CHAT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Gryzun, putative trafficking through Golgi, putative

Species:

Leishmania braziliensis

UniProt:

A4H5Y6_LEIBR

TriTrypDb:

LbrM.10.0040 , LBRM2903_100005300

Length:

791

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Y6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	55	57	PF00675	0.468
CLV_NRD_NRD_1	731	733	PF00675	0.456
CLV_NRD_NRD_1	86	88	PF00675	0.566
CLV_PCSK_KEX2_1	598	600	PF00082	0.418
CLV_PCSK_PC1ET2_1	598	600	PF00082	0.418
CLV_PCSK_PC7_1	594	600	PF00082	0.403
CLV_PCSK_SKI1_1	118	122	PF00082	0.484
CLV_PCSK_SKI1_1	166	170	PF00082	0.565
CLV_PCSK_SKI1_1	17	21	PF00082	0.329
CLV_PCSK_SKI1_1	306	310	PF00082	0.402
CLV_PCSK_SKI1_1	345	349	PF00082	0.286
CLV_PCSK_SKI1_1	368	372	PF00082	0.514
CLV_PCSK_SKI1_1	377	381	PF00082	0.341
CLV_PCSK_SKI1_1	543	547	PF00082	0.526
CLV_PCSK_SKI1_1	599	603	PF00082	0.406
CLV_PCSK_SKI1_1	654	658	PF00082	0.338
CLV_PCSK_SKI1_1	661	665	PF00082	0.428
CLV_PCSK_SKI1_1	742	746	PF00082	0.452
DEG_APCC_DBOX_1	745	753	PF00400	0.424
DEG_SPOP_SBC_1	354	358	PF00917	0.455
DEG_SPOP_SBC_1	363	367	PF00917	0.425
DOC_CKS1_1	690	695	PF01111	0.497
DOC_CKS1_1	748	753	PF01111	0.413
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	690	696	PF00134	0.408
DOC_MAPK_gen_1	228	235	PF00069	0.335
DOC_MAPK_gen_1	374	382	PF00069	0.533
DOC_MAPK_gen_1	56	63	PF00069	0.370
DOC_PP1_RVXF_1	366	372	PF00149	0.402
DOC_PP1_RVXF_1	431	438	PF00149	0.480
DOC_PP1_RVXF_1	597	604	PF00149	0.255
DOC_PP1_RVXF_1	652	658	PF00149	0.454
DOC_PP2B_LxvP_1	242	245	PF13499	0.482
DOC_PP2B_LxvP_1	529	532	PF13499	0.428
DOC_PP2B_LxvP_1	757	760	PF13499	0.379
DOC_PP4_FxxP_1	455	458	PF00568	0.262
DOC_PP4_FxxP_1	480	483	PF00568	0.480
DOC_PP4_FxxP_1	553	556	PF00568	0.602
DOC_PP4_FxxP_1	656	659	PF00568	0.511
DOC_SPAK_OSR1_1	351	355	PF12202	0.473
DOC_SPAK_OSR1_1	761	765	PF12202	0.410
DOC_USP7_MATH_1	186	190	PF00917	0.519
DOC_USP7_MATH_1	21	25	PF00917	0.549
DOC_USP7_MATH_1	304	308	PF00917	0.327
DOC_USP7_MATH_1	353	357	PF00917	0.585
DOC_USP7_MATH_1	363	367	PF00917	0.699
DOC_USP7_MATH_1	512	516	PF00917	0.434
DOC_USP7_MATH_1	776	780	PF00917	0.583
DOC_USP7_MATH_1	786	790	PF00917	0.429
DOC_USP7_UBL2_3	114	118	PF12436	0.439
DOC_WW_Pin1_4	191	196	PF00397	0.517
DOC_WW_Pin1_4	300	305	PF00397	0.495
DOC_WW_Pin1_4	311	316	PF00397	0.423
DOC_WW_Pin1_4	552	557	PF00397	0.599
DOC_WW_Pin1_4	689	694	PF00397	0.460
DOC_WW_Pin1_4	747	752	PF00397	0.558
LIG_14-3-3_CanoR_1	17	25	PF00244	0.492
LIG_14-3-3_CanoR_1	196	203	PF00244	0.385
LIG_14-3-3_CanoR_1	228	237	PF00244	0.501
LIG_14-3-3_CanoR_1	306	311	PF00244	0.464
LIG_14-3-3_CanoR_1	481	487	PF00244	0.318
LIG_14-3-3_CanoR_1	535	539	PF00244	0.520
LIG_14-3-3_CanoR_1	56	63	PF00244	0.396
LIG_14-3-3_CanoR_1	594	601	PF00244	0.462
LIG_14-3-3_CanoR_1	665	673	PF00244	0.379
LIG_14-3-3_CanoR_1	732	736	PF00244	0.408
LIG_14-3-3_CanoR_1	765	775	PF00244	0.405
LIG_Actin_WH2_2	157	172	PF00022	0.560
LIG_BIR_II_1	1	5	PF00653	0.449
LIG_BIR_III_4	208	212	PF00653	0.520
LIG_deltaCOP1_diTrp_1	181	190	PF00928	0.393
LIG_eIF4E_1	541	547	PF01652	0.531
LIG_EVH1_2	385	389	PF00568	0.537
LIG_FHA_1	145	151	PF00498	0.458
LIG_FHA_1	18	24	PF00498	0.325
LIG_FHA_1	196	202	PF00498	0.472
LIG_FHA_1	307	313	PF00498	0.411
LIG_FHA_1	365	371	PF00498	0.518
LIG_FHA_1	499	505	PF00498	0.460
LIG_FHA_1	56	62	PF00498	0.480
LIG_FHA_1	584	590	PF00498	0.425
LIG_FHA_1	633	639	PF00498	0.282
LIG_FHA_1	672	678	PF00498	0.413
LIG_FHA_1	706	712	PF00498	0.475
LIG_FHA_1	767	773	PF00498	0.562
LIG_FHA_2	139	145	PF00498	0.454
LIG_FHA_2	573	579	PF00498	0.508
LIG_FHA_2	607	613	PF00498	0.404
LIG_GBD_Chelix_1	38	46	PF00786	0.484
LIG_IRF3_LxIS_1	696	703	PF10401	0.276
LIG_LIR_Apic_2	479	483	PF02991	0.489
LIG_LIR_Apic_2	551	556	PF02991	0.591
LIG_LIR_Apic_2	692	697	PF02991	0.385
LIG_LIR_Gen_1	10	21	PF02991	0.468
LIG_LIR_Gen_1	142	150	PF02991	0.415
LIG_LIR_Gen_1	286	296	PF02991	0.472
LIG_LIR_Gen_1	664	675	PF02991	0.378
LIG_LIR_LC3C_4	317	320	PF02991	0.274
LIG_LIR_Nem_3	10	16	PF02991	0.445
LIG_LIR_Nem_3	110	116	PF02991	0.449
LIG_LIR_Nem_3	142	148	PF02991	0.417
LIG_LIR_Nem_3	20	25	PF02991	0.475
LIG_LIR_Nem_3	286	292	PF02991	0.446
LIG_LIR_Nem_3	47	53	PF02991	0.404
LIG_LIR_Nem_3	491	496	PF02991	0.437
LIG_LIR_Nem_3	537	541	PF02991	0.480
LIG_LIR_Nem_3	664	670	PF02991	0.459
LIG_LIR_Nem_3	685	691	PF02991	0.438
LIG_LYPXL_yS_3	688	691	PF13949	0.503
LIG_Pex14_2	652	656	PF04695	0.460
LIG_PTB_Apo_2	646	653	PF02174	0.414
LIG_Rb_LxCxE_1	471	491	PF01857	0.268
LIG_REV1ctd_RIR_1	567	576	PF16727	0.540
LIG_SH2_CRK	289	293	PF00017	0.339
LIG_SH2_CRK	493	497	PF00017	0.503
LIG_SH2_CRK	694	698	PF00017	0.430
LIG_SH2_NCK_1	106	110	PF00017	0.341
LIG_SH2_NCK_1	289	293	PF00017	0.339
LIG_SH2_SRC	13	16	PF00017	0.477
LIG_SH2_STAP1	289	293	PF00017	0.359
LIG_SH2_STAP1	541	545	PF00017	0.538
LIG_SH2_STAT3	212	215	PF00017	0.358
LIG_SH2_STAT5	145	148	PF00017	0.439
LIG_SH2_STAT5	251	254	PF00017	0.497
LIG_SH2_STAT5	289	292	PF00017	0.386
LIG_SH2_STAT5	53	56	PF00017	0.439
LIG_SH2_STAT5	538	541	PF00017	0.358
LIG_SH2_STAT5	568	571	PF00017	0.452
LIG_SH2_STAT5	620	623	PF00017	0.468
LIG_SH2_STAT5	627	630	PF00017	0.348
LIG_SH2_STAT5	676	679	PF00017	0.444
LIG_SH2_STAT5	69	72	PF00017	0.278
LIG_SH2_STAT5	780	783	PF00017	0.482
LIG_SH2_STAT5	98	101	PF00017	0.548
LIG_SH3_2	301	306	PF14604	0.524
LIG_SH3_3	189	195	PF00018	0.306
LIG_SH3_3	298	304	PF00018	0.529
LIG_SH3_3	309	315	PF00018	0.510
LIG_SH3_3	317	323	PF00018	0.497
LIG_SH3_3	379	385	PF00018	0.407
LIG_SH3_3	388	394	PF00018	0.366
LIG_SH3_3	423	429	PF00018	0.453
LIG_SH3_3	503	509	PF00018	0.336
LIG_SH3_3	667	673	PF00018	0.445
LIG_SH3_3	90	96	PF00018	0.438
LIG_SUMO_SIM_anti_2	144	150	PF11976	0.410
LIG_SUMO_SIM_anti_2	160	165	PF11976	0.413
LIG_SUMO_SIM_anti_2	612	618	PF11976	0.408
LIG_SUMO_SIM_par_1	146	152	PF11976	0.304
LIG_SUMO_SIM_par_1	266	274	PF11976	0.403
LIG_SUMO_SIM_par_1	283	288	PF11976	0.517
LIG_SUMO_SIM_par_1	442	449	PF11976	0.488
LIG_SUMO_SIM_par_1	696	701	PF11976	0.551
LIG_SUMO_SIM_par_1	769	779	PF11976	0.323
LIG_TRAF2_1	213	216	PF00917	0.532
LIG_TRAF2_1	314	317	PF00917	0.452
LIG_TYR_ITIM	143	148	PF00017	0.288
LIG_TYR_ITIM	287	292	PF00017	0.299
LIG_Vh1_VBS_1	168	186	PF01044	0.303
MOD_CDC14_SPxK_1	303	306	PF00782	0.536
MOD_CDK_SPK_2	191	196	PF00069	0.456
MOD_CDK_SPxK_1	300	306	PF00069	0.520
MOD_CK1_1	138	144	PF00069	0.518
MOD_CK1_1	188	194	PF00069	0.487
MOD_CK1_1	288	294	PF00069	0.436
MOD_CK1_1	412	418	PF00069	0.284
MOD_CK1_1	462	468	PF00069	0.302
MOD_CK1_1	530	536	PF00069	0.545
MOD_CK1_1	7	13	PF00069	0.478
MOD_CK2_1	134	140	PF00069	0.478
MOD_CK2_1	311	317	PF00069	0.456
MOD_CK2_1	436	442	PF00069	0.497
MOD_CK2_1	5	11	PF00069	0.599
MOD_CK2_1	572	578	PF00069	0.492
MOD_CK2_1	623	629	PF00069	0.518
MOD_CK2_1	83	89	PF00069	0.528
MOD_GlcNHglycan	1	4	PF01048	0.489
MOD_GlcNHglycan	109	112	PF01048	0.499
MOD_GlcNHglycan	171	174	PF01048	0.367
MOD_GlcNHglycan	262	265	PF01048	0.458
MOD_GlcNHglycan	326	329	PF01048	0.418
MOD_GlcNHglycan	371	374	PF01048	0.542
MOD_GlcNHglycan	438	441	PF01048	0.457
MOD_GlcNHglycan	461	464	PF01048	0.457
MOD_GlcNHglycan	487	491	PF01048	0.372
MOD_GSK3_1	131	138	PF00069	0.404
MOD_GSK3_1	17	24	PF00069	0.565
MOD_GSK3_1	191	198	PF00069	0.482
MOD_GSK3_1	283	290	PF00069	0.272
MOD_GSK3_1	300	307	PF00069	0.302
MOD_GSK3_1	369	376	PF00069	0.454
MOD_GSK3_1	380	387	PF00069	0.337
MOD_GSK3_1	482	489	PF00069	0.342
MOD_GSK3_1	494	501	PF00069	0.414
MOD_GSK3_1	527	534	PF00069	0.580
MOD_GSK3_1	552	559	PF00069	0.564
MOD_GSK3_1	568	575	PF00069	0.408
MOD_GSK3_1	585	592	PF00069	0.258
MOD_GSK3_1	661	668	PF00069	0.431
MOD_GSK3_1	727	734	PF00069	0.513
MOD_N-GLC_1	705	710	PF02516	0.299
MOD_N-GLC_2	420	422	PF02516	0.274
MOD_NEK2_1	169	174	PF00069	0.360
MOD_NEK2_1	269	274	PF00069	0.456
MOD_NEK2_1	285	290	PF00069	0.408
MOD_NEK2_1	330	335	PF00069	0.381
MOD_NEK2_1	380	385	PF00069	0.414
MOD_NEK2_1	40	45	PF00069	0.482
MOD_NEK2_1	468	473	PF00069	0.342
MOD_NEK2_1	517	522	PF00069	0.424
MOD_NEK2_1	583	588	PF00069	0.392
MOD_NEK2_1	589	594	PF00069	0.394
MOD_NEK2_1	640	645	PF00069	0.302
MOD_NEK2_1	700	705	PF00069	0.509
MOD_NEK2_2	27	32	PF00069	0.543
MOD_OFUCOSY	407	413	PF10250	0.457
MOD_PIKK_1	295	301	PF00454	0.546
MOD_PK_1	88	94	PF00069	0.476
MOD_PKA_2	138	144	PF00069	0.528
MOD_PKA_2	195	201	PF00069	0.419
MOD_PKA_2	534	540	PF00069	0.421
MOD_PKA_2	55	61	PF00069	0.526
MOD_PKA_2	593	599	PF00069	0.466
MOD_PKA_2	731	737	PF00069	0.511
MOD_Plk_1	512	518	PF00069	0.448
MOD_Plk_1	541	547	PF00069	0.482
MOD_Plk_1	622	628	PF00069	0.520
MOD_Plk_1	700	706	PF00069	0.530
MOD_Plk_1	714	720	PF00069	0.361
MOD_Plk_1	776	782	PF00069	0.449
MOD_Plk_2-3	623	629	PF00069	0.415
MOD_Plk_4	131	137	PF00069	0.346
MOD_Plk_4	144	150	PF00069	0.311
MOD_Plk_4	271	277	PF00069	0.480
MOD_Plk_4	34	40	PF00069	0.528
MOD_Plk_4	384	390	PF00069	0.575
MOD_Plk_4	392	398	PF00069	0.565
MOD_Plk_4	512	518	PF00069	0.430
MOD_Plk_4	534	540	PF00069	0.518
MOD_Plk_4	541	547	PF00069	0.467
MOD_Plk_4	623	629	PF00069	0.489
MOD_Plk_4	632	638	PF00069	0.424
MOD_Plk_4	671	677	PF00069	0.362
MOD_Plk_4	776	782	PF00069	0.506
MOD_Plk_4	88	94	PF00069	0.562
MOD_ProDKin_1	191	197	PF00069	0.510
MOD_ProDKin_1	300	306	PF00069	0.493
MOD_ProDKin_1	311	317	PF00069	0.423
MOD_ProDKin_1	552	558	PF00069	0.593
MOD_ProDKin_1	689	695	PF00069	0.461
MOD_ProDKin_1	747	753	PF00069	0.561
MOD_SUMO_for_1	31	34	PF00179	0.504
MOD_SUMO_rev_2	130	135	PF00179	0.390
TRG_DiLeu_BaEn_1	131	136	PF01217	0.302
TRG_DiLeu_BaEn_1	464	469	PF01217	0.409
TRG_DiLeu_BaEn_4	623	629	PF01217	0.439
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.311
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.486
TRG_ENDOCYTIC_2	13	16	PF00928	0.498
TRG_ENDOCYTIC_2	145	148	PF00928	0.457
TRG_ENDOCYTIC_2	289	292	PF00928	0.386
TRG_ENDOCYTIC_2	493	496	PF00928	0.449
TRG_ENDOCYTIC_2	667	670	PF00928	0.459
TRG_ENDOCYTIC_2	688	691	PF00928	0.471
TRG_ER_diArg_1	121	124	PF00400	0.421
TRG_ER_diArg_1	220	223	PF00400	0.454
TRG_ER_diArg_1	63	66	PF00400	0.315
TRG_NES_CRM1_1	224	236	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA1	Leptomonas seymouri	53%	89%
A0A1X0NQK5	Trypanosomatidae	21%	73%
A0A3S7WQY9	Leishmania donovani	79%	84%
A0A422N156	Trypanosoma rangeli	23%	73%
A4HUB1	Leishmania infantum	79%	84%
C9ZVH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	73%
E9AN10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	84%
Q4QHL6	Leishmania major	79%	100%
V5BE46	Trypanosoma cruzi	23%	87%