Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5W3_LEIBR

TriTrypDb:

LbrM.09.1410 , LBRM2903_090020800

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H5W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5W3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	114	116	PF00675	0.493
CLV_NRD_NRD_1	46	48	PF00675	0.372
CLV_PCSK_KEX2_1	114	116	PF00082	0.493
CLV_PCSK_KEX2_1	157	159	PF00082	0.461
CLV_PCSK_KEX2_1	46	48	PF00082	0.372
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.296
CLV_PCSK_PC7_1	153	159	PF00082	0.294
CLV_PCSK_SKI1_1	114	118	PF00082	0.401
CLV_PCSK_SKI1_1	171	175	PF00082	0.430
CLV_PCSK_SKI1_1	187	191	PF00082	0.438
DEG_MDM2_SWIB_1	78	85	PF02201	0.494
DEG_Nend_UBRbox_3	1	3	PF02207	0.670
DOC_CKS1_1	116	121	PF01111	0.410
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.351
DOC_PP2B_LxvP_1	38	41	PF13499	0.349
DOC_USP7_MATH_1	108	112	PF00917	0.490
DOC_USP7_MATH_1	19	23	PF00917	0.457
DOC_USP7_MATH_1	99	103	PF00917	0.491
DOC_USP7_MATH_2	4	10	PF00917	0.480
DOC_WW_Pin1_4	115	120	PF00397	0.403
DOC_WW_Pin1_4	23	28	PF00397	0.553
LIG_14-3-3_CanoR_1	114	119	PF00244	0.547
LIG_14-3-3_CanoR_1	20	29	PF00244	0.600
LIG_14-3-3_CanoR_1	95	99	PF00244	0.524
LIG_Actin_WH2_2	82	97	PF00022	0.398
LIG_FHA_1	115	121	PF00498	0.529
LIG_LIR_Apic_2	93	99	PF02991	0.443
LIG_LIR_Nem_3	138	142	PF02991	0.326
LIG_Pex14_2	78	82	PF04695	0.497
LIG_SH2_GRB2like	65	68	PF00017	0.297
LIG_SH2_STAP1	137	141	PF00017	0.504
LIG_SH2_STAP1	65	69	PF00017	0.433
LIG_SH2_STAT5	44	47	PF00017	0.370
LIG_SH2_STAT5	65	68	PF00017	0.447
MOD_CK2_1	19	25	PF00069	0.638
MOD_GlcNHglycan	144	148	PF01048	0.543
MOD_GlcNHglycan	8	11	PF01048	0.485
MOD_GSK3_1	114	121	PF00069	0.453
MOD_GSK3_1	126	133	PF00069	0.397
MOD_GSK3_1	15	22	PF00069	0.592
MOD_GSK3_1	90	97	PF00069	0.473
MOD_NEK2_1	126	131	PF00069	0.370
MOD_PIKK_1	130	136	PF00454	0.456
MOD_PIKK_1	148	154	PF00454	0.284
MOD_PKA_1	114	120	PF00069	0.535
MOD_PKA_2	114	120	PF00069	0.555
MOD_PKA_2	19	25	PF00069	0.614
MOD_PKA_2	94	100	PF00069	0.437
MOD_Plk_4	108	114	PF00069	0.439
MOD_Plk_4	99	105	PF00069	0.462
MOD_ProDKin_1	115	121	PF00069	0.395
MOD_ProDKin_1	23	29	PF00069	0.544
MOD_SUMO_rev_2	183	191	PF00179	0.550
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.445
TRG_ER_diArg_1	113	115	PF00400	0.494
TRG_ER_diArg_1	45	47	PF00400	0.402
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7T5	Leptomonas seymouri	66%	96%
A0A1X0NJH0	Trypanosomatidae	37%	100%
A0A3Q8IH21	Leishmania donovani	80%	100%
A0A3R7KP70	Trypanosoma rangeli	38%	100%
A4HU58	Leishmania infantum	80%	100%
D0A9N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AMY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QHP0	Leishmania major	81%	100%
V5BI27	Trypanosoma cruzi	38%	100%