Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5U7_LEIBR

TriTrypDb:

LbrM.09.1240 , LBRM2903_090018900

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5U7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5U7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	510	514	PF00656	0.518
CLV_C14_Caspase3-7	577	581	PF00656	0.552
CLV_C14_Caspase3-7	76	80	PF00656	0.794
CLV_NRD_NRD_1	265	267	PF00675	0.503
CLV_NRD_NRD_1	269	271	PF00675	0.566
CLV_NRD_NRD_1	457	459	PF00675	0.712
CLV_NRD_NRD_1	478	480	PF00675	0.699
CLV_NRD_NRD_1	53	55	PF00675	0.744
CLV_NRD_NRD_1	584	586	PF00675	0.499
CLV_NRD_NRD_1	90	92	PF00675	0.782
CLV_PCSK_FUR_1	474	478	PF00082	0.666
CLV_PCSK_KEX2_1	265	267	PF00082	0.503
CLV_PCSK_KEX2_1	269	271	PF00082	0.566
CLV_PCSK_KEX2_1	457	459	PF00082	0.797
CLV_PCSK_KEX2_1	463	465	PF00082	0.813
CLV_PCSK_KEX2_1	474	476	PF00082	0.494
CLV_PCSK_KEX2_1	477	479	PF00082	0.502
CLV_PCSK_KEX2_1	527	529	PF00082	0.508
CLV_PCSK_KEX2_1	53	55	PF00082	0.545
CLV_PCSK_KEX2_1	583	585	PF00082	0.513
CLV_PCSK_KEX2_1	90	92	PF00082	0.638
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.817
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.508
CLV_PCSK_PC7_1	265	271	PF00082	0.515
CLV_PCSK_PC7_1	474	480	PF00082	0.624
CLV_PCSK_SKI1_1	265	269	PF00082	0.605
CLV_PCSK_SKI1_1	520	524	PF00082	0.749
CLV_PCSK_SKI1_1	90	94	PF00082	0.744
CLV_Separin_Metazoa	396	400	PF03568	0.600
DEG_APCC_DBOX_1	264	272	PF00400	0.594
DEG_SCF_FBW7_1	416	422	PF00400	0.549
DOC_CKS1_1	416	421	PF01111	0.550
DOC_CKS1_1	63	68	PF01111	0.666
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.560
DOC_MAPK_gen_1	527	533	PF00069	0.503
DOC_PP2B_LxvP_1	417	420	PF13499	0.732
DOC_PP4_FxxP_1	421	424	PF00568	0.537
DOC_PP4_FxxP_1	529	532	PF00568	0.505
DOC_SPAK_OSR1_1	528	532	PF12202	0.538
DOC_USP7_MATH_1	127	131	PF00917	0.713
DOC_USP7_MATH_1	133	137	PF00917	0.741
DOC_USP7_MATH_1	189	193	PF00917	0.686
DOC_USP7_MATH_1	208	212	PF00917	0.398
DOC_USP7_MATH_1	248	252	PF00917	0.678
DOC_USP7_MATH_1	274	278	PF00917	0.476
DOC_USP7_MATH_1	297	301	PF00917	0.614
DOC_USP7_MATH_1	4	8	PF00917	0.586
DOC_USP7_MATH_1	424	428	PF00917	0.594
DOC_USP7_MATH_1	462	466	PF00917	0.635
DOC_USP7_MATH_1	532	536	PF00917	0.723
DOC_WW_Pin1_4	11	16	PF00397	0.829
DOC_WW_Pin1_4	118	123	PF00397	0.584
DOC_WW_Pin1_4	139	144	PF00397	0.572
DOC_WW_Pin1_4	183	188	PF00397	0.501
DOC_WW_Pin1_4	236	241	PF00397	0.520
DOC_WW_Pin1_4	24	29	PF00397	0.634
DOC_WW_Pin1_4	415	420	PF00397	0.570
DOC_WW_Pin1_4	443	448	PF00397	0.511
DOC_WW_Pin1_4	591	596	PF00397	0.535
DOC_WW_Pin1_4	62	67	PF00397	0.667
LIG_14-3-3_CanoR_1	125	134	PF00244	0.538
LIG_14-3-3_CanoR_1	39	48	PF00244	0.667
LIG_14-3-3_CanoR_1	431	435	PF00244	0.552
LIG_14-3-3_CanoR_1	520	529	PF00244	0.635
LIG_BIR_II_1	1	5	PF00653	0.722
LIG_BRCT_BRCA1_1	426	430	PF00533	0.523
LIG_CtBP_PxDLS_1	344	348	PF00389	0.658
LIG_FHA_1	156	162	PF00498	0.454
LIG_FHA_1	304	310	PF00498	0.619
LIG_FHA_1	411	417	PF00498	0.808
LIG_FHA_1	431	437	PF00498	0.627
LIG_FHA_2	119	125	PF00498	0.561
LIG_FHA_2	575	581	PF00498	0.557
LIG_FHA_2	82	88	PF00498	0.637
LIG_HCF-1_HBM_1	555	558	PF13415	0.535
LIG_IBAR_NPY_1	497	499	PF08397	0.536
LIG_LIR_Apic_2	197	201	PF02991	0.440
LIG_LIR_Apic_2	418	424	PF02991	0.542
LIG_LIR_Apic_2	590	595	PF02991	0.531
LIG_LIR_Gen_1	102	113	PF02991	0.447
LIG_LIR_Gen_1	158	168	PF02991	0.707
LIG_LIR_Gen_1	220	230	PF02991	0.421
LIG_LIR_Gen_1	42	49	PF02991	0.678
LIG_LIR_Nem_3	102	108	PF02991	0.445
LIG_LIR_Nem_3	158	163	PF02991	0.693
LIG_LIR_Nem_3	220	225	PF02991	0.424
LIG_LIR_Nem_3	42	47	PF02991	0.673
LIG_LIR_Nem_3	572	578	PF02991	0.565
LIG_NRBOX	99	105	PF00104	0.452
LIG_PAM2_1	345	357	PF00658	0.623
LIG_PCNA_yPIPBox_3	511	522	PF02747	0.500
LIG_Pex14_1	107	111	PF04695	0.658
LIG_Pex14_1	310	314	PF04695	0.560
LIG_Pex14_2	156	160	PF04695	0.679
LIG_Pex14_2	40	44	PF04695	0.536
LIG_Pex3_1	100	111	PF04882	0.662
LIG_PTAP_UEV_1	65	70	PF05743	0.673
LIG_SH2_CRK	227	231	PF00017	0.550
LIG_SH2_NCK_1	227	231	PF00017	0.550
LIG_SH2_STAP1	314	318	PF00017	0.361
LIG_SH2_STAP1	41	45	PF00017	0.542
LIG_SH2_STAP1	541	545	PF00017	0.502
LIG_SH2_STAT5	227	230	PF00017	0.420
LIG_SH2_STAT5	314	317	PF00017	0.572
LIG_SH2_STAT5	499	502	PF00017	0.528
LIG_SH2_STAT5	558	561	PF00017	0.662
LIG_SH2_STAT5	567	570	PF00017	0.558
LIG_SH3_3	28	34	PF00018	0.799
LIG_SH3_3	337	343	PF00018	0.528
LIG_SH3_3	423	429	PF00018	0.693
LIG_SH3_3	547	553	PF00018	0.734
LIG_SH3_3	60	66	PF00018	0.764
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.391
LIG_SUMO_SIM_par_1	277	283	PF11976	0.391
LIG_SUMO_SIM_par_1	343	348	PF11976	0.660
LIG_TRAF2_1	22	25	PF00917	0.565
LIG_TYR_ITIM	225	230	PF00017	0.417
MOD_CDC14_SPxK_1	446	449	PF00782	0.532
MOD_CDK_SPK_2	118	123	PF00069	0.554
MOD_CDK_SPxK_1	443	449	PF00069	0.524
MOD_CDK_SPxxK_3	118	125	PF00069	0.559
MOD_CK1_1	126	132	PF00069	0.565
MOD_CK1_1	14	20	PF00069	0.594
MOD_CK1_1	210	216	PF00069	0.639
MOD_CK1_1	239	245	PF00069	0.567
MOD_CK1_1	255	261	PF00069	0.632
MOD_CK1_1	312	318	PF00069	0.429
MOD_CK1_1	516	522	PF00069	0.584
MOD_CK1_1	64	70	PF00069	0.710
MOD_CK1_1	74	80	PF00069	0.833
MOD_CK2_1	118	124	PF00069	0.578
MOD_CK2_1	238	244	PF00069	0.566
MOD_CK2_1	24	30	PF00069	0.557
MOD_CK2_1	255	261	PF00069	0.625
MOD_Cter_Amidation	51	54	PF01082	0.517
MOD_DYRK1A_RPxSP_1	139	143	PF00069	0.521
MOD_GlcNHglycan	129	132	PF01048	0.749
MOD_GlcNHglycan	135	138	PF01048	0.627
MOD_GlcNHglycan	18	21	PF01048	0.613
MOD_GlcNHglycan	276	279	PF01048	0.431
MOD_GlcNHglycan	295	298	PF01048	0.544
MOD_GlcNHglycan	319	322	PF01048	0.517
MOD_GlcNHglycan	334	337	PF01048	0.729
MOD_GlcNHglycan	470	473	PF01048	0.644
MOD_GlcNHglycan	483	486	PF01048	0.562
MOD_GlcNHglycan	515	518	PF01048	0.569
MOD_GlcNHglycan	534	537	PF01048	0.721
MOD_GlcNHglycan	56	59	PF01048	0.630
MOD_GlcNHglycan	66	69	PF01048	0.739
MOD_GlcNHglycan	73	76	PF01048	0.841
MOD_GSK3_1	123	130	PF00069	0.698
MOD_GSK3_1	133	140	PF00069	0.675
MOD_GSK3_1	155	162	PF00069	0.683
MOD_GSK3_1	225	232	PF00069	0.420
MOD_GSK3_1	235	242	PF00069	0.567
MOD_GSK3_1	246	253	PF00069	0.713
MOD_GSK3_1	283	290	PF00069	0.520
MOD_GSK3_1	293	300	PF00069	0.600
MOD_GSK3_1	309	316	PF00069	0.524
MOD_GSK3_1	406	413	PF00069	0.710
MOD_GSK3_1	415	422	PF00069	0.640
MOD_GSK3_1	509	516	PF00069	0.768
MOD_GSK3_1	532	539	PF00069	0.712
MOD_GSK3_1	574	581	PF00069	0.567
MOD_GSK3_1	67	74	PF00069	0.746
MOD_N-GLC_1	176	181	PF02516	0.569
MOD_N-GLC_1	424	429	PF02516	0.525
MOD_N-GLC_1	481	486	PF02516	0.548
MOD_N-GLC_1	569	574	PF02516	0.709
MOD_NEK2_1	155	160	PF00069	0.562
MOD_NEK2_1	16	21	PF00069	0.578
MOD_NEK2_1	176	181	PF00069	0.816
MOD_NEK2_1	218	223	PF00069	0.442
MOD_NEK2_1	225	230	PF00069	0.495
MOD_NEK2_1	250	255	PF00069	0.565
MOD_NEK2_1	309	314	PF00069	0.559
MOD_NEK2_1	345	350	PF00069	0.545
MOD_NEK2_1	430	435	PF00069	0.518
MOD_NEK2_1	521	526	PF00069	0.633
MOD_NEK2_1	578	583	PF00069	0.559
MOD_NEK2_1	99	104	PF00069	0.452
MOD_OFUCOSY	223	229	PF10250	0.597
MOD_PIKK_1	39	45	PF00454	0.642
MOD_PIKK_1	578	584	PF00454	0.562
MOD_PIKK_1	67	73	PF00454	0.579
MOD_PKA_1	90	96	PF00069	0.618
MOD_PKA_2	255	261	PF00069	0.474
MOD_PKA_2	430	436	PF00069	0.584
MOD_PKA_2	560	566	PF00069	0.591
MOD_PKA_2	90	96	PF00069	0.578
MOD_Plk_1	356	362	PF00069	0.621
MOD_Plk_1	424	430	PF00069	0.525
MOD_Plk_1	491	497	PF00069	0.817
MOD_Plk_2-3	283	289	PF00069	0.462
MOD_Plk_2-3	486	492	PF00069	0.539
MOD_Plk_4	106	112	PF00069	0.422
MOD_Plk_4	159	165	PF00069	0.574
MOD_Plk_4	345	351	PF00069	0.640
MOD_Plk_4	99	105	PF00069	0.452
MOD_ProDKin_1	11	17	PF00069	0.829
MOD_ProDKin_1	118	124	PF00069	0.586
MOD_ProDKin_1	139	145	PF00069	0.572
MOD_ProDKin_1	183	189	PF00069	0.491
MOD_ProDKin_1	236	242	PF00069	0.529
MOD_ProDKin_1	24	30	PF00069	0.633
MOD_ProDKin_1	415	421	PF00069	0.569
MOD_ProDKin_1	443	449	PF00069	0.513
MOD_ProDKin_1	62	68	PF00069	0.666
MOD_SUMO_rev_2	542	551	PF00179	0.514
TRG_ENDOCYTIC_2	227	230	PF00928	0.420
TRG_ENDOCYTIC_2	41	44	PF00928	0.542
TRG_ER_diArg_1	268	270	PF00400	0.518
TRG_ER_diArg_1	473	476	PF00400	0.693
TRG_ER_diArg_1	477	479	PF00400	0.757
TRG_ER_diArg_1	583	585	PF00400	0.489
TRG_ER_diArg_1	89	91	PF00400	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJF6	Leptomonas seymouri	31%	95%
A0A3S7WQU0	Leishmania donovani	64%	100%
A4HU41	Leishmania infantum	64%	100%
E9AMX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	99%
Q4QHQ6	Leishmania major	65%	99%