C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5Z4_LEIBR

TriTrypDb:

LbrM.10.0130 , LBRM2903_100006200

Length:

759

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Z4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	740	744	PF00656	0.666
CLV_NRD_NRD_1	184	186	PF00675	0.526
CLV_NRD_NRD_1	192	194	PF00675	0.595
CLV_NRD_NRD_1	209	211	PF00675	0.495
CLV_NRD_NRD_1	240	242	PF00675	0.513
CLV_NRD_NRD_1	90	92	PF00675	0.489
CLV_PCSK_KEX2_1	183	185	PF00082	0.522
CLV_PCSK_KEX2_1	297	299	PF00082	0.401
CLV_PCSK_KEX2_1	349	351	PF00082	0.539
CLV_PCSK_KEX2_1	90	92	PF00082	0.543
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.353
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.539
CLV_PCSK_PC7_1	179	185	PF00082	0.390
CLV_PCSK_PC7_1	293	299	PF00082	0.352
CLV_PCSK_PC7_1	86	92	PF00082	0.561
CLV_PCSK_SKI1_1	11	15	PF00082	0.415
CLV_PCSK_SKI1_1	210	214	PF00082	0.555
CLV_PCSK_SKI1_1	297	301	PF00082	0.495
CLV_PCSK_SKI1_1	340	344	PF00082	0.471
CLV_PCSK_SKI1_1	350	354	PF00082	0.548
CLV_PCSK_SKI1_1	423	427	PF00082	0.493
CLV_PCSK_SKI1_1	451	455	PF00082	0.635
CLV_PCSK_SKI1_1	747	751	PF00082	0.535
DEG_APCC_DBOX_1	319	327	PF00400	0.595
DEG_SCF_FBW7_2	526	532	PF00400	0.563
DEG_SPOP_SBC_1	472	476	PF00917	0.779
DOC_CKS1_1	378	383	PF01111	0.402
DOC_CKS1_1	526	531	PF01111	0.562
DOC_CYCLIN_RxL_1	325	339	PF00134	0.349
DOC_MAPK_gen_1	183	189	PF00069	0.470
DOC_MAPK_gen_1	297	306	PF00069	0.408
DOC_MAPK_MEF2A_6	127	134	PF00069	0.487
DOC_MAPK_MEF2A_6	167	175	PF00069	0.470
DOC_MAPK_MEF2A_6	536	544	PF00069	0.739
DOC_MAPK_RevD_3	170	185	PF00069	0.482
DOC_PIKK_1	199	206	PF02985	0.385
DOC_PP1_RVXF_1	73	80	PF00149	0.419
DOC_PP2B_LxvP_1	156	159	PF13499	0.475
DOC_PP2B_LxvP_1	535	538	PF13499	0.541
DOC_PP4_FxxP_1	641	644	PF00568	0.657
DOC_SPAK_OSR1_1	78	82	PF12202	0.507
DOC_SPAK_OSR1_1	9	13	PF12202	0.419
DOC_USP7_MATH_1	433	437	PF00917	0.725
DOC_USP7_MATH_1	472	476	PF00917	0.726
DOC_USP7_MATH_1	552	556	PF00917	0.743
DOC_USP7_MATH_1	606	610	PF00917	0.739
DOC_USP7_MATH_1	612	616	PF00917	0.712
DOC_USP7_MATH_2	713	719	PF00917	0.774
DOC_USP7_UBL2_3	349	353	PF12436	0.623
DOC_USP7_UBL2_3	451	455	PF12436	0.539
DOC_WW_Pin1_4	353	358	PF00397	0.563
DOC_WW_Pin1_4	36	41	PF00397	0.478
DOC_WW_Pin1_4	377	382	PF00397	0.401
DOC_WW_Pin1_4	463	468	PF00397	0.665
DOC_WW_Pin1_4	480	485	PF00397	0.626
DOC_WW_Pin1_4	525	530	PF00397	0.792
DOC_WW_Pin1_4	545	550	PF00397	0.436
DOC_WW_Pin1_4	592	597	PF00397	0.770
DOC_WW_Pin1_4	679	684	PF00397	0.769
LIG_14-3-3_CanoR_1	183	188	PF00244	0.602
LIG_14-3-3_CanoR_1	32	40	PF00244	0.547
LIG_APCC_ABBA_1	132	137	PF00400	0.453
LIG_Clathr_ClatBox_1	174	178	PF01394	0.465
LIG_FHA_1	184	190	PF00498	0.614
LIG_FHA_1	219	225	PF00498	0.543
LIG_FHA_1	274	280	PF00498	0.538
LIG_FHA_1	3	9	PF00498	0.504
LIG_FHA_1	342	348	PF00498	0.378
LIG_FHA_1	378	384	PF00498	0.468
LIG_FHA_1	389	395	PF00498	0.367
LIG_FHA_1	546	552	PF00498	0.621
LIG_FHA_1	653	659	PF00498	0.760
LIG_FHA_1	99	105	PF00498	0.571
LIG_FHA_2	224	230	PF00498	0.553
LIG_FHA_2	275	281	PF00498	0.551
LIG_FHA_2	442	448	PF00498	0.754
LIG_FHA_2	51	57	PF00498	0.431
LIG_IBAR_NPY_1	744	746	PF08397	0.679
LIG_LIR_Apic_2	639	644	PF02991	0.654
LIG_LIR_Apic_2	682	688	PF02991	0.640
LIG_LIR_Gen_1	632	643	PF02991	0.702
LIG_LIR_Nem_3	116	122	PF02991	0.488
LIG_LIR_Nem_3	143	147	PF02991	0.495
LIG_LIR_Nem_3	424	429	PF02991	0.606
LIG_LIR_Nem_3	584	588	PF02991	0.754
LIG_LIR_Nem_3	743	749	PF02991	0.755
LIG_NRBOX	176	182	PF00104	0.575
LIG_SH2_CRK	685	689	PF00017	0.550
LIG_SH2_CRK	746	750	PF00017	0.749
LIG_SH2_STAP1	26	30	PF00017	0.431
LIG_SH2_STAT3	42	45	PF00017	0.540
LIG_SH2_STAT5	236	239	PF00017	0.592
LIG_SH2_STAT5	254	257	PF00017	0.380
LIG_SH2_STAT5	26	29	PF00017	0.429
LIG_SH2_STAT5	42	45	PF00017	0.466
LIG_SH2_STAT5	76	79	PF00017	0.497
LIG_SH2_STAT5	84	87	PF00017	0.517
LIG_SH3_1	523	529	PF00018	0.744
LIG_SH3_1	531	537	PF00018	0.798
LIG_SH3_2	526	531	PF14604	0.601
LIG_SH3_3	12	18	PF00018	0.316
LIG_SH3_3	152	158	PF00018	0.667
LIG_SH3_3	400	406	PF00018	0.562
LIG_SH3_3	459	465	PF00018	0.606
LIG_SH3_3	523	529	PF00018	0.704
LIG_SH3_3	531	537	PF00018	0.721
LIG_SH3_3	600	606	PF00018	0.752
LIG_SUMO_SIM_anti_2	655	660	PF11976	0.537
LIG_SUMO_SIM_par_1	11	16	PF11976	0.477
LIG_TRAF2_1	197	200	PF00917	0.622
LIG_TRFH_1	602	606	PF08558	0.773
LIG_UBA3_1	206	211	PF00899	0.377
MOD_CDK_SPK_2	377	382	PF00069	0.401
MOD_CDK_SPxK_1	525	531	PF00069	0.580
MOD_CDK_SPxxK_3	353	360	PF00069	0.558
MOD_CK1_1	109	115	PF00069	0.360
MOD_CK1_1	36	42	PF00069	0.481
MOD_CK1_1	436	442	PF00069	0.663
MOD_CK1_1	471	477	PF00069	0.685
MOD_CK1_1	570	576	PF00069	0.816
MOD_CK1_1	615	621	PF00069	0.707
MOD_CK1_1	733	739	PF00069	0.730
MOD_CK2_1	194	200	PF00069	0.491
MOD_CK2_1	223	229	PF00069	0.571
MOD_CK2_1	274	280	PF00069	0.599
MOD_CK2_1	50	56	PF00069	0.497
MOD_CK2_1	518	524	PF00069	0.577
MOD_GlcNHglycan	109	112	PF01048	0.474
MOD_GlcNHglycan	45	48	PF01048	0.560
MOD_GlcNHglycan	470	473	PF01048	0.708
MOD_GlcNHglycan	478	481	PF01048	0.764
MOD_GlcNHglycan	506	512	PF01048	0.586
MOD_GlcNHglycan	570	573	PF01048	0.803
MOD_GlcNHglycan	64	67	PF01048	0.399
MOD_GlcNHglycan	696	699	PF01048	0.737
MOD_GlcNHglycan	727	730	PF01048	0.678
MOD_GSK3_1	105	112	PF00069	0.511
MOD_GSK3_1	32	39	PF00069	0.510
MOD_GSK3_1	432	439	PF00069	0.705
MOD_GSK3_1	468	475	PF00069	0.679
MOD_GSK3_1	476	483	PF00069	0.671
MOD_GSK3_1	606	613	PF00069	0.673
MOD_GSK3_1	721	728	PF00069	0.616
MOD_GSK3_1	747	754	PF00069	0.741
MOD_N-GLC_1	165	170	PF02516	0.368
MOD_N-GLC_1	285	290	PF02516	0.532
MOD_N-GLC_1	669	674	PF02516	0.730
MOD_N-GLC_1	730	735	PF02516	0.797
MOD_NEK2_1	258	263	PF00069	0.550
MOD_NEK2_1	336	341	PF00069	0.488
MOD_NEK2_1	460	465	PF00069	0.659
MOD_NEK2_1	544	549	PF00069	0.510
MOD_NEK2_1	567	572	PF00069	0.766
MOD_NEK2_1	589	594	PF00069	0.789
MOD_NEK2_2	669	674	PF00069	0.559
MOD_PIKK_1	433	439	PF00454	0.636
MOD_PIKK_1	98	104	PF00454	0.482
MOD_PKA_1	183	189	PF00069	0.611
MOD_PKA_1	273	279	PF00069	0.417
MOD_PKA_2	183	189	PF00069	0.611
MOD_PKA_2	33	39	PF00069	0.458
MOD_PKA_2	415	421	PF00069	0.698
MOD_PKA_2	676	682	PF00069	0.785
MOD_PKA_2	688	694	PF00069	0.738
MOD_Plk_1	285	291	PF00069	0.546
MOD_Plk_1	497	503	PF00069	0.650
MOD_Plk_1	639	645	PF00069	0.733
MOD_Plk_1	669	675	PF00069	0.673
MOD_Plk_1	98	104	PF00069	0.577
MOD_Plk_2-3	265	271	PF00069	0.546
MOD_Plk_2-3	441	447	PF00069	0.541
MOD_Plk_4	151	157	PF00069	0.457
MOD_Plk_4	24	30	PF00069	0.536
MOD_Plk_4	274	280	PF00069	0.662
MOD_Plk_4	584	590	PF00069	0.782
MOD_ProDKin_1	353	359	PF00069	0.559
MOD_ProDKin_1	36	42	PF00069	0.472
MOD_ProDKin_1	377	383	PF00069	0.403
MOD_ProDKin_1	463	469	PF00069	0.667
MOD_ProDKin_1	480	486	PF00069	0.624
MOD_ProDKin_1	525	531	PF00069	0.796
MOD_ProDKin_1	545	551	PF00069	0.439
MOD_ProDKin_1	592	598	PF00069	0.775
MOD_ProDKin_1	679	685	PF00069	0.772
MOD_SUMO_for_1	299	302	PF00179	0.576
MOD_SUMO_rev_2	197	203	PF00179	0.605
MOD_SUMO_rev_2	268	276	PF00179	0.457
MOD_SUMO_rev_2	324	333	PF00179	0.471
TRG_DiLeu_BaEn_1	56	61	PF01217	0.334
TRG_DiLeu_BaEn_4	301	307	PF01217	0.478
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.362
TRG_ENDOCYTIC_2	26	29	PF00928	0.529
TRG_ENDOCYTIC_2	635	638	PF00928	0.714
TRG_ENDOCYTIC_2	653	656	PF00928	0.618
TRG_ENDOCYTIC_2	746	749	PF00928	0.752
TRG_ENDOCYTIC_2	76	79	PF00928	0.524
TRG_ER_diArg_1	183	185	PF00400	0.522
TRG_ER_diArg_1	408	411	PF00400	0.490
TRG_ER_diArg_1	89	91	PF00400	0.554
TRG_NLS_Bipartite_1	331	352	PF00514	0.376
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	90	95	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD89	Leptomonas seymouri	56%	100%
A0A1X0NRK9	Trypanosomatidae	34%	100%
A0A3Q8I7M1	Leishmania donovani	64%	100%
A0A422NRU0	Trypanosoma rangeli	34%	100%
A4HUC0	Leishmania infantum	65%	100%
E9AN19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4QHK7	Leishmania major	63%	97%
V5B9H5	Trypanosoma cruzi	34%	100%