Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5U6_LEIBR

TriTrypDb:

LbrM.09.1230 , LBRM2903_090018800

Length:

971

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5U6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	609	613	PF00656	0.510
CLV_C14_Caspase3-7	736	740	PF00656	0.671
CLV_C14_Caspase3-7	773	777	PF00656	0.536
CLV_C14_Caspase3-7	786	790	PF00656	0.538
CLV_NRD_NRD_1	197	199	PF00675	0.620
CLV_NRD_NRD_1	221	223	PF00675	0.610
CLV_NRD_NRD_1	31	33	PF00675	0.515
CLV_NRD_NRD_1	314	316	PF00675	0.555
CLV_NRD_NRD_1	719	721	PF00675	0.503
CLV_NRD_NRD_1	723	725	PF00675	0.517
CLV_NRD_NRD_1	91	93	PF00675	0.494
CLV_NRD_NRD_1	952	954	PF00675	0.459
CLV_PCSK_FUR_1	717	721	PF00082	0.466
CLV_PCSK_KEX2_1	213	215	PF00082	0.765
CLV_PCSK_KEX2_1	221	223	PF00082	0.588
CLV_PCSK_KEX2_1	314	316	PF00082	0.555
CLV_PCSK_KEX2_1	716	718	PF00082	0.543
CLV_PCSK_KEX2_1	719	721	PF00082	0.501
CLV_PCSK_KEX2_1	723	725	PF00082	0.531
CLV_PCSK_KEX2_1	91	93	PF00082	0.537
CLV_PCSK_KEX2_1	952	954	PF00082	0.470
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.551
CLV_PCSK_PC1ET2_1	716	718	PF00082	0.523
CLV_PCSK_PC7_1	719	725	PF00082	0.534
CLV_PCSK_SKI1_1	214	218	PF00082	0.602
CLV_PCSK_SKI1_1	33	37	PF00082	0.514
CLV_PCSK_SKI1_1	692	696	PF00082	0.377
CLV_PCSK_SKI1_1	837	841	PF00082	0.346
CLV_PCSK_SKI1_1	880	884	PF00082	0.454
DEG_Nend_UBRbox_1	1	4	PF02207	0.538
DEG_SCF_TRCP1_1	235	241	PF00400	0.530
DEG_SPOP_SBC_1	389	393	PF00917	0.662
DEG_SPOP_SBC_1	485	489	PF00917	0.596
DEG_SPOP_SBC_1	538	542	PF00917	0.584
DEG_SPOP_SBC_1	641	645	PF00917	0.496
DOC_CKS1_1	115	120	PF01111	0.632
DOC_CKS1_1	340	345	PF01111	0.615
DOC_CKS1_1	516	521	PF01111	0.590
DOC_CKS1_1	824	829	PF01111	0.423
DOC_CKS1_1	883	888	PF01111	0.342
DOC_CYCLIN_yCln2_LP_2	824	830	PF00134	0.408
DOC_MAPK_DCC_7	326	335	PF00069	0.544
DOC_MAPK_gen_1	326	335	PF00069	0.544
DOC_MAPK_gen_1	952	960	PF00069	0.431
DOC_MAPK_MEF2A_6	683	691	PF00069	0.391
DOC_PIKK_1	123	131	PF02985	0.595
DOC_PP2B_LxvP_1	320	323	PF13499	0.545
DOC_PP2B_LxvP_1	55	58	PF13499	0.500
DOC_PP2B_LxvP_1	577	580	PF13499	0.539
DOC_PP2B_LxvP_1	845	848	PF13499	0.432
DOC_PP2B_LxvP_1	944	947	PF13499	0.340
DOC_PP2B_PxIxI_1	60	66	PF00149	0.513
DOC_PP4_MxPP_1	884	887	PF00568	0.433
DOC_USP7_MATH_1	166	170	PF00917	0.562
DOC_USP7_MATH_1	252	256	PF00917	0.668
DOC_USP7_MATH_1	389	393	PF00917	0.527
DOC_USP7_MATH_1	398	402	PF00917	0.483
DOC_USP7_MATH_1	424	428	PF00917	0.711
DOC_USP7_MATH_1	431	435	PF00917	0.628
DOC_USP7_MATH_1	485	489	PF00917	0.817
DOC_USP7_MATH_1	499	503	PF00917	0.540
DOC_USP7_MATH_1	529	533	PF00917	0.546
DOC_USP7_MATH_1	538	542	PF00917	0.626
DOC_USP7_MATH_1	585	589	PF00917	0.619
DOC_USP7_MATH_1	6	10	PF00917	0.533
DOC_USP7_MATH_1	618	622	PF00917	0.542
DOC_USP7_MATH_1	675	679	PF00917	0.512
DOC_USP7_MATH_1	742	746	PF00917	0.530
DOC_USP7_MATH_1	774	778	PF00917	0.528
DOC_USP7_MATH_1	807	811	PF00917	0.525
DOC_USP7_UBL2_3	33	37	PF12436	0.514
DOC_WW_Pin1_4	114	119	PF00397	0.791
DOC_WW_Pin1_4	131	136	PF00397	0.451
DOC_WW_Pin1_4	258	263	PF00397	0.613
DOC_WW_Pin1_4	268	273	PF00397	0.610
DOC_WW_Pin1_4	303	308	PF00397	0.604
DOC_WW_Pin1_4	313	318	PF00397	0.582
DOC_WW_Pin1_4	328	333	PF00397	0.676
DOC_WW_Pin1_4	339	344	PF00397	0.535
DOC_WW_Pin1_4	39	44	PF00397	0.543
DOC_WW_Pin1_4	396	401	PF00397	0.628
DOC_WW_Pin1_4	436	441	PF00397	0.598
DOC_WW_Pin1_4	48	53	PF00397	0.629
DOC_WW_Pin1_4	501	506	PF00397	0.707
DOC_WW_Pin1_4	507	512	PF00397	0.798
DOC_WW_Pin1_4	515	520	PF00397	0.620
DOC_WW_Pin1_4	539	544	PF00397	0.673
DOC_WW_Pin1_4	581	586	PF00397	0.661
DOC_WW_Pin1_4	646	651	PF00397	0.588
DOC_WW_Pin1_4	73	78	PF00397	0.444
DOC_WW_Pin1_4	810	815	PF00397	0.555
DOC_WW_Pin1_4	823	828	PF00397	0.357
DOC_WW_Pin1_4	830	835	PF00397	0.376
DOC_WW_Pin1_4	866	871	PF00397	0.472
DOC_WW_Pin1_4	882	887	PF00397	0.346
LIG_14-3-3_CanoR_1	214	220	PF00244	0.662
LIG_14-3-3_CanoR_1	243	248	PF00244	0.606
LIG_14-3-3_CanoR_1	26	35	PF00244	0.508
LIG_14-3-3_CanoR_1	274	282	PF00244	0.625
LIG_14-3-3_CanoR_1	448	457	PF00244	0.608
LIG_14-3-3_CanoR_1	498	508	PF00244	0.682
LIG_14-3-3_CanoR_1	583	592	PF00244	0.551
LIG_14-3-3_CanoR_1	642	650	PF00244	0.605
LIG_14-3-3_CanoR_1	683	688	PF00244	0.399
LIG_14-3-3_CanoR_1	925	929	PF00244	0.351
LIG_APCC_ABBA_1	859	864	PF00400	0.323
LIG_APCC_ABBAyCdc20_2	837	843	PF00400	0.336
LIG_BIR_III_4	277	281	PF00653	0.621
LIG_BIR_III_4	791	795	PF00653	0.541
LIG_FHA_1	110	116	PF00498	0.591
LIG_FHA_1	152	158	PF00498	0.521
LIG_FHA_1	226	232	PF00498	0.668
LIG_FHA_1	242	248	PF00498	0.586
LIG_FHA_1	340	346	PF00498	0.620
LIG_FHA_1	39	45	PF00498	0.536
LIG_FHA_1	487	493	PF00498	0.547
LIG_FHA_1	549	555	PF00498	0.668
LIG_FHA_1	572	578	PF00498	0.661
LIG_FHA_1	677	683	PF00498	0.480
LIG_FHA_1	684	690	PF00498	0.341
LIG_FHA_1	823	829	PF00498	0.391
LIG_FHA_1	953	959	PF00498	0.425
LIG_FHA_2	115	121	PF00498	0.610
LIG_FHA_2	125	131	PF00498	0.563
LIG_FHA_2	132	138	PF00498	0.473
LIG_FHA_2	145	151	PF00498	0.415
LIG_FHA_2	237	243	PF00498	0.637
LIG_FHA_2	502	508	PF00498	0.560
LIG_FHA_2	520	526	PF00498	0.786
LIG_FHA_2	771	777	PF00498	0.642
LIG_FHA_2	893	899	PF00498	0.466
LIG_FHA_2	964	970	PF00498	0.494
LIG_FXI_DFP_1	862	866	PF00024	0.317
LIG_HP1_1	827	831	PF01393	0.436
LIG_Integrin_isoDGR_2	414	416	PF01839	0.699
LIG_LIR_Apic_2	392	398	PF02991	0.552
LIG_LIR_Apic_2	506	511	PF02991	0.671
LIG_LIR_Apic_2	864	870	PF02991	0.399
LIG_LIR_Gen_1	836	847	PF02991	0.356
LIG_LIR_Gen_1	864	873	PF02991	0.360
LIG_LIR_Nem_3	860	865	PF02991	0.346
LIG_LYPXL_S_1	861	865	PF13949	0.315
LIG_Pex14_1	835	839	PF04695	0.356
LIG_Pex14_1	918	922	PF04695	0.331
LIG_Pex14_1	93	97	PF04695	0.491
LIG_SH2_CRK	395	399	PF00017	0.517
LIG_SH2_PTP2	867	870	PF00017	0.322
LIG_SH2_SRC	625	628	PF00017	0.495
LIG_SH2_STAP1	144	148	PF00017	0.504
LIG_SH2_STAT5	139	142	PF00017	0.542
LIG_SH2_STAT5	867	870	PF00017	0.322
LIG_SH3_1	867	873	PF00018	0.335
LIG_SH3_2	297	302	PF14604	0.545
LIG_SH3_3	285	291	PF00018	0.539
LIG_SH3_3	293	299	PF00018	0.531
LIG_SH3_3	301	307	PF00018	0.513
LIG_SH3_3	434	440	PF00018	0.595
LIG_SH3_3	55	61	PF00018	0.532
LIG_SH3_3	557	563	PF00018	0.665
LIG_SH3_3	573	579	PF00018	0.574
LIG_SH3_3	811	817	PF00018	0.565
LIG_SH3_3	867	873	PF00018	0.335
LIG_SH3_3	883	889	PF00018	0.422
LIG_SH3_3	98	104	PF00018	0.486
LIG_SH3_5	863	867	PF00018	0.387
LIG_SUMO_SIM_anti_2	244	251	PF11976	0.541
LIG_SUMO_SIM_anti_2	331	338	PF11976	0.538
LIG_SUMO_SIM_par_1	331	338	PF11976	0.538
LIG_SUMO_SIM_par_1	60	69	PF11976	0.566
LIG_SUMO_SIM_par_1	678	686	PF11976	0.340
LIG_SUMO_SIM_par_1	825	833	PF11976	0.434
LIG_TRAF2_1	204	207	PF00917	0.547
LIG_TRAF2_1	347	350	PF00917	0.639
LIG_TRAF2_1	847	850	PF00917	0.315
LIG_TRAF2_1	966	969	PF00917	0.651
LIG_UBA3_1	687	695	PF00899	0.375
LIG_UBA3_1	896	904	PF00899	0.423
MOD_CDC14_SPxK_1	261	264	PF00782	0.661
MOD_CDK_SPK_2	303	308	PF00069	0.569
MOD_CDK_SPK_2	48	53	PF00069	0.599
MOD_CDK_SPK_2	646	651	PF00069	0.529
MOD_CDK_SPxK_1	258	264	PF00069	0.614
MOD_CDK_SPxK_1	268	274	PF00069	0.611
MOD_CDK_SPxK_1	539	545	PF00069	0.546
MOD_CDK_SPxxK_3	646	653	PF00069	0.510
MOD_CDK_SPxxK_3	830	837	PF00069	0.347
MOD_CK1_1	149	155	PF00069	0.560
MOD_CK1_1	236	242	PF00069	0.590
MOD_CK1_1	257	263	PF00069	0.674
MOD_CK1_1	325	331	PF00069	0.719
MOD_CK1_1	341	347	PF00069	0.679
MOD_CK1_1	360	366	PF00069	0.636
MOD_CK1_1	374	380	PF00069	0.666
MOD_CK1_1	4	10	PF00069	0.530
MOD_CK1_1	488	494	PF00069	0.689
MOD_CK1_1	497	503	PF00069	0.649
MOD_CK1_1	51	57	PF00069	0.510
MOD_CK1_1	510	516	PF00069	0.589
MOD_CK1_1	541	547	PF00069	0.636
MOD_CK1_1	649	655	PF00069	0.617
MOD_CK1_1	664	670	PF00069	0.628
MOD_CK1_1	678	684	PF00069	0.341
MOD_CK1_1	740	746	PF00069	0.560
MOD_CK1_1	747	753	PF00069	0.515
MOD_CK1_1	754	760	PF00069	0.593
MOD_CK1_1	76	82	PF00069	0.439
MOD_CK1_1	772	778	PF00069	0.608
MOD_CK1_1	783	789	PF00069	0.666
MOD_CK1_1	810	816	PF00069	0.507
MOD_CK1_1	948	954	PF00069	0.433
MOD_CK2_1	131	137	PF00069	0.518
MOD_CK2_1	201	207	PF00069	0.604
MOD_CK2_1	247	253	PF00069	0.605
MOD_CK2_1	344	350	PF00069	0.637
MOD_CK2_1	455	461	PF00069	0.534
MOD_CK2_1	501	507	PF00069	0.549
MOD_CK2_1	65	71	PF00069	0.522
MOD_CK2_1	830	836	PF00069	0.403
MOD_CK2_1	892	898	PF00069	0.469
MOD_CK2_1	948	954	PF00069	0.481
MOD_CK2_1	963	969	PF00069	0.571
MOD_GlcNHglycan	154	157	PF01048	0.593
MOD_GlcNHglycan	163	166	PF01048	0.584
MOD_GlcNHglycan	235	238	PF01048	0.575
MOD_GlcNHglycan	250	253	PF01048	0.508
MOD_GlcNHglycan	346	349	PF01048	0.690
MOD_GlcNHglycan	359	362	PF01048	0.580
MOD_GlcNHglycan	409	412	PF01048	0.590
MOD_GlcNHglycan	457	460	PF01048	0.588
MOD_GlcNHglycan	493	496	PF01048	0.624
MOD_GlcNHglycan	587	590	PF01048	0.664
MOD_GlcNHglycan	594	597	PF01048	0.610
MOD_GlcNHglycan	608	611	PF01048	0.532
MOD_GlcNHglycan	632	635	PF01048	0.516
MOD_GlcNHglycan	666	669	PF01048	0.749
MOD_GlcNHglycan	731	734	PF01048	0.659
MOD_GlcNHglycan	739	743	PF01048	0.583
MOD_GlcNHglycan	753	756	PF01048	0.552
MOD_GlcNHglycan	809	812	PF01048	0.631
MOD_GSK3_1	2	9	PF00069	0.532
MOD_GSK3_1	243	250	PF00069	0.604
MOD_GSK3_1	252	259	PF00069	0.607
MOD_GSK3_1	264	271	PF00069	0.611
MOD_GSK3_1	309	316	PF00069	0.615
MOD_GSK3_1	318	325	PF00069	0.709
MOD_GSK3_1	335	342	PF00069	0.571
MOD_GSK3_1	403	410	PF00069	0.555
MOD_GSK3_1	431	438	PF00069	0.629
MOD_GSK3_1	47	54	PF00069	0.605
MOD_GSK3_1	484	491	PF00069	0.655
MOD_GSK3_1	497	504	PF00069	0.584
MOD_GSK3_1	515	522	PF00069	0.618
MOD_GSK3_1	537	544	PF00069	0.644
MOD_GSK3_1	581	588	PF00069	0.615
MOD_GSK3_1	61	68	PF00069	0.434
MOD_GSK3_1	642	649	PF00069	0.732
MOD_GSK3_1	667	674	PF00069	0.547
MOD_GSK3_1	678	685	PF00069	0.363
MOD_GSK3_1	71	78	PF00069	0.510
MOD_GSK3_1	738	745	PF00069	0.615
MOD_GSK3_1	747	754	PF00069	0.595
MOD_GSK3_1	765	772	PF00069	0.494
MOD_GSK3_1	806	813	PF00069	0.632
MOD_GSK3_1	948	955	PF00069	0.417
MOD_N-GLC_1	161	166	PF02516	0.521
MOD_N-GLC_1	257	262	PF02516	0.546
MOD_N-GLC_1	338	343	PF02516	0.530
MOD_N-GLC_1	606	611	PF02516	0.514
MOD_N-GLC_1	728	733	PF02516	0.518
MOD_N-GLC_1	737	742	PF02516	0.505
MOD_N-GLC_1	758	763	PF02516	0.532
MOD_N-GLC_2	801	803	PF02516	0.527
MOD_NEK2_1	1	6	PF00069	0.534
MOD_NEK2_1	256	261	PF00069	0.613
MOD_NEK2_1	309	314	PF00069	0.683
MOD_NEK2_1	335	340	PF00069	0.535
MOD_NEK2_1	38	43	PF00069	0.615
MOD_NEK2_1	466	471	PF00069	0.527
MOD_NEK2_1	592	597	PF00069	0.555
MOD_NEK2_1	619	624	PF00069	0.574
MOD_NEK2_1	640	645	PF00069	0.545
MOD_NEK2_1	722	727	PF00069	0.489
MOD_NEK2_2	31	36	PF00069	0.515
MOD_PIKK_1	546	552	PF00454	0.557
MOD_PKA_1	91	97	PF00069	0.429
MOD_PKA_1	952	958	PF00069	0.425
MOD_PKA_2	1	7	PF00069	0.534
MOD_PKA_2	109	115	PF00069	0.477
MOD_PKA_2	25	31	PF00069	0.506
MOD_PKA_2	273	279	PF00069	0.651
MOD_PKA_2	325	331	PF00069	0.613
MOD_PKA_2	374	380	PF00069	0.675
MOD_PKA_2	497	503	PF00069	0.693
MOD_PKA_2	641	647	PF00069	0.598
MOD_PKA_2	682	688	PF00069	0.395
MOD_PKA_2	722	728	PF00069	0.545
MOD_PKA_2	91	97	PF00069	0.429
MOD_PKA_2	924	930	PF00069	0.351
MOD_PKA_2	952	958	PF00069	0.398
MOD_Plk_1	241	247	PF00069	0.587
MOD_Plk_1	775	781	PF00069	0.595
MOD_Plk_2-3	765	771	PF00069	0.616
MOD_Plk_2-3	785	791	PF00069	0.548
MOD_Plk_4	243	249	PF00069	0.604
MOD_Plk_4	31	37	PF00069	0.515
MOD_Plk_4	341	347	PF00069	0.648
MOD_Plk_4	450	456	PF00069	0.611
MOD_Plk_4	555	561	PF00069	0.550
MOD_Plk_4	619	625	PF00069	0.440
MOD_Plk_4	683	689	PF00069	0.384
MOD_Plk_4	892	898	PF00069	0.404
MOD_ProDKin_1	114	120	PF00069	0.794
MOD_ProDKin_1	131	137	PF00069	0.447
MOD_ProDKin_1	258	264	PF00069	0.614
MOD_ProDKin_1	268	274	PF00069	0.611
MOD_ProDKin_1	303	309	PF00069	0.606
MOD_ProDKin_1	313	319	PF00069	0.583
MOD_ProDKin_1	328	334	PF00069	0.677
MOD_ProDKin_1	339	345	PF00069	0.537
MOD_ProDKin_1	39	45	PF00069	0.544
MOD_ProDKin_1	396	402	PF00069	0.631
MOD_ProDKin_1	436	442	PF00069	0.601
MOD_ProDKin_1	48	54	PF00069	0.628
MOD_ProDKin_1	501	507	PF00069	0.707
MOD_ProDKin_1	515	521	PF00069	0.619
MOD_ProDKin_1	539	545	PF00069	0.674
MOD_ProDKin_1	581	587	PF00069	0.661
MOD_ProDKin_1	646	652	PF00069	0.585
MOD_ProDKin_1	73	79	PF00069	0.442
MOD_ProDKin_1	810	816	PF00069	0.545
MOD_ProDKin_1	823	829	PF00069	0.351
MOD_ProDKin_1	830	836	PF00069	0.368
MOD_ProDKin_1	866	872	PF00069	0.480
MOD_ProDKin_1	882	888	PF00069	0.341
MOD_SUMO_for_1	958	961	PF00179	0.444
MOD_SUMO_rev_2	871	879	PF00179	0.492
TRG_DiLeu_BaEn_1	935	940	PF01217	0.366
TRG_ENDOCYTIC_2	841	844	PF00928	0.364
TRG_ENDOCYTIC_2	862	865	PF00928	0.438
TRG_ER_diArg_1	193	196	PF00400	0.635
TRG_ER_diArg_1	313	315	PF00400	0.548
TRG_ER_diArg_1	650	653	PF00400	0.510
TRG_ER_diArg_1	717	720	PF00400	0.535
TRG_ER_diArg_1	722	724	PF00400	0.556
TRG_ER_diArg_1	90	92	PF00400	0.538
TRG_NLS_MonoCore_2	715	720	PF00514	0.523
TRG_NLS_MonoExtC_3	715	720	PF00514	0.448
TRG_NLS_MonoExtN_4	713	720	PF00514	0.438
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVE1	Leptomonas seymouri	33%	96%
A0A3S5H6E5	Leishmania donovani	59%	96%
A4HU40	Leishmania infantum	64%	100%
E9AMW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	99%
Q4QHQ7	Leishmania major	59%	99%