Dehydrogenase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dehydrogenase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H5Z1_LEIBR

TriTrypDb:

LbrM.10.0090 , LBRM2903_100005800

Length:

440

Annotations

LeishMANIAdb annotations

Homologous to other Eukarytotic short-chain dehydrogenases.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H5Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.247
CLV_C14_Caspase3-7	378	382	PF00656	0.298
CLV_NRD_NRD_1	112	114	PF00675	0.440
CLV_NRD_NRD_1	25	27	PF00675	0.330
CLV_NRD_NRD_1	327	329	PF00675	0.426
CLV_NRD_NRD_1	413	415	PF00675	0.516
CLV_NRD_NRD_1	68	70	PF00675	0.633
CLV_NRD_NRD_1	89	91	PF00675	0.354
CLV_PCSK_FUR_1	411	415	PF00082	0.513
CLV_PCSK_KEX2_1	239	241	PF00082	0.509
CLV_PCSK_KEX2_1	327	329	PF00082	0.426
CLV_PCSK_KEX2_1	413	415	PF00082	0.516
CLV_PCSK_KEX2_1	68	70	PF00082	0.633
CLV_PCSK_KEX2_1	89	91	PF00082	0.354
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.476
CLV_PCSK_PC7_1	323	329	PF00082	0.416
CLV_PCSK_SKI1_1	10	14	PF00082	0.342
CLV_PCSK_SKI1_1	120	124	PF00082	0.433
CLV_PCSK_SKI1_1	194	198	PF00082	0.401
CLV_PCSK_SKI1_1	290	294	PF00082	0.610
CLV_PCSK_SKI1_1	315	319	PF00082	0.449
CLV_PCSK_SKI1_1	357	361	PF00082	0.598
CLV_PCSK_SKI1_1	413	417	PF00082	0.512
CLV_PCSK_SKI1_1	47	51	PF00082	0.205
DEG_APCC_DBOX_1	161	169	PF00400	0.178
DEG_APCC_DBOX_1	46	54	PF00400	0.249
DEG_Nend_UBRbox_4	1	3	PF02207	0.542
DOC_CYCLIN_RxL_1	191	202	PF00134	0.178
DOC_CYCLIN_RxL_1	309	322	PF00134	0.269
DOC_CYCLIN_yCln2_LP_2	169	175	PF00134	0.280
DOC_CYCLIN_yCln2_LP_2	229	235	PF00134	0.315
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.336
DOC_MAPK_FxFP_2	364	367	PF00069	0.362
DOC_MAPK_gen_1	236	246	PF00069	0.305
DOC_MAPK_MEF2A_6	162	169	PF00069	0.276
DOC_MAPK_MEF2A_6	239	248	PF00069	0.276
DOC_PP2B_LxvP_1	11	14	PF13499	0.540
DOC_PP2B_PxIxI_1	217	223	PF00149	0.268
DOC_PP4_FxxP_1	364	367	PF00568	0.319
DOC_USP7_MATH_1	104	108	PF00917	0.651
DOC_USP7_MATH_1	130	134	PF00917	0.303
DOC_USP7_UBL2_3	110	114	PF12436	0.536
DOC_USP7_UBL2_3	426	430	PF12436	0.399
DOC_WW_Pin1_4	105	110	PF00397	0.639
DOC_WW_Pin1_4	185	190	PF00397	0.178
DOC_WW_Pin1_4	214	219	PF00397	0.260
DOC_WW_Pin1_4	301	306	PF00397	0.392
DOC_WW_Pin1_4	397	402	PF00397	0.300
LIG_14-3-3_CanoR_1	113	122	PF00244	0.628
LIG_14-3-3_CanoR_1	187	193	PF00244	0.178
LIG_14-3-3_CanoR_1	207	214	PF00244	0.280
LIG_14-3-3_CanoR_1	263	269	PF00244	0.199
LIG_14-3-3_CanoR_1	98	103	PF00244	0.652
LIG_Actin_WH2_2	149	164	PF00022	0.280
LIG_Actin_WH2_2	33	49	PF00022	0.476
LIG_Actin_WH2_2	347	363	PF00022	0.362
LIG_BRCT_BRCA1_1	246	250	PF00533	0.280
LIG_BRCT_BRCA1_1	384	388	PF00533	0.307
LIG_BRCT_BRCA1_1	95	99	PF00533	0.579
LIG_CtBP_PxDLS_1	4	8	PF00389	0.536
LIG_eIF4E_1	311	317	PF01652	0.261
LIG_FHA_1	215	221	PF00498	0.289
LIG_FHA_1	255	261	PF00498	0.243
LIG_FHA_1	320	326	PF00498	0.245
LIG_FHA_1	330	336	PF00498	0.289
LIG_FHA_1	426	432	PF00498	0.364
LIG_FHA_1	6	12	PF00498	0.575
LIG_FHA_2	144	150	PF00498	0.327
LIG_FHA_2	289	295	PF00498	0.383
LIG_FHA_2	376	382	PF00498	0.291
LIG_FHA_2	391	397	PF00498	0.309
LIG_FHA_2	40	46	PF00498	0.327
LIG_LIR_Apic_2	362	367	PF02991	0.329
LIG_LIR_Gen_1	96	104	PF02991	0.582
LIG_LIR_Nem_3	393	398	PF02991	0.368
LIG_LIR_Nem_3	96	102	PF02991	0.619
LIG_NRBOX	312	318	PF00104	0.298
LIG_PCNA_yPIPBox_3	10	23	PF02747	0.534
LIG_PCNA_yPIPBox_3	310	323	PF02747	0.298
LIG_PCNA_yPIPBox_3	409	418	PF02747	0.314
LIG_PDZ_Class_1	435	440	PF00595	0.260
LIG_Pex14_2	351	355	PF04695	0.411
LIG_Pex14_2	95	99	PF04695	0.543
LIG_REV1ctd_RIR_1	83	94	PF16727	0.497
LIG_SH2_CRK	376	380	PF00017	0.303
LIG_SH2_CRK	395	399	PF00017	0.342
LIG_SH2_CRK	80	84	PF00017	0.191
LIG_SH2_STAP1	242	246	PF00017	0.280
LIG_SH2_STAP1	321	325	PF00017	0.245
LIG_SH2_STAP1	349	353	PF00017	0.333
LIG_SH2_STAP1	80	84	PF00017	0.273
LIG_SH2_STAT5	321	324	PF00017	0.284
LIG_SH2_STAT5	35	38	PF00017	0.644
LIG_SH2_STAT5	376	379	PF00017	0.303
LIG_SH2_STAT5	419	422	PF00017	0.317
LIG_SH2_STAT5	80	83	PF00017	0.327
LIG_SH3_3	299	305	PF00018	0.409
LIG_SH3_3	335	341	PF00018	0.204
LIG_SH3_4	426	433	PF00018	0.383
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.283
LIG_SUMO_SIM_anti_2	314	320	PF11976	0.249
LIG_SUMO_SIM_par_1	140	146	PF11976	0.270
LIG_SUMO_SIM_par_1	400	406	PF11976	0.334
LIG_TYR_ITIM	374	379	PF00017	0.303
LIG_TYR_ITIM	417	422	PF00017	0.324
LIG_UBA3_1	192	197	PF00899	0.178
LIG_UBA3_1	22	27	PF00899	0.527
LIG_Vh1_VBS_1	250	268	PF01044	0.178
MOD_CDK_SPK_2	105	110	PF00069	0.541
MOD_CDK_SPK_2	214	219	PF00069	0.268
MOD_CK1_1	128	134	PF00069	0.378
MOD_CK1_1	267	273	PF00069	0.276
MOD_CK1_1	288	294	PF00069	0.256
MOD_CK1_1	3	9	PF00069	0.536
MOD_CK1_1	425	431	PF00069	0.396
MOD_CK1_1	93	99	PF00069	0.579
MOD_CK2_1	143	149	PF00069	0.327
MOD_CK2_1	39	45	PF00069	0.327
MOD_GlcNHglycan	115	118	PF01048	0.504
MOD_GlcNHglycan	127	130	PF01048	0.410
MOD_GlcNHglycan	208	211	PF01048	0.422
MOD_GlcNHglycan	266	269	PF01048	0.484
MOD_GlcNHglycan	384	387	PF01048	0.535
MOD_GlcNHglycan	59	62	PF01048	0.240
MOD_GlcNHglycan	92	95	PF01048	0.382
MOD_GSK3_1	124	131	PF00069	0.537
MOD_GSK3_1	301	308	PF00069	0.376
MOD_GSK3_1	421	428	PF00069	0.317
MOD_GSK3_1	93	100	PF00069	0.575
MOD_N-GLC_1	309	314	PF02516	0.524
MOD_N-GLC_2	16	18	PF02516	0.332
MOD_N-GLC_2	282	284	PF02516	0.462
MOD_NEK2_1	112	117	PF00069	0.631
MOD_NEK2_1	359	364	PF00069	0.404
MOD_NEK2_1	375	380	PF00069	0.333
MOD_NEK2_1	39	44	PF00069	0.226
MOD_NEK2_1	422	427	PF00069	0.488
MOD_NEK2_2	5	10	PF00069	0.537
MOD_OFUCOSY	284	289	PF10250	0.483
MOD_PKA_1	113	119	PF00069	0.628
MOD_PKA_1	125	131	PF00069	0.635
MOD_PKA_2	112	118	PF00069	0.618
MOD_PKA_2	206	212	PF00069	0.280
MOD_PKA_2	329	335	PF00069	0.351
MOD_PKA_2	97	103	PF00069	0.687
MOD_Plk_1	309	315	PF00069	0.320
MOD_Plk_4	188	194	PF00069	0.204
MOD_Plk_4	274	280	PF00069	0.276
MOD_Plk_4	384	390	PF00069	0.266
MOD_Plk_4	78	84	PF00069	0.269
MOD_ProDKin_1	105	111	PF00069	0.635
MOD_ProDKin_1	185	191	PF00069	0.178
MOD_ProDKin_1	214	220	PF00069	0.260
MOD_ProDKin_1	301	307	PF00069	0.390
MOD_ProDKin_1	397	403	PF00069	0.295
MOD_SUMO_for_1	182	185	PF00179	0.178
TRG_DiLeu_BaEn_1	394	399	PF01217	0.346
TRG_ENDOCYTIC_2	242	245	PF00928	0.280
TRG_ENDOCYTIC_2	376	379	PF00928	0.303
TRG_ENDOCYTIC_2	395	398	PF00928	0.350
TRG_ENDOCYTIC_2	419	422	PF00928	0.317
TRG_ENDOCYTIC_2	80	83	PF00928	0.191
TRG_ER_diArg_1	327	330	PF00400	0.238
TRG_ER_diArg_1	411	414	PF00400	0.284
TRG_ER_diArg_1	89	91	PF00400	0.554
TRG_NES_CRM1_1	410	423	PF08389	0.324
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P0	Leptomonas seymouri	66%	100%
A0A0N0P2S5	Leptomonas seymouri	28%	98%
A0A0N0P2S7	Leptomonas seymouri	25%	86%
A0A0S4ITL0	Bodo saltans	26%	100%
A0A0S4IZG2	Bodo saltans	27%	97%
A0A0S4J1I6	Bodo saltans	25%	100%
A0A0S4JBQ4	Bodo saltans	34%	100%
A0A0S4JFU3	Bodo saltans	27%	100%
A0A1X0NVT8	Trypanosomatidae	29%	88%
A0A1X0P5W3	Trypanosomatidae	26%	99%
A0A3Q8ID46	Leishmania donovani	26%	87%
A0A3Q8IM89	Leishmania donovani	26%	100%
A0A3R7N7S2	Trypanosoma rangeli	28%	100%
A0A3S7WQY1	Leishmania donovani	81%	100%
A0A422N2B6	Trypanosoma rangeli	26%	92%
A2RVM0	Arabidopsis thaliana	25%	100%
A4HMN7	Leishmania braziliensis	26%	100%
A4HUB6	Leishmania infantum	81%	100%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AF39	Leishmania major	27%	100%
E9AH89	Leishmania infantum	24%	87%
E9AHV6	Leishmania infantum	26%	100%
E9AN15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	87%
F4JJR8	Arabidopsis thaliana	27%	100%
G4MVZ5	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	100%
O74959	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q0V6Q2	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	24%	100%
Q4QAE9	Leishmania major	24%	87%
Q4QHL1	Leishmania major	80%	100%
Q8VBZ0	Mus musculus	30%	100%
Q9ERI6	Mus musculus	31%	100%
V5BAF4	Trypanosoma cruzi	26%	92%
V5BJC7	Trypanosoma cruzi	27%	100%
V5BNY6	Trypanosoma cruzi	29%	100%