MMS19 nucleotide excision repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dos2-interacting transcription regulator of RNA-Pol-II, putative

Species:

Leishmania braziliensis

UniProt:

A4H5Y7_LEIBR

TriTrypDb:

LbrM.10.0050 , LBRM2903_100005400

Length:

948

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0097361	CIA complex	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0140535	intracellular protein-containing complex	2	10

Expansion

Sequence features

A4H5Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Y7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006790	sulfur compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0016226	iron-sulfur cluster assembly	4	10
GO:0019538	protein metabolic process	3	10
GO:0022607	cellular component assembly	4	10
GO:0031163	metallo-sulfur cluster assembly	5	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051604	protein maturation	4	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901564	organonitrogen compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.270
CLV_MEL_PAP_1	315	321	PF00089	0.482
CLV_NRD_NRD_1	131	133	PF00675	0.432
CLV_NRD_NRD_1	423	425	PF00675	0.458
CLV_NRD_NRD_1	571	573	PF00675	0.263
CLV_NRD_NRD_1	681	683	PF00675	0.315
CLV_NRD_NRD_1	824	826	PF00675	0.315
CLV_NRD_NRD_1	931	933	PF00675	0.347
CLV_PCSK_FUR_1	226	230	PF00082	0.380
CLV_PCSK_KEX2_1	228	230	PF00082	0.438
CLV_PCSK_KEX2_1	423	425	PF00082	0.277
CLV_PCSK_KEX2_1	571	573	PF00082	0.306
CLV_PCSK_KEX2_1	681	683	PF00082	0.315
CLV_PCSK_KEX2_1	930	932	PF00082	0.346
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.454
CLV_PCSK_PC1ET2_1	930	932	PF00082	0.346
CLV_PCSK_PC7_1	224	230	PF00082	0.438
CLV_PCSK_PC7_1	419	425	PF00082	0.305
CLV_PCSK_SKI1_1	188	192	PF00082	0.461
CLV_PCSK_SKI1_1	22	26	PF00082	0.568
CLV_PCSK_SKI1_1	307	311	PF00082	0.499
CLV_PCSK_SKI1_1	70	74	PF00082	0.484
CLV_PCSK_SKI1_1	707	711	PF00082	0.340
CLV_PCSK_SKI1_1	825	829	PF00082	0.438
CLV_PCSK_SKI1_1	840	844	PF00082	0.230
CLV_PCSK_SKI1_1	858	862	PF00082	0.216
CLV_PCSK_SKI1_1	868	872	PF00082	0.314
CLV_Separin_Metazoa	23	27	PF03568	0.247
CLV_Separin_Metazoa	822	826	PF03568	0.428
DEG_APCC_DBOX_1	839	847	PF00400	0.546
DEG_Nend_UBRbox_3	1	3	PF02207	0.267
DOC_CDC14_PxL_1	762	770	PF14671	0.505
DOC_CKS1_1	41	46	PF01111	0.349
DOC_CYCLIN_RxL_1	277	288	PF00134	0.218
DOC_CYCLIN_RxL_1	304	314	PF00134	0.298
DOC_CYCLIN_RxL_1	836	847	PF00134	0.557
DOC_CYCLIN_RxL_1	881	891	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	529	535	PF00134	0.447
DOC_MAPK_gen_1	217	227	PF00069	0.327
DOC_MAPK_gen_1	228	235	PF00069	0.304
DOC_MAPK_gen_1	913	920	PF00069	0.517
DOC_MAPK_HePTP_8	223	235	PF00069	0.180
DOC_MAPK_JIP1_4	775	781	PF00069	0.562
DOC_MAPK_MEF2A_6	226	235	PF00069	0.314
DOC_MAPK_MEF2A_6	256	264	PF00069	0.236
DOC_MAPK_MEF2A_6	66	73	PF00069	0.261
DOC_MAPK_MEF2A_6	711	720	PF00069	0.599
DOC_MAPK_MEF2A_6	775	783	PF00069	0.481
DOC_MAPK_NFAT4_5	228	236	PF00069	0.312
DOC_PP1_RVXF_1	68	74	PF00149	0.261
DOC_PP1_RVXF_1	856	863	PF00149	0.604
DOC_PP2B_LxvP_1	239	242	PF13499	0.261
DOC_PP2B_LxvP_1	533	536	PF13499	0.445
DOC_PP4_FxxP_1	210	213	PF00568	0.230
DOC_USP7_MATH_1	183	187	PF00917	0.322
DOC_USP7_MATH_1	249	253	PF00917	0.258
DOC_USP7_MATH_1	301	305	PF00917	0.257
DOC_USP7_MATH_1	401	405	PF00917	0.482
DOC_USP7_MATH_1	481	485	PF00917	0.609
DOC_USP7_MATH_1	500	504	PF00917	0.422
DOC_USP7_MATH_1	547	551	PF00917	0.533
DOC_USP7_MATH_1	647	651	PF00917	0.585
DOC_USP7_MATH_2	480	486	PF00917	0.439
DOC_WW_Pin1_4	247	252	PF00397	0.243
DOC_WW_Pin1_4	40	45	PF00397	0.344
DOC_WW_Pin1_4	427	432	PF00397	0.521
DOC_WW_Pin1_4	698	703	PF00397	0.550
DOC_WW_Pin1_4	745	750	PF00397	0.524
LIG_14-3-3_CanoR_1	26	31	PF00244	0.389
LIG_14-3-3_CanoR_1	391	399	PF00244	0.428
LIG_14-3-3_CanoR_1	52	58	PF00244	0.266
LIG_14-3-3_CanoR_1	882	887	PF00244	0.485
LIG_14-3-3_CanoR_1	894	899	PF00244	0.502
LIG_AP2alpha_1	558	562	PF02296	0.498
LIG_AP2alpha_2	349	351	PF02296	0.256
LIG_APCC_ABBA_1	233	238	PF00400	0.261
LIG_APCC_ABBA_1	555	560	PF00400	0.507
LIG_APCC_ABBAyCdc20_2	858	864	PF00400	0.512
LIG_BRCT_BRCA1_1	139	143	PF00533	0.261
LIG_BRCT_BRCA1_1	202	206	PF00533	0.230
LIG_BRCT_BRCA1_1	375	379	PF00533	0.304
LIG_BRCT_BRCA1_1	452	456	PF00533	0.631
LIG_BRCT_BRCA1_1	858	862	PF00533	0.572
LIG_Clathr_ClatBox_1	173	177	PF01394	0.230
LIG_Clathr_ClatBox_1	555	559	PF01394	0.427
LIG_CSL_BTD_1	477	480	PF09270	0.514
LIG_EVH1_2	611	615	PF00568	0.503
LIG_FHA_1	117	123	PF00498	0.261
LIG_FHA_1	145	151	PF00498	0.256
LIG_FHA_1	173	179	PF00498	0.249
LIG_FHA_1	304	310	PF00498	0.308
LIG_FHA_1	356	362	PF00498	0.392
LIG_FHA_1	427	433	PF00498	0.589
LIG_FHA_1	497	503	PF00498	0.610
LIG_FHA_1	550	556	PF00498	0.484
LIG_FHA_1	687	693	PF00498	0.547
LIG_FHA_1	699	705	PF00498	0.623
LIG_FHA_1	85	91	PF00498	0.274
LIG_FHA_2	191	197	PF00498	0.307
LIG_FHA_2	217	223	PF00498	0.230
LIG_FHA_2	252	258	PF00498	0.327
LIG_FHA_2	263	269	PF00498	0.304
LIG_FHA_2	325	331	PF00498	0.314
LIG_FHA_2	415	421	PF00498	0.582
LIG_FHA_2	444	450	PF00498	0.587
LIG_FHA_2	872	878	PF00498	0.449
LIG_GBD_Chelix_1	93	101	PF00786	0.380
LIG_HOMEOBOX	567	570	PF00046	0.433
LIG_IRF3_LxIS_1	92	98	PF10401	0.307
LIG_LIR_Gen_1	108	118	PF02991	0.282
LIG_LIR_Gen_1	189	199	PF02991	0.263
LIG_LIR_Gen_1	354	364	PF02991	0.202
LIG_LIR_Gen_1	376	386	PF02991	0.476
LIG_LIR_Gen_1	393	403	PF02991	0.390
LIG_LIR_Gen_1	453	464	PF02991	0.555
LIG_LIR_Gen_1	490	500	PF02991	0.485
LIG_LIR_Gen_1	512	521	PF02991	0.510
LIG_LIR_Gen_1	564	575	PF02991	0.527
LIG_LIR_Gen_1	738	749	PF02991	0.602
LIG_LIR_Gen_1	759	770	PF02991	0.591
LIG_LIR_LC3C_4	429	434	PF02991	0.435
LIG_LIR_Nem_3	108	114	PF02991	0.269
LIG_LIR_Nem_3	189	194	PF02991	0.263
LIG_LIR_Nem_3	196	202	PF02991	0.213
LIG_LIR_Nem_3	203	209	PF02991	0.201
LIG_LIR_Nem_3	265	270	PF02991	0.312
LIG_LIR_Nem_3	333	338	PF02991	0.329
LIG_LIR_Nem_3	376	382	PF02991	0.353
LIG_LIR_Nem_3	393	399	PF02991	0.407
LIG_LIR_Nem_3	490	496	PF02991	0.452
LIG_LIR_Nem_3	512	516	PF02991	0.633
LIG_LIR_Nem_3	667	672	PF02991	0.578
LIG_LIR_Nem_3	738	744	PF02991	0.590
LIG_LIR_Nem_3	759	765	PF02991	0.583
LIG_LIR_Nem_3	943	947	PF02991	0.563
LIG_MLH1_MIPbox_1	202	206	PF16413	0.230
LIG_NRBOX	155	161	PF00104	0.230
LIG_NRBOX	259	265	PF00104	0.261
LIG_NRBOX	524	530	PF00104	0.561
LIG_NRBOX	550	556	PF00104	0.576
LIG_NRBOX	778	784	PF00104	0.573
LIG_NRBOX	816	822	PF00104	0.625
LIG_NRBOX	91	97	PF00104	0.211
LIG_PCNA_yPIPBox_3	520	529	PF02747	0.531
LIG_PCNA_yPIPBox_3	807	821	PF02747	0.500
LIG_Pex14_2	206	210	PF04695	0.230
LIG_Pex14_2	558	562	PF04695	0.610
LIG_PTB_Apo_2	691	698	PF02174	0.487
LIG_Rb_LxCxE_1	306	327	PF01857	0.308
LIG_REV1ctd_RIR_1	73	83	PF16727	0.230
LIG_SH2_CRK	279	283	PF00017	0.226
LIG_SH2_NCK_1	513	517	PF00017	0.509
LIG_SH2_STAP1	356	360	PF00017	0.199
LIG_SH2_STAP1	440	444	PF00017	0.448
LIG_SH2_STAT3	270	273	PF00017	0.261
LIG_SH2_STAT5	198	201	PF00017	0.264
LIG_SH2_STAT5	205	208	PF00017	0.245
LIG_SH2_STAT5	377	380	PF00017	0.316
LIG_SH2_STAT5	764	767	PF00017	0.548
LIG_SH3_3	111	117	PF00018	0.312
LIG_SH3_3	208	214	PF00018	0.180
LIG_SH3_3	474	480	PF00018	0.503
LIG_SH3_3	529	535	PF00018	0.635
LIG_SUMO_SIM_anti_2	170	175	PF11976	0.331
LIG_SUMO_SIM_anti_2	257	265	PF11976	0.248
LIG_SUMO_SIM_anti_2	552	560	PF11976	0.423
LIG_SUMO_SIM_anti_2	639	644	PF11976	0.522
LIG_SUMO_SIM_anti_2	819	825	PF11976	0.433
LIG_SUMO_SIM_anti_2	87	94	PF11976	0.278
LIG_SUMO_SIM_par_1	158	164	PF11976	0.299
LIG_SUMO_SIM_par_1	170	175	PF11976	0.312
LIG_SUMO_SIM_par_1	29	36	PF11976	0.284
LIG_SUMO_SIM_par_1	429	435	PF11976	0.477
LIG_SUMO_SIM_par_1	552	560	PF11976	0.440
LIG_SUMO_SIM_par_1	816	822	PF11976	0.515
LIG_TRAF2_1	757	760	PF00917	0.513
LIG_TRAF2_1	904	907	PF00917	0.612
LIG_WRC_WIRS_1	138	143	PF05994	0.312
LIG_WRC_WIRS_1	173	178	PF05994	0.226
LIG_WRC_WIRS_1	293	298	PF05994	0.397
LIG_WRC_WIRS_1	736	741	PF05994	0.654
MOD_CDK_SPxK_1	40	46	PF00069	0.344
MOD_CK1_1	201	207	PF00069	0.230
MOD_CK1_1	250	256	PF00069	0.241
MOD_CK1_1	29	35	PF00069	0.258
MOD_CK1_1	443	449	PF00069	0.609
MOD_CK1_1	626	632	PF00069	0.559
MOD_CK1_1	650	656	PF00069	0.558
MOD_CK1_1	829	835	PF00069	0.656
MOD_CK1_1	845	851	PF00069	0.417
MOD_CK2_1	164	170	PF00069	0.279
MOD_CK2_1	183	189	PF00069	0.270
MOD_CK2_1	251	257	PF00069	0.311
MOD_CK2_1	29	35	PF00069	0.239
MOD_CK2_1	324	330	PF00069	0.354
MOD_CK2_1	414	420	PF00069	0.566
MOD_CK2_1	62	68	PF00069	0.218
MOD_CK2_1	748	754	PF00069	0.526
MOD_CK2_1	829	835	PF00069	0.644
MOD_CK2_1	871	877	PF00069	0.445
MOD_CK2_1	901	907	PF00069	0.539
MOD_GlcNHglycan	185	188	PF01048	0.480
MOD_GlcNHglycan	353	356	PF01048	0.504
MOD_GlcNHglycan	393	396	PF01048	0.277
MOD_GlcNHglycan	403	406	PF01048	0.269
MOD_GlcNHglycan	471	474	PF01048	0.288
MOD_GlcNHglycan	563	566	PF01048	0.315
MOD_GlcNHglycan	754	757	PF01048	0.344
MOD_GlcNHglycan	828	831	PF01048	0.423
MOD_GlcNHglycan	936	939	PF01048	0.292
MOD_GSK3_1	137	144	PF00069	0.312
MOD_GSK3_1	243	250	PF00069	0.362
MOD_GSK3_1	262	269	PF00069	0.174
MOD_GSK3_1	29	36	PF00069	0.263
MOD_GSK3_1	351	358	PF00069	0.299
MOD_GSK3_1	373	380	PF00069	0.353
MOD_GSK3_1	382	389	PF00069	0.405
MOD_GSK3_1	422	429	PF00069	0.531
MOD_GSK3_1	496	503	PF00069	0.557
MOD_GSK3_1	545	552	PF00069	0.440
MOD_GSK3_1	632	639	PF00069	0.499
MOD_GSK3_1	703	710	PF00069	0.610
MOD_GSK3_1	748	755	PF00069	0.680
MOD_GSK3_1	825	832	PF00069	0.578
MOD_GSK3_1	84	91	PF00069	0.251
MOD_N-GLC_1	301	306	PF02516	0.574
MOD_N-GLC_1	623	628	PF02516	0.313
MOD_N-GLC_1	862	867	PF02516	0.310
MOD_N-GLC_1	901	906	PF02516	0.329
MOD_NEK2_1	243	248	PF00069	0.258
MOD_NEK2_1	342	347	PF00069	0.347
MOD_NEK2_1	351	356	PF00069	0.309
MOD_NEK2_1	372	377	PF00069	0.391
MOD_NEK2_1	464	469	PF00069	0.445
MOD_NEK2_1	53	58	PF00069	0.247
MOD_NEK2_1	546	551	PF00069	0.517
MOD_NEK2_1	633	638	PF00069	0.482
MOD_NEK2_1	787	792	PF00069	0.515
MOD_NEK2_1	85	90	PF00069	0.363
MOD_NEK2_1	856	861	PF00069	0.576
MOD_NEK2_1	862	867	PF00069	0.542
MOD_NEK2_1	888	893	PF00069	0.530
MOD_NEK2_1	919	924	PF00069	0.519
MOD_NEK2_2	251	256	PF00069	0.327
MOD_PIKK_1	116	122	PF00454	0.337
MOD_PIKK_1	269	275	PF00454	0.261
MOD_PIKK_1	324	330	PF00454	0.323
MOD_PIKK_1	901	907	PF00454	0.567
MOD_PKA_1	825	831	PF00069	0.539
MOD_PKA_2	317	323	PF00069	0.409
MOD_PKA_2	390	396	PF00069	0.648
MOD_PKA_2	422	428	PF00069	0.669
MOD_PKA_2	774	780	PF00069	0.523
MOD_PKB_1	932	940	PF00069	0.540
MOD_Plk_1	144	150	PF00069	0.245
MOD_Plk_1	301	307	PF00069	0.373
MOD_Plk_1	623	629	PF00069	0.489
MOD_Plk_1	862	868	PF00069	0.569
MOD_Plk_2-3	164	170	PF00069	0.270
MOD_Plk_2-3	450	456	PF00069	0.491
MOD_Plk_4	137	143	PF00069	0.297
MOD_Plk_4	190	196	PF00069	0.264
MOD_Plk_4	201	207	PF00069	0.203
MOD_Plk_4	26	32	PF00069	0.286
MOD_Plk_4	355	361	PF00069	0.252
MOD_Plk_4	373	379	PF00069	0.259
MOD_Plk_4	464	470	PF00069	0.446
MOD_Plk_4	487	493	PF00069	0.506
MOD_Plk_4	638	644	PF00069	0.498
MOD_Plk_4	735	741	PF00069	0.585
MOD_Plk_4	774	780	PF00069	0.573
MOD_Plk_4	850	856	PF00069	0.573
MOD_Plk_4	88	94	PF00069	0.369
MOD_Plk_4	894	900	PF00069	0.485
MOD_ProDKin_1	247	253	PF00069	0.243
MOD_ProDKin_1	40	46	PF00069	0.344
MOD_ProDKin_1	427	433	PF00069	0.515
MOD_ProDKin_1	698	704	PF00069	0.544
MOD_ProDKin_1	745	751	PF00069	0.529
MOD_SUMO_for_1	286	289	PF00179	0.312
MOD_SUMO_for_1	565	568	PF00179	0.466
MOD_SUMO_rev_2	845	851	PF00179	0.422
MOD_SUMO_rev_2	904	909	PF00179	0.620
TRG_DiLeu_BaEn_1	616	621	PF01217	0.482
TRG_DiLeu_BaEn_3	108	114	PF01217	0.230
TRG_DiLeu_BaEn_4	906	912	PF01217	0.596
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.284
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.546
TRG_DiLeu_BaLyEn_6	524	529	PF01217	0.555
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.377
TRG_ENDOCYTIC_2	205	208	PF00928	0.230
TRG_ENDOCYTIC_2	236	239	PF00928	0.312
TRG_ENDOCYTIC_2	279	282	PF00928	0.329
TRG_ENDOCYTIC_2	356	359	PF00928	0.254
TRG_ENDOCYTIC_2	513	516	PF00928	0.512
TRG_ENDOCYTIC_2	567	570	PF00928	0.433
TRG_ENDOCYTIC_2	741	744	PF00928	0.630
TRG_ENDOCYTIC_2	764	767	PF00928	0.525
TRG_ER_diArg_1	223	226	PF00400	0.226
TRG_ER_diArg_1	422	424	PF00400	0.454
TRG_ER_diArg_1	570	572	PF00400	0.461
TRG_ER_diArg_1	680	682	PF00400	0.524
TRG_ER_diArg_1	881	884	PF00400	0.509
TRG_ER_diArg_1	931	934	PF00400	0.559
TRG_NLS_MonoExtC_3	929	934	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	868	872	PF00026	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGU9	Leptomonas seymouri	51%	98%
A0A1X0NRK4	Trypanosomatidae	27%	100%
A0A3S7WQY6	Leishmania donovani	79%	100%
A0A422N151	Trypanosoma rangeli	27%	100%
A4HUB2	Leishmania infantum	79%	100%
E9AN11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QHL5	Leishmania major	78%	100%
V5DA22	Trypanosoma cruzi	26%	99%