Bromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bromodomain, putative

Species:

Leishmania braziliensis

UniProt:

A4H5V4_LEIBR

TriTrypDb:

LbrM.09.1310 , LBRM2903_090019800

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5V4

PDB structure(s): 5tck_A , 5tck_B , 5tcm_A , 5tcm_B , 5tcm_C , 6bya_A , 6bya_B , 6bya_C , 6bya_D

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	497	501	PF00656	0.452
CLV_NRD_NRD_1	122	124	PF00675	0.481
CLV_NRD_NRD_1	179	181	PF00675	0.443
CLV_NRD_NRD_1	201	203	PF00675	0.367
CLV_NRD_NRD_1	276	278	PF00675	0.443
CLV_NRD_NRD_1	354	356	PF00675	0.640
CLV_NRD_NRD_1	407	409	PF00675	0.398
CLV_NRD_NRD_1	422	424	PF00675	0.379
CLV_NRD_NRD_1	50	52	PF00675	0.385
CLV_NRD_NRD_1	608	610	PF00675	0.485
CLV_PCSK_KEX2_1	122	124	PF00082	0.481
CLV_PCSK_KEX2_1	148	150	PF00082	0.680
CLV_PCSK_KEX2_1	179	181	PF00082	0.443
CLV_PCSK_KEX2_1	276	278	PF00082	0.443
CLV_PCSK_KEX2_1	356	358	PF00082	0.702
CLV_PCSK_KEX2_1	406	408	PF00082	0.405
CLV_PCSK_KEX2_1	422	424	PF00082	0.379
CLV_PCSK_KEX2_1	50	52	PF00082	0.348
CLV_PCSK_KEX2_1	608	610	PF00082	0.485
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.581
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.702
CLV_PCSK_PC7_1	418	424	PF00082	0.471
CLV_PCSK_SKI1_1	105	109	PF00082	0.470
CLV_PCSK_SKI1_1	407	411	PF00082	0.503
DEG_APCC_DBOX_1	104	112	PF00400	0.453
DEG_APCC_DBOX_1	407	415	PF00400	0.489
DEG_APCC_DBOX_1	417	425	PF00400	0.523
DEG_APCC_DBOX_1	622	630	PF00400	0.495
DEG_SPOP_SBC_1	155	159	PF00917	0.537
DEG_SPOP_SBC_1	338	342	PF00917	0.715
DOC_CDC14_PxL_1	283	291	PF14671	0.402
DOC_CDC14_PxL_1	34	42	PF14671	0.291
DOC_CYCLIN_RxL_1	404	412	PF00134	0.452
DOC_MAPK_DCC_7	372	382	PF00069	0.502
DOC_MAPK_DCC_7	430	440	PF00069	0.382
DOC_MAPK_gen_1	122	129	PF00069	0.607
DOC_MAPK_gen_1	241	250	PF00069	0.385
DOC_MAPK_gen_1	422	428	PF00069	0.600
DOC_MAPK_gen_1	620	628	PF00069	0.486
DOC_MAPK_MEF2A_6	241	250	PF00069	0.297
DOC_MAPK_MEF2A_6	507	515	PF00069	0.560
DOC_MAPK_NFAT4_5	243	251	PF00069	0.367
DOC_MAPK_RevD_3	409	423	PF00069	0.466
DOC_PP2B_LxvP_1	127	130	PF13499	0.699
DOC_PP2B_LxvP_1	399	402	PF13499	0.492
DOC_PP2B_LxvP_1	433	436	PF13499	0.497
DOC_SPAK_OSR1_1	580	584	PF12202	0.403
DOC_USP7_MATH_1	130	134	PF00917	0.632
DOC_USP7_MATH_1	163	167	PF00917	0.526
DOC_USP7_MATH_1	312	316	PF00917	0.738
DOC_USP7_MATH_1	351	355	PF00917	0.692
DOC_USP7_MATH_1	459	463	PF00917	0.656
DOC_USP7_MATH_1	470	474	PF00917	0.500
DOC_USP7_MATH_1	491	495	PF00917	0.482
DOC_USP7_MATH_1	565	569	PF00917	0.542
DOC_WD40_RPTOR_TOS_1	186	192	PF00400	0.497
DOC_WW_Pin1_4	1	6	PF00397	0.639
DOC_WW_Pin1_4	137	142	PF00397	0.722
DOC_WW_Pin1_4	156	161	PF00397	0.708
DOC_WW_Pin1_4	308	313	PF00397	0.644
DOC_WW_Pin1_4	384	389	PF00397	0.598
DOC_WW_Pin1_4	390	395	PF00397	0.490
DOC_WW_Pin1_4	556	561	PF00397	0.570
LIG_14-3-3_CanoR_1	202	206	PF00244	0.210
LIG_14-3-3_CanoR_1	251	257	PF00244	0.365
LIG_14-3-3_CanoR_1	290	295	PF00244	0.502
LIG_14-3-3_CanoR_1	363	373	PF00244	0.715
LIG_14-3-3_CanoR_1	406	412	PF00244	0.594
LIG_14-3-3_CanoR_1	423	429	PF00244	0.344
LIG_Actin_WH2_2	183	200	PF00022	0.422
LIG_Actin_WH2_2	275	292	PF00022	0.401
LIG_AP2alpha_1	498	502	PF02296	0.576
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_CtBP_PxDLS_1	208	212	PF00389	0.264
LIG_deltaCOP1_diTrp_1	261	270	PF00928	0.388
LIG_eIF4E_1	577	583	PF01652	0.387
LIG_FHA_1	385	391	PF00498	0.636
LIG_FHA_1	494	500	PF00498	0.650
LIG_FHA_2	439	445	PF00498	0.463
LIG_IRF3_LxIS_1	616	622	PF10401	0.366
LIG_LIR_Apic_2	554	560	PF02991	0.407
LIG_LIR_Gen_1	238	246	PF02991	0.264
LIG_LIR_Gen_1	261	270	PF02991	0.406
LIG_LIR_Gen_1	42	49	PF02991	0.293
LIG_LIR_Gen_1	509	520	PF02991	0.424
LIG_LIR_Gen_1	542	549	PF02991	0.477
LIG_LIR_Gen_1	572	583	PF02991	0.388
LIG_LIR_Gen_1	636	646	PF02991	0.434
LIG_LIR_Nem_3	192	197	PF02991	0.438
LIG_LIR_Nem_3	238	242	PF02991	0.264
LIG_LIR_Nem_3	261	266	PF02991	0.416
LIG_LIR_Nem_3	269	273	PF02991	0.330
LIG_LIR_Nem_3	36	40	PF02991	0.307
LIG_LIR_Nem_3	42	47	PF02991	0.267
LIG_LIR_Nem_3	509	515	PF02991	0.363
LIG_LIR_Nem_3	542	546	PF02991	0.470
LIG_LIR_Nem_3	572	578	PF02991	0.387
LIG_LIR_Nem_3	636	642	PF02991	0.428
LIG_LYPXL_yS_3	194	197	PF13949	0.437
LIG_LYPXL_yS_3	37	40	PF13949	0.291
LIG_NRBOX	172	178	PF00104	0.314
LIG_PCNA_yPIPBox_3	251	264	PF02747	0.385
LIG_Pex14_2	498	502	PF04695	0.482
LIG_Pex14_2	581	585	PF04695	0.364
LIG_SH2_CRK	44	48	PF00017	0.291
LIG_SH2_CRK	89	93	PF00017	0.385
LIG_SH2_STAP1	66	70	PF00017	0.294
LIG_SH2_STAP1	96	100	PF00017	0.325
LIG_SH2_STAT5	223	226	PF00017	0.331
LIG_SH2_STAT5	39	42	PF00017	0.306
LIG_SH2_STAT5	44	47	PF00017	0.275
LIG_SH2_STAT5	512	515	PF00017	0.371
LIG_SH2_STAT5	575	578	PF00017	0.312
LIG_SH3_3	159	165	PF00018	0.447
LIG_SH3_3	368	374	PF00018	0.653
LIG_SH3_3	391	397	PF00018	0.556
LIG_SH3_3	580	586	PF00018	0.401
LIG_SH3_CIN85_PxpxPR_1	374	379	PF14604	0.512
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.293
LIG_SUMO_SIM_anti_2	514	521	PF11976	0.386
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.328
LIG_TRAF2_1	645	648	PF00917	0.460
MOD_CDK_SPK_2	1	6	PF00069	0.577
MOD_CK1_1	131	137	PF00069	0.576
MOD_CK1_1	154	160	PF00069	0.807
MOD_CK1_1	262	268	PF00069	0.530
MOD_CK1_1	301	307	PF00069	0.605
MOD_CK1_1	308	314	PF00069	0.602
MOD_CK2_1	163	169	PF00069	0.513
MOD_CK2_1	426	432	PF00069	0.419
MOD_CK2_1	438	444	PF00069	0.459
MOD_CK2_1	502	508	PF00069	0.499
MOD_Cter_Amidation	120	123	PF01082	0.465
MOD_GlcNHglycan	130	133	PF01048	0.660
MOD_GlcNHglycan	153	156	PF01048	0.698
MOD_GlcNHglycan	226	229	PF01048	0.413
MOD_GlcNHglycan	307	310	PF01048	0.779
MOD_GlcNHglycan	313	317	PF01048	0.624
MOD_GlcNHglycan	341	344	PF01048	0.611
MOD_GlcNHglycan	449	452	PF01048	0.802
MOD_GlcNHglycan	461	464	PF01048	0.493
MOD_GlcNHglycan	472	475	PF01048	0.383
MOD_GlcNHglycan	493	496	PF01048	0.502
MOD_GlcNHglycan	536	539	PF01048	0.404
MOD_GlcNHglycan	599	602	PF01048	0.570
MOD_GlcNHglycan	611	614	PF01048	0.468
MOD_GSK3_1	128	135	PF00069	0.684
MOD_GSK3_1	137	144	PF00069	0.780
MOD_GSK3_1	147	154	PF00069	0.655
MOD_GSK3_1	197	204	PF00069	0.210
MOD_GSK3_1	222	229	PF00069	0.398
MOD_GSK3_1	231	238	PF00069	0.298
MOD_GSK3_1	262	269	PF00069	0.468
MOD_GSK3_1	285	292	PF00069	0.392
MOD_GSK3_1	301	308	PF00069	0.698
MOD_GSK3_1	334	341	PF00069	0.744
MOD_GSK3_1	443	450	PF00069	0.751
MOD_GSK3_1	457	464	PF00069	0.563
MOD_GSK3_1	587	594	PF00069	0.477
MOD_GSK3_1	615	622	PF00069	0.611
MOD_N-GLC_1	209	214	PF02516	0.258
MOD_N-GLC_1	555	560	PF02516	0.416
MOD_NEK2_1	197	202	PF00069	0.385
MOD_NEK2_1	209	214	PF00069	0.385
MOD_NEK2_1	266	271	PF00069	0.457
MOD_NEK2_1	289	294	PF00069	0.449
MOD_NEK2_1	40	45	PF00069	0.325
MOD_NEK2_1	481	486	PF00069	0.404
MOD_NEK2_1	502	507	PF00069	0.494
MOD_NEK2_1	511	516	PF00069	0.377
MOD_NEK2_1	591	596	PF00069	0.492
MOD_NEK2_1	81	86	PF00069	0.385
MOD_NEK2_2	226	231	PF00069	0.343
MOD_PIKK_1	132	138	PF00454	0.699
MOD_PIKK_1	633	639	PF00454	0.433
MOD_PKA_1	122	128	PF00069	0.497
MOD_PKA_1	148	154	PF00069	0.715
MOD_PKA_1	407	413	PF00069	0.481
MOD_PKA_1	608	614	PF00069	0.469
MOD_PKA_2	122	128	PF00069	0.583
MOD_PKA_2	148	154	PF00069	0.680
MOD_PKA_2	197	203	PF00069	0.385
MOD_PKA_2	289	295	PF00069	0.465
MOD_PKA_2	326	332	PF00069	0.539
MOD_PKA_2	407	413	PF00069	0.484
MOD_PKA_2	414	420	PF00069	0.430
MOD_PKA_2	481	487	PF00069	0.422
MOD_PKA_2	608	614	PF00069	0.738
MOD_PKA_2	619	625	PF00069	0.468
MOD_PKB_1	126	134	PF00069	0.728
MOD_Plk_1	141	147	PF00069	0.636
MOD_Plk_1	209	215	PF00069	0.210
MOD_Plk_1	321	327	PF00069	0.531
MOD_Plk_4	209	215	PF00069	0.326
MOD_Plk_4	226	232	PF00069	0.402
MOD_Plk_4	259	265	PF00069	0.496
MOD_Plk_4	461	467	PF00069	0.385
MOD_Plk_4	481	487	PF00069	0.387
MOD_Plk_4	511	517	PF00069	0.433
MOD_Plk_4	558	564	PF00069	0.496
MOD_ProDKin_1	1	7	PF00069	0.625
MOD_ProDKin_1	137	143	PF00069	0.723
MOD_ProDKin_1	156	162	PF00069	0.696
MOD_ProDKin_1	308	314	PF00069	0.643
MOD_ProDKin_1	384	390	PF00069	0.595
MOD_ProDKin_1	556	562	PF00069	0.535
MOD_SUMO_for_1	101	104	PF00179	0.477
MOD_SUMO_for_1	258	261	PF00179	0.433
TRG_DiLeu_BaEn_1	169	174	PF01217	0.387
TRG_DiLeu_BaEn_1	244	249	PF01217	0.385
TRG_DiLeu_BaEn_2	637	643	PF01217	0.450
TRG_DiLeu_BaEn_4	508	514	PF01217	0.429
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.507
TRG_ENDOCYTIC_2	194	197	PF00928	0.437
TRG_ENDOCYTIC_2	37	40	PF00928	0.291
TRG_ENDOCYTIC_2	44	47	PF00928	0.291
TRG_ENDOCYTIC_2	512	515	PF00928	0.378
TRG_ENDOCYTIC_2	575	578	PF00928	0.400
TRG_ER_diArg_1	122	124	PF00400	0.591
TRG_ER_diArg_1	126	129	PF00400	0.661
TRG_ER_diArg_1	276	278	PF00400	0.474
TRG_ER_diArg_1	405	408	PF00400	0.397
TRG_ER_diArg_1	421	423	PF00400	0.388
TRG_ER_diArg_1	49	51	PF00400	0.385
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3P5	Leptomonas seymouri	56%	98%
A0A3Q8I8I6	Leishmania donovani	82%	100%
A0A3R7RQU7	Trypanosoma rangeli	36%	92%
A4HU48	Leishmania infantum	82%	100%
D0A9M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	80%
E9AMX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QHP9	Leishmania major	82%	100%