Alpha-1,2-Mannosidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H5W7_LEIBR

TriTrypDb:

LbrM.09.1460 , LBRM2903_090021200

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H5W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5W7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	7
GO:0004559	alpha-mannosidase activity	6	7
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	8	7
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0015923	mannosidase activity	5	7
GO:0015924	mannosyl-oligosaccharide mannosidase activity	7	7
GO:0016787	hydrolase activity	2	7
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.365
CLV_NRD_NRD_1	177	179	PF00675	0.481
CLV_NRD_NRD_1	281	283	PF00675	0.443
CLV_NRD_NRD_1	4	6	PF00675	0.371
CLV_NRD_NRD_1	463	465	PF00675	0.565
CLV_NRD_NRD_1	475	477	PF00675	0.461
CLV_NRD_NRD_1	497	499	PF00675	0.542
CLV_PCSK_KEX2_1	3	5	PF00082	0.381
CLV_PCSK_KEX2_1	475	477	PF00082	0.498
CLV_PCSK_KEX2_1	497	499	PF00082	0.542
CLV_PCSK_SKI1_1	129	133	PF00082	0.522
CLV_PCSK_SKI1_1	136	140	PF00082	0.518
CLV_PCSK_SKI1_1	155	159	PF00082	0.477
CLV_PCSK_SKI1_1	178	182	PF00082	0.541
CLV_PCSK_SKI1_1	270	274	PF00082	0.476
CLV_PCSK_SKI1_1	301	305	PF00082	0.422
CLV_PCSK_SKI1_1	307	311	PF00082	0.443
DEG_APCC_DBOX_1	177	185	PF00400	0.344
DEG_APCC_DBOX_1	6	14	PF00400	0.551
DEG_Nend_UBRbox_3	1	3	PF02207	0.565
DEG_SCF_FBW7_1	187	193	PF00400	0.365
DEG_SPOP_SBC_1	138	142	PF00917	0.294
DEG_SPOP_SBC_1	194	198	PF00917	0.368
DEG_SPOP_SBC_1	374	378	PF00917	0.198
DOC_CKS1_1	187	192	PF01111	0.366
DOC_CKS1_1	331	336	PF01111	0.232
DOC_MAPK_gen_1	178	184	PF00069	0.300
DOC_MAPK_gen_1	3	12	PF00069	0.554
DOC_MAPK_gen_1	390	397	PF00069	0.230
DOC_MAPK_gen_1	479	488	PF00069	0.258
DOC_MAPK_MEF2A_6	270	277	PF00069	0.276
DOC_MAPK_MEF2A_6	324	331	PF00069	0.198
DOC_MAPK_NFAT4_5	270	278	PF00069	0.277
DOC_PP1_RVXF_1	13	20	PF00149	0.451
DOC_PP2B_LxvP_1	327	330	PF13499	0.198
DOC_USP7_MATH_1	145	149	PF00917	0.402
DOC_USP7_MATH_1	157	161	PF00917	0.256
DOC_USP7_MATH_1	232	236	PF00917	0.370
DOC_USP7_MATH_1	295	299	PF00917	0.243
DOC_USP7_MATH_1	356	360	PF00917	0.228
DOC_USP7_MATH_1	49	53	PF00917	0.401
DOC_USP7_MATH_1	525	529	PF00917	0.343
DOC_USP7_UBL2_3	132	136	PF12436	0.277
DOC_WW_Pin1_4	122	127	PF00397	0.489
DOC_WW_Pin1_4	186	191	PF00397	0.371
DOC_WW_Pin1_4	215	220	PF00397	0.353
DOC_WW_Pin1_4	330	335	PF00397	0.232
DOC_WW_Pin1_4	512	517	PF00397	0.306
LIG_14-3-3_CanoR_1	230	239	PF00244	0.389
LIG_14-3-3_CanoR_1	307	316	PF00244	0.232
LIG_14-3-3_CanoR_1	419	423	PF00244	0.232
LIG_Actin_WH2_2	117	134	PF00022	0.287
LIG_BRCT_BRCA1_1	147	151	PF00533	0.304
LIG_deltaCOP1_diTrp_1	64	72	PF00928	0.378
LIG_EH1_1	488	496	PF00400	0.294
LIG_FHA_1	123	129	PF00498	0.293
LIG_FHA_1	304	310	PF00498	0.232
LIG_FHA_1	413	419	PF00498	0.198
LIG_FHA_1	509	515	PF00498	0.330
LIG_FHA_1	516	522	PF00498	0.366
LIG_FHA_1	89	95	PF00498	0.370
LIG_FHA_1	99	105	PF00498	0.395
LIG_FHA_2	437	443	PF00498	0.360
LIG_GBD_Chelix_1	25	33	PF00786	0.233
LIG_GBD_Chelix_1	296	304	PF00786	0.398
LIG_LIR_Apic_2	233	239	PF02991	0.385
LIG_LIR_Gen_1	14	24	PF02991	0.427
LIG_LIR_Gen_1	148	158	PF02991	0.273
LIG_LIR_Gen_1	196	206	PF02991	0.379
LIG_LIR_Gen_1	224	232	PF02991	0.329
LIG_LIR_Gen_1	261	269	PF02991	0.304
LIG_LIR_Gen_1	420	430	PF02991	0.243
LIG_LIR_Gen_1	483	491	PF02991	0.256
LIG_LIR_Nem_3	14	19	PF02991	0.432
LIG_LIR_Nem_3	148	154	PF02991	0.288
LIG_LIR_Nem_3	196	202	PF02991	0.365
LIG_LIR_Nem_3	205	210	PF02991	0.344
LIG_LIR_Nem_3	224	229	PF02991	0.315
LIG_LIR_Nem_3	261	265	PF02991	0.318
LIG_LIR_Nem_3	377	383	PF02991	0.234
LIG_LIR_Nem_3	420	425	PF02991	0.270
LIG_LIR_Nem_3	431	437	PF02991	0.207
LIG_LIR_Nem_3	483	488	PF02991	0.253
LIG_NRBOX	299	305	PF00104	0.197
LIG_PCNA_yPIPBox_3	108	121	PF02747	0.258
LIG_Pex14_2	272	276	PF04695	0.241
LIG_Pex14_2	484	488	PF04695	0.219
LIG_SH2_CRK	226	230	PF00017	0.327
LIG_SH2_CRK	262	266	PF00017	0.309
LIG_SH2_CRK	383	387	PF00017	0.198
LIG_SH2_GRB2like	383	386	PF00017	0.198
LIG_SH2_NCK_1	383	387	PF00017	0.232
LIG_SH2_NCK_1	406	410	PF00017	0.243
LIG_SH2_PTP2	27	30	PF00017	0.268
LIG_SH2_SRC	383	386	PF00017	0.232
LIG_SH2_STAP1	262	266	PF00017	0.309
LIG_SH2_STAP1	292	296	PF00017	0.232
LIG_SH2_STAP1	305	309	PF00017	0.232
LIG_SH2_STAT3	89	92	PF00017	0.261
LIG_SH2_STAT5	16	19	PF00017	0.349
LIG_SH2_STAT5	27	30	PF00017	0.349
LIG_SH2_STAT5	305	308	PF00017	0.243
LIG_SH2_STAT5	396	399	PF00017	0.232
LIG_SH2_STAT5	406	409	PF00017	0.232
LIG_SH2_STAT5	422	425	PF00017	0.232
LIG_SH2_STAT5	89	92	PF00017	0.295
LIG_SH3_3	184	190	PF00018	0.369
LIG_SH3_3	328	334	PF00018	0.232
LIG_SH3_3	352	358	PF00018	0.243
LIG_SH3_3	519	525	PF00018	0.321
LIG_SH3_3	63	69	PF00018	0.383
LIG_SH3_3	70	76	PF00018	0.383
LIG_SH3_CIN85_PxpxPR_1	330	335	PF14604	0.243
LIG_Sin3_3	325	332	PF02671	0.243
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.276
LIG_TYR_ITIM	25	30	PF00017	0.241
LIG_WRC_WIRS_1	430	435	PF05994	0.232
LIG_WRC_WIRS_1	481	486	PF05994	0.221
LIG_WW_1	247	250	PF00397	0.380
MOD_CDK_SPK_2	330	335	PF00069	0.232
MOD_CDK_SPxxK_3	122	129	PF00069	0.333
MOD_CK1_1	140	146	PF00069	0.366
MOD_CK1_1	147	153	PF00069	0.313
MOD_CK1_1	208	214	PF00069	0.424
MOD_CK1_1	417	423	PF00069	0.230
MOD_CK1_1	499	505	PF00069	0.357
MOD_CK1_1	515	521	PF00069	0.314
MOD_CK1_1	56	62	PF00069	0.354
MOD_CK2_1	320	326	PF00069	0.306
MOD_CK2_1	429	435	PF00069	0.232
MOD_CK2_1	48	54	PF00069	0.405
MOD_GlcNHglycan	159	162	PF01048	0.579
MOD_GlcNHglycan	199	202	PF01048	0.556
MOD_GlcNHglycan	392	395	PF01048	0.451
MOD_GlcNHglycan	399	402	PF01048	0.417
MOD_GlcNHglycan	469	472	PF01048	0.536
MOD_GlcNHglycan	527	530	PF01048	0.558
MOD_GlcNHglycan	58	61	PF01048	0.582
MOD_GSK3_1	115	122	PF00069	0.316
MOD_GSK3_1	140	147	PF00069	0.378
MOD_GSK3_1	186	193	PF00069	0.402
MOD_GSK3_1	303	310	PF00069	0.232
MOD_GSK3_1	316	323	PF00069	0.232
MOD_GSK3_1	357	364	PF00069	0.232
MOD_GSK3_1	414	421	PF00069	0.233
MOD_GSK3_1	45	52	PF00069	0.418
MOD_GSK3_1	463	470	PF00069	0.354
MOD_GSK3_1	508	515	PF00069	0.292
MOD_GSK3_1	88	95	PF00069	0.442
MOD_N-GLC_1	230	235	PF02516	0.579
MOD_N-GLC_1	316	321	PF02516	0.432
MOD_NEK2_1	115	120	PF00069	0.280
MOD_NEK2_1	139	144	PF00069	0.347
MOD_NEK2_1	249	254	PF00069	0.556
MOD_NEK2_1	303	308	PF00069	0.232
MOD_NEK2_1	320	325	PF00069	0.232
MOD_NEK2_1	375	380	PF00069	0.232
MOD_NEK2_1	418	423	PF00069	0.270
MOD_NEK2_1	429	434	PF00069	0.207
MOD_NEK2_1	436	441	PF00069	0.192
MOD_NEK2_1	508	513	PF00069	0.294
MOD_NEK2_2	414	419	PF00069	0.224
MOD_PIKK_1	230	236	PF00454	0.335
MOD_PIKK_1	88	94	PF00454	0.274
MOD_PKA_2	208	214	PF00069	0.349
MOD_PKA_2	356	362	PF00069	0.243
MOD_PKA_2	418	424	PF00069	0.223
MOD_PKA_2	463	469	PF00069	0.357
MOD_PKA_2	496	502	PF00069	0.363
MOD_PKA_2	56	62	PF00069	0.353
MOD_PKB_1	43	51	PF00069	0.355
MOD_Plk_1	194	200	PF00069	0.357
MOD_Plk_1	316	322	PF00069	0.232
MOD_Plk_1	53	59	PF00069	0.365
MOD_Plk_4	147	153	PF00069	0.295
MOD_Plk_4	232	238	PF00069	0.382
MOD_Plk_4	295	301	PF00069	0.232
MOD_Plk_4	429	435	PF00069	0.232
MOD_Plk_4	469	475	PF00069	0.275
MOD_Plk_4	509	515	PF00069	0.318
MOD_ProDKin_1	122	128	PF00069	0.482
MOD_ProDKin_1	186	192	PF00069	0.371
MOD_ProDKin_1	215	221	PF00069	0.348
MOD_ProDKin_1	330	336	PF00069	0.232
MOD_ProDKin_1	512	518	PF00069	0.309
TRG_ENDOCYTIC_2	16	19	PF00928	0.251
TRG_ENDOCYTIC_2	226	229	PF00928	0.321
TRG_ENDOCYTIC_2	262	265	PF00928	0.315
TRG_ENDOCYTIC_2	27	30	PF00928	0.251
TRG_ENDOCYTIC_2	422	425	PF00928	0.243
TRG_ER_diArg_1	3	5	PF00400	0.581
TRG_ER_diArg_1	474	476	PF00400	0.301
TRG_ER_diArg_1	496	498	PF00400	0.334
TRG_NES_CRM1_1	442	456	PF08389	0.232
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A3	Leptomonas seymouri	51%	96%
A0A3Q8I8J9	Leishmania donovani	74%	81%
A4HU62	Leishmania infantum	75%	99%
E9AMZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4QHN5	Leishmania major	76%	100%