Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania braziliensis

UniProt:

A4H610_LEIBR

TriTrypDb:

LbrM.10.0290 , LBRM2903_100007900 , LBRM2903_100008000

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H610

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H610

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	3
GO:0004518	nuclease activity	4	3
GO:0004527	exonuclease activity	5	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.644
CLV_C14_Caspase3-7	537	541	PF00656	0.529
CLV_C14_Caspase3-7	626	630	PF00656	0.537
CLV_MEL_PAP_1	116	122	PF00089	0.779
CLV_MEL_PAP_1	649	655	PF00089	0.465
CLV_MEL_PAP_1	734	740	PF00089	0.431
CLV_NRD_NRD_1	25	27	PF00675	0.544
CLV_NRD_NRD_1	327	329	PF00675	0.581
CLV_NRD_NRD_1	617	619	PF00675	0.318
CLV_NRD_NRD_1	727	729	PF00675	0.577
CLV_NRD_NRD_1	736	738	PF00675	0.570
CLV_NRD_NRD_1	825	827	PF00675	0.627
CLV_NRD_NRD_1	832	834	PF00675	0.536
CLV_PCSK_KEX2_1	24	26	PF00082	0.592
CLV_PCSK_KEX2_1	327	329	PF00082	0.582
CLV_PCSK_KEX2_1	617	619	PF00082	0.302
CLV_PCSK_KEX2_1	736	738	PF00082	0.580
CLV_PCSK_KEX2_1	825	827	PF00082	0.627
CLV_PCSK_KEX2_1	832	834	PF00082	0.536
CLV_PCSK_PC7_1	613	619	PF00082	0.317
CLV_PCSK_PC7_1	732	738	PF00082	0.637
CLV_PCSK_SKI1_1	136	140	PF00082	0.725
CLV_PCSK_SKI1_1	163	167	PF00082	0.633
CLV_PCSK_SKI1_1	407	411	PF00082	0.467
CLV_PCSK_SKI1_1	604	608	PF00082	0.325
CLV_PCSK_SKI1_1	832	836	PF00082	0.627
CLV_PCSK_SKI1_1	88	92	PF00082	0.649
DEG_APCC_DBOX_1	505	513	PF00400	0.476
DEG_APCC_DBOX_1	831	839	PF00400	0.621
DEG_COP1_1	695	704	PF00400	0.535
DEG_MDM2_SWIB_1	764	771	PF02201	0.659
DEG_SPOP_SBC_1	313	317	PF00917	0.754
DEG_SPOP_SBC_1	468	472	PF00917	0.622
DEG_SPOP_SBC_1	546	550	PF00917	0.537
DOC_CKS1_1	212	217	PF01111	0.538
DOC_CKS1_1	55	60	PF01111	0.776
DOC_CYCLIN_yClb1_LxF_4	604	610	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.666
DOC_MAPK_MEF2A_6	119	127	PF00069	0.778
DOC_MAPK_MEF2A_6	174	181	PF00069	0.608
DOC_PP1_RVXF_1	161	167	PF00149	0.666
DOC_PP1_RVXF_1	294	301	PF00149	0.658
DOC_PP1_RVXF_1	484	491	PF00149	0.312
DOC_PP2B_LxvP_1	285	288	PF13499	0.717
DOC_PP2B_LxvP_1	415	418	PF13499	0.535
DOC_PP2B_LxvP_1	431	434	PF13499	0.486
DOC_PP2B_LxvP_1	681	684	PF13499	0.726
DOC_PP4_FxxP_1	466	469	PF00568	0.486
DOC_PP4_FxxP_1	595	598	PF00568	0.476
DOC_USP7_MATH_1	134	138	PF00917	0.745
DOC_USP7_MATH_1	229	233	PF00917	0.638
DOC_USP7_MATH_1	268	272	PF00917	0.485
DOC_USP7_MATH_1	27	31	PF00917	0.759
DOC_USP7_MATH_1	313	317	PF00917	0.700
DOC_USP7_MATH_1	363	367	PF00917	0.763
DOC_USP7_MATH_1	459	463	PF00917	0.565
DOC_USP7_MATH_1	467	471	PF00917	0.531
DOC_USP7_MATH_1	623	627	PF00917	0.487
DOC_USP7_MATH_1	63	67	PF00917	0.738
DOC_USP7_MATH_1	630	634	PF00917	0.487
DOC_USP7_MATH_1	651	655	PF00917	0.601
DOC_USP7_MATH_1	709	713	PF00917	0.717
DOC_USP7_MATH_1	783	787	PF00917	0.688
DOC_USP7_MATH_1	900	904	PF00917	0.777
DOC_USP7_UBL2_3	74	78	PF12436	0.775
DOC_WW_Pin1_4	111	116	PF00397	0.719
DOC_WW_Pin1_4	158	163	PF00397	0.690
DOC_WW_Pin1_4	211	216	PF00397	0.773
DOC_WW_Pin1_4	339	344	PF00397	0.747
DOC_WW_Pin1_4	380	385	PF00397	0.684
DOC_WW_Pin1_4	386	391	PF00397	0.565
DOC_WW_Pin1_4	50	55	PF00397	0.721
DOC_WW_Pin1_4	801	806	PF00397	0.668
DOC_WW_Pin1_4	918	923	PF00397	0.651
LIG_14-3-3_CanoR_1	108	113	PF00244	0.782
LIG_14-3-3_CanoR_1	119	127	PF00244	0.766
LIG_14-3-3_CanoR_1	133	141	PF00244	0.599
LIG_14-3-3_CanoR_1	26	32	PF00244	0.780
LIG_14-3-3_CanoR_1	38	45	PF00244	0.644
LIG_14-3-3_CanoR_1	506	510	PF00244	0.479
LIG_14-3-3_CanoR_1	526	536	PF00244	0.345
LIG_14-3-3_CanoR_1	650	656	PF00244	0.616
LIG_14-3-3_CanoR_1	761	767	PF00244	0.706
LIG_APCC_ABBA_1	668	673	PF00400	0.579
LIG_BIR_III_2	716	720	PF00653	0.750
LIG_BIR_III_4	303	307	PF00653	0.502
LIG_BIR_III_4	347	351	PF00653	0.616
LIG_BRCT_BRCA1_1	388	392	PF00533	0.706
LIG_BRCT_BRCA1_1	393	397	PF00533	0.632
LIG_BRCT_BRCA1_1	785	789	PF00533	0.473
LIG_CaM_NSCaTE_8	249	256	PF13499	0.661
LIG_deltaCOP1_diTrp_1	461	466	PF00928	0.483
LIG_EH1_1	141	149	PF00400	0.450
LIG_FHA_1	419	425	PF00498	0.523
LIG_FHA_1	512	518	PF00498	0.531
LIG_FHA_1	55	61	PF00498	0.754
LIG_FHA_1	564	570	PF00498	0.550
LIG_FHA_1	589	595	PF00498	0.487
LIG_FHA_1	626	632	PF00498	0.389
LIG_FHA_1	676	682	PF00498	0.659
LIG_FHA_1	843	849	PF00498	0.608
LIG_FHA_1	85	91	PF00498	0.580
LIG_FHA_1	913	919	PF00498	0.578
LIG_FHA_2	197	203	PF00498	0.592
LIG_FHA_2	288	294	PF00498	0.717
LIG_FHA_2	506	512	PF00498	0.487
LIG_FHA_2	548	554	PF00498	0.476
LIG_FHA_2	62	68	PF00498	0.741
LIG_FHA_2	658	664	PF00498	0.525
LIG_FHA_2	690	696	PF00498	0.573
LIG_FHA_2	750	756	PF00498	0.647
LIG_LIR_Apic_2	465	469	PF02991	0.513
LIG_LIR_Apic_2	592	598	PF02991	0.516
LIG_LIR_Gen_1	185	194	PF02991	0.643
LIG_LIR_Gen_1	461	469	PF02991	0.488
LIG_LIR_Gen_1	763	771	PF02991	0.573
LIG_LIR_Gen_1	869	879	PF02991	0.696
LIG_LIR_Nem_3	394	400	PF02991	0.553
LIG_LIR_Nem_3	461	466	PF02991	0.447
LIG_LIR_Nem_3	534	539	PF02991	0.476
LIG_LIR_Nem_3	763	767	PF02991	0.566
LIG_LIR_Nem_3	786	792	PF02991	0.739
LIG_LIR_Nem_3	804	809	PF02991	0.662
LIG_LIR_Nem_3	869	874	PF02991	0.689
LIG_LYPXL_SIV_4	602	610	PF13949	0.537
LIG_Pex14_2	322	326	PF04695	0.515
LIG_Pex14_2	764	768	PF04695	0.671
LIG_Pex14_2	806	810	PF04695	0.502
LIG_PTAP_UEV_1	701	706	PF05743	0.527
LIG_PTAP_UEV_1	784	789	PF05743	0.470
LIG_REV1ctd_RIR_1	163	172	PF16727	0.637
LIG_SH2_CRK	282	286	PF00017	0.718
LIG_SH2_GRB2like	180	183	PF00017	0.620
LIG_SH2_SRC	180	183	PF00017	0.620
LIG_SH2_STAP1	186	190	PF00017	0.638
LIG_SH2_STAP1	413	417	PF00017	0.400
LIG_SH2_STAT5	180	183	PF00017	0.588
LIG_SH2_STAT5	282	285	PF00017	0.739
LIG_SH2_STAT5	587	590	PF00017	0.505
LIG_SH2_STAT5	614	617	PF00017	0.484
LIG_SH2_STAT5	669	672	PF00017	0.447
LIG_SH3_1	756	762	PF00018	0.465
LIG_SH3_3	149	155	PF00018	0.647
LIG_SH3_3	191	197	PF00018	0.705
LIG_SH3_3	461	467	PF00018	0.481
LIG_SH3_3	699	705	PF00018	0.807
LIG_SH3_3	756	762	PF00018	0.613
LIG_SH3_3	775	781	PF00018	0.778
LIG_SH3_3	782	788	PF00018	0.718
LIG_SH3_3	90	96	PF00018	0.818
LIG_SUMO_SIM_anti_2	376	381	PF11976	0.517
LIG_SUMO_SIM_anti_2	508	514	PF11976	0.551
LIG_SUMO_SIM_anti_2	843	851	PF11976	0.518
LIG_SUMO_SIM_par_1	508	514	PF11976	0.507
LIG_SUMO_SIM_par_1	843	851	PF11976	0.599
LIG_TRAF2_1	208	211	PF00917	0.682
LIG_TRAF2_1	444	447	PF00917	0.624
LIG_TRAF2_1	794	797	PF00917	0.770
LIG_TRFH_1	429	433	PF08558	0.472
LIG_TYR_ITIM	280	285	PF00017	0.707
MOD_CDK_SPK_2	158	163	PF00069	0.690
MOD_CDK_SPK_2	918	923	PF00069	0.495
MOD_CDK_SPxxK_3	339	346	PF00069	0.772
MOD_CK1_1	107	113	PF00069	0.697
MOD_CK1_1	218	224	PF00069	0.689
MOD_CK1_1	232	238	PF00069	0.779
MOD_CK1_1	30	36	PF00069	0.631
MOD_CK1_1	312	318	PF00069	0.732
MOD_CK1_1	37	43	PF00069	0.571
MOD_CK1_1	462	468	PF00069	0.429
MOD_CK1_1	686	692	PF00069	0.757
MOD_CK1_1	697	703	PF00069	0.797
MOD_CK1_1	708	714	PF00069	0.722
MOD_CK1_1	812	818	PF00069	0.699
MOD_CK1_1	894	900	PF00069	0.750
MOD_CK2_1	118	124	PF00069	0.692
MOD_CK2_1	182	188	PF00069	0.592
MOD_CK2_1	196	202	PF00069	0.625
MOD_CK2_1	287	293	PF00069	0.655
MOD_CK2_1	61	67	PF00069	0.655
MOD_CK2_1	689	695	PF00069	0.571
MOD_GlcNHglycan	10	13	PF01048	0.742
MOD_GlcNHglycan	136	139	PF01048	0.763
MOD_GlcNHglycan	206	209	PF01048	0.676
MOD_GlcNHglycan	254	257	PF01048	0.667
MOD_GlcNHglycan	29	32	PF01048	0.617
MOD_GlcNHglycan	311	314	PF01048	0.774
MOD_GlcNHglycan	316	319	PF01048	0.780
MOD_GlcNHglycan	33	36	PF01048	0.692
MOD_GlcNHglycan	334	338	PF01048	0.597
MOD_GlcNHglycan	365	368	PF01048	0.736
MOD_GlcNHglycan	373	376	PF01048	0.742
MOD_GlcNHglycan	501	504	PF01048	0.277
MOD_GlcNHglycan	536	539	PF01048	0.276
MOD_GlcNHglycan	625	628	PF01048	0.272
MOD_GlcNHglycan	632	635	PF01048	0.278
MOD_GlcNHglycan	689	692	PF01048	0.739
MOD_GlcNHglycan	695	699	PF01048	0.740
MOD_GlcNHglycan	702	705	PF01048	0.686
MOD_GlcNHglycan	707	710	PF01048	0.577
MOD_GlcNHglycan	711	714	PF01048	0.643
MOD_GlcNHglycan	785	788	PF01048	0.713
MOD_GlcNHglycan	816	819	PF01048	0.697
MOD_GlcNHglycan	876	880	PF01048	0.683
MOD_GlcNHglycan	892	897	PF01048	0.706
MOD_GlcNHglycan	902	905	PF01048	0.675
MOD_GSK3_1	104	111	PF00069	0.706
MOD_GSK3_1	2	9	PF00069	0.707
MOD_GSK3_1	211	218	PF00069	0.769
MOD_GSK3_1	26	33	PF00069	0.648
MOD_GSK3_1	308	315	PF00069	0.717
MOD_GSK3_1	34	41	PF00069	0.650
MOD_GSK3_1	371	378	PF00069	0.712
MOD_GSK3_1	467	474	PF00069	0.621
MOD_GSK3_1	50	57	PF00069	0.737
MOD_GSK3_1	527	534	PF00069	0.572
MOD_GSK3_1	630	637	PF00069	0.589
MOD_GSK3_1	683	690	PF00069	0.649
MOD_GSK3_1	693	700	PF00069	0.773
MOD_GSK3_1	704	711	PF00069	0.751
MOD_GSK3_1	797	804	PF00069	0.733
MOD_GSK3_1	809	816	PF00069	0.594
MOD_GSK3_1	84	91	PF00069	0.703
MOD_GSK3_1	888	895	PF00069	0.698
MOD_LATS_1	23	29	PF00433	0.544
MOD_N-GLC_1	168	173	PF02516	0.636
MOD_N-GLC_1	221	226	PF02516	0.804
MOD_N-GLC_1	686	691	PF02516	0.512
MOD_N-GLC_1	749	754	PF02516	0.642
MOD_NEK2_1	189	194	PF00069	0.629
MOD_NEK2_1	308	313	PF00069	0.688
MOD_NEK2_1	427	432	PF00069	0.567
MOD_NEK2_1	513	518	PF00069	0.389
MOD_NEK2_1	561	566	PF00069	0.483
MOD_NEK2_1	589	594	PF00069	0.513
MOD_NEK2_1	6	11	PF00069	0.539
MOD_NEK2_1	917	922	PF00069	0.626
MOD_NEK2_2	350	355	PF00069	0.688
MOD_NEK2_2	762	767	PF00069	0.699
MOD_NEK2_2	866	871	PF00069	0.692
MOD_PIKK_1	38	44	PF00454	0.538
MOD_PIKK_1	561	567	PF00454	0.507
MOD_PIKK_1	634	640	PF00454	0.618
MOD_PIKK_1	736	742	PF00454	0.670
MOD_PIKK_1	769	775	PF00454	0.537
MOD_PK_1	44	50	PF00069	0.526
MOD_PKA_1	25	31	PF00069	0.545
MOD_PKA_1	736	742	PF00069	0.653
MOD_PKA_2	107	113	PF00069	0.655
MOD_PKA_2	118	124	PF00069	0.782
MOD_PKA_2	25	31	PF00069	0.732
MOD_PKA_2	268	274	PF00069	0.701
MOD_PKA_2	308	314	PF00069	0.627
MOD_PKA_2	37	43	PF00069	0.735
MOD_PKA_2	505	511	PF00069	0.479
MOD_PKA_2	527	533	PF00069	0.508
MOD_PKA_2	534	540	PF00069	0.449
MOD_PKA_2	651	657	PF00069	0.617
MOD_PKA_2	736	742	PF00069	0.670
MOD_PKA_2	760	766	PF00069	0.663
MOD_PKA_2	900	906	PF00069	0.797
MOD_PKB_1	24	32	PF00069	0.638
MOD_PKB_1	307	315	PF00069	0.508
MOD_Plk_1	168	174	PF00069	0.566
MOD_Plk_1	375	381	PF00069	0.678
MOD_Plk_1	445	451	PF00069	0.759
MOD_Plk_1	589	595	PF00069	0.562
MOD_Plk_1	634	640	PF00069	0.588
MOD_Plk_1	776	782	PF00069	0.532
MOD_Plk_1	842	848	PF00069	0.579
MOD_Plk_4	350	356	PF00069	0.675
MOD_Plk_4	459	465	PF00069	0.363
MOD_Plk_4	505	511	PF00069	0.491
MOD_Plk_4	513	519	PF00069	0.471
MOD_Plk_4	563	569	PF00069	0.487
MOD_Plk_4	651	657	PF00069	0.578
MOD_Plk_4	676	682	PF00069	0.714
MOD_Plk_4	842	848	PF00069	0.500
MOD_ProDKin_1	111	117	PF00069	0.716
MOD_ProDKin_1	158	164	PF00069	0.690
MOD_ProDKin_1	211	217	PF00069	0.775
MOD_ProDKin_1	339	345	PF00069	0.744
MOD_ProDKin_1	380	386	PF00069	0.683
MOD_ProDKin_1	50	56	PF00069	0.720
MOD_ProDKin_1	801	807	PF00069	0.669
MOD_ProDKin_1	918	924	PF00069	0.650
MOD_SUMO_rev_2	572	579	PF00179	0.516
MOD_SUMO_rev_2	66	75	PF00179	0.532
TRG_ENDOCYTIC_2	186	189	PF00928	0.633
TRG_ENDOCYTIC_2	282	285	PF00928	0.713
TRG_ENDOCYTIC_2	400	403	PF00928	0.317
TRG_ER_diArg_1	197	200	PF00400	0.666
TRG_ER_diArg_1	24	26	PF00400	0.823
TRG_ER_diArg_1	326	328	PF00400	0.646
TRG_ER_diArg_1	525	528	PF00400	0.554
TRG_ER_diArg_1	532	535	PF00400	0.523
TRG_ER_diArg_1	617	619	PF00400	0.518
TRG_ER_diArg_1	649	652	PF00400	0.588
TRG_ER_diArg_1	736	738	PF00400	0.433
TRG_ER_diArg_1	824	826	PF00400	0.639
TRG_ER_diArg_1	832	834	PF00400	0.529
TRG_NES_CRM1_1	511	527	PF08389	0.551
TRG_NLS_MonoExtN_4	76	82	PF00514	0.768
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	608	612	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	617	621	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK4	Leptomonas seymouri	52%	94%
A0A0S4JVL6	Bodo saltans	30%	100%
A0A1X0NQ48	Trypanosomatidae	36%	100%
A0A3Q8I8M2	Leishmania donovani	72%	100%
A0A422NRV3	Trypanosoma rangeli	39%	100%
A4HUD7	Leishmania infantum	72%	100%
C9ZVF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AN37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QHI9	Leishmania major	72%	100%
V5DA05	Trypanosoma cruzi	36%	100%