Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5Y2_LEIBR

TriTrypDb:

LbrM.09.1620 , LBRM2903_090022700

Length:

181

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H5Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Y2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.470
CLV_NRD_NRD_1	163	165	PF00675	0.608
CLV_NRD_NRD_1	87	89	PF00675	0.426
CLV_PCSK_KEX2_1	86	88	PF00082	0.433
CLV_PCSK_SKI1_1	132	136	PF00082	0.233
CLV_PCSK_SKI1_1	68	72	PF00082	0.464
CLV_PCSK_SKI1_1	87	91	PF00082	0.328
CLV_PCSK_SKI1_1	95	99	PF00082	0.436
CLV_Separin_Metazoa	15	19	PF03568	0.604
DOC_MAPK_gen_1	123	133	PF00069	0.586
DOC_MAPK_gen_1	7	16	PF00069	0.742
DOC_MAPK_MEF2A_6	124	133	PF00069	0.604
DOC_MAPK_NFAT4_5	126	134	PF00069	0.501
DOC_MAPK_RevD_3	109	124	PF00069	0.669
DOC_PP1_RVXF_1	130	136	PF00149	0.411
DOC_PP4_FxxP_1	122	125	PF00568	0.638
DOC_WW_Pin1_4	19	24	PF00397	0.714
DOC_WW_Pin1_4	39	44	PF00397	0.534
DOC_WW_Pin1_4	51	56	PF00397	0.618
LIG_14-3-3_CanoR_1	87	97	PF00244	0.601
LIG_FHA_1	9	15	PF00498	0.796
LIG_FHA_2	10	16	PF00498	0.694
LIG_LIR_Gen_1	117	125	PF02991	0.676
LIG_LIR_Nem_3	117	122	PF02991	0.667
LIG_LIR_Nem_3	91	97	PF02991	0.584
LIG_LYPXL_L_2	61	70	PF13949	0.681
LIG_NRP_CendR_1	180	181	PF00754	0.723
LIG_Pex14_2	137	141	PF04695	0.401
LIG_SH2_SRC	19	22	PF00017	0.747
LIG_SH2_STAT3	158	161	PF00017	0.431
LIG_SH2_STAT5	73	76	PF00017	0.642
LIG_SH3_3	11	17	PF00018	0.673
LIG_SH3_3	143	149	PF00018	0.444
LIG_SH3_3	37	43	PF00018	0.713
MOD_CDK_SPK_2	51	56	PF00069	0.618
MOD_CK1_1	42	48	PF00069	0.739
MOD_CK2_1	19	25	PF00069	0.687
MOD_CK2_1	51	57	PF00069	0.690
MOD_CK2_1	9	15	PF00069	0.711
MOD_GlcNHglycan	116	119	PF01048	0.411
MOD_GlcNHglycan	34	37	PF01048	0.488
MOD_GSK3_1	19	26	PF00069	0.689
MOD_NEK2_1	32	37	PF00069	0.683
MOD_NMyristoyl	1	7	PF02799	0.733
MOD_PIKK_1	88	94	PF00454	0.576
MOD_PKB_1	86	94	PF00069	0.545
MOD_ProDKin_1	19	25	PF00069	0.711
MOD_ProDKin_1	39	45	PF00069	0.531
MOD_ProDKin_1	51	57	PF00069	0.616
MOD_SUMO_rev_2	64	70	PF00179	0.697
TRG_ER_diArg_1	125	128	PF00400	0.639
TRG_ER_diArg_1	179	181	PF00400	0.461
TRG_ER_diArg_1	86	88	PF00400	0.734
TRG_NLS_MonoCore_2	122	127	PF00514	0.700
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JHE9	Bodo saltans	64%	100%
A0A1X0NID1	Trypanosomatidae	62%	96%
A0A3R7KNE8	Trypanosoma rangeli	64%	96%
A0A3S5H6F1	Leishmania donovani	82%	100%
A4HU78	Leishmania infantum	82%	100%
D0A9R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	73%
E9AN08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QHM0	Leishmania major	84%	100%