F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5W6_LEIBR

TriTrypDb:

LbrM.09.1450 , LBRM2903_090021100

Length:

661

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H5W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5W6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.691
CLV_NRD_NRD_1	126	128	PF00675	0.521
CLV_NRD_NRD_1	195	197	PF00675	0.402
CLV_NRD_NRD_1	206	208	PF00675	0.397
CLV_NRD_NRD_1	488	490	PF00675	0.620
CLV_NRD_NRD_1	504	506	PF00675	0.493
CLV_PCSK_KEX2_1	126	128	PF00082	0.398
CLV_PCSK_KEX2_1	206	208	PF00082	0.458
CLV_PCSK_KEX2_1	348	350	PF00082	0.538
CLV_PCSK_KEX2_1	488	490	PF00082	0.582
CLV_PCSK_KEX2_1	5	7	PF00082	0.477
CLV_PCSK_KEX2_1	504	506	PF00082	0.493
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.633
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.475
CLV_PCSK_PC7_1	484	490	PF00082	0.438
CLV_PCSK_SKI1_1	206	210	PF00082	0.388
CLV_PCSK_SKI1_1	213	217	PF00082	0.425
CLV_PCSK_SKI1_1	271	275	PF00082	0.641
CLV_PCSK_SKI1_1	348	352	PF00082	0.607
CLV_PCSK_SKI1_1	35	39	PF00082	0.422
CLV_PCSK_SKI1_1	388	392	PF00082	0.500
CLV_PCSK_SKI1_1	397	401	PF00082	0.531
CLV_PCSK_SKI1_1	41	45	PF00082	0.453
CLV_PCSK_SKI1_1	505	509	PF00082	0.662
DEG_SCF_FBW7_1	42	48	PF00400	0.710
DEG_SPOP_SBC_1	78	82	PF00917	0.666
DOC_CKS1_1	398	403	PF01111	0.263
DOC_CKS1_1	42	47	PF01111	0.688
DOC_CKS1_1	549	554	PF01111	0.255
DOC_CYCLIN_yCln2_LP_2	47	53	PF00134	0.574
DOC_MAPK_MEF2A_6	275	282	PF00069	0.390
DOC_MAPK_MEF2A_6	349	358	PF00069	0.252
DOC_MAPK_MEF2A_6	593	602	PF00069	0.563
DOC_PP1_RVXF_1	239	246	PF00149	0.557
DOC_PP1_RVXF_1	316	323	PF00149	0.436
DOC_PP2B_LxvP_1	47	50	PF13499	0.573
DOC_USP7_MATH_1	273	277	PF00917	0.387
DOC_USP7_MATH_1	304	308	PF00917	0.646
DOC_USP7_MATH_1	344	348	PF00917	0.441
DOC_USP7_MATH_1	366	370	PF00917	0.478
DOC_USP7_UBL2_3	193	197	PF12436	0.587
DOC_WW_Pin1_4	298	303	PF00397	0.221
DOC_WW_Pin1_4	397	402	PF00397	0.398
DOC_WW_Pin1_4	41	46	PF00397	0.700
DOC_WW_Pin1_4	411	416	PF00397	0.384
DOC_WW_Pin1_4	548	553	PF00397	0.330
DOC_WW_Pin1_4	63	68	PF00397	0.762
LIG_14-3-3_CanoR_1	388	393	PF00244	0.316
LIG_14-3-3_CanoR_1	504	510	PF00244	0.396
LIG_14-3-3_CanoR_1	557	561	PF00244	0.405
LIG_14-3-3_CanoR_1	6	11	PF00244	0.635
LIG_Actin_WH2_2	9	25	PF00022	0.565
LIG_AP2alpha_2	453	455	PF02296	0.439
LIG_APCC_ABBA_1	155	160	PF00400	0.642
LIG_APCC_ABBA_1	419	424	PF00400	0.271
LIG_BRCT_BRCA1_1	428	432	PF00533	0.330
LIG_BRCT_BRCA1_1	91	95	PF00533	0.640
LIG_Clathr_ClatBox_1	156	160	PF01394	0.663
LIG_Clathr_ClatBox_1	420	424	PF01394	0.329
LIG_deltaCOP1_diTrp_1	533	542	PF00928	0.357
LIG_eIF4E_1	204	210	PF01652	0.507
LIG_FHA_1	210	216	PF00498	0.682
LIG_FHA_1	281	287	PF00498	0.307
LIG_FHA_1	289	295	PF00498	0.288
LIG_FHA_1	314	320	PF00498	0.546
LIG_FHA_1	32	38	PF00498	0.627
LIG_FHA_1	42	48	PF00498	0.743
LIG_FHA_1	5	11	PF00498	0.665
LIG_FHA_1	576	582	PF00498	0.275
LIG_FHA_1	613	619	PF00498	0.284
LIG_FHA_1	647	653	PF00498	0.314
LIG_FHA_1	80	86	PF00498	0.648
LIG_FHA_2	110	116	PF00498	0.647
LIG_FHA_2	214	220	PF00498	0.572
LIG_FHA_2	290	296	PF00498	0.459
LIG_FHA_2	389	395	PF00498	0.332
LIG_FHA_2	549	555	PF00498	0.331
LIG_FHA_2	63	69	PF00498	0.659
LIG_IRF3_LxIS_1	294	301	PF10401	0.196
LIG_LIR_Apic_2	496	502	PF02991	0.335
LIG_LIR_Gen_1	283	293	PF02991	0.293
LIG_LIR_Gen_1	374	382	PF02991	0.282
LIG_LIR_Gen_1	400	408	PF02991	0.339
LIG_LIR_Gen_1	508	514	PF02991	0.411
LIG_LIR_Gen_1	533	541	PF02991	0.363
LIG_LIR_Gen_1	649	657	PF02991	0.404
LIG_LIR_Nem_3	283	288	PF02991	0.397
LIG_LIR_Nem_3	374	378	PF02991	0.284
LIG_LIR_Nem_3	384	390	PF02991	0.291
LIG_LIR_Nem_3	450	455	PF02991	0.448
LIG_LIR_Nem_3	508	512	PF02991	0.402
LIG_LIR_Nem_3	533	539	PF02991	0.365
LIG_LIR_Nem_3	545	549	PF02991	0.324
LIG_LIR_Nem_3	565	570	PF02991	0.303
LIG_LIR_Nem_3	649	653	PF02991	0.404
LIG_MYND_1	45	49	PF01753	0.656
LIG_NRBOX	647	653	PF00104	0.196
LIG_PCNA_yPIPBox_3	275	286	PF02747	0.334
LIG_Pex14_1	542	546	PF04695	0.360
LIG_REV1ctd_RIR_1	1	10	PF16727	0.705
LIG_SH2_CRK	180	184	PF00017	0.637
LIG_SH2_CRK	482	486	PF00017	0.373
LIG_SH2_CRK	536	540	PF00017	0.429
LIG_SH2_CRK	570	574	PF00017	0.335
LIG_SH2_GRB2like	180	183	PF00017	0.594
LIG_SH2_NCK_1	536	540	PF00017	0.420
LIG_SH2_PTP2	546	549	PF00017	0.321
LIG_SH2_PTP2	656	659	PF00017	0.289
LIG_SH2_SRC	158	161	PF00017	0.585
LIG_SH2_SRC	448	451	PF00017	0.313
LIG_SH2_STAP1	180	184	PF00017	0.621
LIG_SH2_STAP1	427	431	PF00017	0.383
LIG_SH2_STAP1	448	452	PF00017	0.448
LIG_SH2_STAP1	536	540	PF00017	0.332
LIG_SH2_STAP1	564	568	PF00017	0.308
LIG_SH2_STAT3	367	370	PF00017	0.318
LIG_SH2_STAT5	158	161	PF00017	0.572
LIG_SH2_STAT5	189	192	PF00017	0.655
LIG_SH2_STAT5	204	207	PF00017	0.499
LIG_SH2_STAT5	220	223	PF00017	0.586
LIG_SH2_STAT5	265	268	PF00017	0.383
LIG_SH2_STAT5	402	405	PF00017	0.356
LIG_SH2_STAT5	422	425	PF00017	0.205
LIG_SH2_STAT5	536	539	PF00017	0.415
LIG_SH2_STAT5	546	549	PF00017	0.319
LIG_SH2_STAT5	630	633	PF00017	0.342
LIG_SH2_STAT5	656	659	PF00017	0.314
LIG_SH3_3	296	302	PF00018	0.289
LIG_SH3_3	373	379	PF00018	0.376
LIG_SH3_3	39	45	PF00018	0.729
LIG_SUMO_SIM_anti_2	283	292	PF11976	0.365
LIG_SUMO_SIM_anti_2	295	301	PF11976	0.252
LIG_SUMO_SIM_par_1	283	292	PF11976	0.308
LIG_SUMO_SIM_par_1	295	301	PF11976	0.265
LIG_SUMO_SIM_par_1	388	396	PF11976	0.364
LIG_SUMO_SIM_par_1	473	478	PF11976	0.288
LIG_SUMO_SIM_par_1	6	12	PF11976	0.634
LIG_TRFH_1	375	379	PF08558	0.309
LIG_TYR_ITIM	15	20	PF00017	0.670
LIG_TYR_ITIM	534	539	PF00017	0.458
LIG_TYR_ITIM	568	573	PF00017	0.404
LIG_UBA3_1	586	593	PF00899	0.459
LIG_WRC_WIRS_1	282	287	PF05994	0.336
LIG_WRC_WIRS_1	372	377	PF05994	0.335
MOD_CK1_1	109	115	PF00069	0.618
MOD_CK1_1	61	67	PF00069	0.709
MOD_CK1_1	9	15	PF00069	0.641
MOD_CK2_1	133	139	PF00069	0.599
MOD_CK2_1	289	295	PF00069	0.361
MOD_CK2_1	388	394	PF00069	0.390
MOD_CK2_1	548	554	PF00069	0.321
MOD_CK2_1	655	661	PF00069	0.336
MOD_Cter_Amidation	124	127	PF01082	0.385
MOD_DYRK1A_RPxSP_1	41	45	PF00069	0.661
MOD_GlcNHglycan	101	104	PF01048	0.381
MOD_GlcNHglycan	147	150	PF01048	0.434
MOD_GlcNHglycan	308	311	PF01048	0.349
MOD_GlcNHglycan	336	339	PF01048	0.327
MOD_GlcNHglycan	360	363	PF01048	0.643
MOD_GlcNHglycan	406	409	PF01048	0.567
MOD_GlcNHglycan	428	431	PF01048	0.562
MOD_GlcNHglycan	435	438	PF01048	0.517
MOD_GlcNHglycan	468	471	PF01048	0.652
MOD_GlcNHglycan	618	621	PF01048	0.316
MOD_GlcNHglycan	90	94	PF01048	0.450
MOD_GSK3_1	141	148	PF00069	0.679
MOD_GSK3_1	209	216	PF00069	0.677
MOD_GSK3_1	269	276	PF00069	0.395
MOD_GSK3_1	294	301	PF00069	0.414
MOD_GSK3_1	304	311	PF00069	0.668
MOD_GSK3_1	328	335	PF00069	0.233
MOD_GSK3_1	352	359	PF00069	0.412
MOD_GSK3_1	388	395	PF00069	0.340
MOD_GSK3_1	41	48	PF00069	0.684
MOD_GSK3_1	510	517	PF00069	0.307
MOD_GSK3_1	58	65	PF00069	0.597
MOD_GSK3_1	612	619	PF00069	0.394
MOD_GSK3_1	66	73	PF00069	0.664
MOD_GSK3_1	89	96	PF00069	0.645
MOD_LATS_1	87	93	PF00433	0.711
MOD_N-GLC_1	425	430	PF02516	0.558
MOD_N-GLC_1	433	438	PF02516	0.513
MOD_N-GLC_1	466	471	PF02516	0.641
MOD_NEK2_1	209	214	PF00069	0.717
MOD_NEK2_1	22	27	PF00069	0.618
MOD_NEK2_1	236	241	PF00069	0.513
MOD_NEK2_1	269	274	PF00069	0.384
MOD_NEK2_1	280	285	PF00069	0.261
MOD_NEK2_1	287	292	PF00069	0.193
MOD_NEK2_1	294	299	PF00069	0.224
MOD_NEK2_1	327	332	PF00069	0.246
MOD_NEK2_1	339	344	PF00069	0.384
MOD_NEK2_1	358	363	PF00069	0.386
MOD_NEK2_1	4	9	PF00069	0.703
MOD_NEK2_1	60	65	PF00069	0.760
MOD_NEK2_1	616	621	PF00069	0.370
MOD_NEK2_1	95	100	PF00069	0.638
MOD_PIKK_1	366	372	PF00454	0.308
MOD_PIKK_1	475	481	PF00454	0.340
MOD_PKA_2	22	28	PF00069	0.619
MOD_PKA_2	514	520	PF00069	0.368
MOD_PKA_2	556	562	PF00069	0.342
MOD_PKB_1	386	394	PF00069	0.305
MOD_Plk_1	294	300	PF00069	0.322
MOD_Plk_1	356	362	PF00069	0.390
MOD_Plk_1	433	439	PF00069	0.328
MOD_Plk_1	93	99	PF00069	0.668
MOD_Plk_2-3	352	358	PF00069	0.402
MOD_Plk_4	281	287	PF00069	0.345
MOD_Plk_4	289	295	PF00069	0.309
MOD_Plk_4	328	334	PF00069	0.348
MOD_Plk_4	371	377	PF00069	0.413
MOD_Plk_4	594	600	PF00069	0.606
MOD_Plk_4	612	618	PF00069	0.376
MOD_Plk_4	626	632	PF00069	0.366
MOD_Plk_4	646	652	PF00069	0.341
MOD_ProDKin_1	298	304	PF00069	0.221
MOD_ProDKin_1	397	403	PF00069	0.402
MOD_ProDKin_1	41	47	PF00069	0.700
MOD_ProDKin_1	411	417	PF00069	0.351
MOD_ProDKin_1	548	554	PF00069	0.335
MOD_ProDKin_1	63	69	PF00069	0.761
MOD_SUMO_for_1	225	228	PF00179	0.645
TRG_ENDOCYTIC_2	17	20	PF00928	0.675
TRG_ENDOCYTIC_2	180	183	PF00928	0.611
TRG_ENDOCYTIC_2	402	405	PF00928	0.329
TRG_ENDOCYTIC_2	482	485	PF00928	0.292
TRG_ENDOCYTIC_2	536	539	PF00928	0.415
TRG_ENDOCYTIC_2	546	549	PF00928	0.323
TRG_ENDOCYTIC_2	564	567	PF00928	0.334
TRG_ENDOCYTIC_2	570	573	PF00928	0.313
TRG_ENDOCYTIC_2	656	659	PF00928	0.190
TRG_ER_diArg_1	117	120	PF00400	0.657
TRG_ER_diArg_1	205	207	PF00400	0.591
TRG_ER_diArg_1	504	506	PF00400	0.312
TRG_NES_CRM1_1	150	160	PF08389	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M8	Leptomonas seymouri	64%	100%
A0A1X0NIN6	Trypanosomatidae	43%	100%
A0A3Q8I8N7	Leishmania donovani	80%	100%
A0A3R7N0K0	Trypanosoma rangeli	45%	100%
A4HU61	Leishmania infantum	80%	100%
D0A9P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AMZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QHN6	Leishmania major	81%	100%
V5BI21	Trypanosoma cruzi	44%	92%