Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5X2_LEIBR

TriTrypDb:

LbrM.09.1510 , LBRM2903_090021700

Length:

131

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5X2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004792	thiosulfate sulfurtransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016782	transferase activity, transferring sulphur-containing groups	3	7
GO:0016783	sulfurtransferase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.542
CLV_NRD_NRD_1	75	77	PF00675	0.423
CLV_NRD_NRD_1	78	80	PF00675	0.384
DOC_MAPK_gen_1	104	112	PF00069	0.553
DOC_MAPK_gen_1	76	86	PF00069	0.433
DOC_PP4_FxxP_1	6	9	PF00568	0.602
DOC_USP7_UBL2_3	77	81	PF12436	0.568
LIG_14-3-3_CanoR_1	104	112	PF00244	0.486
LIG_14-3-3_CanoR_1	63	73	PF00244	0.453
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BRCT_BRCA1_1	107	111	PF00533	0.566
LIG_FHA_1	25	31	PF00498	0.499
LIG_FHA_2	121	127	PF00498	0.531
LIG_LIR_Apic_2	5	9	PF02991	0.473
LIG_LIR_Nem_3	7	13	PF02991	0.618
LIG_OCRL_FandH_1	54	66	PF00620	0.312
LIG_PCNA_yPIPBox_3	107	120	PF02747	0.387
LIG_PDZ_Class_3	126	131	PF00595	0.585
LIG_Pex14_1	65	69	PF04695	0.446
LIG_Pex14_2	6	10	PF04695	0.681
LIG_SH2_SRC	119	122	PF00017	0.540
LIG_SH2_STAP1	13	17	PF00017	0.667
LIG_SH2_STAT3	13	16	PF00017	0.530
LIG_SH2_STAT5	100	103	PF00017	0.510
LIG_SH2_STAT5	119	122	PF00017	0.480
LIG_SH2_STAT5	31	34	PF00017	0.487
LIG_SH3_1	42	48	PF00018	0.377
LIG_SH3_3	42	48	PF00018	0.476
LIG_SH3_3	72	78	PF00018	0.570
LIG_SH3_4	77	84	PF00018	0.558
LIG_SUMO_SIM_par_1	31	38	PF11976	0.420
LIG_WW_2	45	48	PF00397	0.491
MOD_CK1_1	68	74	PF00069	0.350
MOD_CK1_1	96	102	PF00069	0.579
MOD_CK2_1	120	126	PF00069	0.529
MOD_GlcNHglycan	107	110	PF01048	0.571
MOD_GlcNHglycan	27	30	PF01048	0.663
MOD_GlcNHglycan	95	98	PF01048	0.521
MOD_GSK3_1	64	71	PF00069	0.522
MOD_NEK2_1	120	125	PF00069	0.708
MOD_NEK2_1	64	69	PF00069	0.558
MOD_PIKK_1	120	126	PF00454	0.627
MOD_PKA_2	25	31	PF00069	0.643
MOD_Plk_4	96	102	PF00069	0.492
MOD_SUMO_rev_2	34	44	PF00179	0.526
TRG_NLS_MonoCore_2	75	80	PF00514	0.332
TRG_NLS_MonoExtC_3	75	80	PF00514	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P899	Leptomonas seymouri	57%	100%
A0A0N0P8M5	Leptomonas seymouri	31%	100%
A0A1X0NHS7	Trypanosomatidae	30%	100%
A0A1X0NJI4	Trypanosomatidae	34%	96%
A0A3Q8I7K7	Leishmania donovani	79%	100%
A0A3R7LB88	Trypanosoma rangeli	34%	100%
A0A3R7MT99	Trypanosoma rangeli	29%	96%
A0A3S7WQX1	Leishmania donovani	34%	100%
A4HU67	Leishmania infantum	79%	100%
A4HU69	Leishmania infantum	34%	100%
D0A9P9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	96%
E9AMZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AMZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4QHM8	Leishmania major	33%	100%
Q4QHN0	Leishmania major	79%	100%
V5BI16	Trypanosoma cruzi	31%	81%