Ecdysone-induced protein 74EF

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H5Z6_LEIBR

TriTrypDb:

LbrM.10.0150 , LBRM2903_100006400

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Z6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	258	263	PF00400	0.545
DEG_SPOP_SBC_1	266	270	PF00917	0.646
DEG_SPOP_SBC_1	309	313	PF00917	0.516
DOC_CKS1_1	164	169	PF01111	0.592
DOC_CKS1_1	261	266	PF01111	0.555
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	152	155	PF00134	0.484
DOC_PP2B_LxvP_1	152	155	PF13499	0.562
DOC_PP2B_LxvP_1	215	218	PF13499	0.494
DOC_USP7_MATH_1	16	20	PF00917	0.591
DOC_USP7_MATH_1	171	175	PF00917	0.489
DOC_USP7_MATH_1	265	269	PF00917	0.646
DOC_USP7_MATH_1	284	288	PF00917	0.473
DOC_USP7_MATH_1	307	311	PF00917	0.685
DOC_USP7_MATH_1	82	86	PF00917	0.550
DOC_WW_Pin1_4	163	168	PF00397	0.594
DOC_WW_Pin1_4	185	190	PF00397	0.631
DOC_WW_Pin1_4	205	210	PF00397	0.566
DOC_WW_Pin1_4	220	225	PF00397	0.556
DOC_WW_Pin1_4	256	261	PF00397	0.536
DOC_WW_Pin1_4	267	272	PF00397	0.578
DOC_WW_Pin1_4	324	329	PF00397	0.569
DOC_WW_Pin1_4	343	348	PF00397	0.452
DOC_WW_Pin1_4	357	362	PF00397	0.604
LIG_14-3-3_CanoR_1	172	176	PF00244	0.491
LIG_14-3-3_CanoR_1	278	282	PF00244	0.574
LIG_14-3-3_CanoR_1	308	318	PF00244	0.621
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BRCT_BRCA1_1	18	22	PF00533	0.653
LIG_BRCT_BRCA1_1	48	52	PF00533	0.620
LIG_CtBP_PxDLS_1	112	117	PF00389	0.566
LIG_EVH1_1	153	157	PF00568	0.546
LIG_EVH1_2	194	198	PF00568	0.546
LIG_FHA_1	148	154	PF00498	0.503
LIG_FHA_1	22	28	PF00498	0.539
LIG_FHA_1	238	244	PF00498	0.508
LIG_FHA_1	40	46	PF00498	0.585
LIG_FHA_2	13	19	PF00498	0.551
LIG_LIR_Apic_2	228	232	PF02991	0.462
LIG_LIR_Apic_2	259	265	PF02991	0.547
LIG_LIR_Gen_1	49	58	PF02991	0.633
LIG_LIR_Nem_3	49	55	PF02991	0.562
LIG_NRBOX	72	78	PF00104	0.490
LIG_PCNA_yPIPBox_3	70	81	PF02747	0.502
LIG_PROFILIN_1	154	160	PF00235	0.536
LIG_SH2_CRK	123	127	PF00017	0.612
LIG_SH2_CRK	164	168	PF00017	0.597
LIG_SH2_CRK	179	183	PF00017	0.571
LIG_SH2_CRK	262	266	PF00017	0.558
LIG_SH2_CRK	279	283	PF00017	0.574
LIG_SH2_GRB2like	175	178	PF00017	0.632
LIG_SH2_NCK_1	123	127	PF00017	0.640
LIG_SH2_NCK_1	146	150	PF00017	0.588
LIG_SH2_NCK_1	164	168	PF00017	0.661
LIG_SH2_NCK_1	262	266	PF00017	0.558
LIG_SH2_NCK_1	279	283	PF00017	0.574
LIG_SH2_PTP2	119	122	PF00017	0.498
LIG_SH2_PTP2	229	232	PF00017	0.607
LIG_SH2_SRC	119	122	PF00017	0.498
LIG_SH2_SRC	229	232	PF00017	0.543
LIG_SH2_STAP1	13	17	PF00017	0.509
LIG_SH2_STAP1	175	179	PF00017	0.636
LIG_SH2_STAT5	119	122	PF00017	0.726
LIG_SH2_STAT5	123	126	PF00017	0.777
LIG_SH2_STAT5	229	232	PF00017	0.614
LIG_SH2_STAT5	262	265	PF00017	0.552
LIG_SH2_STAT5	329	332	PF00017	0.626
LIG_SH3_3	100	106	PF00018	0.546
LIG_SH3_3	115	121	PF00018	0.595
LIG_SH3_3	151	157	PF00018	0.564
LIG_SH3_3	190	196	PF00018	0.626
LIG_SH3_3	228	234	PF00018	0.572
LIG_SH3_3	255	261	PF00018	0.531
LIG_SH3_3	269	275	PF00018	0.570
LIG_SH3_3	317	323	PF00018	0.678
LIG_SH3_3	358	364	PF00018	0.667
LIG_SUMO_SIM_par_1	211	216	PF11976	0.504
LIG_TRAF2_1	218	221	PF00917	0.555
LIG_TRAF2_1	236	239	PF00917	0.534
LIG_TRAF2_1	57	60	PF00917	0.567
LIG_TRFH_1	250	254	PF08558	0.486
LIG_TRFH_1	279	283	PF08558	0.574
LIG_UBA3_1	251	257	PF00899	0.508
LIG_WW_1	161	164	PF00397	0.570
LIG_WW_1	315	318	PF00397	0.512
LIG_WW_1	353	356	PF00397	0.586
MOD_CDK_SPK_2	357	362	PF00069	0.515
MOD_CDK_SPxxK_3	185	192	PF00069	0.649
MOD_CDK_SPxxK_3	271	278	PF00069	0.568
MOD_CK1_1	145	151	PF00069	0.649
MOD_CK1_1	165	171	PF00069	0.644
MOD_CK1_1	180	186	PF00069	0.496
MOD_CK1_1	211	217	PF00069	0.592
MOD_CK1_1	256	262	PF00069	0.554
MOD_CK1_1	310	316	PF00069	0.661
MOD_CK2_1	12	18	PF00069	0.681
MOD_CK2_1	194	200	PF00069	0.547
MOD_CK2_1	308	314	PF00069	0.663
MOD_GlcNHglycan	147	150	PF01048	0.678
MOD_GlcNHglycan	179	182	PF01048	0.570
MOD_GlcNHglycan	18	21	PF01048	0.762
MOD_GlcNHglycan	291	294	PF01048	0.661
MOD_GSK3_1	12	19	PF00069	0.746
MOD_GSK3_1	144	151	PF00069	0.686
MOD_GSK3_1	180	187	PF00069	0.642
MOD_GSK3_1	201	208	PF00069	0.634
MOD_GSK3_1	216	223	PF00069	0.437
MOD_GSK3_1	256	263	PF00069	0.552
MOD_GSK3_1	267	274	PF00069	0.580
MOD_GSK3_1	284	291	PF00069	0.579
MOD_GSK3_1	339	346	PF00069	0.609
MOD_N-GLC_1	142	147	PF02516	0.564
MOD_N-GLC_1	289	294	PF02516	0.509
MOD_NEK2_1	202	207	PF00069	0.510
MOD_NEK2_1	225	230	PF00069	0.541
MOD_NEK2_1	243	248	PF00069	0.597
MOD_NEK2_1	289	294	PF00069	0.603
MOD_NEK2_1	297	302	PF00069	0.558
MOD_NEK2_1	334	339	PF00069	0.586
MOD_NEK2_2	136	141	PF00069	0.510
MOD_NEK2_2	339	344	PF00069	0.490
MOD_NEK2_2	47	52	PF00069	0.620
MOD_PIKK_1	216	222	PF00454	0.557
MOD_PKA_2	171	177	PF00069	0.490
MOD_PKA_2	243	249	PF00069	0.559
MOD_PKA_2	277	283	PF00069	0.574
MOD_PKA_2	307	313	PF00069	0.664
MOD_Plk_1	142	148	PF00069	0.568
MOD_Plk_2-3	84	90	PF00069	0.616
MOD_Plk_2-3	96	102	PF00069	0.592
MOD_Plk_4	148	154	PF00069	0.615
MOD_Plk_4	208	214	PF00069	0.786
MOD_Plk_4	225	231	PF00069	0.532
MOD_Plk_4	237	243	PF00069	0.499
MOD_Plk_4	298	304	PF00069	0.591
MOD_Plk_4	47	53	PF00069	0.693
MOD_ProDKin_1	163	169	PF00069	0.591
MOD_ProDKin_1	185	191	PF00069	0.630
MOD_ProDKin_1	205	211	PF00069	0.567
MOD_ProDKin_1	220	226	PF00069	0.557
MOD_ProDKin_1	256	262	PF00069	0.539
MOD_ProDKin_1	267	273	PF00069	0.576
MOD_ProDKin_1	324	330	PF00069	0.569
MOD_ProDKin_1	343	349	PF00069	0.456
MOD_ProDKin_1	357	363	PF00069	0.602
MOD_SUMO_rev_2	84	92	PF00179	0.500
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.489
TRG_DiLeu_LyEn_5	221	226	PF01217	0.481
TRG_ENDOCYTIC_2	123	126	PF00928	0.643
TRG_ENDOCYTIC_2	179	182	PF00928	0.570
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX5	Leptomonas seymouri	54%	99%
A0A3Q8IAY2	Leishmania donovani	79%	99%
A4HUC2	Leishmania infantum	80%	99%
E9AN21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
Q4QHK5	Leishmania major	78%	99%