Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H604_LEIBR

TriTrypDb:

LbrM.10.0230 , LBRM2903_100007300

Length:

272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H604

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H604

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	43	47	PF00656	0.395
CLV_NRD_NRD_1	232	234	PF00675	0.494
CLV_PCSK_KEX2_1	234	236	PF00082	0.492
CLV_PCSK_KEX2_1	262	264	PF00082	0.516
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.391
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.516
CLV_PCSK_SKI1_1	222	226	PF00082	0.353
CLV_PCSK_SKI1_1	4	8	PF00082	0.688
DEG_SCF_FBW7_1	61	68	PF00400	0.396
DEG_SPOP_SBC_1	65	69	PF00917	0.370
DOC_CKS1_1	122	127	PF01111	0.479
DOC_MAPK_gen_1	262	269	PF00069	0.600
DOC_PP4_FxxP_1	122	125	PF00568	0.433
DOC_USP7_MATH_1	161	165	PF00917	0.507
DOC_USP7_UBL2_3	218	222	PF12436	0.579
DOC_WW_Pin1_4	105	110	PF00397	0.346
DOC_WW_Pin1_4	121	126	PF00397	0.432
DOC_WW_Pin1_4	163	168	PF00397	0.560
DOC_WW_Pin1_4	211	216	PF00397	0.658
DOC_WW_Pin1_4	61	66	PF00397	0.394
LIG_14-3-3_CanoR_1	143	147	PF00244	0.352
LIG_14-3-3_CanoR_1	182	189	PF00244	0.510
LIG_14-3-3_CanoR_1	263	271	PF00244	0.601
LIG_14-3-3_CanoR_1	56	62	PF00244	0.353
LIG_BIR_II_1	1	5	PF00653	0.432
LIG_FHA_1	106	112	PF00498	0.507
LIG_FHA_1	184	190	PF00498	0.453
LIG_FHA_2	221	227	PF00498	0.636
LIG_FHA_2	29	35	PF00498	0.464
LIG_LIR_Apic_2	119	125	PF02991	0.425
LIG_LIR_Gen_1	93	103	PF02991	0.358
LIG_LIR_Nem_3	145	150	PF02991	0.446
LIG_LIR_Nem_3	219	224	PF02991	0.561
LIG_LIR_Nem_3	89	95	PF02991	0.442
LIG_PTAP_UEV_1	166	171	PF05743	0.518
LIG_PTB_Apo_2	38	45	PF02174	0.424
LIG_PTB_Phospho_1	38	44	PF10480	0.425
LIG_SH2_CRK	221	225	PF00017	0.558
LIG_SH2_CRK	249	253	PF00017	0.606
LIG_SH2_NCK_1	44	48	PF00017	0.374
LIG_SH2_PTP2	96	99	PF00017	0.286
LIG_SH2_STAP1	92	96	PF00017	0.400
LIG_SH2_STAT5	72	75	PF00017	0.358
LIG_SH2_STAT5	96	99	PF00017	0.377
LIG_SH3_3	122	128	PF00018	0.488
LIG_SH3_3	164	170	PF00018	0.560
LIG_SH3_3	238	244	PF00018	0.586
LIG_SH3_3	249	255	PF00018	0.630
LIG_SUMO_SIM_par_1	11	16	PF11976	0.600
LIG_TYR_ITIM	247	252	PF00017	0.607
LIG_TYR_ITSM	217	224	PF00017	0.560
MOD_CDK_SPxxK_3	211	218	PF00069	0.680
MOD_CK1_1	149	155	PF00069	0.477
MOD_CK1_1	163	169	PF00069	0.508
MOD_CK1_1	33	39	PF00069	0.393
MOD_CK1_1	79	85	PF00069	0.490
MOD_CK2_1	220	226	PF00069	0.639
MOD_GlcNHglycan	167	170	PF01048	0.740
MOD_GlcNHglycan	22	25	PF01048	0.709
MOD_GlcNHglycan	249	252	PF01048	0.407
MOD_GlcNHglycan	92	95	PF01048	0.667
MOD_GSK3_1	142	149	PF00069	0.409
MOD_GSK3_1	161	168	PF00069	0.501
MOD_GSK3_1	216	223	PF00069	0.636
MOD_GSK3_1	57	64	PF00069	0.447
MOD_GSK3_1	75	82	PF00069	0.465
MOD_N-GLC_1	155	160	PF02516	0.755
MOD_N-GLC_1	61	66	PF02516	0.631
MOD_NEK2_1	103	108	PF00069	0.449
MOD_NEK2_1	142	147	PF00069	0.333
MOD_NEK2_1	150	155	PF00069	0.383
MOD_NEK2_1	183	188	PF00069	0.460
MOD_NEK2_1	20	25	PF00069	0.637
MOD_NEK2_1	216	221	PF00069	0.591
MOD_NEK2_1	247	252	PF00069	0.624
MOD_OFUCOSY	154	159	PF10250	0.670
MOD_PIKK_1	161	167	PF00454	0.485
MOD_PKA_1	262	268	PF00069	0.599
MOD_PKA_2	142	148	PF00069	0.356
MOD_PKA_2	262	268	PF00069	0.651
MOD_Plk_1	4	10	PF00069	0.454
MOD_Plk_1	79	85	PF00069	0.411
MOD_Plk_4	129	135	PF00069	0.522
MOD_Plk_4	142	148	PF00069	0.384
MOD_Plk_4	220	226	PF00069	0.582
MOD_ProDKin_1	105	111	PF00069	0.345
MOD_ProDKin_1	121	127	PF00069	0.430
MOD_ProDKin_1	163	169	PF00069	0.562
MOD_ProDKin_1	211	217	PF00069	0.659
MOD_ProDKin_1	61	67	PF00069	0.396
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.655
TRG_ENDOCYTIC_2	221	224	PF00928	0.676
TRG_ENDOCYTIC_2	249	252	PF00928	0.607
TRG_ENDOCYTIC_2	96	99	PF00928	0.412
TRG_ER_diArg_1	232	235	PF00400	0.668
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT1	Leptomonas seymouri	54%	86%
A0A0N1ICA2	Leptomonas seymouri	26%	96%
A0A3S7WR08	Leishmania donovani	68%	98%
A4HUD1	Leishmania infantum	68%	98%
E9AN31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	95%
Q4QHJ5	Leishmania major	71%	100%
Q4QIC3	Leishmania major	28%	92%