Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5W4_LEIBR

TriTrypDb:

LbrM.09.1420 , LBRM2903_090020900

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.818
CLV_NRD_NRD_1	248	250	PF00675	0.838
CLV_NRD_NRD_1	263	265	PF00675	0.559
CLV_PCSK_KEX2_1	229	231	PF00082	0.761
CLV_PCSK_KEX2_1	248	250	PF00082	0.736
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.681
CLV_PCSK_PC7_1	225	231	PF00082	0.671
CLV_PCSK_SKI1_1	77	81	PF00082	0.371
DEG_APCC_DBOX_1	214	222	PF00400	0.672
DEG_SCF_FBW7_2	24	30	PF00400	0.540
DOC_CKS1_1	24	29	PF01111	0.542
DOC_PP2B_LxvP_1	244	247	PF13499	0.567
DOC_PP2B_LxvP_1	39	42	PF13499	0.773
DOC_USP7_MATH_1	126	130	PF00917	0.625
DOC_USP7_MATH_1	176	180	PF00917	0.650
DOC_USP7_MATH_1	40	44	PF00917	0.517
DOC_USP7_MATH_1	62	66	PF00917	0.680
DOC_WW_Pin1_4	11	16	PF00397	0.753
DOC_WW_Pin1_4	192	197	PF00397	0.664
DOC_WW_Pin1_4	23	28	PF00397	0.548
DOC_WW_Pin1_4	239	244	PF00397	0.668
DOC_WW_Pin1_4	253	258	PF00397	0.664
DOC_WW_Pin1_4	60	65	PF00397	0.525
LIG_14-3-3_CanoR_1	177	181	PF00244	0.613
LIG_14-3-3_CanoR_1	215	219	PF00244	0.754
LIG_14-3-3_CanoR_1	230	235	PF00244	0.578
LIG_14-3-3_CanoR_1	248	257	PF00244	0.723
LIG_Actin_WH2_2	217	234	PF00022	0.674
LIG_Clathr_ClatBox_1	112	116	PF01394	0.625
LIG_FHA_1	181	187	PF00498	0.769
LIG_FHA_1	27	33	PF00498	0.581
LIG_GBD_Chelix_1	72	80	PF00786	0.388
LIG_LIR_Apic_2	191	196	PF02991	0.791
LIG_SH2_CRK	193	197	PF00017	0.784
LIG_SH2_STAT3	146	149	PF00017	0.369
LIG_SH2_STAT5	146	149	PF00017	0.369
LIG_SH3_2	243	248	PF14604	0.569
LIG_SH3_2	8	13	PF14604	0.556
LIG_SH3_3	1	7	PF00018	0.690
LIG_SH3_3	240	246	PF00018	0.570
LIG_SH3_3	31	37	PF00018	0.700
LIG_SH3_3	56	62	PF00018	0.549
LIG_SUMO_SIM_par_1	111	118	PF11976	0.626
LIG_TRAF2_1	114	117	PF00917	0.626
LIG_TRAF2_1	217	220	PF00917	0.665
LIG_WW_3	245	249	PF00397	0.575
MOD_CDK_SPxxK_3	192	199	PF00069	0.686
MOD_CK1_1	179	185	PF00069	0.609
MOD_CK1_1	195	201	PF00069	0.535
MOD_CK1_1	233	239	PF00069	0.710
MOD_CK1_1	253	259	PF00069	0.485
MOD_CK2_1	214	220	PF00069	0.672
MOD_GlcNHglycan	116	120	PF01048	0.624
MOD_GlcNHglycan	64	67	PF01048	0.643
MOD_GSK3_1	175	182	PF00069	0.618
MOD_GSK3_1	210	217	PF00069	0.703
MOD_GSK3_1	230	237	PF00069	0.468
MOD_GSK3_1	249	256	PF00069	0.723
MOD_NEK2_1	115	120	PF00069	0.494
MOD_NEK2_1	175	180	PF00069	0.456
MOD_PIKK_1	105	111	PF00454	0.523
MOD_PIKK_1	176	182	PF00454	0.604
MOD_PIKK_1	210	216	PF00454	0.783
MOD_PIKK_1	250	256	PF00454	0.822
MOD_PIKK_1	41	47	PF00454	0.629
MOD_PIKK_1	48	54	PF00454	0.752
MOD_PK_1	230	236	PF00069	0.696
MOD_PKA_1	248	254	PF00069	0.829
MOD_PKA_2	176	182	PF00069	0.688
MOD_PKA_2	201	207	PF00069	0.709
MOD_PKA_2	214	220	PF00069	0.672
MOD_PKA_2	224	230	PF00069	0.668
MOD_PKA_2	247	253	PF00069	0.730
MOD_PKA_2	98	104	PF00069	0.422
MOD_Plk_4	71	77	PF00069	0.398
MOD_ProDKin_1	11	17	PF00069	0.753
MOD_ProDKin_1	192	198	PF00069	0.665
MOD_ProDKin_1	23	29	PF00069	0.549
MOD_ProDKin_1	239	245	PF00069	0.727
MOD_ProDKin_1	253	259	PF00069	0.727
MOD_ProDKin_1	60	66	PF00069	0.523
MOD_SUMO_rev_2	117	126	PF00179	0.377
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.744
TRG_ER_diArg_1	247	249	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A2	Leptomonas seymouri	50%	97%
A0A3S5H6E8	Leishmania donovani	68%	100%
A4HU59	Leishmania infantum	69%	100%
E9AMY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QHN8	Leishmania major	69%	100%