Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5V1_LEIBR

TriTrypDb:

LbrM.09.1280 , LBRM2903_090019400

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5V1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0046914	transition metal ion binding	5	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.681
CLV_NRD_NRD_1	284	286	PF00675	0.487
CLV_NRD_NRD_1	293	295	PF00675	0.499
CLV_NRD_NRD_1	79	81	PF00675	0.503
CLV_PCSK_FUR_1	77	81	PF00082	0.573
CLV_PCSK_KEX2_1	284	286	PF00082	0.578
CLV_PCSK_KEX2_1	293	295	PF00082	0.588
CLV_PCSK_KEX2_1	79	81	PF00082	0.503
CLV_PCSK_SKI1_1	160	164	PF00082	0.596
DEG_SPOP_SBC_1	344	348	PF00917	0.566
DOC_CDC14_PxL_1	197	205	PF14671	0.566
DOC_CDC14_PxL_1	301	309	PF14671	0.517
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.572
DOC_MAPK_gen_1	77	87	PF00069	0.489
DOC_MAPK_MEF2A_6	153	161	PF00069	0.512
DOC_MAPK_MEF2A_6	190	199	PF00069	0.469
DOC_MAPK_MEF2A_6	262	271	PF00069	0.502
DOC_MAPK_MEF2A_6	80	89	PF00069	0.523
DOC_PP2B_LxvP_1	60	63	PF13499	0.619
DOC_PP4_FxxP_1	199	202	PF00568	0.439
DOC_PP4_FxxP_1	99	102	PF00568	0.506
DOC_USP7_MATH_1	102	106	PF00917	0.357
DOC_USP7_MATH_1	12	16	PF00917	0.542
DOC_USP7_MATH_1	138	142	PF00917	0.466
DOC_USP7_MATH_1	2	6	PF00917	0.547
DOC_USP7_MATH_1	252	256	PF00917	0.576
DOC_USP7_MATH_1	392	396	PF00917	0.453
DOC_USP7_MATH_1	431	435	PF00917	0.593
DOC_USP7_MATH_1	46	50	PF00917	0.732
DOC_USP7_MATH_1	65	69	PF00917	0.375
DOC_WW_Pin1_4	263	268	PF00397	0.615
DOC_WW_Pin1_4	54	59	PF00397	0.554
DOC_WW_Pin1_4	8	13	PF00397	0.683
LIG_14-3-3_CanoR_1	293	301	PF00244	0.436
LIG_14-3-3_CanoR_1	381	389	PF00244	0.431
LIG_14-3-3_CanoR_1	8	12	PF00244	0.651
LIG_APCC_ABBA_1	159	164	PF00400	0.497
LIG_BRCT_BRCA1_1	264	268	PF00533	0.533
LIG_EVH1_1	200	204	PF00568	0.552
LIG_EVH1_1	301	305	PF00568	0.436
LIG_FHA_1	137	143	PF00498	0.498
LIG_FHA_1	150	156	PF00498	0.432
LIG_FHA_1	344	350	PF00498	0.576
LIG_FHA_1	82	88	PF00498	0.513
LIG_FHA_2	126	132	PF00498	0.468
LIG_FHA_2	174	180	PF00498	0.506
LIG_FHA_2	225	231	PF00498	0.410
LIG_FHA_2	81	87	PF00498	0.487
LIG_LIR_Apic_2	164	169	PF02991	0.581
LIG_LIR_Gen_1	149	159	PF02991	0.379
LIG_LIR_Gen_1	265	276	PF02991	0.593
LIG_LIR_Gen_1	321	329	PF02991	0.408
LIG_LIR_Gen_1	90	99	PF02991	0.426
LIG_LIR_Nem_3	149	154	PF02991	0.391
LIG_LIR_Nem_3	265	271	PF02991	0.569
LIG_LIR_Nem_3	321	325	PF02991	0.414
LIG_LIR_Nem_3	412	418	PF02991	0.615
LIG_LIR_Nem_3	90	94	PF02991	0.495
LIG_LYPXL_yS_3	304	307	PF13949	0.614
LIG_Pex14_1	218	222	PF04695	0.442
LIG_Pex14_2	162	166	PF04695	0.508
LIG_Pex14_2	95	99	PF04695	0.447
LIG_PTAP_UEV_1	340	345	PF05743	0.557
LIG_SH2_CRK	151	155	PF00017	0.470
LIG_SH2_CRK	338	342	PF00017	0.597
LIG_SH2_CRK	91	95	PF00017	0.398
LIG_SH2_NCK_1	338	342	PF00017	0.540
LIG_SH2_STAP1	151	155	PF00017	0.470
LIG_SH2_STAP1	316	320	PF00017	0.454
LIG_SH2_STAP1	81	85	PF00017	0.511
LIG_SH2_STAT3	316	319	PF00017	0.450
LIG_SH2_STAT5	151	154	PF00017	0.507
LIG_SH2_STAT5	338	341	PF00017	0.549
LIG_SH2_STAT5	350	353	PF00017	0.476
LIG_SH2_STAT5	91	94	PF00017	0.427
LIG_SH3_1	338	344	PF00018	0.560
LIG_SH3_2	305	310	PF14604	0.528
LIG_SH3_3	151	157	PF00018	0.494
LIG_SH3_3	198	204	PF00018	0.626
LIG_SH3_3	299	305	PF00018	0.559
LIG_SH3_3	33	39	PF00018	0.435
LIG_SH3_3	330	336	PF00018	0.426
LIG_SH3_3	338	344	PF00018	0.560
LIG_SH3_3	395	401	PF00018	0.478
LIG_SH3_3	55	61	PF00018	0.626
LIG_TYR_ITIM	89	94	PF00017	0.346
LIG_TYR_ITSM	147	154	PF00017	0.337
LIG_UBA3_1	279	288	PF00899	0.511
LIG_WW_2	201	204	PF00397	0.549
LIG_WW_2	305	308	PF00397	0.446
LIG_WW_3	38	42	PF00397	0.453
MOD_CK1_1	136	142	PF00069	0.461
MOD_CK1_1	366	372	PF00069	0.457
MOD_CK2_1	102	108	PF00069	0.380
MOD_CK2_1	138	144	PF00069	0.549
MOD_CK2_1	173	179	PF00069	0.505
MOD_CK2_1	224	230	PF00069	0.412
MOD_CK2_1	431	437	PF00069	0.547
MOD_CK2_1	46	52	PF00069	0.617
MOD_CK2_1	80	86	PF00069	0.549
MOD_Cter_Amidation	77	80	PF01082	0.529
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.512
MOD_GlcNHglycan	106	112	PF01048	0.432
MOD_GlcNHglycan	120	123	PF01048	0.490
MOD_GlcNHglycan	253	257	PF01048	0.594
MOD_GlcNHglycan	420	423	PF01048	0.617
MOD_GlcNHglycan	49	52	PF01048	0.725
MOD_GSK3_1	134	141	PF00069	0.602
MOD_GSK3_1	142	149	PF00069	0.427
MOD_GSK3_1	169	176	PF00069	0.487
MOD_GSK3_1	2	9	PF00069	0.634
MOD_GSK3_1	252	259	PF00069	0.526
MOD_GSK3_1	284	291	PF00069	0.488
MOD_GSK3_1	339	346	PF00069	0.506
MOD_GSK3_1	363	370	PF00069	0.472
MOD_GSK3_1	388	395	PF00069	0.547
MOD_N-GLC_1	263	268	PF02516	0.586
MOD_N-GLC_1	47	52	PF02516	0.483
MOD_N-GLC_2	242	244	PF02516	0.454
MOD_NEK2_1	418	423	PF00069	0.588
MOD_PIKK_1	136	142	PF00454	0.506
MOD_PIKK_1	173	179	PF00454	0.442
MOD_PK_1	363	369	PF00069	0.463
MOD_PKA_1	284	290	PF00069	0.398
MOD_PKA_2	224	230	PF00069	0.583
MOD_PKA_2	284	290	PF00069	0.398
MOD_PKA_2	292	298	PF00069	0.409
MOD_PKA_2	339	345	PF00069	0.564
MOD_PKA_2	7	13	PF00069	0.687
MOD_Plk_1	81	87	PF00069	0.385
MOD_Plk_4	318	324	PF00069	0.561
MOD_Plk_4	345	351	PF00069	0.549
MOD_ProDKin_1	263	269	PF00069	0.616
MOD_ProDKin_1	54	60	PF00069	0.554
MOD_ProDKin_1	8	14	PF00069	0.681
MOD_SUMO_for_1	362	365	PF00179	0.663
TRG_DiLeu_BaEn_2	29	35	PF01217	0.512
TRG_DiLeu_BaEn_2	317	323	PF01217	0.400
TRG_ENDOCYTIC_2	151	154	PF00928	0.507
TRG_ENDOCYTIC_2	304	307	PF00928	0.614
TRG_ENDOCYTIC_2	91	94	PF00928	0.468
TRG_ER_diArg_1	283	285	PF00400	0.592
TRG_ER_diArg_1	76	79	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P570	Leptomonas seymouri	43%	100%
A0A0S4JNP6	Bodo saltans	24%	100%
A0A3S7WQU3	Leishmania donovani	65%	100%
A4HU45	Leishmania infantum	65%	100%
E9AMX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QHQ2	Leishmania major	65%	99%
V5DEB3	Trypanosoma cruzi	25%	100%