4a-hydroxytetrahydrobiopterin dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pterin 4 alpha carbinolamine dehydratase, putative

Species:

Leishmania braziliensis

UniProt:

A4H608_LEIBR

TriTrypDb:

LbrM.10.0270 , LBRM2903_100007700

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H608

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H608

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006729	tetrahydrobiopterin biosynthetic process	6	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019751	polyol metabolic process	4	11
GO:0034311	diol metabolic process	5	11
GO:0034312	diol biosynthetic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0042558	pteridine-containing compound metabolic process	4	11
GO:0042559	pteridine-containing compound biosynthetic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046146	tetrahydrobiopterin metabolic process	5	11
GO:0046165	alcohol biosynthetic process	4	11
GO:0046173	polyol biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	5	11
GO:0016829	lyase activity	2	11
GO:0016835	carbon-oxygen lyase activity	3	11
GO:0016836	hydro-lyase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.515
CLV_C14_Caspase3-7	245	249	PF00656	0.556
CLV_C14_Caspase3-7	94	98	PF00656	0.649
CLV_NRD_NRD_1	200	202	PF00675	0.486
CLV_NRD_NRD_1	208	210	PF00675	0.553
CLV_NRD_NRD_1	234	236	PF00675	0.423
CLV_NRD_NRD_1	71	73	PF00675	0.425
CLV_PCSK_KEX2_1	184	186	PF00082	0.297
CLV_PCSK_KEX2_1	208	210	PF00082	0.518
CLV_PCSK_KEX2_1	234	236	PF00082	0.423
CLV_PCSK_KEX2_1	71	73	PF00082	0.425
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.297
CLV_PCSK_PC7_1	180	186	PF00082	0.297
CLV_PCSK_SKI1_1	83	87	PF00082	0.404
DEG_SCF_FBW7_1	118	124	PF00400	0.478
DEG_SPOP_SBC_1	104	108	PF00917	0.726
DOC_CKS1_1	118	123	PF01111	0.479
DOC_PP4_FxxP_1	23	26	PF00568	0.737
DOC_USP7_MATH_1	103	107	PF00917	0.715
DOC_USP7_MATH_1	113	117	PF00917	0.523
DOC_USP7_MATH_1	35	39	PF00917	0.570
DOC_WW_Pin1_4	117	122	PF00397	0.524
DOC_WW_Pin1_4	173	178	PF00397	0.252
DOC_WW_Pin1_4	256	261	PF00397	0.626
LIG_14-3-3_CanoR_1	20	24	PF00244	0.643
LIG_14-3-3_CanoR_1	234	239	PF00244	0.499
LIG_14-3-3_CanoR_1	251	260	PF00244	0.692
LIG_14-3-3_CanoR_1	28	36	PF00244	0.674
LIG_Actin_WH2_2	225	241	PF00022	0.514
LIG_BRCT_BRCA1_1	175	179	PF00533	0.279
LIG_FHA_1	169	175	PF00498	0.321
LIG_FHA_1	238	244	PF00498	0.599
LIG_LIR_Apic_2	22	26	PF02991	0.480
LIG_LIR_Gen_1	120	131	PF02991	0.592
LIG_LIR_Gen_1	134	145	PF02991	0.306
LIG_LIR_Gen_1	49	60	PF02991	0.555
LIG_LIR_Nem_3	120	126	PF02991	0.637
LIG_LIR_Nem_3	134	140	PF02991	0.299
LIG_LIR_Nem_3	176	182	PF02991	0.279
LIG_LIR_Nem_3	49	55	PF02991	0.554
LIG_NRBOX	2	8	PF00104	0.495
LIG_Pex14_1	151	155	PF04695	0.296
LIG_Pex14_1	88	92	PF04695	0.496
LIG_PTAP_UEV_1	12	17	PF05743	0.474
LIG_PTB_Apo_2	191	198	PF02174	0.385
LIG_PTB_Phospho_1	191	197	PF10480	0.297
LIG_SH2_NCK_1	92	96	PF00017	0.604
LIG_SH2_SRC	173	176	PF00017	0.297
LIG_SH2_SRC	92	95	PF00017	0.507
LIG_SH2_STAP1	92	96	PF00017	0.604
LIG_SH2_STAT5	144	147	PF00017	0.303
LIG_SH2_STAT5	173	176	PF00017	0.297
LIG_SH3_2	13	18	PF14604	0.476
LIG_SH3_3	10	16	PF00018	0.476
LIG_SH3_3	115	121	PF00018	0.694
LIG_TRAF2_1	242	245	PF00917	0.556
LIG_ULM_U2AF65_1	201	206	PF00076	0.492
MOD_CDK_SPxxK_3	173	180	PF00069	0.252
MOD_CDK_SPxxK_3	256	263	PF00069	0.458
MOD_CK1_1	106	112	PF00069	0.741
MOD_CK1_1	124	130	PF00069	0.327
MOD_CK1_1	200	206	PF00069	0.371
MOD_CK1_1	252	258	PF00069	0.666
MOD_CK1_1	31	37	PF00069	0.679
MOD_CK1_1	38	44	PF00069	0.517
MOD_CK2_1	111	117	PF00069	0.726
MOD_CK2_1	180	186	PF00069	0.279
MOD_CK2_1	265	271	PF00069	0.706
MOD_GlcNHglycan	111	114	PF01048	0.661
MOD_GlcNHglycan	254	257	PF01048	0.584
MOD_GlcNHglycan	33	36	PF01048	0.676
MOD_GlcNHglycan	37	40	PF01048	0.667
MOD_GSK3_1	103	110	PF00069	0.746
MOD_GSK3_1	113	120	PF00069	0.733
MOD_GSK3_1	161	168	PF00069	0.322
MOD_GSK3_1	252	259	PF00069	0.598
MOD_GSK3_1	31	38	PF00069	0.637
MOD_GSK3_1	7	14	PF00069	0.616
MOD_N-GLC_1	197	202	PF02516	0.312
MOD_NEK2_1	19	24	PF00069	0.649
MOD_NEK2_1	55	60	PF00069	0.507
MOD_NEK2_1	7	12	PF00069	0.561
MOD_NEK2_1	81	86	PF00069	0.392
MOD_PIKK_1	121	127	PF00454	0.461
MOD_PIKK_1	39	45	PF00454	0.603
MOD_PKA_1	234	240	PF00069	0.367
MOD_PKA_2	19	25	PF00069	0.619
MOD_PKA_2	200	206	PF00069	0.504
MOD_PKA_2	234	240	PF00069	0.561
MOD_PKA_2	7	13	PF00069	0.616
MOD_ProDKin_1	117	123	PF00069	0.524
MOD_ProDKin_1	173	179	PF00069	0.252
MOD_ProDKin_1	256	262	PF00069	0.630
TRG_DiLeu_BaEn_2	141	147	PF01217	0.410
TRG_DiLeu_BaEn_2	76	82	PF01217	0.410
TRG_ENDOCYTIC_2	144	147	PF00928	0.279
TRG_ENDOCYTIC_2	92	95	PF00928	0.598
TRG_ER_diArg_1	208	210	PF00400	0.553
TRG_ER_diArg_1	71	74	PF00400	0.428
TRG_NLS_Bipartite_1	184	205	PF00514	0.395
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W5	Leptomonas seymouri	66%	100%
A0A0S4IXY6	Bodo saltans	42%	100%
A0A1X0NQ34	Trypanosomatidae	59%	100%
A0A3S7WR02	Leishmania donovani	78%	100%
A4HUD5	Leishmania infantum	78%	100%
C9ZVG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	88%
E9AN35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QHJ1	Leishmania major	77%	100%
V5BIH1	Trypanosoma cruzi	59%	100%