J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5X1_LEIBR

TriTrypDb:

LbrM.09.1500 , LBRM2903_090021600

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5X1

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0006458	'de novo' protein folding	3	1
GO:0009987	cellular process	1	1
GO:0042026	protein refolding	3	1
GO:0051084	'de novo' post-translational protein folding	4	1
GO:0051085	chaperone cofactor-dependent protein refolding	4	1
GO:0061077	chaperone-mediated protein folding	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.288
CLV_NRD_NRD_1	153	155	PF00675	0.460
CLV_NRD_NRD_1	260	262	PF00675	0.660
CLV_NRD_NRD_1	362	364	PF00675	0.629
CLV_NRD_NRD_1	40	42	PF00675	0.509
CLV_NRD_NRD_1	410	412	PF00675	0.513
CLV_PCSK_KEX2_1	153	155	PF00082	0.477
CLV_PCSK_KEX2_1	204	206	PF00082	0.516
CLV_PCSK_KEX2_1	260	262	PF00082	0.601
CLV_PCSK_KEX2_1	270	272	PF00082	0.677
CLV_PCSK_KEX2_1	382	384	PF00082	0.612
CLV_PCSK_KEX2_1	60	62	PF00082	0.272
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.479
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.795
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.600
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.289
CLV_PCSK_SKI1_1	103	107	PF00082	0.652
DEG_Nend_UBRbox_3	1	3	PF02207	0.548
DEG_SPOP_SBC_1	118	122	PF00917	0.485
DEG_SPOP_SBC_1	386	390	PF00917	0.494
DEG_SPOP_SBC_1	78	82	PF00917	0.422
DOC_CYCLIN_RxL_1	99	109	PF00134	0.533
DOC_MAPK_gen_1	41	49	PF00069	0.454
DOC_USP7_MATH_1	118	122	PF00917	0.780
DOC_USP7_MATH_1	188	192	PF00917	0.762
DOC_USP7_MATH_1	386	390	PF00917	0.629
DOC_USP7_MATH_1	71	75	PF00917	0.349
DOC_USP7_MATH_1	78	82	PF00917	0.349
DOC_WW_Pin1_4	114	119	PF00397	0.630
DOC_WW_Pin1_4	180	185	PF00397	0.657
DOC_WW_Pin1_4	283	288	PF00397	0.538
DOC_WW_Pin1_4	330	335	PF00397	0.651
LIG_14-3-3_CanoR_1	110	118	PF00244	0.559
LIG_14-3-3_CanoR_1	163	173	PF00244	0.452
LIG_14-3-3_CanoR_1	205	213	PF00244	0.401
LIG_14-3-3_CanoR_1	251	258	PF00244	0.551
LIG_14-3-3_CanoR_1	29	35	PF00244	0.438
LIG_14-3-3_CanoR_1	357	367	PF00244	0.613
LIG_14-3-3_CanoR_1	84	92	PF00244	0.404
LIG_APCC_ABBA_1	221	226	PF00400	0.389
LIG_BRCT_BRCA1_1	228	232	PF00533	0.391
LIG_EH_1	312	316	PF12763	0.592
LIG_FHA_2	125	131	PF00498	0.455
LIG_FHA_2	209	215	PF00498	0.443
LIG_FHA_2	34	40	PF00498	0.421
LIG_FHA_2	52	58	PF00498	0.314
LIG_FHA_2	74	80	PF00498	0.328
LIG_LIR_Apic_2	323	328	PF02991	0.622
LIG_LIR_Gen_1	229	237	PF02991	0.383
LIG_LIR_Gen_1	293	303	PF02991	0.566
LIG_LIR_Nem_3	229	233	PF02991	0.382
LIG_LIR_Nem_3	289	295	PF02991	0.530
LIG_LIR_Nem_3	333	338	PF02991	0.761
LIG_LIR_Nem_3	345	351	PF02991	0.524
LIG_SH2_CRK	325	329	PF00017	0.741
LIG_SH2_CRK	44	48	PF00017	0.271
LIG_SH2_CRK	92	96	PF00017	0.271
LIG_SH2_NCK_1	325	329	PF00017	0.602
LIG_SH2_NCK_1	384	388	PF00017	0.502
LIG_SH2_SRC	224	227	PF00017	0.406
LIG_SH2_SRC	304	307	PF00017	0.657
LIG_SH2_STAP1	145	149	PF00017	0.420
LIG_SH2_STAP1	304	308	PF00017	0.475
LIG_SH2_STAT5	126	129	PF00017	0.465
LIG_SH2_STAT5	283	286	PF00017	0.461
LIG_SH3_CIN85_PxpxPR_1	184	189	PF14604	0.515
LIG_TRAF2_1	307	310	PF00917	0.616
MOD_CDK_SPxxK_3	180	187	PF00069	0.510
MOD_CK1_1	120	126	PF00069	0.669
MOD_CK1_1	207	213	PF00069	0.573
MOD_CK1_1	23	29	PF00069	0.519
MOD_CK1_1	390	396	PF00069	0.556
MOD_CK1_1	74	80	PF00069	0.404
MOD_CK1_1	83	89	PF00069	0.404
MOD_CK2_1	208	214	PF00069	0.566
MOD_CK2_1	283	289	PF00069	0.593
MOD_CK2_1	304	310	PF00069	0.616
MOD_Cter_Amidation	202	205	PF01082	0.630
MOD_Cter_Amidation	409	412	PF01082	0.513
MOD_GlcNHglycan	112	115	PF01048	0.584
MOD_GlcNHglycan	184	187	PF01048	0.773
MOD_GlcNHglycan	191	194	PF01048	0.584
MOD_GlcNHglycan	240	243	PF01048	0.540
MOD_GlcNHglycan	25	28	PF01048	0.640
MOD_GlcNHglycan	305	309	PF01048	0.614
MOD_GlcNHglycan	344	347	PF01048	0.557
MOD_GlcNHglycan	392	395	PF01048	0.722
MOD_GlcNHglycan	398	401	PF01048	0.729
MOD_GlcNHglycan	407	410	PF01048	0.767
MOD_GlcNHglycan	51	54	PF01048	0.356
MOD_GlcNHglycan	76	79	PF01048	0.362
MOD_GSK3_1	106	113	PF00069	0.505
MOD_GSK3_1	114	121	PF00069	0.635
MOD_GSK3_1	124	131	PF00069	0.581
MOD_GSK3_1	204	211	PF00069	0.520
MOD_GSK3_1	277	284	PF00069	0.727
MOD_GSK3_1	359	366	PF00069	0.697
MOD_GSK3_1	386	393	PF00069	0.670
MOD_GSK3_1	49	56	PF00069	0.335
MOD_GSK3_1	73	80	PF00069	0.358
MOD_LATS_1	275	281	PF00433	0.492
MOD_LATS_1	401	407	PF00433	0.506
MOD_N-GLC_1	118	123	PF02516	0.666
MOD_N-GLC_1	330	335	PF02516	0.559
MOD_N-GLC_1	359	364	PF02516	0.711
MOD_N-GLC_1	74	79	PF02516	0.360
MOD_NEK2_1	106	111	PF00069	0.708
MOD_NEK2_1	20	25	PF00069	0.616
MOD_NEK2_2	91	96	PF00069	0.349
MOD_PKA_1	204	210	PF00069	0.509
MOD_PKA_1	363	369	PF00069	0.756
MOD_PKA_2	109	115	PF00069	0.497
MOD_PKA_2	128	134	PF00069	0.562
MOD_PKA_2	188	194	PF00069	0.689
MOD_PKA_2	197	203	PF00069	0.457
MOD_PKA_2	204	210	PF00069	0.484
MOD_PKA_2	250	256	PF00069	0.439
MOD_PKA_2	83	89	PF00069	0.404
MOD_PKB_1	187	195	PF00069	0.662
MOD_Plk_2-3	226	232	PF00069	0.396
MOD_Plk_4	121	127	PF00069	0.578
MOD_Plk_4	277	283	PF00069	0.491
MOD_ProDKin_1	114	120	PF00069	0.630
MOD_ProDKin_1	180	186	PF00069	0.658
MOD_ProDKin_1	283	289	PF00069	0.539
MOD_ProDKin_1	330	336	PF00069	0.652
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.374
TRG_ENDOCYTIC_2	137	140	PF00928	0.484
TRG_ENDOCYTIC_2	145	148	PF00928	0.389
TRG_ENDOCYTIC_2	295	298	PF00928	0.659
TRG_ENDOCYTIC_2	348	351	PF00928	0.579
TRG_ENDOCYTIC_2	367	370	PF00928	0.493
TRG_ENDOCYTIC_2	44	47	PF00928	0.285
TRG_ENDOCYTIC_2	62	65	PF00928	0.271
TRG_ENDOCYTIC_2	92	95	PF00928	0.319
TRG_ER_diArg_1	152	154	PF00400	0.455
TRG_ER_diArg_1	7	10	PF00400	0.577
TRG_NLS_Bipartite_1	260	274	PF00514	0.568
TRG_NLS_Bipartite_1	41	63	PF00514	0.335
TRG_NLS_MonoExtC_3	58	64	PF00514	0.314
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I106	Leptomonas seymouri	57%	98%
A0A1X0NII8	Trypanosomatidae	41%	100%
A0A3Q8IC04	Leishmania donovani	78%	100%
A0A3R7KNF9	Trypanosoma rangeli	43%	100%
A4HU66	Leishmania infantum	78%	100%
D0A9P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AMZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QHN1	Leishmania major	81%	100%
V5BMJ5	Trypanosoma cruzi	40%	100%