DUF3496 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5Y1_LEIBR

TriTrypDb:

LbrM.09.1610 , LBRM2903_090022600

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Y1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.664
CLV_NRD_NRD_1	101	103	PF00675	0.467
CLV_NRD_NRD_1	131	133	PF00675	0.457
CLV_NRD_NRD_1	140	142	PF00675	0.461
CLV_NRD_NRD_1	195	197	PF00675	0.586
CLV_NRD_NRD_1	291	293	PF00675	0.522
CLV_NRD_NRD_1	588	590	PF00675	0.766
CLV_PCSK_KEX2_1	101	103	PF00082	0.597
CLV_PCSK_KEX2_1	189	191	PF00082	0.636
CLV_PCSK_KEX2_1	195	197	PF00082	0.713
CLV_PCSK_KEX2_1	290	292	PF00082	0.555
CLV_PCSK_KEX2_1	588	590	PF00082	0.766
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.543
CLV_PCSK_SKI1_1	271	275	PF00082	0.539
CLV_PCSK_SKI1_1	442	446	PF00082	0.348
CLV_PCSK_SKI1_1	577	581	PF00082	0.682
CLV_PCSK_SKI1_1	649	653	PF00082	0.635
CLV_PCSK_SKI1_1	66	70	PF00082	0.500
DEG_APCC_DBOX_1	259	267	PF00400	0.579
DEG_APCC_DBOX_1	270	278	PF00400	0.526
DOC_MAPK_gen_1	130	140	PF00069	0.570
DOC_MAPK_gen_1	644	652	PF00069	0.498
DOC_MAPK_MEF2A_6	465	473	PF00069	0.472
DOC_PIKK_1	559	567	PF02985	0.439
DOC_USP7_MATH_1	112	116	PF00917	0.603
DOC_USP7_MATH_1	444	448	PF00917	0.552
DOC_USP7_MATH_1	67	71	PF00917	0.504
DOC_USP7_UBL2_3	104	108	PF12436	0.593
DOC_WW_Pin1_4	1	6	PF00397	0.575
DOC_WW_Pin1_4	19	24	PF00397	0.660
LIG_14-3-3_CanoR_1	132	138	PF00244	0.500
LIG_14-3-3_CanoR_1	159	166	PF00244	0.557
LIG_14-3-3_CanoR_1	218	225	PF00244	0.712
LIG_14-3-3_CanoR_1	554	558	PF00244	0.554
LIG_14-3-3_CanoR_1	58	63	PF00244	0.560
LIG_14-3-3_CanoR_1	599	603	PF00244	0.724
LIG_14-3-3_CanoR_1	611	619	PF00244	0.458
LIG_14-3-3_CanoR_1	629	634	PF00244	0.406
LIG_14-3-3_CanoR_1	66	76	PF00244	0.573
LIG_14-3-3_CanoR_1	87	91	PF00244	0.625
LIG_14-3-3_CterR_2	660	663	PF00244	0.712
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BIR_III_2	238	242	PF00653	0.522
LIG_CaM_IQ_9	452	467	PF13499	0.598
LIG_DLG_GKlike_1	629	637	PF00625	0.405
LIG_FHA_1	198	204	PF00498	0.692
LIG_FHA_1	211	217	PF00498	0.581
LIG_FHA_1	229	235	PF00498	0.517
LIG_FHA_1	468	474	PF00498	0.567
LIG_FHA_2	149	155	PF00498	0.583
LIG_FHA_2	212	218	PF00498	0.641
LIG_FHA_2	260	266	PF00498	0.536
LIG_FHA_2	284	290	PF00498	0.638
LIG_FHA_2	314	320	PF00498	0.582
LIG_FHA_2	629	635	PF00498	0.547
LIG_Integrin_RGD_1	489	491	PF01839	0.533
LIG_LIR_Gen_1	61	68	PF02991	0.565
LIG_LIR_Nem_3	61	65	PF02991	0.561
LIG_NRBOX	133	139	PF00104	0.509
LIG_NRBOX	244	250	PF00104	0.619
LIG_NRBOX	49	55	PF00104	0.399
LIG_PTB_Apo_2	427	434	PF02174	0.481
LIG_RPA_C_Fungi	584	596	PF08784	0.520
LIG_SH2_GRB2like	478	481	PF00017	0.489
LIG_SH2_SRC	62	65	PF00017	0.589
LIG_SH2_STAP1	357	361	PF00017	0.571
LIG_SH2_STAP1	401	405	PF00017	0.445
LIG_SH2_STAP1	72	76	PF00017	0.547
LIG_SH2_STAT5	454	457	PF00017	0.458
LIG_SUMO_SIM_par_1	275	280	PF11976	0.628
LIG_SUMO_SIM_par_1	469	475	PF11976	0.568
LIG_SUMO_SIM_par_1	578	584	PF11976	0.722
LIG_TRAF2_1	151	154	PF00917	0.543
LIG_TRAF2_1	420	423	PF00917	0.594
LIG_TRAF2_1	447	450	PF00917	0.570
LIG_TRAF2_1	636	639	PF00917	0.545
LIG_UBA3_1	137	142	PF00899	0.334
LIG_UBA3_1	53	60	PF00899	0.383
MOD_CK1_1	115	121	PF00069	0.537
MOD_CK1_1	161	167	PF00069	0.462
MOD_CK1_1	197	203	PF00069	0.733
MOD_CK1_1	211	217	PF00069	0.664
MOD_CK1_1	282	288	PF00069	0.544
MOD_CK1_1	313	319	PF00069	0.580
MOD_CK1_1	523	529	PF00069	0.617
MOD_CK2_1	148	154	PF00069	0.564
MOD_CK2_1	19	25	PF00069	0.637
MOD_CK2_1	211	217	PF00069	0.655
MOD_CK2_1	283	289	PF00069	0.517
MOD_CK2_1	313	319	PF00069	0.531
MOD_CK2_1	338	344	PF00069	0.490
MOD_CK2_1	345	351	PF00069	0.476
MOD_CK2_1	417	423	PF00069	0.527
MOD_CK2_1	444	450	PF00069	0.528
MOD_CK2_1	518	524	PF00069	0.486
MOD_CK2_1	578	584	PF00069	0.508
MOD_CK2_1	628	634	PF00069	0.584
MOD_CK2_1	67	73	PF00069	0.583
MOD_CK2_1	89	95	PF00069	0.629
MOD_Cter_Amidation	99	102	PF01082	0.536
MOD_GlcNHglycan	1	4	PF01048	0.687
MOD_GlcNHglycan	264	269	PF01048	0.532
MOD_GlcNHglycan	364	367	PF01048	0.627
MOD_GlcNHglycan	375	378	PF01048	0.449
MOD_GlcNHglycan	414	417	PF01048	0.459
MOD_GlcNHglycan	419	422	PF01048	0.448
MOD_GlcNHglycan	639	642	PF01048	0.390
MOD_GSK3_1	148	155	PF00069	0.559
MOD_GSK3_1	157	164	PF00069	0.481
MOD_GSK3_1	19	26	PF00069	0.555
MOD_GSK3_1	208	215	PF00069	0.607
MOD_GSK3_1	224	231	PF00069	0.485
MOD_GSK3_1	279	286	PF00069	0.534
MOD_GSK3_1	364	371	PF00069	0.510
MOD_GSK3_1	444	451	PF00069	0.525
MOD_GSK3_1	549	556	PF00069	0.459
MOD_GSK3_1	629	636	PF00069	0.628
MOD_N-GLC_1	299	304	PF02516	0.566
MOD_N-GLC_1	368	373	PF02516	0.567
MOD_N-GLC_1	423	428	PF02516	0.567
MOD_N-GLC_1	533	538	PF02516	0.607
MOD_N-GLC_1	549	554	PF02516	0.377
MOD_NEK2_1	152	157	PF00069	0.635
MOD_NEK2_1	228	233	PF00069	0.687
MOD_NEK2_1	277	282	PF00069	0.509
MOD_NEK2_1	364	369	PF00069	0.613
MOD_NEK2_1	518	523	PF00069	0.473
MOD_NEK2_1	53	58	PF00069	0.403
MOD_NEK2_1	553	558	PF00069	0.630
MOD_NEK2_1	567	572	PF00069	0.522
MOD_NEK2_1	633	638	PF00069	0.441
MOD_NEK2_1	86	91	PF00069	0.708
MOD_NEK2_2	72	77	PF00069	0.579
MOD_PIKK_1	171	177	PF00454	0.623
MOD_PIKK_1	217	223	PF00454	0.629
MOD_PIKK_1	279	285	PF00454	0.400
MOD_PIKK_1	338	344	PF00454	0.559
MOD_PIKK_1	589	595	PF00454	0.530
MOD_PIKK_1	67	73	PF00454	0.578
MOD_PKA_2	158	164	PF00069	0.593
MOD_PKA_2	178	184	PF00069	0.315
MOD_PKA_2	194	200	PF00069	0.723
MOD_PKA_2	217	223	PF00069	0.714
MOD_PKA_2	259	265	PF00069	0.518
MOD_PKA_2	310	316	PF00069	0.584
MOD_PKA_2	553	559	PF00069	0.557
MOD_PKA_2	598	604	PF00069	0.713
MOD_PKA_2	610	616	PF00069	0.579
MOD_PKA_2	628	634	PF00069	0.574
MOD_PKA_2	86	92	PF00069	0.620
MOD_PKB_1	177	185	PF00069	0.500
MOD_Plk_1	115	121	PF00069	0.530
MOD_Plk_1	211	217	PF00069	0.685
MOD_Plk_1	264	270	PF00069	0.551
MOD_Plk_1	299	305	PF00069	0.567
MOD_Plk_1	318	324	PF00069	0.584
MOD_Plk_1	338	344	PF00069	0.495
MOD_Plk_1	345	351	PF00069	0.522
MOD_Plk_1	423	429	PF00069	0.570
MOD_Plk_1	448	454	PF00069	0.529
MOD_Plk_1	533	539	PF00069	0.601
MOD_Plk_1	549	555	PF00069	0.442
MOD_Plk_1	633	639	PF00069	0.650
MOD_Plk_1	72	78	PF00069	0.612
MOD_Plk_2-3	212	218	PF00069	0.617
MOD_Plk_2-3	423	429	PF00069	0.572
MOD_Plk_2-3	472	478	PF00069	0.466
MOD_Plk_2-3	578	584	PF00069	0.722
MOD_Plk_4	133	139	PF00069	0.517
MOD_Plk_4	423	429	PF00069	0.572
MOD_Plk_4	533	539	PF00069	0.624
MOD_ProDKin_1	1	7	PF00069	0.574
MOD_ProDKin_1	19	25	PF00069	0.662
MOD_SUMO_for_1	562	565	PF00179	0.435
MOD_SUMO_rev_2	153	157	PF00179	0.389
MOD_SUMO_rev_2	244	253	PF00179	0.563
MOD_SUMO_rev_2	493	502	PF00179	0.589
TRG_DiLeu_BaEn_1	423	428	PF01217	0.567
TRG_DiLeu_BaEn_1	503	508	PF01217	0.605
TRG_DiLeu_BaEn_2	428	434	PF01217	0.573
TRG_DiLeu_BaEn_3	331	337	PF01217	0.558
TRG_DiLeu_BaLyEn_6	324	329	PF01217	0.612
TRG_ENDOCYTIC_2	62	65	PF00928	0.577
TRG_ER_diArg_1	190	193	PF00400	0.646
TRG_ER_diArg_1	203	206	PF00400	0.486
TRG_ER_diArg_1	290	292	PF00400	0.620
TRG_ER_diArg_1	333	336	PF00400	0.357
TRG_ER_diArg_1	539	542	PF00400	0.505
TRG_NES_CRM1_1	520	535	PF08389	0.543
TRG_NLS_MonoExtC_3	188	194	PF00514	0.453
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	635	639	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGV3	Leptomonas seymouri	55%	100%
A0A1X0NJR6	Trypanosomatidae	41%	88%
A0A3Q8IH29	Leishmania donovani	81%	100%
A0A422NZK3	Trypanosoma rangeli	40%	88%
A4HU77	Leishmania infantum	81%	100%
D0A9Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	88%
E9AN07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QHM1	Leishmania major	81%	100%
V5BI13	Trypanosoma cruzi	39%	88%