LeishMANIAdb
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PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PDZ domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4H600_LEIBR
TriTrypDb:
LbrM.10.0190 , LBRM2903_100006800 *
Length:
667

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H600
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H600

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 202 204 PF00675 0.698
CLV_NRD_NRD_1 506 508 PF00675 0.596
CLV_NRD_NRD_1 97 99 PF00675 0.534
CLV_PCSK_KEX2_1 202 204 PF00082 0.610
CLV_PCSK_KEX2_1 506 508 PF00082 0.596
CLV_PCSK_KEX2_1 97 99 PF00082 0.534
CLV_PCSK_PC7_1 502 508 PF00082 0.601
CLV_PCSK_SKI1_1 188 192 PF00082 0.678
CLV_PCSK_SKI1_1 268 272 PF00082 0.466
CLV_PCSK_SKI1_1 427 431 PF00082 0.836
CLV_PCSK_SKI1_1 635 639 PF00082 0.471
CLV_PCSK_SKI1_1 8 12 PF00082 0.491
DEG_APCC_DBOX_1 148 156 PF00400 0.839
DEG_APCC_DBOX_1 236 244 PF00400 0.455
DEG_APCC_DBOX_1 279 287 PF00400 0.723
DEG_APCC_DBOX_1 634 642 PF00400 0.471
DEG_COP1_1 333 342 PF00400 0.560
DEG_SCF_FBW7_1 377 384 PF00400 0.587
DEG_SCF_FBW7_1 65 72 PF00400 0.596
DEG_SCF_FBW7_2 74 81 PF00400 0.545
DEG_SPOP_SBC_1 126 130 PF00917 0.787
DEG_SPOP_SBC_1 175 179 PF00917 0.585
DEG_SPOP_SBC_1 550 554 PF00917 0.693
DOC_MAPK_gen_1 280 287 PF00069 0.475
DOC_MAPK_JIP1_4 259 265 PF00069 0.498
DOC_MAPK_MEF2A_6 259 267 PF00069 0.487
DOC_MAPK_MEF2A_6 280 287 PF00069 0.475
DOC_MAPK_MEF2A_6 616 623 PF00069 0.433
DOC_MAPK_NFAT4_5 616 624 PF00069 0.277
DOC_PP2B_LxvP_1 164 167 PF13499 0.590
DOC_PP2B_LxvP_1 581 584 PF13499 0.391
DOC_PP2B_PxIxI_1 167 173 PF00149 0.577
DOC_USP7_MATH_1 114 118 PF00917 0.730
DOC_USP7_MATH_1 120 124 PF00917 0.754
DOC_USP7_MATH_1 126 130 PF00917 0.730
DOC_USP7_MATH_1 160 164 PF00917 0.841
DOC_USP7_MATH_1 175 179 PF00917 0.578
DOC_USP7_MATH_1 338 342 PF00917 0.706
DOC_USP7_MATH_1 381 385 PF00917 0.834
DOC_USP7_MATH_1 425 429 PF00917 0.680
DOC_USP7_MATH_1 435 439 PF00917 0.707
DOC_USP7_MATH_1 48 52 PF00917 0.733
DOC_USP7_MATH_1 497 501 PF00917 0.764
DOC_USP7_MATH_1 550 554 PF00917 0.816
DOC_USP7_MATH_1 558 562 PF00917 0.699
DOC_USP7_MATH_1 63 67 PF00917 0.596
DOC_USP7_MATH_1 69 73 PF00917 0.785
DOC_USP7_UBL2_3 33 37 PF12436 0.741
DOC_WW_Pin1_4 130 135 PF00397 0.754
DOC_WW_Pin1_4 155 160 PF00397 0.842
DOC_WW_Pin1_4 313 318 PF00397 0.705
DOC_WW_Pin1_4 325 330 PF00397 0.648
DOC_WW_Pin1_4 351 356 PF00397 0.736
DOC_WW_Pin1_4 361 366 PF00397 0.567
DOC_WW_Pin1_4 377 382 PF00397 0.583
DOC_WW_Pin1_4 437 442 PF00397 0.677
DOC_WW_Pin1_4 464 469 PF00397 0.579
DOC_WW_Pin1_4 487 492 PF00397 0.586
DOC_WW_Pin1_4 59 64 PF00397 0.843
DOC_WW_Pin1_4 65 70 PF00397 0.767
DOC_WW_Pin1_4 74 79 PF00397 0.572
LIG_14-3-3_CanoR_1 161 167 PF00244 0.595
LIG_14-3-3_CanoR_1 188 194 PF00244 0.545
LIG_14-3-3_CanoR_1 259 264 PF00244 0.559
LIG_14-3-3_CanoR_1 348 352 PF00244 0.585
LIG_14-3-3_CanoR_1 459 466 PF00244 0.621
LIG_14-3-3_CanoR_1 473 480 PF00244 0.590
LIG_14-3-3_CanoR_1 511 516 PF00244 0.609
LIG_Actin_WH2_1 205 222 PF00022 0.441
LIG_Actin_WH2_2 96 114 PF00022 0.532
LIG_BIR_II_1 1 5 PF00653 0.676
LIG_BRCT_BRCA1_1 43 47 PF00533 0.714
LIG_deltaCOP1_diTrp_1 81 86 PF00928 0.757
LIG_DLG_GKlike_1 259 267 PF00625 0.487
LIG_EVH1_1 152 156 PF00568 0.840
LIG_EVH1_1 362 366 PF00568 0.577
LIG_FHA_1 308 314 PF00498 0.576
LIG_FHA_1 75 81 PF00498 0.540
LIG_FHA_2 194 200 PF00498 0.498
LIG_FHA_2 301 307 PF00498 0.720
LIG_FHA_2 318 324 PF00498 0.530
LIG_FHA_2 4 10 PF00498 0.495
LIG_FHA_2 503 509 PF00498 0.597
LIG_FHA_2 519 525 PF00498 0.529
LIG_GBD_Chelix_1 283 291 PF00786 0.744
LIG_Integrin_RGD_1 616 618 PF01839 0.433
LIG_LIR_Apic_2 336 340 PF02991 0.713
LIG_LIR_Apic_2 533 537 PF02991 0.585
LIG_LIR_Gen_1 9 18 PF02991 0.478
LIG_LIR_Nem_3 9 14 PF02991 0.475
LIG_MYND_1 153 157 PF01753 0.840
LIG_PCNA_yPIPBox_3 220 230 PF02747 0.677
LIG_PDZ_Class_2 662 667 PF00595 0.510
LIG_Pex14_1 82 86 PF04695 0.754
LIG_SH2_CRK 337 341 PF00017 0.711
LIG_SH2_NCK_1 337 341 PF00017 0.711
LIG_SH2_NCK_1 534 538 PF00017 0.580
LIG_SH2_STAT5 17 20 PF00017 0.515
LIG_SH2_STAT5 242 245 PF00017 0.568
LIG_SH2_STAT5 401 404 PF00017 0.567
LIG_SH2_STAT5 534 537 PF00017 0.582
LIG_SH3_1 442 448 PF00018 0.593
LIG_SH3_2 156 161 PF14604 0.591
LIG_SH3_3 147 153 PF00018 0.804
LIG_SH3_3 154 160 PF00018 0.764
LIG_SH3_3 360 366 PF00018 0.700
LIG_SH3_3 370 376 PF00018 0.797
LIG_SH3_3 442 448 PF00018 0.776
LIG_SH3_3 463 469 PF00018 0.735
LIG_SH3_3 483 489 PF00018 0.534
LIG_SH3_3 602 608 PF00018 0.277
LIG_SUMO_SIM_anti_2 169 174 PF11976 0.616
LIG_SUMO_SIM_par_1 658 664 PF11976 0.401
LIG_WRC_WIRS_1 339 344 PF05994 0.545
LIG_WRC_WIRS_1 83 88 PF05994 0.755
LIG_WW_2 153 156 PF00397 0.838
LIG_WW_3 133 137 PF00397 0.592
LIG_WW_3 158 162 PF00397 0.621
MOD_CDC14_SPxK_1 133 136 PF00782 0.592
MOD_CDC14_SPxK_1 158 161 PF00782 0.620
MOD_CDC14_SPxK_1 354 357 PF00782 0.584
MOD_CDK_SPK_2 437 442 PF00069 0.608
MOD_CDK_SPxK_1 130 136 PF00069 0.601
MOD_CDK_SPxK_1 155 161 PF00069 0.618
MOD_CDK_SPxK_1 351 357 PF00069 0.588
MOD_CK1_1 101 107 PF00069 0.523
MOD_CK1_1 127 133 PF00069 0.849
MOD_CK1_1 174 180 PF00069 0.622
MOD_CK1_1 192 198 PF00069 0.601
MOD_CK1_1 210 216 PF00069 0.358
MOD_CK1_1 327 333 PF00069 0.702
MOD_CK1_1 341 347 PF00069 0.570
MOD_CK1_1 428 434 PF00069 0.838
MOD_CK1_1 437 443 PF00069 0.713
MOD_CK1_1 487 493 PF00069 0.578
MOD_CK1_1 514 520 PF00069 0.751
MOD_CK1_1 551 557 PF00069 0.810
MOD_CK1_1 72 78 PF00069 0.730
MOD_CK2_1 16 22 PF00069 0.726
MOD_CK2_1 210 216 PF00069 0.428
MOD_CK2_1 502 508 PF00069 0.791
MOD_CK2_1 518 524 PF00069 0.531
MOD_CK2_1 626 632 PF00069 0.277
MOD_Cter_Amidation 200 203 PF01082 0.606
MOD_GlcNHglycan 1 4 PF01048 0.790
MOD_GlcNHglycan 11 14 PF01048 0.564
MOD_GlcNHglycan 112 115 PF01048 0.722
MOD_GlcNHglycan 116 119 PF01048 0.775
MOD_GlcNHglycan 121 125 PF01048 0.747
MOD_GlcNHglycan 173 176 PF01048 0.580
MOD_GlcNHglycan 178 181 PF01048 0.586
MOD_GlcNHglycan 209 212 PF01048 0.486
MOD_GlcNHglycan 329 332 PF01048 0.807
MOD_GlcNHglycan 367 370 PF01048 0.682
MOD_GlcNHglycan 383 386 PF01048 0.757
MOD_GlcNHglycan 455 458 PF01048 0.632
MOD_GlcNHglycan 556 559 PF01048 0.593
MOD_GlcNHglycan 584 587 PF01048 0.448
MOD_GSK3_1 110 117 PF00069 0.641
MOD_GSK3_1 120 127 PF00069 0.766
MOD_GSK3_1 171 178 PF00069 0.631
MOD_GSK3_1 188 195 PF00069 0.678
MOD_GSK3_1 255 262 PF00069 0.580
MOD_GSK3_1 309 316 PF00069 0.732
MOD_GSK3_1 347 354 PF00069 0.741
MOD_GSK3_1 361 368 PF00069 0.642
MOD_GSK3_1 377 384 PF00069 0.649
MOD_GSK3_1 391 398 PF00069 0.682
MOD_GSK3_1 407 414 PF00069 0.653
MOD_GSK3_1 427 434 PF00069 0.664
MOD_GSK3_1 453 460 PF00069 0.806
MOD_GSK3_1 48 55 PF00069 0.555
MOD_GSK3_1 502 509 PF00069 0.774
MOD_GSK3_1 510 517 PF00069 0.766
MOD_GSK3_1 550 557 PF00069 0.739
MOD_GSK3_1 59 66 PF00069 0.789
MOD_N-GLC_1 188 193 PF02516 0.547
MOD_NEK2_1 193 198 PF00069 0.651
MOD_NEK2_1 399 404 PF00069 0.566
MOD_NEK2_1 458 463 PF00069 0.619
MOD_PIKK_1 641 647 PF00454 0.530
MOD_PK_1 511 517 PF00069 0.609
MOD_PK_1 599 605 PF00069 0.530
MOD_PKA_1 506 512 PF00069 0.598
MOD_PKA_2 160 166 PF00069 0.834
MOD_PKA_2 233 239 PF00069 0.656
MOD_PKA_2 258 264 PF00069 0.561
MOD_PKA_2 300 306 PF00069 0.633
MOD_PKA_2 347 353 PF00069 0.663
MOD_PKA_2 431 437 PF00069 0.848
MOD_PKA_2 458 464 PF00069 0.620
MOD_PKA_2 506 512 PF00069 0.851
MOD_PKA_2 653 659 PF00069 0.473
MOD_Plk_1 168 174 PF00069 0.784
MOD_Plk_1 188 194 PF00069 0.646
MOD_Plk_4 300 306 PF00069 0.567
MOD_Plk_4 395 401 PF00069 0.566
MOD_Plk_4 551 557 PF00069 0.700
MOD_Plk_4 82 88 PF00069 0.502
MOD_Plk_4 98 104 PF00069 0.465
MOD_ProDKin_1 130 136 PF00069 0.756
MOD_ProDKin_1 155 161 PF00069 0.845
MOD_ProDKin_1 313 319 PF00069 0.700
MOD_ProDKin_1 325 331 PF00069 0.646
MOD_ProDKin_1 351 357 PF00069 0.739
MOD_ProDKin_1 361 367 PF00069 0.569
MOD_ProDKin_1 377 383 PF00069 0.581
MOD_ProDKin_1 437 443 PF00069 0.679
MOD_ProDKin_1 464 470 PF00069 0.582
MOD_ProDKin_1 487 493 PF00069 0.578
MOD_ProDKin_1 59 65 PF00069 0.837
MOD_ProDKin_1 74 80 PF00069 0.566
MOD_SUMO_rev_2 28 34 PF00179 0.735
TRG_DiLeu_BaLyEn_6 38 43 PF01217 0.490
TRG_ER_diArg_1 202 205 PF00400 0.549
TRG_ER_diArg_1 237 240 PF00400 0.718
TRG_ER_diArg_1 279 282 PF00400 0.726
TRG_ER_diArg_1 97 99 PF00400 0.534
TRG_Pf-PMV_PEXEL_1 224 228 PF00026 0.715
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.748

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WQZ0 Leishmania donovani 59% 100%
A4HUC6 Leishmania infantum 59% 100%
E9AN26 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
Q4QHK0 Leishmania major 58% 98%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS