RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H5U9_LEIBR

TriTrypDb:

LbrM.09.1260 , LBRM2903_090019200

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 2
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H5U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5U9

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.631
CLV_NRD_NRD_1	139	141	PF00675	0.385
CLV_NRD_NRD_1	145	147	PF00675	0.383
CLV_NRD_NRD_1	152	154	PF00675	0.367
CLV_NRD_NRD_1	313	315	PF00675	0.429
CLV_PCSK_FUR_1	311	315	PF00082	0.426
CLV_PCSK_KEX2_1	138	140	PF00082	0.385
CLV_PCSK_KEX2_1	152	154	PF00082	0.337
CLV_PCSK_KEX2_1	203	205	PF00082	0.324
CLV_PCSK_KEX2_1	313	315	PF00082	0.429
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.310
CLV_PCSK_PC7_1	199	205	PF00082	0.229
CLV_PCSK_SKI1_1	147	151	PF00082	0.385
CLV_PCSK_SKI1_1	157	161	PF00082	0.353
CLV_PCSK_SKI1_1	212	216	PF00082	0.313
CLV_PCSK_SKI1_1	227	231	PF00082	0.326
CLV_PCSK_SKI1_1	351	355	PF00082	0.460
DEG_APCC_DBOX_1	17	25	PF00400	0.474
DEG_SPOP_SBC_1	263	267	PF00917	0.621
DEG_SPOP_SBC_1	85	89	PF00917	0.412
DOC_CKS1_1	51	56	PF01111	0.479
DOC_CYCLIN_RxL_1	144	155	PF00134	0.593
DOC_CYCLIN_RxL_1	224	233	PF00134	0.613
DOC_MAPK_gen_1	311	319	PF00069	0.676
DOC_PP1_RVXF_1	128	135	PF00149	0.456
DOC_PP4_FxxP_1	219	222	PF00568	0.584
DOC_USP7_MATH_1	103	107	PF00917	0.418
DOC_USP7_MATH_1	11	15	PF00917	0.483
DOC_USP7_MATH_1	299	303	PF00917	0.675
DOC_USP7_MATH_1	312	316	PF00917	0.673
DOC_USP7_MATH_1	353	357	PF00917	0.648
DOC_USP7_MATH_1	380	384	PF00917	0.655
DOC_USP7_MATH_1	5	9	PF00917	0.581
DOC_WW_Pin1_4	187	192	PF00397	0.525
DOC_WW_Pin1_4	244	249	PF00397	0.734
DOC_WW_Pin1_4	354	359	PF00397	0.737
DOC_WW_Pin1_4	368	373	PF00397	0.655
DOC_WW_Pin1_4	50	55	PF00397	0.480
LIG_14-3-3_CanoR_1	18	22	PF00244	0.435
LIG_14-3-3_CanoR_1	311	320	PF00244	0.688
LIG_14-3-3_CanoR_1	348	358	PF00244	0.676
LIG_14-3-3_CanoR_1	45	49	PF00244	0.440
LIG_Actin_RPEL_3	123	142	PF02755	0.457
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_BIR_III_4	173	177	PF00653	0.474
LIG_EH_1	328	332	PF12763	0.720
LIG_EH1_1	223	231	PF00400	0.604
LIG_eIF4E_1	145	151	PF01652	0.581
LIG_eIF4E_1	224	230	PF01652	0.599
LIG_FHA_1	18	24	PF00498	0.436
LIG_FHA_1	314	320	PF00498	0.709
LIG_FHA_1	355	361	PF00498	0.699
LIG_FHA_1	51	57	PF00498	0.534
LIG_FHA_1	68	74	PF00498	0.408
LIG_FHA_1	92	98	PF00498	0.474
LIG_FHA_2	264	270	PF00498	0.620
LIG_FHA_2	285	291	PF00498	0.708
LIG_FHA_2	376	382	PF00498	0.732
LIG_Integrin_isoDGR_2	349	351	PF01839	0.457
LIG_LIR_Gen_1	25	35	PF02991	0.455
LIG_LIR_Gen_1	303	312	PF02991	0.643
LIG_LIR_Gen_1	58	66	PF02991	0.483
LIG_LIR_Nem_3	25	30	PF02991	0.437
LIG_LIR_Nem_3	303	309	PF02991	0.644
LIG_LIR_Nem_3	387	391	PF02991	0.819
LIG_LIR_Nem_3	47	51	PF02991	0.445
LIG_PCNA_PIPBox_1	125	134	PF02747	0.457
LIG_SH2_CRK	335	339	PF00017	0.754
LIG_SH2_CRK	388	392	PF00017	0.623
LIG_SH2_CRK	51	55	PF00017	0.479
LIG_SH2_NCK_1	335	339	PF00017	0.754
LIG_SH2_STAP1	59	63	PF00017	0.390
LIG_SH2_STAT3	225	228	PF00017	0.591
LIG_SH2_STAT5	225	228	PF00017	0.701
LIG_SH2_STAT5	335	338	PF00017	0.659
LIG_SH2_STAT5	48	51	PF00017	0.595
LIG_SH3_1	245	251	PF00018	0.647
LIG_SH3_3	245	251	PF00018	0.647
LIG_SH3_3	306	312	PF00018	0.627
LIG_SH3_3	355	361	PF00018	0.680
LIG_SH3_3	62	68	PF00018	0.530
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.323
LIG_SUMO_SIM_par_1	115	122	PF11976	0.323
LIG_TRAF2_1	340	343	PF00917	0.659
MOD_CK1_1	247	253	PF00069	0.739
MOD_CK1_1	292	298	PF00069	0.687
MOD_CK1_1	300	306	PF00069	0.682
MOD_CK1_1	9	15	PF00069	0.434
MOD_CK2_1	11	17	PF00069	0.415
MOD_CK2_1	230	236	PF00069	0.653
MOD_CK2_1	247	253	PF00069	0.625
MOD_CK2_1	263	269	PF00069	0.617
MOD_CK2_1	304	310	PF00069	0.629
MOD_CK2_1	337	343	PF00069	0.659
MOD_CK2_1	368	374	PF00069	0.706
MOD_GlcNHglycan	105	108	PF01048	0.467
MOD_GlcNHglycan	125	128	PF01048	0.375
MOD_GlcNHglycan	212	215	PF01048	0.380
MOD_GlcNHglycan	230	233	PF01048	0.341
MOD_GlcNHglycan	294	297	PF01048	0.505
MOD_GlcNHglycan	299	302	PF01048	0.470
MOD_GlcNHglycan	32	35	PF01048	0.632
MOD_GlcNHglycan	351	354	PF01048	0.611
MOD_GlcNHglycan	381	385	PF01048	0.495
MOD_GlcNHglycan	78	81	PF01048	0.671
MOD_GlcNHglycan	8	11	PF01048	0.647
MOD_GSK3_1	119	126	PF00069	0.375
MOD_GSK3_1	228	235	PF00069	0.547
MOD_GSK3_1	285	292	PF00069	0.780
MOD_GSK3_1	300	307	PF00069	0.670
MOD_GSK3_1	333	340	PF00069	0.698
MOD_GSK3_1	349	356	PF00069	0.798
MOD_GSK3_1	380	387	PF00069	0.709
MOD_GSK3_1	5	12	PF00069	0.458
MOD_N-GLC_1	239	244	PF02516	0.447
MOD_N-GLC_1	91	96	PF02516	0.718
MOD_NEK2_1	112	117	PF00069	0.375
MOD_NEK2_1	119	124	PF00069	0.313
MOD_NEK2_1	22	27	PF00069	0.458
MOD_NEK2_1	230	235	PF00069	0.559
MOD_NEK2_1	30	35	PF00069	0.469
MOD_OFUCOSY	83	90	PF10250	0.666
MOD_PKA_1	313	319	PF00069	0.635
MOD_PKA_2	17	23	PF00069	0.503
MOD_PKA_2	312	318	PF00069	0.754
MOD_PKA_2	333	339	PF00069	0.749
MOD_PKA_2	375	381	PF00069	0.646
MOD_PKA_2	44	50	PF00069	0.416
MOD_PKB_1	311	319	PF00069	0.632
MOD_Plk_1	289	295	PF00069	0.680
MOD_Plk_4	112	118	PF00069	0.288
MOD_Plk_4	119	125	PF00069	0.253
MOD_Plk_4	17	23	PF00069	0.458
MOD_Plk_4	44	50	PF00069	0.450
MOD_ProDKin_1	187	193	PF00069	0.525
MOD_ProDKin_1	244	250	PF00069	0.733
MOD_ProDKin_1	354	360	PF00069	0.736
MOD_ProDKin_1	368	374	PF00069	0.656
MOD_ProDKin_1	50	56	PF00069	0.479
MOD_SUMO_for_1	159	162	PF00179	0.613
MOD_SUMO_rev_2	162	171	PF00179	0.604
TRG_ENDOCYTIC_2	335	338	PF00928	0.754
TRG_ENDOCYTIC_2	388	391	PF00928	0.813
TRG_ENDOCYTIC_2	59	62	PF00928	0.487
TRG_ER_diArg_1	138	140	PF00400	0.585
TRG_ER_diArg_1	151	153	PF00400	0.506
TRG_ER_diArg_1	311	314	PF00400	0.627
TRG_ER_diArg_1	331	334	PF00400	0.790
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQW1	Leishmania donovani	71%	94%
A4HU43	Leishmania infantum	72%	94%
E9AMX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	95%
Q4QHQ4	Leishmania major	66%	100%