Putative leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5Z9_LEIBR

TriTrypDb:

LbrM.10.0180 , LBRM2903_100006700

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4H5Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	149	153	PF00082	0.388
DEG_APCC_DBOX_1	51	59	PF00400	0.550
DOC_CDC14_PxL_1	142	150	PF14671	0.360
DOC_CKS1_1	158	163	PF01111	0.594
DOC_CYCLIN_RxL_1	146	154	PF00134	0.424
DOC_MAPK_gen_1	98	107	PF00069	0.388
DOC_MAPK_MEF2A_6	189	197	PF00069	0.558
DOC_MAPK_MEF2A_6	204	211	PF00069	0.597
DOC_PP1_RVXF_1	76	82	PF00149	0.425
DOC_PP2B_LxvP_1	143	146	PF13499	0.314
DOC_USP7_MATH_1	175	179	PF00917	0.563
DOC_USP7_MATH_1	199	203	PF00917	0.571
DOC_WW_Pin1_4	157	162	PF00397	0.570
DOC_WW_Pin1_4	67	72	PF00397	0.676
DOC_WW_Pin1_4	7	12	PF00397	0.674
LIG_14-3-3_CanoR_1	104	108	PF00244	0.382
LIG_14-3-3_CanoR_1	149	154	PF00244	0.424
LIG_14-3-3_CanoR_1	65	73	PF00244	0.663
LIG_Actin_WH2_2	75	92	PF00022	0.665
LIG_BRCT_BRCA1_1	35	39	PF00533	0.696
LIG_Clathr_ClatBox_1	12	16	PF01394	0.456
LIG_CSL_BTD_1	113	116	PF09270	0.424
LIG_FHA_1	15	21	PF00498	0.664
LIG_FHA_2	158	164	PF00498	0.630
LIG_FHA_2	221	227	PF00498	0.672
LIG_LIR_Gen_1	188	199	PF02991	0.508
LIG_LIR_Gen_1	205	212	PF02991	0.569
LIG_LIR_Gen_1	85	92	PF02991	0.538
LIG_LIR_Nem_3	113	117	PF02991	0.396
LIG_LIR_Nem_3	188	194	PF02991	0.571
LIG_LIR_Nem_3	196	200	PF02991	0.424
LIG_LIR_Nem_3	205	211	PF02991	0.352
LIG_LIR_Nem_3	5	9	PF02991	0.445
LIG_LIR_Nem_3	85	89	PF02991	0.529
LIG_MAD2	149	157	PF02301	0.449
LIG_PCNA_yPIPBox_3	101	115	PF02747	0.449
LIG_Pex14_2	35	39	PF04695	0.705
LIG_PTB_Apo_2	153	160	PF02174	0.424
LIG_PTB_Phospho_1	153	159	PF10480	0.449
LIG_SH2_CRK	86	90	PF00017	0.545
LIG_SH2_CRK	9	13	PF00017	0.452
LIG_SH2_SRC	172	175	PF00017	0.658
LIG_SH2_STAP1	191	195	PF00017	0.447
LIG_SH2_STAT5	159	162	PF00017	0.699
LIG_SH2_STAT5	172	175	PF00017	0.598
LIG_SH2_STAT5	220	223	PF00017	0.575
LIG_SH2_STAT5	34	37	PF00017	0.638
LIG_SH2_STAT5	86	89	PF00017	0.561
LIG_SH3_3	1	7	PF00018	0.634
LIG_SUMO_SIM_anti_2	53	59	PF11976	0.570
LIG_SUMO_SIM_par_1	149	154	PF11976	0.338
LIG_TRAF2_1	124	127	PF00917	0.338
LIG_TRAF2_1	160	163	PF00917	0.680
LIG_WRC_WIRS_1	194	199	PF05994	0.540
MOD_CDK_SPK_2	67	72	PF00069	0.676
MOD_CK1_1	85	91	PF00069	0.667
MOD_CK1_1	94	100	PF00069	0.530
MOD_CK2_1	157	163	PF00069	0.621
MOD_CK2_1	220	226	PF00069	0.655
MOD_CK2_1	97	103	PF00069	0.553
MOD_GlcNHglycan	180	184	PF01048	0.670
MOD_GSK3_1	175	182	PF00069	0.588
MOD_GSK3_1	216	223	PF00069	0.559
MOD_GSK3_1	29	36	PF00069	0.570
MOD_GSK3_1	67	74	PF00069	0.671
MOD_GSK3_1	88	95	PF00069	0.657
MOD_N-GLC_1	39	44	PF02516	0.703
MOD_N-GLC_1	82	87	PF02516	0.515
MOD_NEK2_1	33	38	PF00069	0.579
MOD_NEK2_1	82	87	PF00069	0.515
MOD_NEK2_2	29	34	PF00069	0.674
MOD_PKA_2	64	70	PF00069	0.594
MOD_PKA_2	71	77	PF00069	0.621
MOD_PKA_2	97	103	PF00069	0.557
MOD_PKB_1	147	155	PF00069	0.449
MOD_Plk_1	82	88	PF00069	0.529
MOD_Plk_1	92	98	PF00069	0.566
MOD_Plk_4	110	116	PF00069	0.449
MOD_Plk_4	168	174	PF00069	0.609
MOD_Plk_4	216	222	PF00069	0.388
MOD_Plk_4	29	35	PF00069	0.610
MOD_ProDKin_1	157	163	PF00069	0.577
MOD_ProDKin_1	67	73	PF00069	0.673
MOD_ProDKin_1	7	13	PF00069	0.675
MOD_SUMO_rev_2	162	167	PF00179	0.458
TRG_ENDOCYTIC_2	190	193	PF00928	0.513
TRG_ENDOCYTIC_2	86	89	PF00928	0.526
TRG_ENDOCYTIC_2	9	12	PF00928	0.452
TRG_ER_diArg_1	146	149	PF00400	0.449
TRG_ER_diArg_1	221	224	PF00400	0.643
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B1	Leptomonas seymouri	62%	100%
A0A0S4J897	Bodo saltans	45%	82%
A0A1X0NQ44	Trypanosomatidae	54%	100%
A0A3S7WQZ4	Leishmania donovani	83%	99%
A0A422NRS7	Trypanosoma rangeli	54%	100%
A4HUC5	Leishmania infantum	84%	99%
C9ZVG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AN24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q01730	Mus musculus	30%	85%
Q15404	Homo sapiens	30%	85%
Q32NT4	Xenopus laevis	25%	67%
Q4QHK2	Leishmania major	81%	100%
Q5E9C0	Bos taurus	30%	85%
V5BIH6	Trypanosoma cruzi	54%	100%