Amastin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Amastin

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania braziliensis

UniProt:

A4H606_LEIBR

TriTrypDb:

LbrM.10.0250 , LBRM2903_100007500

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A4H606

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H606

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.397
CLV_NRD_NRD_1	60	62	PF00675	0.261
CLV_PCSK_KEX2_1	115	117	PF00082	0.518
CLV_PCSK_SKI1_1	116	120	PF00082	0.482
DOC_MAPK_gen_1	145	154	PF00069	0.397
DOC_MAPK_HePTP_8	142	154	PF00069	0.204
DOC_MAPK_MEF2A_6	145	154	PF00069	0.451
DOC_MAPK_MEF2A_6	333	341	PF00069	0.554
DOC_USP7_MATH_1	236	240	PF00917	0.376
DOC_USP7_MATH_1	289	293	PF00917	0.391
DOC_USP7_UBL2_3	329	333	PF12436	0.397
DOC_WW_Pin1_4	102	107	PF00397	0.248
DOC_WW_Pin1_4	231	236	PF00397	0.442
LIG_14-3-3_CanoR_1	216	224	PF00244	0.485
LIG_14-3-3_CanoR_1	280	285	PF00244	0.294
LIG_14-3-3_CanoR_1	301	311	PF00244	0.306
LIG_14-3-3_CanoR_1	358	363	PF00244	0.314
LIG_APCC_ABBA_1	258	263	PF00400	0.206
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BRCT_BRCA1_1	304	308	PF00533	0.321
LIG_BRCT_BRCA1_1	31	35	PF00533	0.570
LIG_BRCT_BRCA1_1	342	346	PF00533	0.387
LIG_BRCT_BRCA1_1	73	77	PF00533	0.384
LIG_FHA_1	151	157	PF00498	0.286
LIG_FHA_1	158	164	PF00498	0.335
LIG_FHA_1	219	225	PF00498	0.563
LIG_FHA_1	255	261	PF00498	0.366
LIG_FHA_1	263	269	PF00498	0.273
LIG_FHA_1	305	311	PF00498	0.325
LIG_FHA_1	340	346	PF00498	0.359
LIG_FHA_1	362	368	PF00498	0.314
LIG_FHA_1	392	398	PF00498	0.303
LIG_FHA_1	406	412	PF00498	0.326
LIG_GBD_Chelix_1	134	142	PF00786	0.258
LIG_LIR_Apic_2	372	378	PF02991	0.248
LIG_LIR_Gen_1	123	132	PF02991	0.418
LIG_LIR_Gen_1	167	176	PF02991	0.376
LIG_LIR_Gen_1	203	212	PF02991	0.361
LIG_LIR_Gen_1	305	316	PF02991	0.348
LIG_LIR_Gen_1	342	352	PF02991	0.437
LIG_LIR_Gen_1	74	85	PF02991	0.276
LIG_LIR_Nem_3	105	110	PF02991	0.274
LIG_LIR_Nem_3	123	128	PF02991	0.440
LIG_LIR_Nem_3	167	171	PF02991	0.405
LIG_LIR_Nem_3	174	178	PF02991	0.358
LIG_LIR_Nem_3	257	262	PF02991	0.264
LIG_LIR_Nem_3	305	311	PF02991	0.370
LIG_LIR_Nem_3	342	347	PF02991	0.359
LIG_LIR_Nem_3	387	391	PF02991	0.265
LIG_LIR_Nem_3	74	80	PF02991	0.276
LIG_LIR_Nem_3	97	102	PF02991	0.299
LIG_NRBOX	127	133	PF00104	0.231
LIG_Pex14_2	318	322	PF04695	0.256
LIG_PTB_Apo_2	170	177	PF02174	0.204
LIG_PTB_Phospho_1	170	176	PF10480	0.204
LIG_RPA_C_Fungi	187	199	PF08784	0.258
LIG_SH2_CRK	178	182	PF00017	0.255
LIG_SH2_CRK	232	236	PF00017	0.399
LIG_SH2_CRK	375	379	PF00017	0.445
LIG_SH2_GRB2like	272	275	PF00017	0.327
LIG_SH2_NCK_1	232	236	PF00017	0.204
LIG_SH2_STAT5	413	416	PF00017	0.373
LIG_SH3_3	364	370	PF00018	0.471
LIG_SUMO_SIM_anti_2	158	163	PF11976	0.204
LIG_SUMO_SIM_anti_2	312	319	PF11976	0.204
LIG_SUMO_SIM_par_1	130	136	PF11976	0.334
LIG_SUMO_SIM_par_1	152	158	PF11976	0.308
LIG_SUMO_SIM_par_1	160	167	PF11976	0.323
LIG_SUMO_SIM_par_1	197	203	PF11976	0.405
LIG_SUMO_SIM_par_1	245	251	PF11976	0.374
LIG_SUMO_SIM_par_1	312	319	PF11976	0.227
LIG_TRAF2_1	42	45	PF00917	0.486
LIG_TYR_ITIM	270	275	PF00017	0.288
LIG_TYR_ITIM	411	416	PF00017	0.373
LIG_UBA3_1	137	145	PF00899	0.277
LIG_WRC_WIRS_1	201	206	PF05994	0.365
LIG_WRC_WIRS_1	317	322	PF05994	0.288
LIG_WRC_WIRS_1	72	77	PF05994	0.230
MOD_CDK_SPxK_1	102	108	PF00069	0.204
MOD_CK1_1	133	139	PF00069	0.400
MOD_CK1_1	309	315	PF00069	0.393
MOD_CK1_1	71	77	PF00069	0.373
MOD_CK2_1	220	226	PF00069	0.405
MOD_CK2_1	280	286	PF00069	0.318
MOD_CMANNOS	96	99	PF00535	0.373
MOD_Cter_Amidation	59	62	PF01082	0.302
MOD_GlcNHglycan	1	4	PF01048	0.613
MOD_GlcNHglycan	20	23	PF01048	0.611
MOD_GlcNHglycan	238	241	PF01048	0.383
MOD_GlcNHglycan	242	245	PF01048	0.388
MOD_GlcNHglycan	304	307	PF01048	0.417
MOD_GlcNHglycan	364	367	PF01048	0.424
MOD_GlcNHglycan	401	404	PF01048	0.407
MOD_GlcNHglycan	57	61	PF01048	0.517
MOD_GSK3_1	218	225	PF00069	0.596
MOD_GSK3_1	231	238	PF00069	0.307
MOD_GSK3_1	248	255	PF00069	0.431
MOD_GSK3_1	289	296	PF00069	0.330
MOD_GSK3_1	302	309	PF00069	0.384
MOD_GSK3_1	316	323	PF00069	0.491
MOD_GSK3_1	353	360	PF00069	0.407
MOD_GSK3_1	6	13	PF00069	0.517
MOD_N-GLC_1	10	15	PF02516	0.525
MOD_N-GLC_1	102	107	PF02516	0.312
MOD_N-GLC_1	218	223	PF02516	0.487
MOD_N-GLC_1	280	285	PF02516	0.405
MOD_N-GLC_1	29	34	PF02516	0.533
MOD_NEK2_1	150	155	PF00069	0.317
MOD_NEK2_1	218	223	PF00069	0.552
MOD_NEK2_1	248	253	PF00069	0.429
MOD_NEK2_1	302	307	PF00069	0.401
MOD_NEK2_1	316	321	PF00069	0.367
MOD_NEK2_1	339	344	PF00069	0.411
MOD_NEK2_1	362	367	PF00069	0.464
MOD_NEK2_1	399	404	PF00069	0.381
MOD_NEK2_1	79	84	PF00069	0.361
MOD_PIKK_1	252	258	PF00454	0.286
MOD_PIKK_1	293	299	PF00454	0.453
MOD_PKA_2	357	363	PF00069	0.385
MOD_PKA_2	6	12	PF00069	0.538
MOD_Plk_1	218	224	PF00069	0.338
MOD_Plk_1	280	286	PF00069	0.510
MOD_Plk_1	29	35	PF00069	0.580
MOD_Plk_4	133	139	PF00069	0.383
MOD_Plk_4	150	156	PF00069	0.295
MOD_Plk_4	157	163	PF00069	0.341
MOD_Plk_4	254	260	PF00069	0.326
MOD_Plk_4	340	346	PF00069	0.386
MOD_ProDKin_1	102	108	PF00069	0.275
MOD_ProDKin_1	231	237	PF00069	0.204
TRG_ENDOCYTIC_2	178	181	PF00928	0.511
TRG_ENDOCYTIC_2	272	275	PF00928	0.474
TRG_ENDOCYTIC_2	413	416	PF00928	0.373
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X2	Leptomonas seymouri	26%	82%
A0A0N1PC74	Leptomonas seymouri	25%	83%
A0A0N1PCA2	Leptomonas seymouri	54%	100%
A0A0S4IH58	Bodo saltans	25%	71%
A0A3Q8I8Q6	Leishmania donovani	25%	85%
A0A3S7WR28	Leishmania donovani	66%	100%
A0A3S7X1E1	Leishmania donovani	27%	81%
A4H605	Leishmania braziliensis	24%	100%
A4HGF8	Leishmania braziliensis	28%	80%
A4HUD2	Leishmania infantum	25%	85%
A4HUD3	Leishmania infantum	67%	100%
A4I3I9	Leishmania infantum	28%	81%
E9AN32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	88%
E9AN33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
E9AZT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	80%
Q4Q8F3	Leishmania major	27%	100%
Q4QHJ3	Leishmania major	67%	100%
Q4QHJ4	Leishmania major	26%	100%