Putative nucleoside phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleoside phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H5Z8_LEIBR

TriTrypDb:

LbrM.10.0170 , LBRM2903_100006600

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 5
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H5Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Z8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009132	nucleoside diphosphate metabolic process	5	1
GO:0009134	nucleoside diphosphate catabolic process	6	1
GO:0009987	cellular process	1	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	10
GO:0004382	GDP phosphatase activity	7	5
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017076	purine nucleotide binding	4	9
GO:0017110	nucleoside diphosphate phosphatase activity	6	5
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	470	474	PF00656	0.291
CLV_C14_Caspase3-7	500	504	PF00656	0.266
CLV_NRD_NRD_1	147	149	PF00675	0.697
CLV_NRD_NRD_1	169	171	PF00675	0.690
CLV_NRD_NRD_1	198	200	PF00675	0.593
CLV_NRD_NRD_1	322	324	PF00675	0.457
CLV_PCSK_KEX2_1	147	149	PF00082	0.703
CLV_PCSK_KEX2_1	169	171	PF00082	0.690
CLV_PCSK_KEX2_1	434	436	PF00082	0.390
CLV_PCSK_KEX2_1	522	524	PF00082	0.487
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.390
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.487
CLV_PCSK_SKI1_1	112	116	PF00082	0.726
CLV_PCSK_SKI1_1	127	131	PF00082	0.668
CLV_PCSK_SKI1_1	18	22	PF00082	0.385
CLV_PCSK_SKI1_1	406	410	PF00082	0.466
CLV_PCSK_SKI1_1	425	429	PF00082	0.567
CLV_PCSK_SKI1_1	545	549	PF00082	0.513
DOC_CYCLIN_yCln2_LP_2	546	552	PF00134	0.343
DOC_MAPK_DCC_7	543	552	PF00069	0.343
DOC_MAPK_gen_1	11	21	PF00069	0.432
DOC_MAPK_gen_1	543	552	PF00069	0.371
DOC_MAPK_MEF2A_6	14	23	PF00069	0.505
DOC_MAPK_MEF2A_6	490	497	PF00069	0.190
DOC_PP1_RVXF_1	423	430	PF00149	0.301
DOC_PP4_FxxP_1	565	568	PF00568	0.190
DOC_USP7_MATH_1	168	172	PF00917	0.438
DOC_USP7_MATH_1	364	368	PF00917	0.346
DOC_USP7_MATH_1	45	49	PF00917	0.549
DOC_USP7_MATH_1	451	455	PF00917	0.359
DOC_USP7_MATH_1	471	475	PF00917	0.254
DOC_USP7_MATH_1	589	593	PF00917	0.361
DOC_USP7_MATH_1	598	602	PF00917	0.318
DOC_USP7_UBL2_3	604	608	PF12436	0.376
DOC_WW_Pin1_4	290	295	PF00397	0.269
DOC_WW_Pin1_4	456	461	PF00397	0.304
LIG_14-3-3_CanoR_1	107	115	PF00244	0.498
LIG_14-3-3_CanoR_1	135	144	PF00244	0.510
LIG_14-3-3_CanoR_1	169	177	PF00244	0.451
LIG_14-3-3_CanoR_1	398	404	PF00244	0.362
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BIR_III_2	503	507	PF00653	0.224
LIG_BRCT_BRCA1_1	209	213	PF00533	0.270
LIG_BRCT_BRCA1_1	579	583	PF00533	0.371
LIG_deltaCOP1_diTrp_1	272	278	PF00928	0.371
LIG_eIF4E_1	577	583	PF01652	0.190
LIG_FHA_1	136	142	PF00498	0.529
LIG_FHA_1	298	304	PF00498	0.270
LIG_FHA_1	310	316	PF00498	0.270
LIG_FHA_1	324	330	PF00498	0.331
LIG_FHA_1	366	372	PF00498	0.276
LIG_FHA_1	377	383	PF00498	0.269
LIG_FHA_1	422	428	PF00498	0.329
LIG_FHA_1	457	463	PF00498	0.364
LIG_FHA_1	497	503	PF00498	0.269
LIG_FHA_1	571	577	PF00498	0.287
LIG_FHA_1	650	656	PF00498	0.270
LIG_FHA_1	96	102	PF00498	0.443
LIG_FHA_2	291	297	PF00498	0.341
LIG_FHA_2	451	457	PF00498	0.355
LIG_FHA_2	551	557	PF00498	0.190
LIG_GBD_Chelix_1	19	27	PF00786	0.212
LIG_LIR_Gen_1	272	281	PF02991	0.372
LIG_LIR_Gen_1	491	502	PF02991	0.190
LIG_LIR_Gen_1	580	589	PF02991	0.270
LIG_LIR_Gen_1	643	651	PF02991	0.317
LIG_LIR_Gen_1	652	660	PF02991	0.241
LIG_LIR_Nem_3	254	260	PF02991	0.311
LIG_LIR_Nem_3	272	278	PF02991	0.372
LIG_LIR_Nem_3	414	418	PF02991	0.341
LIG_LIR_Nem_3	491	497	PF02991	0.305
LIG_LIR_Nem_3	503	508	PF02991	0.278
LIG_LIR_Nem_3	580	586	PF02991	0.270
LIG_LIR_Nem_3	645	651	PF02991	0.299
LIG_LIR_Nem_3	652	656	PF02991	0.262
LIG_NRBOX	581	587	PF00104	0.190
LIG_Pex14_2	579	583	PF04695	0.371
LIG_PTB_Apo_2	599	606	PF02174	0.176
LIG_SH2_CRK	209	213	PF00017	0.287
LIG_SH2_CRK	257	261	PF00017	0.190
LIG_SH2_CRK	653	657	PF00017	0.327
LIG_SH2_NCK_1	209	213	PF00017	0.287
LIG_SH2_NCK_1	660	664	PF00017	0.357
LIG_SH2_SRC	411	414	PF00017	0.263
LIG_SH2_STAP1	209	213	PF00017	0.285
LIG_SH2_STAP1	512	516	PF00017	0.190
LIG_SH2_STAP1	577	581	PF00017	0.286
LIG_SH2_STAP1	644	648	PF00017	0.339
LIG_SH2_STAP1	649	653	PF00017	0.331
LIG_SH2_STAP1	677	681	PF00017	0.304
LIG_SH2_STAT3	512	515	PF00017	0.266
LIG_SH2_STAT5	651	654	PF00017	0.307
LIG_SH3_3	162	168	PF00018	0.387
LIG_SH3_3	379	385	PF00018	0.287
LIG_SH3_3	561	567	PF00018	0.271
LIG_SH3_3	604	610	PF00018	0.357
LIG_SUMO_SIM_anti_2	244	251	PF11976	0.343
LIG_SUMO_SIM_par_1	686	691	PF11976	0.315
LIG_SUMO_SIM_par_1	98	104	PF11976	0.516
LIG_TRAF2_1	340	343	PF00917	0.371
LIG_TRAF2_1	553	556	PF00917	0.355
LIG_TYR_ITIM	255	260	PF00017	0.318
LIG_UBA3_1	141	145	PF00899	0.350
LIG_UBA3_1	252	258	PF00899	0.358
LIG_UBA3_1	305	310	PF00899	0.371
LIG_UBA3_1	427	434	PF00899	0.334
LIG_WRC_WIRS_1	355	360	PF05994	0.190
MOD_CK1_1	110	116	PF00069	0.471
MOD_CK1_1	458	464	PF00069	0.250
MOD_CK2_1	150	156	PF00069	0.415
MOD_CK2_1	290	296	PF00069	0.341
MOD_CK2_1	337	343	PF00069	0.318
MOD_CK2_1	471	477	PF00069	0.241
MOD_CK2_1	550	556	PF00069	0.190
MOD_CK2_1	672	678	PF00069	0.232
MOD_Cter_Amidation	432	435	PF01082	0.390
MOD_GlcNHglycan	109	112	PF01048	0.727
MOD_GlcNHglycan	171	174	PF01048	0.663
MOD_GlcNHglycan	235	238	PF01048	0.469
MOD_GlcNHglycan	331	334	PF01048	0.466
MOD_GlcNHglycan	399	402	PF01048	0.493
MOD_GlcNHglycan	442	445	PF01048	0.466
MOD_GlcNHglycan	453	456	PF01048	0.555
MOD_GlcNHglycan	469	472	PF01048	0.492
MOD_GlcNHglycan	674	677	PF01048	0.376
MOD_GlcNHglycan	77	80	PF01048	0.683
MOD_GSK3_1	121	128	PF00069	0.472
MOD_GSK3_1	442	449	PF00069	0.314
MOD_GSK3_1	451	458	PF00069	0.248
MOD_GSK3_1	467	474	PF00069	0.161
MOD_GSK3_1	672	679	PF00069	0.312
MOD_N-GLC_1	135	140	PF02516	0.717
MOD_N-GLC_1	467	472	PF02516	0.522
MOD_N-GLC_1	570	575	PF02516	0.548
MOD_N-GLC_1	589	594	PF02516	0.346
MOD_NEK2_1	129	134	PF00069	0.369
MOD_NEK2_1	297	302	PF00069	0.270
MOD_NEK2_1	31	36	PF00069	0.308
MOD_NEK2_1	329	334	PF00069	0.266
MOD_NEK2_1	354	359	PF00069	0.224
MOD_NEK2_1	623	628	PF00069	0.350
MOD_NEK2_1	647	652	PF00069	0.266
MOD_NEK2_1	683	688	PF00069	0.274
MOD_NEK2_1	75	80	PF00069	0.373
MOD_NEK2_1	97	102	PF00069	0.387
MOD_NEK2_2	386	391	PF00069	0.260
MOD_NEK2_2	404	409	PF00069	0.287
MOD_NEK2_2	636	641	PF00069	0.346
MOD_PIKK_1	230	236	PF00454	0.190
MOD_PIKK_1	376	382	PF00454	0.270
MOD_PKA_1	169	175	PF00069	0.461
MOD_PKA_1	323	329	PF00069	0.190
MOD_PKA_1	672	678	PF00069	0.176
MOD_PKA_2	134	140	PF00069	0.351
MOD_PKA_2	168	174	PF00069	0.477
MOD_PKA_2	329	335	PF00069	0.266
MOD_PKA_2	359	365	PF00069	0.273
MOD_PKA_2	397	403	PF00069	0.301
MOD_PKA_2	445	451	PF00069	0.190
MOD_PKA_2	45	51	PF00069	0.465
MOD_PKA_2	518	524	PF00069	0.190
MOD_PKB_1	105	113	PF00069	0.527
MOD_PKB_1	321	329	PF00069	0.343
MOD_Plk_1	386	392	PF00069	0.339
MOD_Plk_1	589	595	PF00069	0.371
MOD_Plk_4	207	213	PF00069	0.280
MOD_Plk_4	323	329	PF00069	0.338
MOD_Plk_4	386	392	PF00069	0.190
MOD_Plk_4	683	689	PF00069	0.268
MOD_ProDKin_1	290	296	PF00069	0.269
MOD_ProDKin_1	456	462	PF00069	0.304
MOD_SUMO_for_1	151	154	PF00179	0.345
MOD_SUMO_for_1	59	62	PF00179	0.443
MOD_SUMO_for_1	640	643	PF00179	0.339
MOD_SUMO_rev_2	601	610	PF00179	0.357
TRG_DiLeu_BaEn_3	477	483	PF01217	0.190
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.371
TRG_ENDOCYTIC_2	209	212	PF00928	0.287
TRG_ENDOCYTIC_2	257	260	PF00928	0.230
TRG_ENDOCYTIC_2	644	647	PF00928	0.339
TRG_ENDOCYTIC_2	653	656	PF00928	0.339
TRG_ER_diArg_1	168	170	PF00400	0.553
TRG_ER_diArg_1	318	321	PF00400	0.311
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.719
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	304	309	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E8	Leptomonas seymouri	46%	100%
A0A1X0NQR7	Trypanosomatidae	32%	100%
A0A3R7NV38	Trypanosoma rangeli	34%	100%
A0A3S7WR18	Leishmania donovani	70%	100%
A4HUC4	Leishmania infantum	70%	100%
C9ZVG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AN23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
P40009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q28CF8	Xenopus tropicalis	20%	100%
Q4QHK3	Leishmania major	69%	99%
Q5REF6	Pongo abelii	22%	100%
Q8TGH6	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	100%
Q9DBT4	Mus musculus	21%	100%
Q9HEM6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	100%
Q9NQZ7	Homo sapiens	22%	100%
Q9Y227	Homo sapiens	22%	100%