Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H603_LEIBR

TriTrypDb:

LbrM.10.0220 , LBRM2903_100007200

Length:

711

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H603

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H603

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.596
CLV_C14_Caspase3-7	205	209	PF00656	0.654
CLV_C14_Caspase3-7	341	345	PF00656	0.553
CLV_NRD_NRD_1	347	349	PF00675	0.412
CLV_NRD_NRD_1	528	530	PF00675	0.438
CLV_NRD_NRD_1	546	548	PF00675	0.522
CLV_NRD_NRD_1	661	663	PF00675	0.509
CLV_PCSK_KEX2_1	347	349	PF00082	0.412
CLV_PCSK_KEX2_1	528	530	PF00082	0.438
CLV_PCSK_KEX2_1	546	548	PF00082	0.522
CLV_PCSK_KEX2_1	661	663	PF00082	0.514
CLV_PCSK_PC7_1	657	663	PF00082	0.500
CLV_PCSK_SKI1_1	170	174	PF00082	0.463
CLV_PCSK_SKI1_1	347	351	PF00082	0.412
CLV_PCSK_SKI1_1	65	69	PF00082	0.642
DEG_APCC_DBOX_1	150	158	PF00400	0.492
DEG_COP1_1	602	611	PF00400	0.442
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DEG_SCF_FBW7_2	680	686	PF00400	0.461
DOC_CKS1_1	48	53	PF01111	0.499
DOC_CKS1_1	496	501	PF01111	0.492
DOC_CKS1_1	680	685	PF01111	0.453
DOC_CYCLIN_RxL_1	543	552	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	281	287	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	550	556	PF00134	0.476
DOC_MAPK_gen_1	151	160	PF00069	0.563
DOC_MAPK_gen_1	528	535	PF00069	0.435
DOC_MAPK_MEF2A_6	261	268	PF00069	0.453
DOC_MAPK_MEF2A_6	528	535	PF00069	0.435
DOC_MAPK_MEF2A_6	578	586	PF00069	0.347
DOC_PP1_RVXF_1	624	630	PF00149	0.548
DOC_PP2B_LxvP_1	264	267	PF13499	0.439
DOC_PP4_MxPP_1	707	710	PF00568	0.510
DOC_USP7_MATH_1	192	196	PF00917	0.561
DOC_USP7_MATH_1	375	379	PF00917	0.499
DOC_USP7_MATH_1	419	423	PF00917	0.635
DOC_USP7_MATH_1	456	460	PF00917	0.549
DOC_USP7_MATH_1	504	508	PF00917	0.680
DOC_USP7_MATH_1	536	540	PF00917	0.496
DOC_USP7_MATH_1	594	598	PF00917	0.544
DOC_USP7_MATH_1	607	611	PF00917	0.431
DOC_USP7_MATH_1	638	642	PF00917	0.504
DOC_USP7_MATH_1	67	71	PF00917	0.605
DOC_USP7_MATH_1	76	80	PF00917	0.595
DOC_USP7_MATH_1	97	101	PF00917	0.490
DOC_USP7_MATH_2	24	30	PF00917	0.606
DOC_WW_Pin1_4	132	137	PF00397	0.591
DOC_WW_Pin1_4	280	285	PF00397	0.557
DOC_WW_Pin1_4	34	39	PF00397	0.599
DOC_WW_Pin1_4	355	360	PF00397	0.449
DOC_WW_Pin1_4	47	52	PF00397	0.648
DOC_WW_Pin1_4	479	484	PF00397	0.399
DOC_WW_Pin1_4	495	500	PF00397	0.480
DOC_WW_Pin1_4	515	520	PF00397	0.499
DOC_WW_Pin1_4	549	554	PF00397	0.566
DOC_WW_Pin1_4	562	567	PF00397	0.562
DOC_WW_Pin1_4	601	606	PF00397	0.474
DOC_WW_Pin1_4	679	684	PF00397	0.637
DOC_WW_Pin1_4	92	97	PF00397	0.596
LIG_14-3-3_CanoR_1	151	161	PF00244	0.543
LIG_14-3-3_CanoR_1	175	179	PF00244	0.489
LIG_14-3-3_CanoR_1	193	203	PF00244	0.552
LIG_14-3-3_CanoR_1	3	10	PF00244	0.756
LIG_14-3-3_CanoR_1	308	314	PF00244	0.480
LIG_14-3-3_CanoR_1	347	356	PF00244	0.472
LIG_14-3-3_CanoR_1	39	47	PF00244	0.524
LIG_14-3-3_CanoR_1	440	445	PF00244	0.535
LIG_14-3-3_CanoR_1	491	495	PF00244	0.562
LIG_14-3-3_CanoR_1	65	73	PF00244	0.503
LIG_BIR_III_4	367	371	PF00653	0.417
LIG_BRCT_BRCA1_1	258	262	PF00533	0.573
LIG_deltaCOP1_diTrp_1	42	47	PF00928	0.584
LIG_eIF4E_1	447	453	PF01652	0.726
LIG_FAT_LD_1	614	622	PF03623	0.318
LIG_FHA_1	175	181	PF00498	0.468
LIG_FHA_1	194	200	PF00498	0.541
LIG_FHA_1	20	26	PF00498	0.681
LIG_FHA_1	218	224	PF00498	0.534
LIG_FHA_1	284	290	PF00498	0.502
LIG_FHA_1	297	303	PF00498	0.530
LIG_FHA_1	390	396	PF00498	0.527
LIG_FHA_1	48	54	PF00498	0.497
LIG_FHA_1	556	562	PF00498	0.564
LIG_FHA_1	618	624	PF00498	0.300
LIG_FHA_1	680	686	PF00498	0.562
LIG_FHA_2	203	209	PF00498	0.661
LIG_FHA_2	406	412	PF00498	0.523
LIG_FHA_2	496	502	PF00498	0.494
LIG_FHA_2	682	688	PF00498	0.491
LIG_FHA_2	9	15	PF00498	0.752
LIG_GBD_Chelix_1	700	708	PF00786	0.340
LIG_LIR_Gen_1	29	40	PF02991	0.597
LIG_LIR_Gen_1	295	304	PF02991	0.481
LIG_LIR_Gen_1	694	704	PF02991	0.339
LIG_LIR_Nem_3	29	35	PF02991	0.601
LIG_LIR_Nem_3	295	300	PF02991	0.476
LIG_LIR_Nem_3	343	349	PF02991	0.484
LIG_LIR_Nem_3	464	470	PF02991	0.445
LIG_LIR_Nem_3	694	700	PF02991	0.423
LIG_NRBOX	153	159	PF00104	0.496
LIG_SH2_CRK	297	301	PF00017	0.624
LIG_SH2_GRB2like	447	450	PF00017	0.566
LIG_SH2_NCK_1	111	115	PF00017	0.612
LIG_SH2_NCK_1	635	639	PF00017	0.501
LIG_SH2_SRC	447	450	PF00017	0.588
LIG_SH2_STAP1	467	471	PF00017	0.510
LIG_SH2_STAT5	184	187	PF00017	0.559
LIG_SH2_STAT5	297	300	PF00017	0.502
LIG_SH2_STAT5	32	35	PF00017	0.635
LIG_SH2_STAT5	328	331	PF00017	0.563
LIG_SH2_STAT5	447	450	PF00017	0.524
LIG_SH2_STAT5	52	55	PF00017	0.459
LIG_SH2_STAT5	525	528	PF00017	0.481
LIG_SH3_3	235	241	PF00018	0.572
LIG_SH3_3	32	38	PF00018	0.611
LIG_SH3_3	353	359	PF00018	0.542
LIG_SH3_3	42	48	PF00018	0.585
LIG_SH3_3	422	428	PF00018	0.631
LIG_SH3_3	493	499	PF00018	0.453
LIG_SH3_3	677	683	PF00018	0.485
LIG_SH3_3	93	99	PF00018	0.658
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.549
LIG_SUMO_SIM_anti_2	222	228	PF11976	0.432
LIG_SUMO_SIM_par_1	22	30	PF11976	0.484
LIG_TRAF2_1	290	293	PF00917	0.486
LIG_TRAF2_1	409	412	PF00917	0.462
LIG_TRAF2_1	613	616	PF00917	0.485
LIG_UBA3_1	617	626	PF00899	0.294
LIG_Vh1_VBS_1	212	230	PF01044	0.445
LIG_WW_2	238	241	PF00397	0.452
MOD_CDK_SPK_2	34	39	PF00069	0.483
MOD_CDK_SPK_2	495	500	PF00069	0.480
MOD_CDK_SPxK_1	479	485	PF00069	0.398
MOD_CDK_SPxxK_3	132	139	PF00069	0.582
MOD_CK1_1	152	158	PF00069	0.548
MOD_CK1_1	283	289	PF00069	0.560
MOD_CK1_1	295	301	PF00069	0.504
MOD_CK1_1	396	402	PF00069	0.612
MOD_CK1_1	507	513	PF00069	0.531
MOD_CK1_1	695	701	PF00069	0.410
MOD_CK2_1	229	235	PF00069	0.430
MOD_CK2_1	287	293	PF00069	0.605
MOD_CK2_1	405	411	PF00069	0.527
MOD_CMANNOS	44	47	PF00535	0.589
MOD_Cter_Amidation	544	547	PF01082	0.572
MOD_DYRK1A_RPxSP_1	355	359	PF00069	0.446
MOD_DYRK1A_RPxSP_1	495	499	PF00069	0.472
MOD_GlcNHglycan	115	120	PF01048	0.511
MOD_GlcNHglycan	187	190	PF01048	0.499
MOD_GlcNHglycan	196	199	PF01048	0.551
MOD_GlcNHglycan	289	292	PF01048	0.583
MOD_GlcNHglycan	362	365	PF01048	0.430
MOD_GlcNHglycan	378	381	PF01048	0.630
MOD_GlcNHglycan	398	401	PF01048	0.436
MOD_GlcNHglycan	442	445	PF01048	0.669
MOD_GlcNHglycan	477	480	PF01048	0.593
MOD_GlcNHglycan	508	512	PF01048	0.563
MOD_GlcNHglycan	566	569	PF01048	0.532
MOD_GlcNHglycan	609	612	PF01048	0.500
MOD_GlcNHglycan	640	643	PF01048	0.603
MOD_GlcNHglycan	696	700	PF01048	0.345
MOD_GlcNHglycan	75	79	PF01048	0.581
MOD_GSK3_1	225	232	PF00069	0.450
MOD_GSK3_1	283	290	PF00069	0.613
MOD_GSK3_1	292	299	PF00069	0.586
MOD_GSK3_1	34	41	PF00069	0.513
MOD_GSK3_1	389	396	PF00069	0.600
MOD_GSK3_1	419	426	PF00069	0.495
MOD_GSK3_1	475	482	PF00069	0.416
MOD_GSK3_1	490	497	PF00069	0.473
MOD_GSK3_1	507	514	PF00069	0.755
MOD_GSK3_1	599	606	PF00069	0.567
MOD_GSK3_1	675	682	PF00069	0.492
MOD_N-GLC_1	536	541	PF02516	0.641
MOD_NEK2_1	1	6	PF00069	0.635
MOD_NEK2_1	225	230	PF00069	0.403
MOD_NEK2_1	309	314	PF00069	0.493
MOD_NEK2_1	33	38	PF00069	0.571
MOD_NEK2_1	413	418	PF00069	0.476
MOD_NEK2_1	475	480	PF00069	0.422
MOD_NEK2_1	494	499	PF00069	0.566
MOD_NEK2_1	556	561	PF00069	0.537
MOD_NEK2_1	599	604	PF00069	0.523
MOD_NEK2_1	617	622	PF00069	0.287
MOD_NEK2_2	490	495	PF00069	0.410
MOD_OFUCOSY	591	598	PF10250	0.551
MOD_PIKK_1	347	353	PF00454	0.414
MOD_PIKK_1	536	542	PF00454	0.639
MOD_PKA_1	347	353	PF00069	0.414
MOD_PKA_2	152	158	PF00069	0.539
MOD_PKA_2	174	180	PF00069	0.526
MOD_PKA_2	192	198	PF00069	0.556
MOD_PKA_2	2	8	PF00069	0.661
MOD_PKA_2	347	353	PF00069	0.471
MOD_PKA_2	354	360	PF00069	0.525
MOD_PKA_2	38	44	PF00069	0.515
MOD_PKA_2	490	496	PF00069	0.564
MOD_PKA_2	656	662	PF00069	0.448
MOD_Plk_1	292	298	PF00069	0.484
MOD_Plk_1	393	399	PF00069	0.641
MOD_Plk_1	423	429	PF00069	0.487
MOD_Plk_1	695	701	PF00069	0.396
MOD_Plk_1	702	708	PF00069	0.474
MOD_Plk_4	137	143	PF00069	0.663
MOD_Plk_4	168	174	PF00069	0.467
MOD_Plk_4	229	235	PF00069	0.517
MOD_Plk_4	703	709	PF00069	0.488
MOD_Plk_4	97	103	PF00069	0.503
MOD_ProDKin_1	132	138	PF00069	0.585
MOD_ProDKin_1	280	286	PF00069	0.559
MOD_ProDKin_1	34	40	PF00069	0.600
MOD_ProDKin_1	355	361	PF00069	0.447
MOD_ProDKin_1	47	53	PF00069	0.649
MOD_ProDKin_1	479	485	PF00069	0.398
MOD_ProDKin_1	495	501	PF00069	0.485
MOD_ProDKin_1	515	521	PF00069	0.493
MOD_ProDKin_1	549	555	PF00069	0.567
MOD_ProDKin_1	562	568	PF00069	0.557
MOD_ProDKin_1	601	607	PF00069	0.467
MOD_ProDKin_1	679	685	PF00069	0.626
MOD_ProDKin_1	92	98	PF00069	0.595
MOD_SUMO_rev_2	135	141	PF00179	0.527
MOD_SUMO_rev_2	271	281	PF00179	0.479
TRG_DiLeu_BaEn_1	696	701	PF01217	0.331
TRG_DiLeu_BaEn_2	384	390	PF01217	0.448
TRG_ENDOCYTIC_2	297	300	PF00928	0.622
TRG_ENDOCYTIC_2	32	35	PF00928	0.493
TRG_ER_diArg_1	150	153	PF00400	0.559
TRG_ER_diArg_1	346	348	PF00400	0.413
TRG_ER_diArg_1	439	442	PF00400	0.520
TRG_ER_diArg_1	527	529	PF00400	0.363
TRG_ER_diArg_1	546	548	PF00400	0.713
TRG_NES_CRM1_1	254	269	PF08389	0.579
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	546	551	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	649	653	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE3	Leptomonas seymouri	38%	100%
A0A3S7WR11	Leishmania donovani	71%	99%
A4HUD0	Leishmania infantum	71%	99%
E9AN30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	99%
Q4QHJ6	Leishmania major	70%	100%