SRP40_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SRP40, C-terminal domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5Z2_LEIBR

TriTrypDb:

LbrM.10.0100 , LBRM2903_100005900

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H5Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Z2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	63	67	PF00656	0.693
CLV_NRD_NRD_1	153	155	PF00675	0.590
CLV_NRD_NRD_1	179	181	PF00675	0.430
CLV_NRD_NRD_1	24	26	PF00675	0.685
CLV_PCSK_KEX2_1	179	181	PF00082	0.430
CLV_Separin_Metazoa	213	217	PF03568	0.430
DOC_CKS1_1	166	171	PF01111	0.537
DOC_PP1_RVXF_1	186	192	PF00149	0.376
DOC_USP7_MATH_1	135	139	PF00917	0.737
DOC_USP7_UBL2_3	106	110	PF12436	0.702
DOC_USP7_UBL2_3	111	115	PF12436	0.735
DOC_USP7_UBL2_3	220	224	PF12436	0.385
DOC_USP7_UBL2_3	226	230	PF12436	0.389
DOC_WW_Pin1_4	110	115	PF00397	0.640
DOC_WW_Pin1_4	165	170	PF00397	0.777
DOC_WW_Pin1_4	49	54	PF00397	0.596
DOC_WW_Pin1_4	77	82	PF00397	0.736
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_FHA_1	129	135	PF00498	0.711
LIG_FHA_2	58	64	PF00498	0.618
LIG_LIR_Nem_3	177	181	PF02991	0.724
LIG_SH2_SRC	62	65	PF00017	0.532
LIG_SH2_STAT3	46	49	PF00017	0.718
LIG_SH2_STAT5	12	15	PF00017	0.572
LIG_SH2_STAT5	46	49	PF00017	0.466
LIG_SH2_STAT5	7	10	PF00017	0.587
LIG_SH3_3	101	107	PF00018	0.695
LIG_SH3_4	106	113	PF00018	0.607
LIG_SxIP_EBH_1	77	86	PF03271	0.791
LIG_TRAF2_1	201	204	PF00917	0.249
MOD_CDK_SPK_2	110	115	PF00069	0.697
MOD_CDK_SPxxK_3	79	86	PF00069	0.709
MOD_CK1_1	128	134	PF00069	0.792
MOD_CK2_1	247	253	PF00069	0.633
MOD_Cter_Amidation	140	143	PF01082	0.702
MOD_Cter_Amidation	34	37	PF01082	0.719
MOD_GlcNHglycan	107	110	PF01048	0.607
MOD_GlcNHglycan	137	140	PF01048	0.813
MOD_GSK3_1	105	112	PF00069	0.809
MOD_GSK3_1	124	131	PF00069	0.625
MOD_GSK3_1	75	82	PF00069	0.765
MOD_N-GLC_1	174	179	PF02516	0.697
MOD_N-GLC_1	57	62	PF02516	0.651
MOD_NEK2_1	214	219	PF00069	0.440
MOD_PKA_1	105	111	PF00069	0.795
MOD_Plk_1	100	106	PF00069	0.692
MOD_Plk_1	238	244	PF00069	0.430
MOD_Plk_1	57	63	PF00069	0.516
MOD_ProDKin_1	110	116	PF00069	0.636
MOD_ProDKin_1	165	171	PF00069	0.773
MOD_ProDKin_1	49	55	PF00069	0.597
MOD_ProDKin_1	77	83	PF00069	0.733
TRG_DiLeu_BaEn_4	203	209	PF01217	0.249
TRG_ER_diArg_1	178	180	PF00400	0.677
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.749
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8F0	Bodo saltans	40%	100%
A0A1X0NQ23	Trypanosomatidae	48%	100%
A0A3S5H6F2	Leishmania donovani	74%	98%
A4HUB7	Leishmania infantum	74%	98%
E9AN16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4QHL0	Leishmania major	76%	100%