Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H5Z0_LEIBR

TriTrypDb:

LbrM.10.0080 , LBRM2903_100005700

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Z0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.445
CLV_NRD_NRD_1	137	139	PF00675	0.555
CLV_NRD_NRD_1	142	144	PF00675	0.480
CLV_NRD_NRD_1	219	221	PF00675	0.427
CLV_PCSK_KEX2_1	137	139	PF00082	0.555
CLV_PCSK_KEX2_1	142	144	PF00082	0.509
CLV_PCSK_KEX2_1	219	221	PF00082	0.427
CLV_PCSK_PC7_1	138	144	PF00082	0.490
CLV_PCSK_SKI1_1	241	245	PF00082	0.381
CLV_PCSK_SKI1_1	63	67	PF00082	0.495
DEG_APCC_DBOX_1	60	68	PF00400	0.545
DEG_SPOP_SBC_1	328	332	PF00917	0.385
DEG_SPOP_SBC_1	71	75	PF00917	0.445
DOC_CYCLIN_RxL_1	60	70	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.399
DOC_MAPK_gen_1	115	125	PF00069	0.464
DOC_MAPK_gen_1	142	149	PF00069	0.420
DOC_MAPK_gen_1	219	229	PF00069	0.425
DOC_MAPK_gen_1	61	69	PF00069	0.548
DOC_MAPK_MEF2A_6	61	69	PF00069	0.444
DOC_WW_Pin1_4	36	41	PF00397	0.626
LIG_14-3-3_CanoR_1	118	124	PF00244	0.570
LIG_14-3-3_CanoR_1	142	150	PF00244	0.445
LIG_14-3-3_CanoR_1	171	175	PF00244	0.629
LIG_14-3-3_CanoR_1	220	229	PF00244	0.423
LIG_14-3-3_CanoR_1	241	247	PF00244	0.377
LIG_14-3-3_CanoR_1	282	286	PF00244	0.376
LIG_14-3-3_CanoR_1	327	337	PF00244	0.401
LIG_14-3-3_CanoR_1	63	68	PF00244	0.498
LIG_14-3-3_CanoR_1	72	77	PF00244	0.490
LIG_BIR_II_1	1	5	PF00653	0.439
LIG_BRCT_BRCA1_1	74	78	PF00533	0.511
LIG_Clathr_ClatBox_1	243	247	PF01394	0.259
LIG_Clathr_ClatBox_1	64	68	PF01394	0.496
LIG_FHA_1	142	148	PF00498	0.426
LIG_FHA_1	15	21	PF00498	0.667
LIG_FHA_1	164	170	PF00498	0.414
LIG_FHA_1	209	215	PF00498	0.362
LIG_FHA_1	64	70	PF00498	0.507
LIG_FHA_2	243	249	PF00498	0.383
LIG_FHA_2	310	316	PF00498	0.594
LIG_LIR_Apic_2	19	25	PF02991	0.477
LIG_LIR_Gen_1	269	279	PF02991	0.381
LIG_LIR_Gen_1	292	303	PF02991	0.384
LIG_LIR_Gen_1	339	343	PF02991	0.322
LIG_LIR_Gen_1	48	55	PF02991	0.459
LIG_LIR_Gen_1	75	82	PF02991	0.491
LIG_LIR_Nem_3	105	111	PF02991	0.440
LIG_LIR_Nem_3	269	275	PF02991	0.383
LIG_LIR_Nem_3	292	298	PF02991	0.374
LIG_LIR_Nem_3	339	343	PF02991	0.322
LIG_LIR_Nem_3	48	53	PF02991	0.451
LIG_LIR_Nem_3	75	81	PF02991	0.489
LIG_LIR_Nem_3	9	15	PF02991	0.470
LIG_PDZ_Class_1	338	343	PF00595	0.387
LIG_RPA_C_Fungi	138	150	PF08784	0.398
LIG_RPA_C_Fungi	215	227	PF08784	0.383
LIG_SH2_CRK	12	16	PF00017	0.469
LIG_SH2_CRK	22	26	PF00017	0.494
LIG_SH2_NCK_1	172	176	PF00017	0.451
LIG_SH2_SRC	162	165	PF00017	0.612
LIG_SH2_STAP1	250	254	PF00017	0.371
LIG_SH2_STAP1	338	342	PF00017	0.383
LIG_SH2_STAT5	124	127	PF00017	0.577
LIG_SH2_STAT5	250	253	PF00017	0.339
LIG_SH2_STAT5	272	275	PF00017	0.376
LIG_SH2_STAT5	44	47	PF00017	0.454
LIG_SH2_STAT5	97	100	PF00017	0.577
LIG_SH3_3	257	263	PF00018	0.413
LIG_SH3_3	87	93	PF00018	0.467
LIG_SH3_5	93	97	PF00018	0.472
LIG_SUMO_SIM_anti_2	144	152	PF11976	0.372
LIG_SUMO_SIM_par_1	63	68	PF11976	0.432
LIG_SUMO_SIM_par_1	87	92	PF11976	0.534
LIG_WRC_WIRS_1	243	248	PF05994	0.375
LIG_WRC_WIRS_1	50	55	PF05994	0.621
MOD_CK1_1	145	151	PF00069	0.436
MOD_CK1_1	173	179	PF00069	0.510
MOD_CK1_1	183	189	PF00069	0.368
MOD_CK1_1	202	208	PF00069	0.415
MOD_CK1_1	289	295	PF00069	0.377
MOD_CK1_1	309	315	PF00069	0.322
MOD_CK1_1	331	337	PF00069	0.410
MOD_CK1_1	36	42	PF00069	0.583
MOD_CK1_1	70	76	PF00069	0.523
MOD_CK2_1	242	248	PF00069	0.377
MOD_CK2_1	96	102	PF00069	0.570
MOD_GlcNHglycan	144	147	PF01048	0.399
MOD_GlcNHglycan	151	154	PF01048	0.418
MOD_GlcNHglycan	188	191	PF01048	0.657
MOD_GlcNHglycan	203	207	PF01048	0.370
MOD_GlcNHglycan	229	232	PF01048	0.309
MOD_GlcNHglycan	259	263	PF01048	0.528
MOD_GlcNHglycan	268	271	PF01048	0.392
MOD_GlcNHglycan	276	279	PF01048	0.303
MOD_GlcNHglycan	308	311	PF01048	0.414
MOD_GlcNHglycan	333	336	PF01048	0.399
MOD_GSK3_1	141	148	PF00069	0.409
MOD_GSK3_1	182	189	PF00069	0.476
MOD_GSK3_1	274	281	PF00069	0.434
MOD_GSK3_1	29	36	PF00069	0.626
MOD_GSK3_1	327	334	PF00069	0.393
MOD_GSK3_1	45	52	PF00069	0.434
MOD_GSK3_1	63	70	PF00069	0.502
MOD_LATS_1	140	146	PF00433	0.464
MOD_NEK2_1	141	146	PF00069	0.430
MOD_NEK2_1	149	154	PF00069	0.477
MOD_NEK2_1	207	212	PF00069	0.293
MOD_NEK2_1	227	232	PF00069	0.308
MOD_NEK2_1	298	303	PF00069	0.502
MOD_NEK2_1	67	72	PF00069	0.678
MOD_NEK2_1	8	13	PF00069	0.516
MOD_NEK2_1	81	86	PF00069	0.456
MOD_NEK2_2	119	124	PF00069	0.530
MOD_PK_1	72	78	PF00069	0.526
MOD_PKA_1	142	148	PF00069	0.441
MOD_PKA_2	117	123	PF00069	0.686
MOD_PKA_2	141	147	PF00069	0.511
MOD_PKA_2	170	176	PF00069	0.664
MOD_PKA_2	221	227	PF00069	0.424
MOD_PKA_2	281	287	PF00069	0.380
MOD_PKA_2	29	35	PF00069	0.526
MOD_PKA_2	71	77	PF00069	0.532
MOD_PKB_1	61	69	PF00069	0.510
MOD_Plk_1	183	189	PF00069	0.483
MOD_Plk_1	202	208	PF00069	0.415
MOD_Plk_1	248	254	PF00069	0.390
MOD_Plk_1	67	73	PF00069	0.458
MOD_Plk_4	119	125	PF00069	0.530
MOD_Plk_4	145	151	PF00069	0.479
MOD_Plk_4	183	189	PF00069	0.483
MOD_Plk_4	268	274	PF00069	0.391
MOD_Plk_4	281	287	PF00069	0.342
MOD_Plk_4	309	315	PF00069	0.441
MOD_Plk_4	74	80	PF00069	0.454
MOD_ProDKin_1	36	42	PF00069	0.622
TRG_DiLeu_BaEn_1	203	208	PF01217	0.391
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.506
TRG_ENDOCYTIC_2	12	15	PF00928	0.475
TRG_ENDOCYTIC_2	272	275	PF00928	0.376
TRG_ER_diArg_1	136	138	PF00400	0.545
TRG_ER_diArg_1	141	143	PF00400	0.551
TRG_ER_diArg_1	219	222	PF00400	0.465
TRG_ER_diArg_1	61	64	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ49	Leptomonas seymouri	47%	100%
A0A3S7WQY3	Leishmania donovani	82%	100%
A4HUB5	Leishmania infantum	83%	100%
E9AN14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QHL2	Leishmania major	80%	100%