Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5Z7_LEIBR

TriTrypDb:

LbrM.10.0160 , LBRM2903_100006500

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Z7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.602
CLV_NRD_NRD_1	27	29	PF00675	0.415
CLV_NRD_NRD_1	282	284	PF00675	0.512
CLV_NRD_NRD_1	72	74	PF00675	0.483
CLV_NRD_NRD_1	83	85	PF00675	0.372
CLV_NRD_NRD_1	99	101	PF00675	0.428
CLV_PCSK_KEX2_1	282	284	PF00082	0.512
CLV_PCSK_KEX2_1	72	74	PF00082	0.483
CLV_PCSK_KEX2_1	83	85	PF00082	0.372
CLV_PCSK_SKI1_1	125	129	PF00082	0.507
CLV_PCSK_SKI1_1	250	254	PF00082	0.400
DEG_APCC_DBOX_1	148	156	PF00400	0.339
DEG_APCC_DBOX_1	52	60	PF00400	0.491
DEG_SPOP_SBC_1	229	233	PF00917	0.642
DOC_USP7_MATH_1	209	213	PF00917	0.499
DOC_USP7_MATH_1	229	233	PF00917	0.682
DOC_USP7_MATH_1	368	372	PF00917	0.603
DOC_USP7_MATH_1	443	447	PF00917	0.538
DOC_WW_Pin1_4	347	352	PF00397	0.622
DOC_WW_Pin1_4	364	369	PF00397	0.468
LIG_14-3-3_CanoR_1	354	360	PF00244	0.685
LIG_14-3-3_CanoR_1	362	370	PF00244	0.627
LIG_14-3-3_CanoR_1	46	50	PF00244	0.304
LIG_Actin_WH2_2	31	48	PF00022	0.342
LIG_BRCT_BRCA1_1	212	216	PF00533	0.562
LIG_BRCT_BRCA1_1	332	336	PF00533	0.608
LIG_BRCT_BRCA1_1	414	418	PF00533	0.505
LIG_EVH1_2	386	390	PF00568	0.508
LIG_FHA_1	158	164	PF00498	0.482
LIG_FHA_1	236	242	PF00498	0.646
LIG_FHA_1	244	250	PF00498	0.558
LIG_FHA_1	251	257	PF00498	0.333
LIG_FHA_1	262	268	PF00498	0.304
LIG_FHA_1	296	302	PF00498	0.559
LIG_FHA_1	348	354	PF00498	0.711
LIG_FHA_1	45	51	PF00498	0.549
LIG_FHA_2	56	62	PF00498	0.530
LIG_GBD_Chelix_1	134	142	PF00786	0.507
LIG_LIR_Gen_1	271	280	PF02991	0.342
LIG_LIR_Gen_1	405	412	PF02991	0.503
LIG_LIR_Nem_3	213	219	PF02991	0.557
LIG_LIR_Nem_3	405	411	PF02991	0.500
LIG_LIR_Nem_3	415	421	PF02991	0.487
LIG_PCNA_yPIPBox_3	72	81	PF02747	0.567
LIG_SH2_STAP1	17	21	PF00017	0.507
LIG_SH2_STAT5	251	254	PF00017	0.503
LIG_SH2_STAT5	273	276	PF00017	0.477
LIG_SH3_3	212	218	PF00018	0.568
LIG_SH3_3	367	373	PF00018	0.618
LIG_SH3_3	8	14	PF00018	0.429
LIG_TRAF2_1	107	110	PF00917	0.503
LIG_TRAF2_1	58	61	PF00917	0.566
LIG_UBA3_1	81	89	PF00899	0.510
LIG_WW_1	14	17	PF00397	0.531
MOD_CDK_SPxxK_3	347	354	PF00069	0.615
MOD_CK1_1	225	231	PF00069	0.681
MOD_CK1_1	342	348	PF00069	0.557
MOD_CK1_1	393	399	PF00069	0.566
MOD_CK1_1	401	407	PF00069	0.641
MOD_CK1_1	416	422	PF00069	0.643
MOD_CK1_1	446	452	PF00069	0.627
MOD_CK1_1	55	61	PF00069	0.584
MOD_CK2_1	116	122	PF00069	0.370
MOD_CK2_1	265	271	PF00069	0.577
MOD_CK2_1	55	61	PF00069	0.460
MOD_GlcNHglycan	205	208	PF01048	0.762
MOD_GlcNHglycan	212	215	PF01048	0.705
MOD_GlcNHglycan	227	230	PF01048	0.624
MOD_GlcNHglycan	342	345	PF01048	0.587
MOD_GlcNHglycan	364	367	PF01048	0.580
MOD_GlcNHglycan	398	401	PF01048	0.604
MOD_GlcNHglycan	415	418	PF01048	0.471
MOD_GSK3_1	188	195	PF00069	0.726
MOD_GSK3_1	221	228	PF00069	0.640
MOD_GSK3_1	229	236	PF00069	0.563
MOD_GSK3_1	261	268	PF00069	0.467
MOD_GSK3_1	339	346	PF00069	0.567
MOD_GSK3_1	354	361	PF00069	0.590
MOD_GSK3_1	364	371	PF00069	0.538
MOD_GSK3_1	392	399	PF00069	0.653
MOD_GSK3_1	412	419	PF00069	0.615
MOD_LATS_1	220	226	PF00433	0.634
MOD_N-GLC_1	331	336	PF02516	0.476
MOD_N-GLC_1	393	398	PF02516	0.487
MOD_NEK2_1	113	118	PF00069	0.457
MOD_NEK2_1	331	336	PF00069	0.657
MOD_NEK2_1	390	395	PF00069	0.525
MOD_NEK2_1	411	416	PF00069	0.636
MOD_NEK2_1	45	50	PF00069	0.444
MOD_NEK2_1	52	57	PF00069	0.552
MOD_NEK2_1	85	90	PF00069	0.472
MOD_PIKK_1	295	301	PF00454	0.520
MOD_PKA_2	221	227	PF00069	0.796
MOD_PKA_2	45	51	PF00069	0.309
MOD_PKA_2	52	58	PF00069	0.545
MOD_Plk_1	331	337	PF00069	0.588
MOD_Plk_1	393	399	PF00069	0.486
MOD_Plk_4	45	51	PF00069	0.484
MOD_ProDKin_1	347	353	PF00069	0.625
MOD_ProDKin_1	364	370	PF00069	0.470
MOD_SUMO_for_1	127	130	PF00179	0.483
MOD_SUMO_rev_2	105	113	PF00179	0.457
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.340
TRG_ENDOCYTIC_2	273	276	PF00928	0.337
TRG_ENDOCYTIC_2	67	70	PF00928	0.467
TRG_ER_diArg_1	282	284	PF00400	0.568
TRG_ER_diArg_1	50	53	PF00400	0.429
TRG_ER_diArg_1	82	84	PF00400	0.431
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JC19	Bodo saltans	26%	100%
A0A3R7MLU6	Trypanosoma rangeli	32%	99%
A0A3S7WR07	Leishmania donovani	77%	90%
A4HUC3	Leishmania infantum	77%	90%
E9AN22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	92%
Q4QHK4	Leishmania major	75%	100%
V5DA15	Trypanosoma cruzi	32%	100%