Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5W5_LEIBR

TriTrypDb:

LbrM.09.1430 , LBRM2903_090021000

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.550
CLV_NRD_NRD_1	28	30	PF00675	0.655
CLV_NRD_NRD_1	381	383	PF00675	0.568
CLV_NRD_NRD_1	442	444	PF00675	0.547
CLV_PCSK_KEX2_1	110	112	PF00082	0.473
CLV_PCSK_KEX2_1	28	30	PF00082	0.657
CLV_PCSK_KEX2_1	381	383	PF00082	0.512
CLV_PCSK_SKI1_1	110	114	PF00082	0.473
CLV_PCSK_SKI1_1	322	326	PF00082	0.541
CLV_PCSK_SKI1_1	351	355	PF00082	0.475
CLV_PCSK_SKI1_1	428	432	PF00082	0.633
CLV_PCSK_SKI1_1	462	466	PF00082	0.472
CLV_PCSK_SKI1_1	545	549	PF00082	0.517
CLV_PCSK_SKI1_1	74	78	PF00082	0.462
DEG_APCC_DBOX_1	321	329	PF00400	0.534
DEG_APCC_DBOX_1	350	358	PF00400	0.499
DEG_Nend_Nbox_1	1	3	PF02207	0.554
DEG_SCF_FBW7_1	518	525	PF00400	0.587
DEG_SPOP_SBC_1	370	374	PF00917	0.506
DEG_SPOP_SBC_1	435	439	PF00917	0.466
DEG_SPOP_SBC_1	44	48	PF00917	0.655
DOC_CYCLIN_RxL_1	422	434	PF00134	0.611
DOC_CYCLIN_RxL_1	459	468	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	257	263	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.315
DOC_MAPK_DCC_7	251	261	PF00069	0.518
DOC_MAPK_HePTP_8	348	360	PF00069	0.502
DOC_MAPK_MEF2A_6	351	360	PF00069	0.501
DOC_MAPK_NFAT4_5	351	359	PF00069	0.543
DOC_PP2B_LxvP_1	257	260	PF13499	0.618
DOC_PP2B_LxvP_1	302	305	PF13499	0.579
DOC_PP4_FxxP_1	274	277	PF00568	0.361
DOC_PP4_FxxP_1	324	327	PF00568	0.572
DOC_USP7_MATH_1	166	170	PF00917	0.721
DOC_USP7_MATH_1	284	288	PF00917	0.719
DOC_USP7_MATH_1	363	367	PF00917	0.577
DOC_USP7_MATH_1	435	439	PF00917	0.553
DOC_USP7_MATH_1	45	49	PF00917	0.743
DOC_USP7_MATH_1	50	54	PF00917	0.714
DOC_USP7_MATH_1	61	65	PF00917	0.575
DOC_WW_Pin1_4	101	106	PF00397	0.690
DOC_WW_Pin1_4	431	436	PF00397	0.611
DOC_WW_Pin1_4	518	523	PF00397	0.593
LIG_14-3-3_CanoR_1	209	218	PF00244	0.587
LIG_14-3-3_CanoR_1	355	361	PF00244	0.478
LIG_14-3-3_CanoR_1	381	389	PF00244	0.521
LIG_14-3-3_CanoR_1	568	573	PF00244	0.494
LIG_14-3-3_CanoR_1	74	80	PF00244	0.607
LIG_Actin_WH2_2	113	130	PF00022	0.545
LIG_APCC_ABBA_1	547	552	PF00400	0.399
LIG_BRCT_BRCA1_1	320	324	PF00533	0.576
LIG_BRCT_BRCA1_1	410	414	PF00533	0.525
LIG_BRCT_BRCA1_1	65	69	PF00533	0.579
LIG_CaM_NSCaTE_8	452	459	PF13499	0.549
LIG_Clathr_ClatBox_1	394	398	PF01394	0.396
LIG_Clathr_ClatBox_1	464	468	PF01394	0.410
LIG_EH1_1	423	431	PF00400	0.599
LIG_EVH1_2	276	280	PF00568	0.405
LIG_FHA_1	122	128	PF00498	0.555
LIG_FHA_1	13	19	PF00498	0.601
LIG_FHA_1	139	145	PF00498	0.697
LIG_FHA_1	189	195	PF00498	0.485
LIG_FHA_1	260	266	PF00498	0.578
LIG_FHA_1	390	396	PF00498	0.379
LIG_FHA_2	328	334	PF00498	0.514
LIG_FHA_2	339	345	PF00498	0.568
LIG_FHA_2	507	513	PF00498	0.543
LIG_LIR_Apic_2	271	277	PF02991	0.490
LIG_LIR_Apic_2	321	327	PF02991	0.580
LIG_LIR_Apic_2	391	396	PF02991	0.496
LIG_LIR_Gen_1	116	123	PF02991	0.594
LIG_LIR_Gen_1	193	204	PF02991	0.547
LIG_LIR_Gen_1	490	495	PF02991	0.582
LIG_LIR_Nem_3	116	120	PF02991	0.545
LIG_LIR_Nem_3	193	199	PF02991	0.551
LIG_LIR_Nem_3	449	455	PF02991	0.490
LIG_LIR_Nem_3	458	464	PF02991	0.346
LIG_LIR_Nem_3	573	579	PF02991	0.491
LIG_LIR_Nem_3	80	85	PF02991	0.554
LIG_NRBOX	245	251	PF00104	0.497
LIG_PAM2_1	314	326	PF00658	0.344
LIG_PCNA_yPIPBox_3	240	250	PF02747	0.599
LIG_SH2_CRK	461	465	PF00017	0.428
LIG_SH2_NCK_1	340	344	PF00017	0.607
LIG_SH2_SRC	85	88	PF00017	0.698
LIG_SH2_STAP1	457	461	PF00017	0.551
LIG_SH2_STAP1	491	495	PF00017	0.576
LIG_SH2_STAT3	362	365	PF00017	0.559
LIG_SH2_STAT3	457	460	PF00017	0.545
LIG_SH2_STAT5	310	313	PF00017	0.454
LIG_SH2_STAT5	340	343	PF00017	0.443
LIG_SH2_STAT5	550	553	PF00017	0.426
LIG_SH2_STAT5	85	88	PF00017	0.698
LIG_SH3_3	55	61	PF00018	0.554
LIG_SUMO_SIM_anti_2	503	509	PF11976	0.580
LIG_SUMO_SIM_par_1	462	468	PF11976	0.460
LIG_TRAF2_1	571	574	PF00917	0.499
LIG_TYR_ITIM	307	312	PF00017	0.517
LIG_UBA3_1	463	469	PF00899	0.509
LIG_UBA3_1	506	514	PF00899	0.544
MOD_CDK_SPxK_1	518	524	PF00069	0.594
MOD_CK1_1	138	144	PF00069	0.659
MOD_CK1_1	233	239	PF00069	0.688
MOD_CK1_1	372	378	PF00069	0.676
MOD_CK1_1	434	440	PF00069	0.697
MOD_CK1_1	48	54	PF00069	0.687
MOD_CK1_1	482	488	PF00069	0.581
MOD_CK1_1	64	70	PF00069	0.588
MOD_CK1_1	75	81	PF00069	0.678
MOD_CK2_1	144	150	PF00069	0.630
MOD_CK2_1	221	227	PF00069	0.518
MOD_CK2_1	327	333	PF00069	0.450
MOD_CK2_1	506	512	PF00069	0.536
MOD_CK2_1	568	574	PF00069	0.500
MOD_CK2_1	75	81	PF00069	0.618
MOD_GlcNHglycan	146	149	PF01048	0.605
MOD_GlcNHglycan	169	172	PF01048	0.701
MOD_GlcNHglycan	185	188	PF01048	0.489
MOD_GlcNHglycan	196	199	PF01048	0.446
MOD_GlcNHglycan	287	290	PF01048	0.698
MOD_GlcNHglycan	297	300	PF01048	0.516
MOD_GlcNHglycan	341	344	PF01048	0.524
MOD_GlcNHglycan	410	413	PF01048	0.437
MOD_GlcNHglycan	451	455	PF01048	0.475
MOD_GlcNHglycan	457	460	PF01048	0.470
MOD_GlcNHglycan	47	50	PF01048	0.713
MOD_GlcNHglycan	484	487	PF01048	0.596
MOD_GlcNHglycan	63	66	PF01048	0.529
MOD_GSK3_1	10	17	PF00069	0.603
MOD_GSK3_1	134	141	PF00069	0.642
MOD_GSK3_1	162	169	PF00069	0.736
MOD_GSK3_1	179	186	PF00069	0.683
MOD_GSK3_1	190	197	PF00069	0.600
MOD_GSK3_1	314	321	PF00069	0.600
MOD_GSK3_1	368	375	PF00069	0.699
MOD_GSK3_1	397	404	PF00069	0.510
MOD_GSK3_1	430	437	PF00069	0.589
MOD_GSK3_1	44	51	PF00069	0.737
MOD_GSK3_1	446	453	PF00069	0.513
MOD_GSK3_1	478	485	PF00069	0.597
MOD_GSK3_1	502	509	PF00069	0.461
MOD_GSK3_1	518	525	PF00069	0.433
MOD_GSK3_1	61	68	PF00069	0.578
MOD_GSK3_1	77	84	PF00069	0.600
MOD_N-GLC_1	2	7	PF02516	0.678
MOD_N-GLC_1	284	289	PF02516	0.473
MOD_N-GLC_1	478	483	PF02516	0.613
MOD_NEK2_1	10	15	PF00069	0.521
MOD_NEK2_1	119	124	PF00069	0.591
MOD_NEK2_1	144	149	PF00069	0.692
MOD_NEK2_1	18	23	PF00069	0.467
MOD_NEK2_1	190	195	PF00069	0.536
MOD_NEK2_1	2	7	PF00069	0.647
MOD_NEK2_1	356	361	PF00069	0.501
MOD_NEK2_1	389	394	PF00069	0.494
MOD_NEK2_1	397	402	PF00069	0.494
MOD_NEK2_1	429	434	PF00069	0.613
MOD_NEK2_1	506	511	PF00069	0.479
MOD_NEK2_1	539	544	PF00069	0.692
MOD_NEK2_1	69	74	PF00069	0.608
MOD_PIKK_1	18	24	PF00454	0.569
MOD_PIKK_1	2	8	PF00454	0.608
MOD_PK_1	568	574	PF00069	0.490
MOD_PKA_1	28	34	PF00069	0.573
MOD_PKA_2	183	189	PF00069	0.639
MOD_PKA_2	27	33	PF00069	0.664
MOD_Plk_1	2	8	PF00069	0.602
MOD_Plk_1	397	403	PF00069	0.539
MOD_Plk_2-3	81	87	PF00069	0.664
MOD_Plk_4	190	196	PF00069	0.561
MOD_Plk_4	230	236	PF00069	0.713
MOD_Plk_4	245	251	PF00069	0.334
MOD_Plk_4	356	362	PF00069	0.477
MOD_Plk_4	389	395	PF00069	0.288
MOD_Plk_4	490	496	PF00069	0.518
MOD_Plk_4	502	508	PF00069	0.527
MOD_Plk_4	65	71	PF00069	0.506
MOD_ProDKin_1	101	107	PF00069	0.681
MOD_ProDKin_1	431	437	PF00069	0.618
MOD_ProDKin_1	518	524	PF00069	0.594
TRG_DiLeu_BaEn_1	512	517	PF01217	0.480
TRG_DiLeu_BaLyEn_6	425	430	PF01217	0.564
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.493
TRG_ENDOCYTIC_2	309	312	PF00928	0.545
TRG_ENDOCYTIC_2	461	464	PF00928	0.426
TRG_ENDOCYTIC_2	491	494	PF00928	0.478
TRG_ER_diArg_1	381	384	PF00400	0.570
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2L4	Leptomonas seymouri	54%	96%
A0A3Q8I8N5	Leishmania donovani	81%	100%
A0A3R7NSE1	Trypanosoma rangeli	29%	100%
A4HU60	Leishmania infantum	81%	100%
D0A9P2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AMZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QHN7	Leishmania major	82%	100%
V5BMK0	Trypanosoma cruzi	28%	100%