REJ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5W1_LEIBR

TriTrypDb:

LbrM.09.1390 , LBRM2903_090020600

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 1
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H5W1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5W1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.403
CLV_C14_Caspase3-7	178	182	PF00656	0.458
CLV_C14_Caspase3-7	538	542	PF00656	0.359
CLV_NRD_NRD_1	141	143	PF00675	0.621
CLV_NRD_NRD_1	353	355	PF00675	0.601
CLV_NRD_NRD_1	415	417	PF00675	0.370
CLV_NRD_NRD_1	548	550	PF00675	0.630
CLV_PCSK_KEX2_1	353	355	PF00082	0.601
CLV_PCSK_KEX2_1	89	91	PF00082	0.558
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.558
DEG_APCC_DBOX_1	2	10	PF00400	0.401
DEG_Nend_UBRbox_3	1	3	PF02207	0.383
DEG_SCF_FBW7_1	299	305	PF00400	0.278
DOC_CKS1_1	299	304	PF01111	0.282
DOC_MAPK_gen_1	300	309	PF00069	0.319
DOC_MAPK_gen_1	481	489	PF00069	0.540
DOC_MAPK_gen_1	501	511	PF00069	0.529
DOC_MAPK_gen_1	89	99	PF00069	0.364
DOC_MAPK_MEF2A_6	15	22	PF00069	0.409
DOC_MAPK_MEF2A_6	265	273	PF00069	0.356
DOC_MAPK_MEF2A_6	303	311	PF00069	0.314
DOC_MAPK_MEF2A_6	481	489	PF00069	0.540
DOC_MAPK_MEF2A_6	504	513	PF00069	0.414
DOC_PP1_RVXF_1	274	281	PF00149	0.406
DOC_PP1_RVXF_1	341	348	PF00149	0.375
DOC_PP1_RVXF_1	397	403	PF00149	0.219
DOC_PP2B_LxvP_1	307	310	PF13499	0.327
DOC_PP4_FxxP_1	412	415	PF00568	0.426
DOC_USP7_MATH_1	105	109	PF00917	0.361
DOC_USP7_MATH_1	134	138	PF00917	0.429
DOC_USP7_MATH_1	144	148	PF00917	0.418
DOC_USP7_MATH_1	170	174	PF00917	0.412
DOC_USP7_MATH_1	198	202	PF00917	0.325
DOC_USP7_MATH_1	302	306	PF00917	0.308
DOC_USP7_MATH_1	380	384	PF00917	0.354
DOC_USP7_MATH_1	496	500	PF00917	0.558
DOC_USP7_MATH_1	56	60	PF00917	0.425
DOC_USP7_MATH_1	83	87	PF00917	0.375
DOC_USP7_UBL2_3	419	423	PF12436	0.575
DOC_USP7_UBL2_3	550	554	PF12436	0.405
DOC_WW_Pin1_4	130	135	PF00397	0.570
DOC_WW_Pin1_4	176	181	PF00397	0.470
DOC_WW_Pin1_4	298	303	PF00397	0.280
DOC_WW_Pin1_4	383	388	PF00397	0.412
DOC_WW_Pin1_4	411	416	PF00397	0.551
LIG_14-3-3_CanoR_1	149	155	PF00244	0.434
LIG_14-3-3_CanoR_1	303	308	PF00244	0.298
LIG_14-3-3_CanoR_1	401	410	PF00244	0.212
LIG_14-3-3_CanoR_1	429	437	PF00244	0.570
LIG_14-3-3_CanoR_1	484	490	PF00244	0.514
LIG_14-3-3_CanoR_1	5	10	PF00244	0.433
LIG_14-3-3_CanoR_1	92	98	PF00244	0.425
LIG_Actin_WH2_2	387	403	PF00022	0.322
LIG_BRCT_BRCA1_1	406	410	PF00533	0.274
LIG_FHA_1	304	310	PF00498	0.318
LIG_FHA_1	428	434	PF00498	0.649
LIG_FHA_1	447	453	PF00498	0.546
LIG_FHA_1	68	74	PF00498	0.505
LIG_FHA_2	117	123	PF00498	0.436
LIG_FHA_2	213	219	PF00498	0.339
LIG_FHA_2	357	363	PF00498	0.392
LIG_FHA_2	452	458	PF00498	0.477
LIG_FHA_2	488	494	PF00498	0.498
LIG_LIR_Gen_1	218	226	PF02991	0.387
LIG_LIR_Gen_1	312	323	PF02991	0.369
LIG_LIR_Gen_1	330	339	PF02991	0.344
LIG_LIR_Gen_1	359	365	PF02991	0.423
LIG_LIR_Gen_1	367	378	PF02991	0.362
LIG_LIR_Gen_1	404	412	PF02991	0.212
LIG_LIR_Gen_1	488	497	PF02991	0.556
LIG_LIR_Nem_3	218	222	PF02991	0.394
LIG_LIR_Nem_3	249	254	PF02991	0.409
LIG_LIR_Nem_3	312	318	PF02991	0.469
LIG_LIR_Nem_3	330	334	PF02991	0.380
LIG_LIR_Nem_3	359	363	PF02991	0.406
LIG_LIR_Nem_3	367	373	PF02991	0.389
LIG_LIR_Nem_3	404	409	PF02991	0.212
LIG_LIR_Nem_3	488	492	PF02991	0.504
LIG_PCNA_yPIPBox_3	62	75	PF02747	0.368
LIG_PCNA_yPIPBox_3	81	92	PF02747	0.414
LIG_Pex14_1	313	317	PF04695	0.340
LIG_Pex14_2	402	406	PF04695	0.278
LIG_PTB_Apo_2	504	511	PF02174	0.540
LIG_PTB_Phospho_1	504	510	PF10480	0.544
LIG_SH2_CRK	315	319	PF00017	0.391
LIG_SH2_GRB2like	254	257	PF00017	0.362
LIG_SH2_NCK_1	214	218	PF00017	0.362
LIG_SH2_PTP2	219	222	PF00017	0.378
LIG_SH2_PTP2	510	513	PF00017	0.227
LIG_SH2_STAP1	12	16	PF00017	0.413
LIG_SH2_STAP1	199	203	PF00017	0.347
LIG_SH2_STAP1	360	364	PF00017	0.362
LIG_SH2_STAT3	502	505	PF00017	0.564
LIG_SH2_STAT3	532	535	PF00017	0.365
LIG_SH2_STAT3	54	57	PF00017	0.423
LIG_SH2_STAT5	214	217	PF00017	0.345
LIG_SH2_STAT5	219	222	PF00017	0.341
LIG_SH2_STAT5	254	257	PF00017	0.383
LIG_SH2_STAT5	297	300	PF00017	0.334
LIG_SH2_STAT5	372	375	PF00017	0.366
LIG_SH2_STAT5	393	396	PF00017	0.389
LIG_SH2_STAT5	436	439	PF00017	0.533
LIG_SH2_STAT5	466	469	PF00017	0.504
LIG_SH2_STAT5	510	513	PF00017	0.274
LIG_SH2_STAT5	532	535	PF00017	0.365
LIG_SH2_STAT5	539	542	PF00017	0.379
LIG_SH2_STAT5	68	71	PF00017	0.429
LIG_SH3_3	217	223	PF00018	0.313
LIG_SH3_3	333	339	PF00018	0.413
LIG_SH3_3	489	495	PF00018	0.528
LIG_Sin3_3	110	117	PF02671	0.383
LIG_SUMO_SIM_anti_2	524	530	PF11976	0.359
LIG_SUMO_SIM_par_1	447	454	PF11976	0.529
LIG_SUMO_SIM_par_1	518	524	PF11976	0.253
MOD_CDC14_SPxK_1	414	417	PF00782	0.582
MOD_CDK_SPK_2	298	303	PF00069	0.280
MOD_CDK_SPK_2	411	416	PF00069	0.418
MOD_CDK_SPxK_1	411	417	PF00069	0.417
MOD_CK1_1	182	188	PF00069	0.429
MOD_CK1_1	210	216	PF00069	0.357
MOD_CK1_1	261	267	PF00069	0.304
MOD_CK1_1	319	325	PF00069	0.343
MOD_CK1_1	383	389	PF00069	0.431
MOD_CK1_1	395	401	PF00069	0.248
MOD_CK1_1	404	410	PF00069	0.299
MOD_CK1_1	444	450	PF00069	0.543
MOD_CK2_1	172	178	PF00069	0.427
MOD_CK2_1	212	218	PF00069	0.340
MOD_CK2_1	356	362	PF00069	0.397
MOD_GlcNHglycan	155	158	PF01048	0.663
MOD_GlcNHglycan	172	175	PF01048	0.625
MOD_GlcNHglycan	230	233	PF01048	0.474
MOD_GlcNHglycan	289	292	PF01048	0.644
MOD_GlcNHglycan	403	406	PF01048	0.286
MOD_GlcNHglycan	430	433	PF01048	0.299
MOD_GlcNHglycan	58	61	PF01048	0.644
MOD_GlcNHglycan	81	84	PF01048	0.658
MOD_GSK3_1	130	137	PF00069	0.411
MOD_GSK3_1	144	151	PF00069	0.417
MOD_GSK3_1	172	179	PF00069	0.434
MOD_GSK3_1	182	189	PF00069	0.384
MOD_GSK3_1	228	235	PF00069	0.281
MOD_GSK3_1	298	305	PF00069	0.413
MOD_GSK3_1	364	371	PF00069	0.415
MOD_GSK3_1	411	418	PF00069	0.397
MOD_GSK3_1	446	453	PF00069	0.535
MOD_GSK3_1	79	86	PF00069	0.479
MOD_N-GLC_1	170	175	PF02516	0.615
MOD_N-GLC_1	210	215	PF02516	0.549
MOD_N-GLC_1	255	260	PF02516	0.585
MOD_N-GLC_1	303	308	PF02516	0.561
MOD_N-GLC_1	380	385	PF02516	0.563
MOD_NEK2_1	169	174	PF00069	0.453
MOD_NEK2_1	240	245	PF00069	0.403
MOD_NEK2_1	287	292	PF00069	0.461
MOD_NEK2_1	392	397	PF00069	0.389
MOD_NEK2_1	410	415	PF00069	0.485
MOD_NEK2_1	427	432	PF00069	0.621
MOD_NEK2_1	450	455	PF00069	0.568
MOD_PIKK_1	105	111	PF00454	0.368
MOD_PIKK_1	172	178	PF00454	0.471
MOD_PIKK_1	179	185	PF00454	0.490
MOD_PIKK_1	238	244	PF00454	0.337
MOD_PKA_2	148	154	PF00069	0.407
MOD_PKA_2	207	213	PF00069	0.391
MOD_PKA_2	302	308	PF00069	0.320
MOD_PKA_2	415	421	PF00069	0.577
MOD_PKA_2	428	434	PF00069	0.519
MOD_PKA_2	480	486	PF00069	0.488
MOD_PKB_1	3	11	PF00069	0.434
MOD_Plk_1	210	216	PF00069	0.357
MOD_Plk_1	255	261	PF00069	0.509
MOD_Plk_1	303	309	PF00069	0.332
MOD_Plk_1	319	325	PF00069	0.358
MOD_Plk_1	450	456	PF00069	0.533
MOD_Plk_2-3	451	457	PF00069	0.473
MOD_Plk_4	319	325	PF00069	0.385
MOD_Plk_4	473	479	PF00069	0.600
MOD_Plk_4	61	67	PF00069	0.374
MOD_Plk_4	83	89	PF00069	0.437
MOD_ProDKin_1	130	136	PF00069	0.570
MOD_ProDKin_1	176	182	PF00069	0.468
MOD_ProDKin_1	298	304	PF00069	0.283
MOD_ProDKin_1	383	389	PF00069	0.415
MOD_ProDKin_1	411	417	PF00069	0.549
MOD_SUMO_rev_2	268	278	PF00179	0.385
TRG_ENDOCYTIC_2	219	222	PF00928	0.354
TRG_ENDOCYTIC_2	315	318	PF00928	0.387
TRG_ENDOCYTIC_2	360	363	PF00928	0.408
TRG_ENDOCYTIC_2	510	513	PF00928	0.274
TRG_ENDOCYTIC_2	531	534	PF00928	0.362
TRG_ER_diArg_1	3	6	PF00400	0.423
TRG_ER_diArg_1	353	355	PF00400	0.401
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJG0	Leptomonas seymouri	37%	93%
A0A3S5H6E7	Leishmania donovani	64%	93%
A4HU56	Leishmania infantum	64%	93%
E9AMY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	94%
Q4QHP2	Leishmania major	63%	100%