Putative DEAD/DEAH box helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial

Species:

Leishmania braziliensis

UniProt:

A4H5Z5_LEIBR

TriTrypDb:

LbrM.10.0140 , LBRM2903_100006300

Length:

721

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005730	nucleolus	5	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	3
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	4
GO:1990904	ribonucleoprotein complex	2	2
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4H5Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Z5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006364	rRNA processing	8	4
GO:0006396	RNA processing	6	4
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016070	RNA metabolic process	5	5
GO:0016072	rRNA metabolic process	7	4
GO:0030490	maturation of SSU-rRNA	9	4
GO:0034470	ncRNA processing	7	4
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034660	ncRNA metabolic process	6	4
GO:0043170	macromolecule metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0046483	heterocycle metabolic process	3	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5
GO:0009451	RNA modification	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0043412	macromolecule modification	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	23
GO:0003676	nucleic acid binding	3	23
GO:0003824	catalytic activity	1	23
GO:0004386	helicase activity	2	23
GO:0005488	binding	1	23
GO:0005524	ATP binding	5	23
GO:0017076	purine nucleotide binding	4	23
GO:0030554	adenyl nucleotide binding	5	23
GO:0032553	ribonucleotide binding	3	23
GO:0032555	purine ribonucleotide binding	4	23
GO:0032559	adenyl ribonucleotide binding	5	23
GO:0035639	purine ribonucleoside triphosphate binding	4	23
GO:0036094	small molecule binding	2	23
GO:0043167	ion binding	2	23
GO:0043168	anion binding	3	23
GO:0097159	organic cyclic compound binding	2	23
GO:0097367	carbohydrate derivative binding	2	23
GO:0140640	catalytic activity, acting on a nucleic acid	2	23
GO:0140657	ATP-dependent activity	1	23
GO:1901265	nucleoside phosphate binding	3	23
GO:1901363	heterocyclic compound binding	2	23
GO:0003724	RNA helicase activity	3	7
GO:0008186	ATP-dependent activity, acting on RNA	2	7
GO:0016787	hydrolase activity	2	16
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0003723	RNA binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.556
CLV_NRD_NRD_1	139	141	PF00675	0.622
CLV_NRD_NRD_1	387	389	PF00675	0.305
CLV_NRD_NRD_1	474	476	PF00675	0.457
CLV_NRD_NRD_1	566	568	PF00675	0.272
CLV_NRD_NRD_1	693	695	PF00675	0.682
CLV_NRD_NRD_1	698	700	PF00675	0.636
CLV_PCSK_FUR_1	696	700	PF00082	0.614
CLV_PCSK_KEX2_1	139	141	PF00082	0.622
CLV_PCSK_KEX2_1	525	527	PF00082	0.224
CLV_PCSK_KEX2_1	568	570	PF00082	0.225
CLV_PCSK_KEX2_1	693	695	PF00082	0.704
CLV_PCSK_KEX2_1	698	700	PF00082	0.662
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.224
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.245
CLV_PCSK_PC7_1	694	700	PF00082	0.605
CLV_PCSK_SKI1_1	187	191	PF00082	0.522
CLV_PCSK_SKI1_1	319	323	PF00082	0.277
CLV_PCSK_SKI1_1	448	452	PF00082	0.358
CLV_PCSK_SKI1_1	498	502	PF00082	0.602
DEG_APCC_DBOX_1	497	505	PF00400	0.339
DEG_SCF_FBW7_1	284	291	PF00400	0.378
DEG_SPOP_SBC_1	324	328	PF00917	0.418
DOC_ANK_TNKS_1	138	145	PF00023	0.534
DOC_CKS1_1	396	401	PF01111	0.485
DOC_CKS1_1	676	681	PF01111	0.561
DOC_MAPK_DCC_7	159	169	PF00069	0.465
DOC_MAPK_gen_1	388	396	PF00069	0.437
DOC_MAPK_gen_1	525	531	PF00069	0.467
DOC_PP2B_LxvP_1	466	469	PF13499	0.291
DOC_PP2B_LxvP_1	550	553	PF13499	0.424
DOC_PP4_FxxP_1	263	266	PF00568	0.475
DOC_PP4_FxxP_1	633	636	PF00568	0.328
DOC_USP7_MATH_1	288	292	PF00917	0.468
DOC_USP7_MATH_1	298	302	PF00917	0.485
DOC_USP7_MATH_1	323	327	PF00917	0.461
DOC_USP7_MATH_1	373	377	PF00917	0.481
DOC_USP7_MATH_1	503	507	PF00917	0.406
DOC_USP7_MATH_1	672	676	PF00917	0.602
DOC_USP7_MATH_1	90	94	PF00917	0.567
DOC_WW_Pin1_4	15	20	PF00397	0.485
DOC_WW_Pin1_4	177	182	PF00397	0.649
DOC_WW_Pin1_4	232	237	PF00397	0.536
DOC_WW_Pin1_4	284	289	PF00397	0.424
DOC_WW_Pin1_4	395	400	PF00397	0.485
DOC_WW_Pin1_4	430	435	PF00397	0.436
DOC_WW_Pin1_4	476	481	PF00397	0.442
DOC_WW_Pin1_4	675	680	PF00397	0.635
DOC_WW_Pin1_4	715	720	PF00397	0.660
LIG_14-3-3_CanoR_1	347	351	PF00244	0.486
LIG_14-3-3_CanoR_1	404	413	PF00244	0.471
LIG_14-3-3_CanoR_1	510	518	PF00244	0.373
LIG_14-3-3_CanoR_1	53	63	PF00244	0.478
LIG_14-3-3_CanoR_1	626	636	PF00244	0.427
LIG_14-3-3_CanoR_1	650	656	PF00244	0.412
LIG_Actin_WH2_2	336	354	PF00022	0.406
LIG_APCC_ABBA_1	37	42	PF00400	0.563
LIG_BRCT_BRCA1_1	629	633	PF00533	0.327
LIG_Clathr_ClatBox_1	427	431	PF01394	0.408
LIG_eIF4E_1	63	69	PF01652	0.608
LIG_EVH1_2	165	169	PF00568	0.489
LIG_FHA_1	401	407	PF00498	0.442
LIG_FHA_1	480	486	PF00498	0.581
LIG_FHA_1	541	547	PF00498	0.448
LIG_FHA_1	630	636	PF00498	0.294
LIG_FHA_1	643	649	PF00498	0.391
LIG_FHA_1	676	682	PF00498	0.567
LIG_FHA_1	690	696	PF00498	0.608
LIG_FHA_1	83	89	PF00498	0.575
LIG_FHA_2	16	22	PF00498	0.483
LIG_FHA_2	43	49	PF00498	0.490
LIG_FHA_2	486	492	PF00498	0.464
LIG_FHA_2	536	542	PF00498	0.509
LIG_KLC1_Yacidic_2	592	597	PF13176	0.378
LIG_LIR_Apic_2	24	29	PF02991	0.607
LIG_LIR_Apic_2	260	266	PF02991	0.380
LIG_LIR_Apic_2	294	300	PF02991	0.490
LIG_LIR_Apic_2	630	636	PF02991	0.322
LIG_LIR_Apic_2	673	679	PF02991	0.569
LIG_LIR_Gen_1	379	386	PF02991	0.378
LIG_LIR_Nem_3	21	26	PF02991	0.675
LIG_LIR_Nem_3	34	40	PF02991	0.609
LIG_LIR_Nem_3	379	384	PF02991	0.378
LIG_LIR_Nem_3	571	576	PF02991	0.378
LIG_PCNA_yPIPBox_3	650	664	PF02747	0.363
LIG_Rb_LxCxE_1	460	479	PF01857	0.323
LIG_Rb_pABgroove_1	512	520	PF01858	0.347
LIG_SH2_CRK	26	30	PF00017	0.459
LIG_SH2_CRK	297	301	PF00017	0.479
LIG_SH2_CRK	357	361	PF00017	0.486
LIG_SH2_CRK	371	375	PF00017	0.486
LIG_SH2_CRK	477	481	PF00017	0.352
LIG_SH2_CRK	605	609	PF00017	0.461
LIG_SH2_NCK_1	297	301	PF00017	0.410
LIG_SH2_NCK_1	381	385	PF00017	0.378
LIG_SH2_NCK_1	605	609	PF00017	0.445
LIG_SH2_SRC	26	29	PF00017	0.505
LIG_SH2_SRC	63	66	PF00017	0.480
LIG_SH2_STAP1	23	27	PF00017	0.466
LIG_SH2_STAP1	357	361	PF00017	0.385
LIG_SH2_STAP1	381	385	PF00017	0.378
LIG_SH2_STAT3	215	218	PF00017	0.431
LIG_SH2_STAT5	442	445	PF00017	0.294
LIG_SH2_STAT5	532	535	PF00017	0.457
LIG_SH2_STAT5	595	598	PF00017	0.560
LIG_SH2_STAT5	614	617	PF00017	0.510
LIG_SH3_2	163	168	PF14604	0.472
LIG_SH3_3	146	152	PF00018	0.597
LIG_SH3_3	160	166	PF00018	0.693
LIG_SH3_3	269	275	PF00018	0.436
LIG_SH3_3	332	338	PF00018	0.477
LIG_SH3_3	393	399	PF00018	0.511
LIG_SH3_3	426	432	PF00018	0.378
LIG_SUMO_SIM_anti_2	245	251	PF11976	0.291
LIG_SUMO_SIM_anti_2	301	306	PF11976	0.410
LIG_SUMO_SIM_par_1	28	34	PF11976	0.510
LIG_SUMO_SIM_par_1	417	422	PF11976	0.532
LIG_SUMO_SIM_par_1	426	431	PF11976	0.568
LIG_SUMO_SIM_par_1	482	488	PF11976	0.400
LIG_TRAF2_1	488	491	PF00917	0.469
LIG_TRAF2_1	538	541	PF00917	0.424
LIG_UBA3_1	305	309	PF00899	0.424
MOD_CDK_SPxK_1	232	238	PF00069	0.452
MOD_CDK_SPxxK_3	177	184	PF00069	0.498
MOD_CDK_SPxxK_3	430	437	PF00069	0.483
MOD_CDK_SPxxK_3	675	682	PF00069	0.564
MOD_CK1_1	261	267	PF00069	0.454
MOD_CK1_1	291	297	PF00069	0.503
MOD_CK1_1	326	332	PF00069	0.432
MOD_CK1_1	479	485	PF00069	0.393
MOD_CK1_1	551	557	PF00069	0.486
MOD_CK1_1	675	681	PF00069	0.595
MOD_CK1_1	689	695	PF00069	0.573
MOD_CK1_1	93	99	PF00069	0.573
MOD_CK2_1	373	379	PF00069	0.416
MOD_CK2_1	42	48	PF00069	0.469
MOD_CK2_1	485	491	PF00069	0.483
MOD_CK2_1	535	541	PF00069	0.437
MOD_Cter_Amidation	696	699	PF01082	0.649
MOD_GlcNHglycan	260	263	PF01048	0.405
MOD_GlcNHglycan	289	293	PF01048	0.293
MOD_GlcNHglycan	550	553	PF01048	0.286
MOD_GlcNHglycan	56	59	PF01048	0.554
MOD_GlcNHglycan	561	564	PF01048	0.286
MOD_GlcNHglycan	623	626	PF01048	0.239
MOD_GlcNHglycan	712	715	PF01048	0.654
MOD_GlcNHglycan	92	95	PF01048	0.813
MOD_GSK3_1	213	220	PF00069	0.646
MOD_GSK3_1	264	271	PF00069	0.345
MOD_GSK3_1	284	291	PF00069	0.444
MOD_GSK3_1	323	330	PF00069	0.414
MOD_GSK3_1	346	353	PF00069	0.476
MOD_GSK3_1	400	407	PF00069	0.389
MOD_GSK3_1	481	488	PF00069	0.474
MOD_GSK3_1	548	555	PF00069	0.459
MOD_GSK3_1	706	713	PF00069	0.529
MOD_GSK3_1	93	100	PF00069	0.561
MOD_N-GLC_1	197	202	PF02516	0.681
MOD_N-GLC_1	656	661	PF02516	0.312
MOD_NEK2_1	135	140	PF00069	0.652
MOD_NEK2_1	217	222	PF00069	0.589
MOD_NEK2_1	258	263	PF00069	0.400
MOD_NEK2_1	268	273	PF00069	0.220
MOD_NEK2_1	343	348	PF00069	0.515
MOD_NEK2_1	356	361	PF00069	0.490
MOD_NEK2_1	481	486	PF00069	0.498
MOD_NEK2_1	546	551	PF00069	0.497
MOD_NEK2_1	656	661	PF00069	0.395
MOD_NEK2_2	33	38	PF00069	0.454
MOD_NEK2_2	56	61	PF00069	0.449
MOD_PKA_2	264	270	PF00069	0.440
MOD_PKA_2	346	352	PF00069	0.486
MOD_PKA_2	509	515	PF00069	0.284
MOD_PKA_2	535	541	PF00069	0.499
MOD_PKA_2	649	655	PF00069	0.370
MOD_PKB_1	702	710	PF00069	0.453
MOD_Plk_1	197	203	PF00069	0.530
MOD_Plk_1	33	39	PF00069	0.526
MOD_Plk_1	41	47	PF00069	0.482
MOD_Plk_1	656	662	PF00069	0.560
MOD_Plk_1	672	678	PF00069	0.592
MOD_Plk_2-3	42	48	PF00069	0.469
MOD_Plk_4	264	270	PF00069	0.353
MOD_Plk_4	346	352	PF00069	0.498
MOD_Plk_4	469	475	PF00069	0.464
MOD_Plk_4	481	487	PF00069	0.380
MOD_Plk_4	552	558	PF00069	0.497
MOD_Plk_4	629	635	PF00069	0.355
MOD_Plk_4	93	99	PF00069	0.578
MOD_ProDKin_1	15	21	PF00069	0.484
MOD_ProDKin_1	177	183	PF00069	0.651
MOD_ProDKin_1	232	238	PF00069	0.541
MOD_ProDKin_1	284	290	PF00069	0.424
MOD_ProDKin_1	395	401	PF00069	0.485
MOD_ProDKin_1	430	436	PF00069	0.436
MOD_ProDKin_1	476	482	PF00069	0.440
MOD_ProDKin_1	675	681	PF00069	0.637
MOD_ProDKin_1	715	721	PF00069	0.666
TRG_DiLeu_BaEn_1	363	368	PF01217	0.451
TRG_ENDOCYTIC_2	357	360	PF00928	0.486
TRG_ENDOCYTIC_2	371	374	PF00928	0.486
TRG_ENDOCYTIC_2	381	384	PF00928	0.394
TRG_ER_diArg_1	139	141	PF00400	0.489
TRG_ER_diArg_1	566	569	PF00400	0.425
TRG_ER_diArg_1	693	696	PF00400	0.655
TRG_ER_diArg_1	701	704	PF00400	0.659
TRG_NES_CRM1_1	606	616	PF08389	0.442
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	699	703	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R1	Leptomonas seymouri	56%	91%
A0A0S4J5D6	Bodo saltans	23%	100%
A0A1X0NRS9	Trypanosomatidae	32%	93%
A0A3Q8ID91	Leishmania donovani	27%	100%
A0A3Q8IQY6	Leishmania donovani	25%	100%
A0A3S5H5X3	Leishmania donovani	22%	100%
A0A3S7WR01	Leishmania donovani	69%	92%
A0A3S7X579	Leishmania donovani	25%	100%
A0A3S7XAT8	Leishmania donovani	23%	100%
A1CHL3	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	24%	90%
A3GG51	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	23%	86%
A4H4Y0	Leishmania braziliensis	23%	100%
A4HGR1	Leishmania braziliensis	26%	100%
A4HK20	Leishmania braziliensis	23%	100%
A4HK38	Leishmania braziliensis	25%	100%
A4HP49	Leishmania braziliensis	22%	100%
A4HP82	Leishmania braziliensis	25%	100%
A4HT33	Leishmania infantum	22%	100%
A4HUC1	Leishmania infantum	69%	92%
A4HZF8	Leishmania infantum	20%	100%
A4I3T6	Leishmania infantum	27%	100%
A4I7M5	Leishmania infantum	25%	100%
A4IDF6	Leishmania infantum	23%	100%
A4IDI7	Leishmania infantum	25%	100%
A5DF03	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	22%	100%
E9AN20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	98%
E9ASV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ASZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B028	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B2I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q1K8	Leishmania major	24%	100%
Q4Q1N9	Leishmania major	22%	100%
Q4Q5M6	Leishmania major	25%	100%
Q4Q858	Leishmania major	27%	100%
Q4QHK6	Leishmania major	69%	100%
Q4QIQ9	Leishmania major	23%	100%
Q4QJI9	Leishmania major	22%	100%
Q5N7W4	Oryza sativa subsp. japonica	23%	100%
Q6CDS6	Yarrowia lipolytica (strain CLIB 122 / E 150)	22%	100%
Q92841	Homo sapiens	24%	99%
Q9LYJ9	Arabidopsis thaliana	23%	100%
V5BII0	Trypanosoma cruzi	35%	100%
V5D8J9	Trypanosoma cruzi	22%	100%