Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania braziliensis

UniProt:

A4H605_LEIBR

TriTrypDb:

LbrM.10.0240 , LBRM2903_100007400

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4H605

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H605

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.486
CLV_NRD_NRD_1	94	96	PF00675	0.420
CLV_PCSK_FUR_1	92	96	PF00082	0.372
CLV_PCSK_KEX2_1	53	55	PF00082	0.376
CLV_PCSK_KEX2_1	94	96	PF00082	0.418
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.325
CLV_PCSK_SKI1_1	267	271	PF00082	0.438
CLV_PCSK_SKI1_1	414	418	PF00082	0.289
CLV_PCSK_SKI1_1	74	78	PF00082	0.405
CLV_PCSK_SKI1_1	79	83	PF00082	0.405
DEG_MDM2_SWIB_1	302	310	PF02201	0.474
DOC_MAPK_gen_1	314	323	PF00069	0.449
DOC_MAPK_gen_1	383	393	PF00069	0.312
DOC_MAPK_gen_1	414	422	PF00069	0.469
DOC_MAPK_HePTP_8	341	353	PF00069	0.218
DOC_MAPK_MEF2A_6	316	325	PF00069	0.449
DOC_MAPK_MEF2A_6	344	353	PF00069	0.218
DOC_PP1_RVXF_1	314	321	PF00149	0.449
DOC_USP7_MATH_1	208	212	PF00917	0.276
DOC_USP7_MATH_1	25	29	PF00917	0.705
DOC_USP7_MATH_1	269	273	PF00917	0.206
DOC_USP7_MATH_1	31	35	PF00917	0.702
DOC_USP7_MATH_1	37	41	PF00917	0.702
DOC_WW_Pin1_4	447	452	PF00397	0.255
LIG_14-3-3_CanoR_1	144	150	PF00244	0.243
LIG_14-3-3_CanoR_1	169	176	PF00244	0.281
LIG_14-3-3_CanoR_1	366	371	PF00244	0.413
LIG_14-3-3_CanoR_1	95	101	PF00244	0.595
LIG_BIR_II_1	1	5	PF00653	0.755
LIG_BRCT_BRCA1_1	244	248	PF00533	0.280
LIG_BRCT_BRCA1_1	418	422	PF00533	0.344
LIG_BRCT_BRCA1_1	425	429	PF00533	0.352
LIG_FHA_1	208	214	PF00498	0.251
LIG_FHA_1	291	297	PF00498	0.282
LIG_FHA_1	305	311	PF00498	0.575
LIG_FHA_1	313	319	PF00498	0.555
LIG_FHA_1	394	400	PF00498	0.267
LIG_FHA_1	494	500	PF00498	0.338
LIG_FHA_2	117	123	PF00498	0.638
LIG_FHA_2	13	19	PF00498	0.757
LIG_FHA_2	46	52	PF00498	0.730
LIG_FHA_2	478	484	PF00498	0.222
LIG_GBD_Chelix_1	432	440	PF00786	0.205
LIG_LIR_Gen_1	245	256	PF02991	0.320
LIG_LIR_Gen_1	382	392	PF02991	0.298
LIG_LIR_Gen_1	395	405	PF02991	0.314
LIG_LIR_Gen_1	426	437	PF02991	0.402
LIG_LIR_Gen_1	455	465	PF02991	0.294
LIG_LIR_Gen_1	483	489	PF02991	0.211
LIG_LIR_LC3C_4	252	257	PF02991	0.338
LIG_LIR_Nem_3	242	246	PF02991	0.321
LIG_LIR_Nem_3	247	251	PF02991	0.341
LIG_LIR_Nem_3	252	256	PF02991	0.371
LIG_LIR_Nem_3	329	335	PF02991	0.320
LIG_LIR_Nem_3	345	349	PF02991	0.249
LIG_LIR_Nem_3	382	387	PF02991	0.293
LIG_LIR_Nem_3	395	401	PF02991	0.314
LIG_LIR_Nem_3	426	432	PF02991	0.320
LIG_LIR_Nem_3	459	465	PF02991	0.290
LIG_LIR_Nem_3	473	479	PF02991	0.265
LIG_LIR_Nem_3	483	488	PF02991	0.298
LIG_PAM2_1	148	160	PF00658	0.249
LIG_Pex14_1	342	346	PF04695	0.289
LIG_Pex14_2	239	243	PF04695	0.282
LIG_Pex14_2	244	248	PF04695	0.282
LIG_Pex14_2	302	306	PF04695	0.458
LIG_Rb_LxCxE_1	66	83	PF01857	0.515
LIG_REV1ctd_RIR_1	300	308	PF16727	0.329
LIG_SH2_CRK	147	151	PF00017	0.338
LIG_SH2_CRK	384	388	PF00017	0.255
LIG_SH2_CRK	462	466	PF00017	0.347
LIG_SH2_PTP2	322	325	PF00017	0.276
LIG_SH2_STAP1	199	203	PF00017	0.232
LIG_SH2_STAP1	281	285	PF00017	0.205
LIG_SH2_STAP1	424	428	PF00017	0.426
LIG_SH2_STAT3	199	202	PF00017	0.249
LIG_SH2_STAT5	14	17	PF00017	0.623
LIG_SH2_STAT5	147	150	PF00017	0.345
LIG_SH2_STAT5	262	265	PF00017	0.209
LIG_SH2_STAT5	3	6	PF00017	0.635
LIG_SH2_STAT5	301	304	PF00017	0.205
LIG_SH2_STAT5	322	325	PF00017	0.338
LIG_SH2_STAT5	339	342	PF00017	0.222
LIG_SH2_STAT5	415	418	PF00017	0.531
LIG_SH2_STAT5	479	482	PF00017	0.227
LIG_SH3_3	40	46	PF00018	0.613
LIG_SH3_3	5	11	PF00018	0.697
LIG_SUMO_SIM_anti_2	293	299	PF11976	0.243
LIG_SUMO_SIM_anti_2	496	501	PF11976	0.337
LIG_SUMO_SIM_par_1	434	439	PF11976	0.295
LIG_TRAF2_1	15	18	PF00917	0.639
LIG_TYR_ITIM	145	150	PF00017	0.338
LIG_TYR_ITSM	380	387	PF00017	0.198
LIG_UBA3_1	295	304	PF00899	0.259
LIG_WRC_WIRS_1	213	218	PF05994	0.321
LIG_WRC_WIRS_1	240	245	PF05994	0.338
LIG_WRC_WIRS_1	367	372	PF05994	0.294
MOD_CK1_1	118	124	PF00069	0.626
MOD_CK1_1	242	248	PF00069	0.385
MOD_CK1_1	249	255	PF00069	0.304
MOD_CK1_1	309	315	PF00069	0.619
MOD_CK1_1	372	378	PF00069	0.329
MOD_CK2_1	118	124	PF00069	0.640
MOD_CK2_1	12	18	PF00069	0.818
MOD_CK2_1	464	470	PF00069	0.321
MOD_CK2_1	477	483	PF00069	0.291
MOD_Cter_Amidation	172	175	PF01082	0.486
MOD_GlcNHglycan	171	174	PF01048	0.466
MOD_GlcNHglycan	223	226	PF01048	0.344
MOD_GlcNHglycan	271	274	PF01048	0.406
MOD_GlcNHglycan	311	314	PF01048	0.460
MOD_GlcNHglycan	466	469	PF01048	0.568
MOD_GlcNHglycan	489	492	PF01048	0.373
MOD_GSK3_1	145	152	PF00069	0.276
MOD_GSK3_1	208	215	PF00069	0.333
MOD_GSK3_1	235	242	PF00069	0.479
MOD_GSK3_1	362	369	PF00069	0.285
MOD_GSK3_1	372	379	PF00069	0.264
MOD_NEK2_1	157	162	PF00069	0.337
MOD_NEK2_1	168	173	PF00069	0.275
MOD_NEK2_1	235	240	PF00069	0.460
MOD_NEK2_1	244	249	PF00069	0.319
MOD_NEK2_1	290	295	PF00069	0.241
MOD_NEK2_1	371	376	PF00069	0.378
MOD_NEK2_1	392	397	PF00069	0.373
MOD_NEK2_1	416	421	PF00069	0.464
MOD_NEK2_1	487	492	PF00069	0.394
MOD_NEK2_2	306	311	PF00069	0.544
MOD_NEK2_2	424	429	PF00069	0.205
MOD_PIKK_1	116	122	PF00454	0.655
MOD_PIKK_1	12	18	PF00454	0.817
MOD_PIKK_1	25	31	PF00454	0.716
MOD_PKA_2	168	174	PF00069	0.275
MOD_PKA_2	179	185	PF00069	0.241
MOD_PKA_2	362	368	PF00069	0.314
MOD_Plk_1	195	201	PF00069	0.256
MOD_Plk_1	65	71	PF00069	0.623
MOD_Plk_2-3	477	483	PF00069	0.222
MOD_Plk_4	145	151	PF00069	0.346
MOD_Plk_4	208	214	PF00069	0.355
MOD_Plk_4	235	241	PF00069	0.463
MOD_Plk_4	281	287	PF00069	0.324
MOD_Plk_4	337	343	PF00069	0.310
MOD_Plk_4	351	357	PF00069	0.248
MOD_Plk_4	366	372	PF00069	0.370
MOD_Plk_4	393	399	PF00069	0.336
MOD_Plk_4	416	422	PF00069	0.475
MOD_Plk_4	424	430	PF00069	0.352
MOD_Plk_4	452	458	PF00069	0.267
MOD_Plk_4	493	499	PF00069	0.348
MOD_ProDKin_1	447	453	PF00069	0.255
MOD_SUMO_rev_2	124	133	PF00179	0.588
MOD_SUMO_rev_2	186	192	PF00179	0.242
TRG_DiLeu_BaEn_1	483	488	PF01217	0.338
TRG_DiLeu_BaEn_4	17	23	PF01217	0.637
TRG_ENDOCYTIC_2	147	150	PF00928	0.338
TRG_ENDOCYTIC_2	260	263	PF00928	0.377
TRG_ENDOCYTIC_2	322	325	PF00928	0.402
TRG_ENDOCYTIC_2	384	387	PF00928	0.302
TRG_ENDOCYTIC_2	462	465	PF00928	0.294
TRG_ER_diArg_1	94	96	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X2	Leptomonas seymouri	60%	100%
A0A0N1PC74	Leptomonas seymouri	26%	100%
A0A0N1PCA2	Leptomonas seymouri	28%	100%
A0A3Q8I8Q6	Leishmania donovani	71%	100%
A0A3S7WR28	Leishmania donovani	27%	100%
A0A3S7X1E1	Leishmania donovani	29%	98%
A4H606	Leishmania braziliensis	24%	100%
A4HGF8	Leishmania braziliensis	27%	97%
A4HUD2	Leishmania infantum	71%	100%
A4HUD3	Leishmania infantum	27%	100%
A4I3I9	Leishmania infantum	29%	98%
E9AN32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9AN33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AZT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	97%
Q4Q8F3	Leishmania major	28%	100%
Q4QHJ3	Leishmania major	27%	100%
Q4QHJ4	Leishmania major	70%	96%