Histone H2B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H2B

Gene product:

histone H2B

Species:

Leishmania braziliensis

UniProt:

A4H5W2_LEIBR

TriTrypDb:

LbrM.09.1400 , LBRM2903_090020700

Length:

111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

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Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	23
GO:0005634	nucleus	5	21
GO:0032991	protein-containing complex	1	23
GO:0032993	protein-DNA complex	2	23
GO:0043226	organelle	2	21
GO:0043227	membrane-bounded organelle	3	21
GO:0043229	intracellular organelle	3	21
GO:0043231	intracellular membrane-bounded organelle	4	21
GO:0044815	DNA packaging complex	2	23
GO:0110165	cellular anatomical entity	1	21

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Expansion

Sequence features

A4H5W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5W2

Function

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Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	3
GO:0006334	nucleosome assembly	7	3
GO:0006338	chromatin remodeling	5	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022607	cellular component assembly	4	3
GO:0034728	nucleosome organization	6	3
GO:0043933	protein-containing complex organization	4	3
GO:0065003	protein-containing complex assembly	5	3
GO:0065004	protein-DNA complex assembly	6	3

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	23
GO:0003677	DNA binding	4	23
GO:0005198	structural molecule activity	1	23
GO:0005488	binding	1	23
GO:0005515	protein binding	2	23
GO:0030527	structural constituent of chromatin	2	23
GO:0046982	protein heterodimerization activity	4	23
GO:0046983	protein dimerization activity	3	23
GO:0097159	organic cyclic compound binding	2	23
GO:1901363	heterocyclic compound binding	2	23

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.329
CLV_NRD_NRD_1	5	7	PF00675	0.695
CLV_NRD_NRD_1	8	10	PF00675	0.736
CLV_PCSK_FUR_1	20	24	PF00082	0.194
CLV_PCSK_KEX2_1	19	21	PF00082	0.303
CLV_PCSK_KEX2_1	22	24	PF00082	0.322
CLV_PCSK_KEX2_1	5	7	PF00082	0.509
CLV_PCSK_KEX2_1	74	76	PF00082	0.296
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.306
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.296

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD10	Leptomonas seymouri	44%	78%
A0A0N1PDG4	Leptomonas seymouri	84%	100%
A0A0S4IT56	Bodo saltans	49%	76%
A0A1X0NWS2	Trypanosomatidae	45%	78%
A0A2R8Y619	Homo sapiens	51%	91%
A0A381MG06	Leishmania infantum	79%	100%
A0A3R7MD18	Trypanosoma rangeli	67%	100%
A0A3R7NJN4	Trypanosoma rangeli	71%	99%
A0A3S5H748	Leishmania donovani	79%	100%
A0A3S5H7I6	Leishmania donovani	47%	78%

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