Leucine-rich repeat-containing protein 71

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5X9_LEIBR

TriTrypDb:

LbrM.09.1590 , LBRM2903_090022400

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A4H5X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	30	32	PF00675	0.414
CLV_NRD_NRD_1	328	330	PF00675	0.504
CLV_PCSK_KEX2_1	30	32	PF00082	0.379
CLV_PCSK_KEX2_1	48	50	PF00082	0.398
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.303
CLV_PCSK_SKI1_1	161	165	PF00082	0.284
CLV_PCSK_SKI1_1	208	212	PF00082	0.517
CLV_PCSK_SKI1_1	299	303	PF00082	0.484
CLV_PCSK_SKI1_1	4	8	PF00082	0.614
CLV_PCSK_SKI1_1	48	52	PF00082	0.407
DEG_SCF_FBW7_1	283	288	PF00400	0.491
DOC_ANK_TNKS_1	220	227	PF00023	0.424
DOC_CDC14_PxL_1	89	97	PF14671	0.344
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.514
DOC_MAPK_gen_1	208	217	PF00069	0.516
DOC_MAPK_MEF2A_6	11	19	PF00069	0.547
DOC_MAPK_MEF2A_6	90	97	PF00069	0.494
DOC_PP2B_LxvP_1	134	137	PF13499	0.394
DOC_PP2B_PxIxI_1	14	20	PF00149	0.573
DOC_USP7_MATH_1	10	14	PF00917	0.669
DOC_USP7_MATH_1	285	289	PF00917	0.509
DOC_USP7_MATH_1	297	301	PF00917	0.405
DOC_USP7_MATH_1	323	327	PF00917	0.554
DOC_USP7_MATH_1	35	39	PF00917	0.306
DOC_USP7_UBL2_3	331	335	PF12436	0.575
DOC_USP7_UBL2_3	4	8	PF12436	0.716
DOC_WW_Pin1_4	281	286	PF00397	0.434
LIG_14-3-3_CanoR_1	154	160	PF00244	0.424
LIG_14-3-3_CanoR_1	305	313	PF00244	0.491
LIG_14-3-3_CanoR_1	49	57	PF00244	0.281
LIG_Actin_WH2_2	260	276	PF00022	0.470
LIG_Actin_WH2_2	80	98	PF00022	0.383
LIG_AP2alpha_2	41	43	PF02296	0.272
LIG_EH_1	126	130	PF12763	0.391
LIG_FHA_1	158	164	PF00498	0.340
LIG_FHA_1	308	314	PF00498	0.460
LIG_FHA_1	84	90	PF00498	0.237
LIG_IRF3_LxIS_1	301	307	PF10401	0.452
LIG_LIR_Nem_3	118	123	PF02991	0.513
LIG_LIR_Nem_3	165	169	PF02991	0.304
LIG_LIR_Nem_3	191	197	PF02991	0.320
LIG_LIR_Nem_3	41	46	PF02991	0.489
LIG_LYPXL_yS_3	92	95	PF13949	0.327
LIG_PCNA_yPIPBox_3	154	163	PF02747	0.424
LIG_PTAP_UEV_1	11	16	PF05743	0.416
LIG_SH2_CRK	120	124	PF00017	0.542
LIG_SH2_CRK	194	198	PF00017	0.338
LIG_SH2_CRK	315	319	PF00017	0.516
LIG_SH2_STAT5	148	151	PF00017	0.459
LIG_SH2_STAT5	152	155	PF00017	0.477
LIG_SH2_STAT5	194	197	PF00017	0.338
LIG_SH3_3	39	45	PF00018	0.514
LIG_SH3_3	63	69	PF00018	0.413
LIG_SH3_3	85	91	PF00018	0.474
LIG_SH3_3	9	15	PF00018	0.522
LIG_SUMO_SIM_anti_2	107	115	PF11976	0.424
LIG_SUMO_SIM_anti_2	212	219	PF11976	0.452
LIG_SUMO_SIM_par_1	107	115	PF11976	0.374
LIG_SUMO_SIM_par_1	259	265	PF11976	0.460
LIG_SUMO_SIM_par_1	317	322	PF11976	0.430
LIG_TYR_ITIM	192	197	PF00017	0.320
LIG_TYR_ITIM	313	318	PF00017	0.536
LIG_UBA3_1	291	299	PF00899	0.285
LIG_UBA3_1	77	82	PF00899	0.264
MOD_CK1_1	155	161	PF00069	0.433
MOD_CK1_1	185	191	PF00069	0.398
MOD_CK1_1	213	219	PF00069	0.424
MOD_CK1_1	307	313	PF00069	0.537
MOD_CK2_1	238	244	PF00069	0.501
MOD_CK2_1	283	289	PF00069	0.515
MOD_Cter_Amidation	333	336	PF01082	0.649
MOD_GlcNHglycan	12	15	PF01048	0.652
MOD_GlcNHglycan	178	181	PF01048	0.346
MOD_GlcNHglycan	285	288	PF01048	0.510
MOD_GlcNHglycan	320	324	PF01048	0.529
MOD_GSK3_1	182	189	PF00069	0.394
MOD_GSK3_1	279	286	PF00069	0.442
MOD_GSK3_1	291	298	PF00069	0.345
MOD_GSK3_1	319	326	PF00069	0.403
MOD_N-GLC_1	155	160	PF02516	0.307
MOD_N-GLC_1	183	188	PF02516	0.290
MOD_N-GLC_1	213	218	PF02516	0.424
MOD_N-GLC_2	279	281	PF02516	0.406
MOD_NEK2_1	248	253	PF00069	0.378
MOD_NEK2_1	291	296	PF00069	0.381
MOD_PIKK_1	115	121	PF00454	0.367
MOD_PKA_1	330	336	PF00069	0.615
MOD_PKA_2	304	310	PF00069	0.489
MOD_Plk_1	155	161	PF00069	0.304
MOD_Plk_1	183	189	PF00069	0.307
MOD_Plk_1	213	219	PF00069	0.395
MOD_Plk_1	52	58	PF00069	0.400
MOD_Plk_4	213	219	PF00069	0.452
MOD_Plk_4	83	89	PF00069	0.232
MOD_ProDKin_1	281	287	PF00069	0.427
MOD_SUMO_for_1	50	53	PF00179	0.395
MOD_SUMO_for_1	6	9	PF00179	0.468
MOD_SUMO_rev_2	75	84	PF00179	0.369
TRG_ENDOCYTIC_2	120	123	PF00928	0.471
TRG_ENDOCYTIC_2	194	197	PF00928	0.320
TRG_ENDOCYTIC_2	315	318	PF00928	0.438
TRG_ENDOCYTIC_2	92	95	PF00928	0.327
TRG_ER_diArg_1	29	31	PF00400	0.412
TRG_ER_diLys_1	335	338	PF00400	0.689
TRG_NLS_Bipartite_1	30	52	PF00514	0.297
TRG_NLS_MonoCore_2	328	333	PF00514	0.580
TRG_NLS_MonoExtC_3	47	53	PF00514	0.286
TRG_NLS_MonoExtN_4	328	334	PF00514	0.549
TRG_NLS_MonoExtN_4	45	52	PF00514	0.301
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA8	Leptomonas seymouri	70%	100%
A0A0S4JEI1	Bodo saltans	39%	90%
A0A1X0NI28	Trypanosomatidae	48%	100%
A0A1X0P2M5	Trypanosomatidae	27%	97%
A0A1X0P4Z4	Trypanosomatidae	23%	86%
A0A3Q8IDE6	Leishmania donovani	28%	85%
A0A3R7L7Y9	Trypanosoma rangeli	26%	76%
A0A3R7N0J2	Trypanosoma rangeli	46%	100%
A0A3S5H6F0	Leishmania donovani	86%	100%
A4HU75	Leishmania infantum	87%	100%
A4I2T1	Leishmania infantum	28%	85%
C9ZQG3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	96%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	75%
D0A9Q7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ADA9	Leishmania major	28%	85%
E9AN05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	85%
P10775	Sus scrofa	25%	74%
P29315	Rattus norvegicus	26%	74%
Q4QHM3	Leishmania major	87%	100%
Q91VI7	Mus musculus	26%	74%
V5BDE5	Trypanosoma cruzi	46%	98%