Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5X3_LEIBR

TriTrypDb:

LbrM.09.1520 , LBRM2903_090021800

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5X3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004792	thiosulfate sulfurtransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016782	transferase activity, transferring sulphur-containing groups	3	9
GO:0016783	sulfurtransferase activity	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.544
CLV_PCSK_SKI1_1	10	14	PF00082	0.451
DEG_Nend_Nbox_1	1	3	PF02207	0.511
DOC_CKS1_1	132	137	PF01111	0.614
DOC_PP4_FxxP_1	81	84	PF00568	0.394
DOC_USP7_MATH_1	135	139	PF00917	0.661
DOC_USP7_MATH_1	23	27	PF00917	0.371
DOC_WW_Pin1_4	131	136	PF00397	0.579
DOC_WW_Pin1_4	142	147	PF00397	0.660
DOC_WW_Pin1_4	64	69	PF00397	0.471
LIG_FHA_1	3	9	PF00498	0.535
LIG_FHA_1	40	46	PF00498	0.428
LIG_FHA_1	89	95	PF00498	0.509
LIG_LIR_Apic_2	78	84	PF02991	0.413
LIG_LIR_Gen_1	74	84	PF02991	0.527
LIG_LIR_Nem_3	74	80	PF02991	0.527
LIG_Pex14_1	125	129	PF04695	0.463
LIG_Pex14_2	121	125	PF04695	0.456
LIG_Pex14_2	77	81	PF04695	0.430
LIG_SH2_CRK	132	136	PF00017	0.609
LIG_SH2_STAT5	11	14	PF00017	0.381
LIG_SH2_STAT5	7	10	PF00017	0.475
LIG_SH2_STAT5	96	99	PF00017	0.448
LIG_SH3_3	54	60	PF00018	0.448
LIG_SUMO_SIM_par_1	35	42	PF11976	0.451
MOD_CK1_1	144	150	PF00069	0.648
MOD_CK1_1	67	73	PF00069	0.397
MOD_CK2_1	38	44	PF00069	0.468
MOD_CK2_1	67	73	PF00069	0.525
MOD_CMANNOS	125	128	PF00535	0.284
MOD_GlcNHglycan	102	105	PF01048	0.287
MOD_GlcNHglycan	121	124	PF01048	0.248
MOD_GlcNHglycan	137	140	PF01048	0.653
MOD_GlcNHglycan	52	55	PF01048	0.294
MOD_GSK3_1	131	138	PF00069	0.629
MOD_GSK3_1	60	67	PF00069	0.458
MOD_N-GLC_1	119	124	PF02516	0.270
MOD_NEK2_1	121	126	PF00069	0.481
MOD_NEK2_1	2	7	PF00069	0.463
MOD_PIKK_1	88	94	PF00454	0.456
MOD_PKA_2	2	8	PF00069	0.538
MOD_PKA_2	39	45	PF00069	0.451
MOD_Plk_4	67	73	PF00069	0.509
MOD_ProDKin_1	131	137	PF00069	0.595
MOD_ProDKin_1	142	148	PF00069	0.659
MOD_ProDKin_1	64	70	PF00069	0.471
TRG_ENDOCYTIC_2	11	14	PF00928	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG29	Leptomonas seymouri	64%	100%
A0A1X0NHS7	Trypanosomatidae	38%	100%
A0A1X0NIC3	Trypanosomatidae	37%	100%
A0A1X0NJI4	Trypanosomatidae	27%	100%
A0A1X0NJQ7	Trypanosomatidae	50%	100%
A0A3R7LB88	Trypanosoma rangeli	34%	100%
A0A3R7P0U7	Trypanosoma rangeli	47%	100%
A0A3S7WQW6	Leishmania donovani	85%	100%
A0A3S7WQX1	Leishmania donovani	35%	100%
A4H5X4	Leishmania braziliensis	35%	100%
A4HU68	Leishmania infantum	85%	100%
A4HU69	Leishmania infantum	35%	100%
D0A9Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AMZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9AMZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
P22978	Drosophila melanogaster	32%	100%
Q08742	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
Q10215	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q4QHM8	Leishmania major	38%	100%
Q4QHM9	Leishmania major	84%	100%
V5BMN5	Trypanosoma cruzi	49%	100%
V5BMN9	Trypanosoma cruzi	35%	100%