PPPDE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PPPDE putative peptidase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5V8_LEIBR

TriTrypDb:

LbrM.09.1350 , LBRM2903_090020200

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5V8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016579	protein deubiquitination	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070646	protein modification by small protein removal	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0008233	peptidase activity	3	16
GO:0016787	hydrolase activity	2	16
GO:0140096	catalytic activity, acting on a protein	2	16
GO:0019783	ubiquitin-like protein peptidase activity	4	2
GO:0101005	deubiquitinase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.418
CLV_PCSK_SKI1_1	161	165	PF00082	0.504
DEG_APCC_DBOX_1	160	168	PF00400	0.281
DEG_APCC_DBOX_1	181	189	PF00400	0.234
DOC_CYCLIN_yCln2_LP_2	150	153	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	188	191	PF00134	0.372
DOC_MAPK_MEF2A_6	182	189	PF00069	0.406
DOC_PP2B_LxvP_1	150	153	PF13499	0.447
DOC_PP2B_LxvP_1	188	191	PF13499	0.354
DOC_PP4_FxxP_1	219	222	PF00568	0.474
DOC_USP7_MATH_1	13	17	PF00917	0.518
DOC_USP7_MATH_1	163	167	PF00917	0.586
DOC_USP7_MATH_1	19	23	PF00917	0.658
DOC_USP7_MATH_1	3	7	PF00917	0.720
DOC_USP7_MATH_1	90	94	PF00917	0.465
DOC_WW_Pin1_4	21	26	PF00397	0.621
DOC_WW_Pin1_4	91	96	PF00397	0.438
LIG_14-3-3_CanoR_1	182	186	PF00244	0.522
LIG_14-3-3_CanoR_1	91	95	PF00244	0.491
LIG_APCC_ABBA_1	189	194	PF00400	0.268
LIG_eIF4E_1	183	189	PF01652	0.380
LIG_LIR_Apic_2	216	222	PF02991	0.443
LIG_LIR_Gen_1	130	140	PF02991	0.456
LIG_LIR_Nem_3	130	135	PF02991	0.432
LIG_MYND_1	186	190	PF01753	0.340
LIG_Pex14_2	142	146	PF04695	0.422
LIG_Pex14_2	98	102	PF04695	0.509
LIG_SH2_CRK	132	136	PF00017	0.435
LIG_SH2_CRK	183	187	PF00017	0.376
LIG_SH2_CRK	46	50	PF00017	0.368
LIG_SH2_STAP1	199	203	PF00017	0.514
LIG_SH2_STAP1	70	74	PF00017	0.514
LIG_SH2_STAT3	103	106	PF00017	0.497
LIG_SH2_STAT5	103	106	PF00017	0.422
LIG_SH2_STAT5	203	206	PF00017	0.541
LIG_SH3_3	184	190	PF00018	0.339
LIG_SH3_3	84	90	PF00018	0.403
LIG_TRAF2_1	113	116	PF00917	0.367
LIG_WRC_WIRS_1	118	123	PF05994	0.422
MOD_CK1_1	6	12	PF00069	0.636
MOD_CK2_1	9	15	PF00069	0.482
MOD_GlcNHglycan	109	112	PF01048	0.329
MOD_GlcNHglycan	11	14	PF01048	0.608
MOD_GlcNHglycan	15	18	PF01048	0.605
MOD_GlcNHglycan	21	24	PF01048	0.519
MOD_GlcNHglycan	80	85	PF01048	0.295
MOD_GSK3_1	117	124	PF00069	0.461
MOD_GSK3_1	159	166	PF00069	0.388
MOD_GSK3_1	211	218	PF00069	0.503
MOD_GSK3_1	3	10	PF00069	0.609
MOD_GSK3_1	50	57	PF00069	0.502
MOD_N-GLC_1	3	8	PF02516	0.496
MOD_NEK2_1	117	122	PF00069	0.415
MOD_NEK2_1	215	220	PF00069	0.427
MOD_PIKK_1	104	110	PF00454	0.463
MOD_PKA_2	181	187	PF00069	0.483
MOD_PKA_2	194	200	PF00069	0.314
MOD_PKA_2	90	96	PF00069	0.397
MOD_Plk_1	215	221	PF00069	0.439
MOD_Plk_1	6	12	PF00069	0.674
MOD_Plk_4	123	129	PF00069	0.412
MOD_Plk_4	163	169	PF00069	0.527
MOD_Plk_4	199	205	PF00069	0.541
MOD_Plk_4	215	221	PF00069	0.406
MOD_Plk_4	50	56	PF00069	0.481
MOD_ProDKin_1	21	27	PF00069	0.612
MOD_ProDKin_1	91	97	PF00069	0.438
TRG_ENDOCYTIC_2	132	135	PF00928	0.435
TRG_ENDOCYTIC_2	46	49	PF00928	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVE7	Leptomonas seymouri	50%	91%
A0A0N1PCI8	Leptomonas seymouri	62%	99%
A0A0S4JCD5	Bodo saltans	25%	81%
A0A1X0NHT4	Trypanosomatidae	41%	77%
A0A3Q8IAW2	Leishmania donovani	76%	100%
A0A3S7WQX3	Leishmania donovani	59%	87%
A0A422NZN2	Trypanosoma rangeli	38%	91%
A4HU52	Leishmania infantum	76%	100%
A4HU53	Leishmania infantum	59%	87%
D0A9N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
E9AMY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
E9AMY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	87%
H2KZK4	Caenorhabditis elegans	27%	66%
Q4QHP4	Leishmania major	56%	100%
Q4QHP5	Leishmania major	75%	98%
Q93VG8	Arabidopsis thaliana	30%	99%
V5BMK8	Trypanosoma cruzi	42%	67%