00179	0.838
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.570
TRG_ENDOCYTIC_2	241	244	PF00928	0.545
TRG_ENDOCYTIC_2	272	275	PF00928	0.650
TRG_ER_diArg_1	193	195	PF00400	0.525
TRG_ER_diArg_1	450	453	PF00400	0.692
TRG_ER_diArg_1	601	603	PF00400	0.521
TRG_NLS_MonoCore_2	449	454	PF00514	0.849
TRG_NLS_MonoExtC_3	450	455	PF00514	0.846
TRG_NLS_MonoExtN_4	447	454	PF00514	0.843
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8R5	Leptomonas seymouri	51%	100%
A0A3S7WR22	Leishmania donovani	78%	100%
A4HUE0	Leishmania infantum	78%	100%
E9AN40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QHI6	Leishmania major	78%	100%