Putative paraflagellar rod component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania braziliensis

UniProt:

A4H5W0_LEIBR

TriTrypDb:

LbrM.09.1380 , LBRM2903_090020500

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	30
GO:0031514	motile cilium	5	30
GO:0042995	cell projection	2	30
GO:0043226	organelle	2	30
GO:0043227	membrane-bounded organelle	3	30
GO:0110165	cellular anatomical entity	1	30
GO:0120025	plasma membrane bounded cell projection	3	30
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H5W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5W0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	30
GO:0005515	protein binding	2	30
GO:0005516	calmodulin binding	3	30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.361
CLV_C14_Caspase3-7	263	267	PF00656	0.211
CLV_C14_Caspase3-7	37	41	PF00656	0.579
CLV_C14_Caspase3-7	457	461	PF00656	0.384
CLV_NRD_NRD_1	180	182	PF00675	0.425
CLV_NRD_NRD_1	300	302	PF00675	0.357
CLV_NRD_NRD_1	313	315	PF00675	0.325
CLV_NRD_NRD_1	372	374	PF00675	0.385
CLV_PCSK_FUR_1	370	374	PF00082	0.230
CLV_PCSK_KEX2_1	180	182	PF00082	0.411
CLV_PCSK_KEX2_1	226	228	PF00082	0.395
CLV_PCSK_KEX2_1	372	374	PF00082	0.342
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.419
CLV_PCSK_SKI1_1	103	107	PF00082	0.518
CLV_PCSK_SKI1_1	127	131	PF00082	0.292
CLV_PCSK_SKI1_1	182	186	PF00082	0.461
CLV_PCSK_SKI1_1	265	269	PF00082	0.253
CLV_PCSK_SKI1_1	337	341	PF00082	0.357
CLV_PCSK_SKI1_1	540	544	PF00082	0.362
DEG_APCC_DBOX_1	469	477	PF00400	0.297
DEG_Nend_UBRbox_3	1	3	PF02207	0.420
DEG_SPOP_SBC_1	587	591	PF00917	0.635
DOC_CYCLIN_RxL_1	121	134	PF00134	0.441
DOC_CYCLIN_RxL_1	223	234	PF00134	0.503
DOC_MAPK_gen_1	301	310	PF00069	0.159
DOC_MAPK_MEF2A_6	303	312	PF00069	0.159
DOC_PP1_RVXF_1	224	231	PF00149	0.482
DOC_PP4_FxxP_1	519	522	PF00568	0.294
DOC_USP7_MATH_1	267	271	PF00917	0.417
DOC_USP7_MATH_1	400	404	PF00917	0.346
DOC_USP7_MATH_1	458	462	PF00917	0.214
DOC_USP7_MATH_1	587	591	PF00917	0.638
DOC_USP7_UBL2_3	255	259	PF12436	0.330
DOC_USP7_UBL2_3	265	269	PF12436	0.319
DOC_USP7_UBL2_3	298	302	PF12436	0.159
LIG_14-3-3_CanoR_1	337	344	PF00244	0.386
LIG_14-3-3_CanoR_1	353	361	PF00244	0.193
LIG_Actin_WH2_2	315	332	PF00022	0.384
LIG_APCC_ABBA_1	258	263	PF00400	0.159
LIG_BRCT_BRCA1_1	415	419	PF00533	0.186
LIG_FHA_1	142	148	PF00498	0.445
LIG_FHA_1	164	170	PF00498	0.416
LIG_FHA_1	272	278	PF00498	0.398
LIG_FHA_1	338	344	PF00498	0.422
LIG_FHA_1	436	442	PF00498	0.350
LIG_FHA_1	533	539	PF00498	0.375
LIG_FHA_2	117	123	PF00498	0.457
LIG_FHA_2	232	238	PF00498	0.549
LIG_FHA_2	353	359	PF00498	0.355
LIG_LIR_Apic_2	516	522	PF02991	0.307
LIG_LIR_Gen_1	3	12	PF02991	0.385
LIG_LIR_Gen_1	358	368	PF02991	0.292
LIG_LIR_Gen_1	416	427	PF02991	0.279
LIG_LIR_Gen_1	498	509	PF02991	0.308
LIG_LIR_Nem_3	3	7	PF02991	0.383
LIG_LIR_Nem_3	358	363	PF02991	0.292
LIG_LIR_Nem_3	40	45	PF02991	0.533
LIG_LIR_Nem_3	416	422	PF02991	0.275
LIG_LIR_Nem_3	463	469	PF02991	0.413
LIG_LIR_Nem_3	498	504	PF02991	0.308
LIG_PDZ_Class_2	600	605	PF00595	0.492
LIG_SH2_CRK	4	8	PF00017	0.477
LIG_SH2_NCK_1	4	8	PF00017	0.313
LIG_SH2_SRC	212	215	PF00017	0.403
LIG_SH2_SRC	4	7	PF00017	0.309
LIG_SH2_SRC	544	547	PF00017	0.584
LIG_SH2_STAP1	194	198	PF00017	0.467
LIG_SH2_STAP1	218	222	PF00017	0.430
LIG_SH2_STAP1	224	228	PF00017	0.429
LIG_SH2_STAT5	128	131	PF00017	0.537
LIG_SH2_STAT5	212	215	PF00017	0.417
LIG_SH2_STAT5	220	223	PF00017	0.408
LIG_SH2_STAT5	377	380	PF00017	0.308
LIG_SH2_STAT5	391	394	PF00017	0.274
LIG_SH2_STAT5	45	48	PF00017	0.426
LIG_SH2_STAT5	544	547	PF00017	0.465
LIG_SH3_2	9	14	PF14604	0.495
LIG_SH3_3	137	143	PF00018	0.456
LIG_SH3_3	145	151	PF00018	0.467
LIG_SH3_3	594	600	PF00018	0.659
LIG_SH3_3	6	12	PF00018	0.481
LIG_SUMO_SIM_par_1	146	152	PF11976	0.579
LIG_SUMO_SIM_par_1	202	207	PF11976	0.415
LIG_TRAF2_1	233	236	PF00917	0.597
LIG_TRAF2_1	356	359	PF00917	0.360
LIG_TRAF2_1	387	390	PF00917	0.323
LIG_TRAF2_1	522	525	PF00917	0.335
LIG_WW_1	8	11	PF00397	0.513
MOD_CK1_1	110	116	PF00069	0.444
MOD_CK2_1	229	235	PF00069	0.438
MOD_CK2_1	352	358	PF00069	0.361
MOD_CK2_1	507	513	PF00069	0.348
MOD_GlcNHglycan	112	115	PF01048	0.533
MOD_GlcNHglycan	171	176	PF01048	0.460
MOD_GlcNHglycan	269	272	PF01048	0.400
MOD_GlcNHglycan	401	405	PF01048	0.337
MOD_GlcNHglycan	456	459	PF01048	0.233
MOD_GlcNHglycan	590	593	PF01048	0.652
MOD_GSK3_1	267	274	PF00069	0.270
MOD_GSK3_1	431	438	PF00069	0.384
MOD_GSK3_1	454	461	PF00069	0.292
MOD_GSK3_1	508	515	PF00069	0.197
MOD_N-GLC_1	538	543	PF02516	0.380
MOD_NEK2_1	131	136	PF00069	0.491
MOD_NEK2_1	304	309	PF00069	0.448
MOD_NEK2_1	507	512	PF00069	0.387
MOD_NEK2_2	431	436	PF00069	0.328
MOD_PIKK_1	182	188	PF00454	0.378
MOD_PIKK_1	337	343	PF00454	0.408
MOD_PIKK_1	490	496	PF00454	0.292
MOD_PKA_2	352	358	PF00069	0.308
MOD_PKA_2	454	460	PF00069	0.299
MOD_Plk_1	304	310	PF00069	0.407
MOD_Plk_1	431	437	PF00069	0.308
MOD_Plk_1	538	544	PF00069	0.319
MOD_Plk_2-3	413	419	PF00069	0.197
MOD_Plk_4	49	55	PF00069	0.481
MOD_SUMO_for_1	169	172	PF00179	0.560
MOD_SUMO_for_1	347	350	PF00179	0.299
MOD_SUMO_rev_2	252	257	PF00179	0.545
MOD_SUMO_rev_2	262	267	PF00179	0.294
MOD_SUMO_rev_2	307	316	PF00179	0.448
TRG_DiLeu_BaEn_1	561	566	PF01217	0.393
TRG_DiLeu_BaEn_2	414	420	PF01217	0.287
TRG_ENDOCYTIC_2	128	131	PF00928	0.500
TRG_ENDOCYTIC_2	218	221	PF00928	0.343
TRG_ENDOCYTIC_2	4	7	PF00928	0.472
TRG_ENDOCYTIC_2	423	426	PF00928	0.284
TRG_ER_diArg_1	124	127	PF00400	0.476
TRG_ER_diArg_1	370	373	PF00400	0.394
TRG_ER_diArg_1	534	537	PF00400	0.328
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P573	Leptomonas seymouri	62%	99%
A0A0N1IFZ5	Leptomonas seymouri	24%	100%
A0A0S4IPM7	Bodo saltans	30%	100%
A0A0S4IZY8	Bodo saltans	23%	100%
A0A0S4JS20	Bodo saltans	22%	100%
A0A1X0NI51	Trypanosomatidae	43%	100%
A0A1X0NYU4	Trypanosomatidae	23%	100%
A0A1X0P0B7	Trypanosomatidae	22%	100%
A0A381MH18	Leishmania infantum	24%	100%
A0A3Q8IAP5	Leishmania donovani	24%	100%
A0A3R7KDB9	Trypanosoma rangeli	23%	100%
A0A3R7P0W8	Trypanosoma rangeli	47%	100%
A0A3S5IRI8	Trypanosoma rangeli	22%	100%
A0A3S7WQV4	Leishmania donovani	78%	100%
A4H8S1	Leishmania braziliensis	22%	100%
A4HU55	Leishmania infantum	78%	100%
A4HX40	Leishmania infantum	24%	100%
C9ZLC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
C9ZLC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
C9ZU76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	88%
C9ZVV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A9N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AMY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9AQV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	91%
P22225	Trypanosoma brucei brucei	23%	100%
Q4QEM2	Leishmania major	24%	100%
Q4QHP3	Leishmania major	79%	100%
V5BDF9	Trypanosoma cruzi	47%	100%
V5BDW8	Trypanosoma cruzi	21%	100%