SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5W8_LEIBR

TriTrypDb:

LbrM.09.1470 , LBRM2903_090021300

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5W8

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.354
CLV_C14_Caspase3-7	311	315	PF00656	0.532
CLV_NRD_NRD_1	165	167	PF00675	0.619
CLV_NRD_NRD_1	175	177	PF00675	0.585
CLV_NRD_NRD_1	189	191	PF00675	0.391
CLV_NRD_NRD_1	229	231	PF00675	0.649
CLV_NRD_NRD_1	531	533	PF00675	0.579
CLV_NRD_NRD_1	79	81	PF00675	0.579
CLV_PCSK_KEX2_1	165	167	PF00082	0.613
CLV_PCSK_KEX2_1	175	177	PF00082	0.560
CLV_PCSK_KEX2_1	189	191	PF00082	0.397
CLV_PCSK_KEX2_1	229	231	PF00082	0.599
CLV_PCSK_KEX2_1	440	442	PF00082	0.551
CLV_PCSK_KEX2_1	531	533	PF00082	0.599
CLV_PCSK_KEX2_1	79	81	PF00082	0.594
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.622
CLV_PCSK_SKI1_1	129	133	PF00082	0.442
CLV_PCSK_SKI1_1	176	180	PF00082	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.516
DOC_CKS1_1	4	9	PF01111	0.464
DOC_CYCLIN_RxL_1	186	197	PF00134	0.609
DOC_MAPK_DCC_7	342	351	PF00069	0.538
DOC_MAPK_gen_1	165	172	PF00069	0.521
DOC_MAPK_HePTP_8	126	138	PF00069	0.412
DOC_MAPK_HePTP_8	339	351	PF00069	0.562
DOC_MAPK_MEF2A_6	129	138	PF00069	0.395
DOC_MAPK_MEF2A_6	165	174	PF00069	0.403
DOC_MAPK_MEF2A_6	342	351	PF00069	0.510
DOC_PP2B_LxvP_1	297	300	PF13499	0.573
DOC_PP2B_LxvP_1	304	307	PF13499	0.481
DOC_USP7_MATH_1	207	211	PF00917	0.550
DOC_USP7_MATH_1	410	414	PF00917	0.685
DOC_WW_Pin1_4	140	145	PF00397	0.518
DOC_WW_Pin1_4	235	240	PF00397	0.658
DOC_WW_Pin1_4	3	8	PF00397	0.537
DOC_WW_Pin1_4	34	39	PF00397	0.657
DOC_WW_Pin1_4	459	464	PF00397	0.771
DOC_WW_Pin1_4	465	470	PF00397	0.804
DOC_WW_Pin1_4	477	482	PF00397	0.718
LIG_14-3-3_CanoR_1	111	116	PF00244	0.511
LIG_14-3-3_CanoR_1	175	179	PF00244	0.642
LIG_14-3-3_CanoR_1	283	293	PF00244	0.579
LIG_14-3-3_CanoR_1	476	484	PF00244	0.637
LIG_14-3-3_CanoR_1	73	81	PF00244	0.434
LIG_APCC_ABBA_1	351	356	PF00400	0.440
LIG_APCC_ABBAyCdc20_2	402	408	PF00400	0.574
LIG_BIR_III_2	161	165	PF00653	0.619
LIG_BIR_III_2	41	45	PF00653	0.549
LIG_BRCT_BRCA1_1	420	424	PF00533	0.711
LIG_CtBP_PxDLS_1	389	395	PF00389	0.562
LIG_DCNL_PONY_1	1	4	PF03556	0.508
LIG_deltaCOP1_diTrp_1	492	501	PF00928	0.407
LIG_EH1_1	287	295	PF00400	0.580
LIG_FHA_1	133	139	PF00498	0.385
LIG_FHA_1	195	201	PF00498	0.515
LIG_FHA_1	236	242	PF00498	0.529
LIG_FHA_1	285	291	PF00498	0.546
LIG_FHA_1	49	55	PF00498	0.469
LIG_FHA_1	9	15	PF00498	0.489
LIG_FHA_2	156	162	PF00498	0.351
LIG_FHA_2	309	315	PF00498	0.510
LIG_FHA_2	414	420	PF00498	0.673
LIG_Pex14_1	495	499	PF04695	0.400
LIG_SH2_GRB2like	33	36	PF00017	0.718
LIG_SH2_NCK_1	396	400	PF00017	0.637
LIG_SH2_STAT5	139	142	PF00017	0.412
LIG_SH2_STAT5	245	248	PF00017	0.630
LIG_SH3_3	149	155	PF00018	0.494
LIG_SH3_3	161	167	PF00018	0.498
LIG_SH3_3	341	347	PF00018	0.580
LIG_SH3_3	538	544	PF00018	0.636
LIG_SH3_3	564	570	PF00018	0.594
LIG_SUMO_SIM_par_1	295	302	PF11976	0.548
LIG_SUMO_SIM_par_1	308	315	PF11976	0.569
LIG_TRAF2_1	388	391	PF00917	0.496
LIG_TRAF2_1	504	507	PF00917	0.628
LIG_TYR_ITIM	394	399	PF00017	0.558
MOD_CDK_SPxK_1	3	9	PF00069	0.469
MOD_CDK_SPxxK_3	465	472	PF00069	0.754
MOD_CK1_1	110	116	PF00069	0.571
MOD_CK1_1	117	123	PF00069	0.590
MOD_CK1_1	177	183	PF00069	0.627
MOD_CK1_1	251	257	PF00069	0.657
MOD_CK1_1	3	9	PF00069	0.538
MOD_CK1_1	34	40	PF00069	0.679
MOD_CK1_1	413	419	PF00069	0.708
MOD_CK1_1	464	470	PF00069	0.703
MOD_CK2_1	412	418	PF00069	0.661
MOD_CK2_1	501	507	PF00069	0.498
MOD_GlcNHglycan	116	119	PF01048	0.633
MOD_GlcNHglycan	250	253	PF01048	0.618
MOD_GlcNHglycan	314	317	PF01048	0.347
MOD_GlcNHglycan	320	325	PF01048	0.355
MOD_GlcNHglycan	418	423	PF01048	0.751
MOD_GlcNHglycan	424	427	PF01048	0.733
MOD_GlcNHglycan	469	472	PF01048	0.610
MOD_GSK3_1	107	114	PF00069	0.516
MOD_GSK3_1	308	315	PF00069	0.459
MOD_GSK3_1	374	381	PF00069	0.494
MOD_GSK3_1	418	425	PF00069	0.683
MOD_GSK3_1	44	51	PF00069	0.512
MOD_GSK3_1	461	468	PF00069	0.761
MOD_GSK3_1	475	482	PF00069	0.715
MOD_GSK3_1	8	15	PF00069	0.500
MOD_GSK3_1	92	99	PF00069	0.476
MOD_N-GLC_1	34	39	PF02516	0.715
MOD_N-GLC_1	358	363	PF02516	0.292
MOD_N-GLC_1	465	470	PF02516	0.822
MOD_NEK2_1	132	137	PF00069	0.398
MOD_NEK2_1	138	143	PF00069	0.411
MOD_NEK2_1	174	179	PF00069	0.621
MOD_NEK2_1	2	7	PF00069	0.532
MOD_NEK2_1	26	31	PF00069	0.606
MOD_NEK2_1	312	317	PF00069	0.482
MOD_NEK2_1	331	336	PF00069	0.461
MOD_NEK2_1	358	363	PF00069	0.500
MOD_NEK2_1	514	519	PF00069	0.667
MOD_PIKK_1	12	18	PF00454	0.529
MOD_PIKK_1	251	257	PF00454	0.619
MOD_PIKK_1	72	78	PF00454	0.527
MOD_PKA_2	110	116	PF00069	0.584
MOD_PKA_2	174	180	PF00069	0.644
MOD_PKA_2	194	200	PF00069	0.537
MOD_PKA_2	248	254	PF00069	0.587
MOD_PKA_2	410	416	PF00069	0.710
MOD_PKA_2	475	481	PF00069	0.519
MOD_PKA_2	72	78	PF00069	0.480
MOD_PKA_2	8	14	PF00069	0.602
MOD_Plk_1	320	326	PF00069	0.569
MOD_Plk_4	237	243	PF00069	0.570
MOD_Plk_4	299	305	PF00069	0.532
MOD_Plk_4	347	353	PF00069	0.560
MOD_ProDKin_1	140	146	PF00069	0.516
MOD_ProDKin_1	235	241	PF00069	0.652
MOD_ProDKin_1	3	9	PF00069	0.536
MOD_ProDKin_1	34	40	PF00069	0.659
MOD_ProDKin_1	459	465	PF00069	0.773
MOD_ProDKin_1	477	483	PF00069	0.709
MOD_SUMO_rev_2	15	24	PF00179	0.476
MOD_SUMO_rev_2	413	422	PF00179	0.686
TRG_ENDOCYTIC_2	396	399	PF00928	0.611
TRG_ENDOCYTIC_2	443	446	PF00928	0.597
TRG_ER_diArg_1	164	166	PF00400	0.617
TRG_ER_diArg_1	174	176	PF00400	0.584
TRG_ER_diArg_1	188	190	PF00400	0.423
TRG_ER_diArg_1	228	230	PF00400	0.615
TRG_ER_diArg_1	333	336	PF00400	0.438
TRG_ER_diArg_1	520	523	PF00400	0.530
TRG_ER_diArg_1	530	532	PF00400	0.517
TRG_ER_diArg_1	78	80	PF00400	0.610
TRG_NLS_MonoExtC_3	531	536	PF00514	0.599
TRG_NLS_MonoExtN_4	531	536	PF00514	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB06	Leptomonas seymouri	62%	99%
A0A0S4JCA3	Bodo saltans	28%	92%
A0A1X0NHU4	Trypanosomatidae	37%	100%
A0A3S7WQW9	Leishmania donovani	82%	100%
A0A422NZM7	Trypanosoma rangeli	38%	100%
A4HU63	Leishmania infantum	82%	100%
D0A9P4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	95%
E9AMZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QHN4	Leishmania major	82%	100%
V5AY09	Trypanosoma cruzi	39%	100%