Putative mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H5V5_LEIBR

TriTrypDb:

LbrM.09.1320 , LBRM2903_090019900

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4H5V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5V5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.501
CLV_NRD_NRD_1	263	265	PF00675	0.688
CLV_NRD_NRD_1	343	345	PF00675	0.579
CLV_PCSK_KEX2_1	107	109	PF00082	0.294
CLV_PCSK_KEX2_1	263	265	PF00082	0.676
CLV_PCSK_KEX2_1	343	345	PF00082	0.680
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.308
CLV_PCSK_SKI1_1	314	318	PF00082	0.180
DOC_CYCLIN_RxL_1	105	116	PF00134	0.287
DOC_CYCLIN_yCln2_LP_2	306	312	PF00134	0.541
DOC_MAPK_DCC_7	95	103	PF00069	0.476
DOC_MAPK_MEF2A_6	95	103	PF00069	0.467
DOC_PP1_RVXF_1	106	113	PF00149	0.343
DOC_PP1_RVXF_1	222	229	PF00149	0.365
DOC_USP7_MATH_1	106	110	PF00917	0.338
DOC_USP7_MATH_1	12	16	PF00917	0.538
DOC_USP7_MATH_1	274	278	PF00917	0.454
DOC_USP7_MATH_1	71	75	PF00917	0.387
DOC_WW_Pin1_4	244	249	PF00397	0.391
LIG_14-3-3_CanoR_1	314	321	PF00244	0.505
LIG_14-3-3_CterR_2	343	348	PF00244	0.348
LIG_BIR_III_4	131	135	PF00653	0.377
LIG_BRCT_BRCA1_1	108	112	PF00533	0.343
LIG_Clathr_ClatBox_1	284	288	PF01394	0.428
LIG_deltaCOP1_diTrp_1	116	121	PF00928	0.360
LIG_deltaCOP1_diTrp_1	25	34	PF00928	0.417
LIG_EH1_1	299	307	PF00400	0.380
LIG_FHA_1	16	22	PF00498	0.540
LIG_FHA_1	278	284	PF00498	0.320
LIG_FHA_1	315	321	PF00498	0.341
LIG_FHA_1	335	341	PF00498	0.218
LIG_FHA_1	50	56	PF00498	0.308
LIG_FHA_1	59	65	PF00498	0.541
LIG_LIR_Gen_1	225	236	PF02991	0.260
LIG_LIR_Gen_1	280	287	PF02991	0.201
LIG_LIR_Nem_3	209	214	PF02991	0.513
LIG_LIR_Nem_3	230	235	PF02991	0.238
LIG_LIR_Nem_3	280	284	PF02991	0.315
LIG_PCNA_yPIPBox_3	107	118	PF02747	0.393
LIG_Pex14_1	117	121	PF04695	0.360
LIG_Pex14_1	281	285	PF04695	0.308
LIG_Pex14_2	214	218	PF04695	0.393
LIG_SH2_CRK	220	224	PF00017	0.232
LIG_SH2_CRK	236	240	PF00017	0.293
LIG_SH2_CRK	313	317	PF00017	0.455
LIG_SH2_STAP1	334	338	PF00017	0.330
LIG_SH2_STAT5	232	235	PF00017	0.322
LIG_SUMO_SIM_anti_2	38	44	PF11976	0.353
LIG_TYR_ITIM	311	316	PF00017	0.537
LIG_UBA3_1	283	291	PF00899	0.309
MOD_CK1_1	15	21	PF00069	0.514
MOD_CK1_1	192	198	PF00069	0.380
MOD_CK1_1	262	268	PF00069	0.346
MOD_CK1_1	277	283	PF00069	0.235
MOD_CK1_1	74	80	PF00069	0.546
MOD_CK1_1	83	89	PF00069	0.543
MOD_GlcNHglycan	136	139	PF01048	0.690
MOD_GlcNHglycan	141	144	PF01048	0.602
MOD_GlcNHglycan	164	167	PF01048	0.211
MOD_GlcNHglycan	271	274	PF01048	0.363
MOD_GlcNHglycan	326	329	PF01048	0.366
MOD_GSK3_1	158	165	PF00069	0.305
MOD_GSK3_1	184	191	PF00069	0.455
MOD_GSK3_1	197	204	PF00069	0.455
MOD_GSK3_1	249	256	PF00069	0.480
MOD_GSK3_1	334	341	PF00069	0.238
MOD_GSK3_1	70	77	PF00069	0.464
MOD_GSK3_1	8	15	PF00069	0.450
MOD_NEK2_1	16	21	PF00069	0.344
MOD_NEK2_1	316	321	PF00069	0.328
MOD_NEK2_1	35	40	PF00069	0.404
MOD_NEK2_1	8	13	PF00069	0.378
MOD_NEK2_2	201	206	PF00069	0.533
MOD_NEK2_2	227	232	PF00069	0.260
MOD_NEK2_2	286	291	PF00069	0.308
MOD_PIKK_1	184	190	PF00454	0.455
MOD_PIKK_1	192	198	PF00454	0.455
MOD_PKA_2	262	268	PF00069	0.427
MOD_PKA_2	74	80	PF00069	0.506
MOD_Plk_1	334	340	PF00069	0.330
MOD_Plk_4	159	165	PF00069	0.307
MOD_Plk_4	16	22	PF00069	0.492
MOD_Plk_4	171	177	PF00069	0.273
MOD_Plk_4	227	233	PF00069	0.300
MOD_Plk_4	289	295	PF00069	0.513
MOD_Plk_4	316	322	PF00069	0.324
MOD_Plk_4	334	340	PF00069	0.301
MOD_Plk_4	35	41	PF00069	0.409
MOD_Plk_4	49	55	PF00069	0.384
MOD_Plk_4	77	83	PF00069	0.476
MOD_ProDKin_1	244	250	PF00069	0.394
TRG_ENDOCYTIC_2	215	218	PF00928	0.319
TRG_ENDOCYTIC_2	220	223	PF00928	0.298
TRG_ENDOCYTIC_2	232	235	PF00928	0.216
TRG_ENDOCYTIC_2	236	239	PF00928	0.285
TRG_ENDOCYTIC_2	313	316	PF00928	0.454
TRG_ER_diArg_1	343	345	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K309	Rattus norvegicus	24%	100%
A0A0N0P7T5	Leptomonas seymouri	26%	100%
A0A0N0P7X0	Leptomonas seymouri	24%	100%
A0A0N1HX25	Leptomonas seymouri	61%	97%
A0A0N1I8T5	Leptomonas seymouri	23%	100%
A0A0N1IMA2	Leptomonas seymouri	25%	100%
A0A0S4IV98	Bodo saltans	25%	100%
A0A0S4IZG7	Bodo saltans	26%	100%
A0A0S4J045	Bodo saltans	23%	98%
A0A0S4JIA4	Bodo saltans	25%	82%
A0A0S4JM95	Bodo saltans	23%	100%
A0A0S4JQI3	Bodo saltans	41%	97%
A0A1X0NFT4	Trypanosomatidae	26%	100%
A0A1X0NIA3	Trypanosomatidae	48%	100%
A0A1X0NJD2	Trypanosomatidae	27%	100%
A0A1X0NLW7	Trypanosomatidae	25%	100%
A0A1X0NUT2	Trypanosomatidae	23%	99%
A0A1X0P4Q9	Trypanosomatidae	23%	100%
A0A3R7KGU8	Trypanosoma rangeli	24%	100%
A0A3R7N0M4	Trypanosoma rangeli	51%	100%
A0A3R7RT89	Trypanosoma rangeli	26%	100%
A0A3S5H6E6	Leishmania donovani	76%	100%
A0A3S5H6W7	Leishmania donovani	23%	91%
A0A3S7WVJ8	Leishmania donovani	25%	100%
A0A3S7WYS1	Leishmania donovani	22%	100%
A0A422NF39	Trypanosoma rangeli	23%	100%
A0A422NVT9	Trypanosoma rangeli	26%	100%
A0PC02	Ochotona dauurica	23%	100%
A1CIF6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	23%	100%
A1CWA4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	22%	100%
A1DI57	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	100%
A2ASZ8	Mus musculus	24%	74%
A2CEQ0	Danio rerio	23%	74%
A2R5A0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	100%
A4H8E6	Leishmania braziliensis	22%	100%
A4HDW8	Leishmania braziliensis	22%	94%
A4HHT5	Leishmania braziliensis	23%	100%
A4HU49	Leishmania infantum	75%	100%
A4HWS0	Leishmania infantum	23%	91%
A4HYC8	Leishmania infantum	25%	100%
A4I163	Leishmania infantum	22%	100%
A4QNX2	Danio rerio	25%	100%
A4RF23	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	23%	100%
A4RPU0	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	25%	100%
A5DX39	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	20%	100%
A5PJZ1	Bos taurus	25%	73%
A6RAY2	Ajellomyces capsulatus (strain NAm1 / WU24)	24%	99%
A6RF73	Ajellomyces capsulatus (strain NAm1 / WU24)	24%	100%
A6SL61	Botryotinia fuckeliana (strain B05.10)	26%	100%
A7TIQ0	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	24%	100%
B0DK57	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	26%	100%
B0Y4J4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	22%	100%
B2VSU4	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	25%	100%
B8ZHC9	Rattus norvegicus	24%	100%
C9ZW54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A5E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A728	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A9N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AEE0	Leishmania major	22%	100%
E9ALE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AMX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9AS62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AX97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
O18757	Oryctolagus cuniculus	24%	73%
O59674	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
O77792	Bos taurus	26%	100%
O94370	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O97562	Sus scrofa	26%	100%
P04575	Mesocricetus auratus	23%	100%
P04633	Rattus norvegicus	24%	100%
P10566	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P12242	Mus musculus	23%	100%
P14271	Oryctolagus cuniculus	23%	100%
P25874	Homo sapiens	24%	100%
P32331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P38087	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P38152	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P38921	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P55851	Homo sapiens	26%	100%
P55916	Homo sapiens	24%	100%
P56499	Rattus norvegicus	24%	100%
P56500	Rattus norvegicus	25%	100%
P56501	Mus musculus	26%	100%
P70406	Mus musculus	25%	100%
Q08DK7	Bos taurus	26%	100%
Q0CEN9	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	26%	100%
Q0CT66	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	25%	100%
Q0UUH1	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	23%	100%
Q0V7M4	Bos taurus	24%	74%
Q10248	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q12289	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
Q12375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q18P97	Suncus murinus	25%	100%
Q1DRJ3	Coccidioides immitis (strain RS)	24%	100%
Q1E7P0	Coccidioides immitis (strain RS)	25%	100%
Q1ECW7	Danio rerio	25%	100%
Q1LZB3	Bos taurus	23%	100%
Q27257	Caenorhabditis elegans	22%	100%
Q287T7	Danio rerio	22%	100%
Q2UCW8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	25%	100%
Q3MHI3	Bos taurus	24%	100%
Q3SZI5	Bos taurus	26%	100%
Q3TZX3	Mus musculus	23%	100%
Q4QA75	Leishmania major	22%	95%
Q4QDA4	Leishmania major	25%	100%
Q4QHP8	Leishmania major	75%	100%
Q4WQC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	22%	100%
Q4X022	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54BM3	Dictyostelium discoideum	22%	100%
Q54FE6	Dictyostelium discoideum	22%	100%
Q54S10	Dictyostelium discoideum	22%	89%
Q54VX4	Dictyostelium discoideum	23%	100%
Q54W11	Dictyostelium discoideum	23%	100%
Q55DY8	Dictyostelium discoideum	23%	100%
Q55E45	Dictyostelium discoideum	22%	100%
Q55E85	Dictyostelium discoideum	23%	100%
Q55GE2	Dictyostelium discoideum	22%	100%
Q59Q36	Candida albicans (strain SC5314 / ATCC MYA-2876)	21%	100%
Q5AVW1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	100%
Q5B717	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	100%
Q5HZE0	Rattus norvegicus	25%	100%
Q5NVC1	Pongo abelii	22%	100%
Q5R5A8	Pongo abelii	26%	100%
Q5XH95	Xenopus tropicalis	24%	68%
Q5XHA0	Xenopus tropicalis	24%	74%
Q5ZKP7	Gallus gallus	22%	100%
Q66H23	Rattus norvegicus	22%	100%
Q66L49	Danio rerio	22%	73%
Q6BPW0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	21%	100%
Q6C107	Yarrowia lipolytica (strain CLIB 122 / E 150)	21%	100%
Q6CNY8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q6DFK2	Xenopus laevis	21%	100%
Q6DG32	Danio rerio	23%	100%
Q6FR88	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	100%
Q6GQS1	Mus musculus	25%	75%
Q6IS41	Mus musculus	24%	100%
Q6J329	Rattus norvegicus	24%	100%
Q6KCM7	Homo sapiens	24%	74%
Q6NUK1	Homo sapiens	24%	73%
Q6NYZ6	Danio rerio	24%	74%
Q6P036	Danio rerio	25%	100%
Q6ZT89	Homo sapiens	24%	100%
Q75EP3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	22%	100%
Q7S2H8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	100%
Q7T0U6	Xenopus laevis	23%	74%
Q7T292	Danio rerio	23%	93%
Q7XA87	Arabidopsis thaliana	25%	100%
Q7ZY36	Xenopus laevis	23%	74%
Q7ZYD5	Xenopus laevis	25%	68%
Q86HN8	Dictyostelium discoideum	24%	80%
Q8BL03	Mus musculus	25%	100%
Q8BMD8	Mus musculus	24%	73%
Q8BVN7	Mus musculus	23%	100%
Q8BW66	Mus musculus	23%	100%
Q8K3P6	Rattus norvegicus	24%	74%
Q8K404	Dicrostonyx groenlandicus	23%	100%
Q8N5S1	Homo sapiens	24%	94%
Q8N8R3	Homo sapiens	26%	100%
Q8R0Z5	Mus musculus	23%	96%
Q920G8	Mus musculus	21%	100%
Q922G0	Mus musculus	23%	100%
Q96A46	Homo sapiens	23%	96%
Q96CQ1	Homo sapiens	23%	100%
Q96U08	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
Q99JD3	Rattus norvegicus	24%	100%
Q9BSK2	Homo sapiens	22%	100%
Q9BV35	Homo sapiens	26%	74%
Q9BXI2	Homo sapiens	26%	100%
Q9CA93	Arabidopsis thaliana	27%	100%
Q9FI43	Arabidopsis thaliana	22%	71%
Q9FLS8	Arabidopsis thaliana	22%	73%
Q9GMZ1	Canis lupus familiaris	25%	100%
Q9HC21	Homo sapiens	23%	100%
Q9N2J1	Canis lupus familiaris	25%	100%
Q9NYZ2	Homo sapiens	21%	100%
Q9P3T7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9P6N6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9VAY3	Drosophila melanogaster	25%	92%
Q9VQ37	Drosophila melanogaster	22%	95%
Q9VQG4	Drosophila melanogaster	24%	100%
Q9W720	Danio rerio	27%	100%
Q9W725	Cyprinus carpio	26%	100%
Q9WVD5	Mus musculus	25%	100%
Q9Y619	Homo sapiens	26%	100%
V5BD15	Trypanosoma cruzi	26%	100%
V5BI33	Trypanosoma cruzi	52%	100%
V5BP20	Trypanosoma cruzi	24%	100%
V5BSW1	Trypanosoma cruzi	22%	100%
V5BVW0	Trypanosoma cruzi	27%	100%