MsrB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5V3_LEIBR

TriTrypDb:

LbrM.09.1300 , LBRM2903_090019700

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5V3

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	76	80	PF00656	0.469
CLV_NRD_NRD_1	71	73	PF00675	0.639
CLV_PCSK_KEX2_1	118	120	PF00082	0.366
CLV_PCSK_KEX2_1	71	73	PF00082	0.639
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.366
CLV_PCSK_PC7_1	114	120	PF00082	0.350
DEG_COP1_1	79	89	PF00400	0.454
DEG_Nend_UBRbox_2	1	3	PF02207	0.722
DEG_SPOP_SBC_1	178	182	PF00917	0.438
DOC_CKS1_1	154	159	PF01111	0.400
DOC_PP4_FxxP_1	100	103	PF00568	0.351
DOC_USP7_MATH_1	19	23	PF00917	0.625
DOC_WW_Pin1_4	103	108	PF00397	0.429
DOC_WW_Pin1_4	153	158	PF00397	0.403
DOC_WW_Pin1_4	180	185	PF00397	0.713
LIG_14-3-3_CanoR_1	168	174	PF00244	0.545
LIG_14-3-3_CanoR_1	179	184	PF00244	0.647
LIG_14-3-3_CanoR_1	65	69	PF00244	0.440
LIG_BRCT_BRCA1_1	86	90	PF00533	0.424
LIG_FHA_1	104	110	PF00498	0.541
LIG_FHA_1	90	96	PF00498	0.435
LIG_FHA_2	28	34	PF00498	0.642
LIG_LIR_Apic_2	97	103	PF02991	0.362
LIG_SH2_CRK	171	175	PF00017	0.383
LIG_SH2_NCK_1	171	175	PF00017	0.383
LIG_SH2_STAT5	129	132	PF00017	0.370
LIG_SH3_3	119	125	PF00018	0.586
LIG_SH3_3	54	60	PF00018	0.466
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.462
MOD_CDK_SPxxK_3	153	160	PF00069	0.396
MOD_CK1_1	147	153	PF00069	0.387
MOD_CK1_1	172	178	PF00069	0.585
MOD_CK1_1	22	28	PF00069	0.662
MOD_GlcNHglycan	171	174	PF01048	0.551
MOD_GlcNHglycan	4	7	PF01048	0.738
MOD_GlcNHglycan	81	85	PF01048	0.684
MOD_GlcNHglycan	86	89	PF01048	0.626
MOD_GSK3_1	138	145	PF00069	0.389
MOD_GSK3_1	169	176	PF00069	0.590
MOD_GSK3_1	80	87	PF00069	0.642
MOD_NEK2_1	169	174	PF00069	0.586
MOD_NEK2_1	95	100	PF00069	0.512
MOD_NEK2_2	64	69	PF00069	0.703
MOD_PIKK_1	138	144	PF00454	0.340
MOD_PIKK_1	73	79	PF00454	0.550
MOD_PKA_2	178	184	PF00069	0.673
MOD_PKA_2	64	70	PF00069	0.692
MOD_Plk_1	19	25	PF00069	0.537
MOD_Plk_4	124	130	PF00069	0.412
MOD_Plk_4	19	25	PF00069	0.595
MOD_Plk_4	95	101	PF00069	0.368
MOD_ProDKin_1	103	109	PF00069	0.426
MOD_ProDKin_1	153	159	PF00069	0.397
TRG_ER_diArg_1	46	49	PF00400	0.399
TRG_ER_diArg_1	70	72	PF00400	0.697

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S9	Leptomonas seymouri	63%	100%
A0A0S4JFW8	Bodo saltans	45%	100%
A0A1X0NI01	Trypanosomatidae	48%	100%
A0A3S7WQX0	Leishmania donovani	75%	100%
A0A422NZK2	Trypanosoma rangeli	52%	100%
A4HU47	Leishmania infantum	75%	100%
D0A9M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	94%
E9AMX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QHQ0	Leishmania major	74%	100%
Q570P7	Arabidopsis thaliana	26%	100%
V5BMP4	Trypanosoma cruzi	53%	100%