EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Radial spoke protein 11

Species:

Leishmania braziliensis

UniProt:

A4H5Y0_LEIBR

TriTrypDb:

LbrM.09.1600 , LBRM2903_090022500

Length:

161

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5Y0

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005509	calcium ion binding	5	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.585
CLV_NRD_NRD_1	96	98	PF00675	0.569
CLV_PCSK_KEX2_1	96	98	PF00082	0.561
CLV_PCSK_SKI1_1	152	156	PF00082	0.412
DEG_Nend_UBRbox_3	1	3	PF02207	0.601
DOC_CKS1_1	49	54	PF01111	0.305
DOC_USP7_MATH_1	68	72	PF00917	0.502
DOC_USP7_UBL2_3	21	25	PF12436	0.392
DOC_WW_Pin1_4	48	53	PF00397	0.307
LIG_14-3-3_CanoR_1	119	125	PF00244	0.641
LIG_BIR_III_4	54	58	PF00653	0.369
LIG_BRCT_BRCA1_1	152	156	PF00533	0.335
LIG_BRCT_BRCA1_1	38	42	PF00533	0.328
LIG_CtBP_PxDLS_1	13	17	PF00389	0.410
LIG_FHA_1	22	28	PF00498	0.402
LIG_FHA_2	49	55	PF00498	0.318
LIG_LIR_Apic_2	103	108	PF02991	0.467
LIG_LIR_Apic_2	47	52	PF02991	0.531
LIG_LIR_Nem_3	153	159	PF02991	0.469
LIG_LIR_Nem_3	39	45	PF02991	0.510
LIG_SH2_CRK	49	53	PF00017	0.420
LIG_SH2_NCK_1	49	53	PF00017	0.420
LIG_SH2_STAP1	23	27	PF00017	0.367
LIG_SH2_STAP1	38	42	PF00017	0.328
LIG_SH2_STAT5	23	26	PF00017	0.424
LIG_SH3_3	74	80	PF00018	0.481
LIG_SUMO_SIM_par_1	147	153	PF11976	0.426
LIG_SUMO_SIM_par_1	75	84	PF11976	0.488
LIG_TRAF2_1	80	83	PF00917	0.613
LIG_WRC_WIRS_1	151	156	PF05994	0.307
MOD_CK1_1	84	90	PF00069	0.653
MOD_CK2_1	120	126	PF00069	0.564
MOD_GlcNHglycan	140	143	PF01048	0.606
MOD_GlcNHglycan	38	41	PF01048	0.329
MOD_GlcNHglycan	46	49	PF01048	0.391
MOD_GlcNHglycan	5	8	PF01048	0.547
MOD_GlcNHglycan	70	73	PF01048	0.687
MOD_GlcNHglycan	81	86	PF01048	0.561
MOD_GSK3_1	44	51	PF00069	0.299
MOD_GSK3_1	62	69	PF00069	0.692
MOD_NEK2_1	118	123	PF00069	0.411
MOD_PIKK_1	84	90	PF00454	0.657
MOD_PKA_2	118	124	PF00069	0.456
MOD_Plk_2-3	128	134	PF00069	0.449
MOD_Plk_4	15	21	PF00069	0.434
MOD_ProDKin_1	48	54	PF00069	0.307
MOD_SUMO_rev_2	121	129	PF00179	0.609
TRG_DiLeu_BaEn_1	110	115	PF01217	0.530
TRG_DiLeu_BaEn_2	149	155	PF01217	0.310
TRG_ER_diArg_1	95	97	PF00400	0.558
TRG_NES_CRM1_1	113	128	PF08389	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R7	Leptomonas seymouri	62%	99%
A0A0S4JCS1	Bodo saltans	44%	93%
A0A1X0NI72	Trypanosomatidae	44%	96%
A0A3R7KW38	Trypanosoma rangeli	43%	93%
A0A3S7WQX2	Leishmania donovani	79%	100%
A4HU76	Leishmania infantum	79%	100%
D0A9Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	82%
E9AN06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QHM2	Leishmania major	76%	100%
V5DED0	Trypanosoma cruzi	42%	98%