Putative nucleolar protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein 56, putative

Species:

Leishmania braziliensis

UniProt:

A4H602_LEIBR

TriTrypDb:

LbrM.10.0210 , LBRM2903_100007100

Length:

471

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	12
GO:0030684	preribosome	3	12
GO:0031428	box C/D RNP complex	4	12
GO:0032040	small-subunit processome	4	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A4H602

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H602

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0022613	ribonucleoprotein complex biogenesis	4	12
GO:0042254	ribosome biogenesis	5	12
GO:0044085	cellular component biogenesis	3	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0030515	snoRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	443	445	PF00675	0.513
CLV_NRD_NRD_1	447	449	PF00675	0.524
CLV_NRD_NRD_1	464	466	PF00675	0.673
CLV_PCSK_KEX2_1	279	281	PF00082	0.354
CLV_PCSK_KEX2_1	445	447	PF00082	0.522
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.349
CLV_PCSK_PC1ET2_1	445	447	PF00082	0.537
CLV_PCSK_PC7_1	275	281	PF00082	0.349
CLV_PCSK_PC7_1	441	447	PF00082	0.572
CLV_PCSK_SKI1_1	257	261	PF00082	0.279
CLV_PCSK_SKI1_1	288	292	PF00082	0.334
CLV_PCSK_SKI1_1	298	302	PF00082	0.263
CLV_PCSK_SKI1_1	343	347	PF00082	0.289
CLV_PCSK_SKI1_1	386	390	PF00082	0.329
CLV_PCSK_SKI1_1	88	92	PF00082	0.517
DOC_CDC14_PxL_1	300	308	PF14671	0.489
DOC_MAPK_MEF2A_6	214	222	PF00069	0.489
DOC_PP1_RVXF_1	159	165	PF00149	0.485
DOC_PP1_RVXF_1	413	419	PF00149	0.489
DOC_PP1_RVXF_1	46	53	PF00149	0.513
DOC_PP2B_LxvP_1	113	116	PF13499	0.557
DOC_PP2B_LxvP_1	301	304	PF13499	0.500
DOC_PP4_FxxP_1	55	58	PF00568	0.500
DOC_USP7_MATH_1	258	262	PF00917	0.493
DOC_USP7_MATH_1	461	465	PF00917	0.718
DOC_USP7_UBL2_3	317	321	PF12436	0.489
DOC_USP7_UBL2_3	445	449	PF12436	0.555
DOC_USP7_UBL2_3	462	466	PF12436	0.772
DOC_USP7_UBL2_3	87	91	PF12436	0.502
DOC_WW_Pin1_4	328	333	PF00397	0.549
DOC_WW_Pin1_4	353	358	PF00397	0.489
DOC_WW_Pin1_4	41	46	PF00397	0.496
DOC_WW_Pin1_4	455	460	PF00397	0.760
DOC_WW_Pin1_4	54	59	PF00397	0.472
DOC_WW_Pin1_4	8	13	PF00397	0.413
LIG_14-3-3_CanoR_1	225	229	PF00244	0.496
LIG_14-3-3_CanoR_1	280	285	PF00244	0.491
LIG_APCC_ABBA_1	130	135	PF00400	0.450
LIG_BIR_II_1	1	5	PF00653	0.488
LIG_BIR_III_2	398	402	PF00653	0.549
LIG_deltaCOP1_diTrp_1	196	202	PF00928	0.489
LIG_deltaCOP1_diTrp_1	268	277	PF00928	0.489
LIG_EH1_1	293	301	PF00400	0.489
LIG_eIF4E_1	215	221	PF01652	0.489
LIG_EVH1_2	400	404	PF00568	0.489
LIG_FHA_1	21	27	PF00498	0.569
LIG_FHA_1	333	339	PF00498	0.489
LIG_FHA_2	20	26	PF00498	0.457
LIG_FHA_2	34	40	PF00498	0.485
LIG_GBD_Chelix_1	291	299	PF00786	0.349
LIG_GBD_Chelix_1	389	397	PF00786	0.289
LIG_LIR_Gen_1	13	20	PF02991	0.549
LIG_LIR_Gen_1	268	278	PF02991	0.489
LIG_LIR_Gen_1	39	47	PF02991	0.489
LIG_LIR_Gen_1	437	443	PF02991	0.516
LIG_LIR_Nem_3	13	18	PF02991	0.490
LIG_LIR_Nem_3	268	274	PF02991	0.489
LIG_LIR_Nem_3	356	362	PF02991	0.487
LIG_LIR_Nem_3	39	43	PF02991	0.486
LIG_LIR_Nem_3	4	9	PF02991	0.356
LIG_LIR_Nem_3	437	442	PF02991	0.481
LIG_LIR_Nem_3	44	49	PF02991	0.491
LIG_LIR_Nem_3	51	55	PF02991	0.493
LIG_PCNA_yPIPBox_3	288	300	PF02747	0.489
LIG_Pex14_2	363	367	PF04695	0.489
LIG_Pex14_2	76	80	PF04695	0.395
LIG_SH2_CRK	215	219	PF00017	0.489
LIG_SH2_CRK	359	363	PF00017	0.489
LIG_SH2_CRK	439	443	PF00017	0.484
LIG_SH2_GRB2like	215	218	PF00017	0.575
LIG_SH2_NCK_1	215	219	PF00017	0.500
LIG_SH2_NCK_1	9	13	PF00017	0.513
LIG_SH2_SRC	215	218	PF00017	0.575
LIG_SH2_STAP1	215	219	PF00017	0.489
LIG_SH2_STAP1	255	259	PF00017	0.500
LIG_SH2_STAT5	294	297	PF00017	0.489
LIG_SH2_STAT5	382	385	PF00017	0.489
LIG_SH3_3	206	212	PF00018	0.488
LIG_SH3_3	97	103	PF00018	0.518
LIG_TRAF2_1	22	25	PF00917	0.500
LIG_TRAF2_1	227	230	PF00917	0.464
LIG_TRAF2_1	231	234	PF00917	0.459
LIG_TYR_ITIM	213	218	PF00017	0.500
LIG_UBA3_1	179	185	PF00899	0.376
LIG_UBA3_1	189	195	PF00899	0.457
LIG_UBA3_1	345	353	PF00899	0.489
LIG_WRC_WIRS_1	274	279	PF05994	0.549
LIG_WRC_WIRS_1	40	45	PF05994	0.487
LIG_WRC_WIRS_1	49	54	PF05994	0.485
MOD_CDK_SPK_2	353	358	PF00069	0.489
MOD_CDK_SPK_2	455	460	PF00069	0.760
MOD_CDK_SPxxK_3	41	48	PF00069	0.500
MOD_CDK_SPxxK_3	455	462	PF00069	0.765
MOD_CK1_1	331	337	PF00069	0.549
MOD_CK1_1	41	47	PF00069	0.573
MOD_CK2_1	19	25	PF00069	0.457
MOD_CK2_1	224	230	PF00069	0.464
MOD_CMANNOS	197	200	PF00535	0.289
MOD_GlcNHglycan	106	109	PF01048	0.448
MOD_GlcNHglycan	176	179	PF01048	0.414
MOD_GlcNHglycan	73	76	PF01048	0.391
MOD_GSK3_1	317	324	PF00069	0.489
MOD_GSK3_1	328	335	PF00069	0.489
MOD_GSK3_1	71	78	PF00069	0.388
MOD_N-GLC_1	304	309	PF02516	0.289
MOD_N-GLC_2	224	226	PF02516	0.199
MOD_NEK2_1	1	6	PF00069	0.472
MOD_NEK2_1	310	315	PF00069	0.575
MOD_NEK2_1	33	38	PF00069	0.562
MOD_NEK2_1	363	368	PF00069	0.489
MOD_NEK2_1	418	423	PF00069	0.490
MOD_PIKK_1	304	310	PF00454	0.549
MOD_PKA_2	20	26	PF00069	0.558
MOD_PKA_2	224	230	PF00069	0.489
MOD_PKA_2	369	375	PF00069	0.566
MOD_Plk_1	304	310	PF00069	0.549
MOD_Plk_1	38	44	PF00069	0.510
MOD_Plk_4	1	7	PF00069	0.449
MOD_Plk_4	363	369	PF00069	0.489
MOD_Plk_4	399	405	PF00069	0.564
MOD_ProDKin_1	328	334	PF00069	0.549
MOD_ProDKin_1	353	359	PF00069	0.489
MOD_ProDKin_1	41	47	PF00069	0.496
MOD_ProDKin_1	455	461	PF00069	0.762
MOD_ProDKin_1	54	60	PF00069	0.472
MOD_ProDKin_1	8	14	PF00069	0.413
MOD_SUMO_for_1	90	93	PF00179	0.651
MOD_SUMO_rev_2	229	238	PF00179	0.549
MOD_SUMO_rev_2	97	105	PF00179	0.433
TRG_ENDOCYTIC_2	15	18	PF00928	0.500
TRG_ENDOCYTIC_2	215	218	PF00928	0.489
TRG_ENDOCYTIC_2	359	362	PF00928	0.488
TRG_ENDOCYTIC_2	439	442	PF00928	0.485
TRG_ER_diArg_1	443	446	PF00400	0.544
TRG_NES_CRM1_1	181	196	PF08389	0.489
TRG_NLS_Bipartite_1	444	466	PF00514	0.682
TRG_NLS_MonoCore_2	349	354	PF00514	0.489
TRG_NLS_MonoExtC_3	461	466	PF00514	0.647
TRG_NLS_MonoExtN_4	347	354	PF00514	0.489
TRG_NLS_MonoExtN_4	459	466	PF00514	0.647
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD49	Leptomonas seymouri	36%	100%
A0A0N1PE54	Leptomonas seymouri	91%	99%
A0A0S4IXK2	Bodo saltans	78%	100%
A0A0S4JJS5	Bodo saltans	37%	100%
A0A1X0NRL9	Trypanosomatidae	79%	97%
A0A1X0NUB3	Trypanosomatidae	38%	100%
A0A3R7NI91	Trypanosoma rangeli	38%	100%
A0A3R7NLD9	Trypanosoma rangeli	79%	97%
A0A3S5H6F4	Leishmania donovani	94%	100%
A0A3S5H6V9	Leishmania donovani	37%	100%
A1CL70	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	42%	80%
A1D688	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	42%	80%
A2QE38	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	40%	81%
A3LUT0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	41%	91%
A4H8A6	Leishmania braziliensis	37%	100%
A4HUC9	Leishmania infantum	94%	100%
A4HWM6	Leishmania infantum	37%	100%
A5DHW0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	39%	93%
A5E4V9	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	40%	91%
A6QYH8	Ajellomyces capsulatus (strain NAm1 / WU24)	42%	74%
A6RMY5	Botryotinia fuckeliana (strain B05.10)	44%	83%
A6ZPE5	Saccharomyces cerevisiae (strain YJM789)	41%	92%
A7F2R6	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	44%	83%
A7TIF5	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	40%	92%
C9ZVG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	98%
C9ZXR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
E9AN29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
E9AQD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B3J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
O00567	Homo sapiens	47%	79%
O04656	Arabidopsis thaliana	38%	100%
O04658	Arabidopsis thaliana	42%	88%
O94514	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	95%
P0CP26	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	39%	83%
P0CP27	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	39%	83%
Q0CQH1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	41%	82%
Q12460	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	93%
Q12499	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	92%
Q1E1Q5	Coccidioides immitis (strain RS)	41%	78%
Q21276	Caenorhabditis elegans	45%	97%
Q2UC04	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	41%	81%
Q3SZ63	Bos taurus	47%	79%
Q4PBF2	Ustilago maydis (strain 521 / FGSC 9021)	40%	81%
Q4Q4L0	Leishmania major	22%	100%
Q4QF42	Leishmania major	37%	100%
Q4QHJ7	Leishmania major	94%	100%
Q4R779	Macaca fascicularis	37%	89%
Q4WYK9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	42%	80%
Q54MT2	Dictyostelium discoideum	46%	87%
Q55FI4	Dictyostelium discoideum	40%	74%
Q59S06	Candida albicans (strain SC5314 / ATCC MYA-2876)	40%	91%
Q5B8G3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	41%	80%
Q5RA29	Pongo abelii	47%	79%
Q6BIX6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	39%	91%
Q6CG46	Yarrowia lipolytica (strain CLIB 122 / E 150)	40%	91%
Q6CKR8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	39%	92%
Q6DFW4	Mus musculus	37%	88%
Q6FQ21	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	41%	92%
Q753I4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	40%	92%
Q8X066	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	39%	79%
Q95K50	Macaca fascicularis	47%	79%
Q9D6Z1	Mus musculus	47%	81%
Q9MAB3	Arabidopsis thaliana	41%	88%
Q9P7S7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	93%
Q9QZ86	Rattus norvegicus	37%	88%
Q9Y2X3	Homo sapiens	37%	89%
V5AU06	Trypanosoma cruzi	78%	98%
V5BK67	Trypanosoma cruzi	38%	100%