Skp1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5U5_LEIBR

TriTrypDb:

LbrM.09.1220 , LBRM2903_090018700

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H5U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5U5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901575	organic substance catabolic process	3	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.745
CLV_MEL_PAP_1	128	134	PF00089	0.488
CLV_NRD_NRD_1	164	166	PF00675	0.543
CLV_NRD_NRD_1	183	185	PF00675	0.623
CLV_PCSK_KEX2_1	183	185	PF00082	0.623
CLV_PCSK_SKI1_1	165	169	PF00082	0.506
CLV_PCSK_SKI1_1	25	29	PF00082	0.530
CLV_PCSK_SKI1_1	70	74	PF00082	0.548
CLV_PCSK_SKI1_1	93	97	PF00082	0.504
DOC_CYCLIN_RxL_1	22	32	PF00134	0.301
DOC_MAPK_gen_1	113	123	PF00069	0.502
LIG_14-3-3_CanoR_1	131	138	PF00244	0.467
LIG_14-3-3_CanoR_1	93	102	PF00244	0.480
LIG_Actin_WH2_2	117	133	PF00022	0.519
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_BIR_III_2	57	61	PF00653	0.446
LIG_FHA_1	86	92	PF00498	0.540
LIG_FHA_1	94	100	PF00498	0.459
LIG_FHA_2	173	179	PF00498	0.478
LIG_FHA_2	21	27	PF00498	0.535
LIG_GBD_Chelix_1	120	128	PF00786	0.485
LIG_LIR_Gen_1	78	83	PF02991	0.448
LIG_LIR_Nem_3	78	82	PF02991	0.391
LIG_NRBOX	119	125	PF00104	0.439
LIG_SH2_CRK	79	83	PF00017	0.502
LIG_SH2_PTP2	142	145	PF00017	0.263
LIG_SH2_STAP1	15	19	PF00017	0.543
LIG_SH2_STAP1	188	192	PF00017	0.488
LIG_SH2_STAP1	68	72	PF00017	0.410
LIG_SH2_STAT5	119	122	PF00017	0.438
LIG_SH2_STAT5	142	145	PF00017	0.348
LIG_SH3_3	14	20	PF00018	0.456
LIG_SUMO_SIM_anti_2	71	78	PF11976	0.529
LIG_TRAF2_1	175	178	PF00917	0.502
LIG_TRAF2_1	2	5	PF00917	0.625
LIG_TRFH_1	79	83	PF08558	0.525
MOD_CK1_1	13	19	PF00069	0.536
MOD_CK1_1	133	139	PF00069	0.480
MOD_CK2_1	172	178	PF00069	0.481
MOD_CK2_1	20	26	PF00069	0.537
MOD_GlcNHglycan	12	15	PF01048	0.598
MOD_GlcNHglycan	135	138	PF01048	0.473
MOD_GlcNHglycan	48	52	PF01048	0.596
MOD_GSK3_1	81	88	PF00069	0.551
MOD_N-GLC_1	10	15	PF02516	0.569
MOD_NEK2_1	130	135	PF00069	0.468
MOD_NEK2_1	7	12	PF00069	0.503
MOD_PIKK_1	130	136	PF00454	0.469
MOD_PIKK_1	93	99	PF00454	0.578
MOD_PKA_2	130	136	PF00069	0.469
MOD_PKA_2	7	13	PF00069	0.513
MOD_SUMO_for_1	61	64	PF00179	0.578
TRG_DiLeu_BaEn_4	177	183	PF01217	0.481
TRG_ENDOCYTIC_2	142	145	PF00928	0.460
TRG_ENDOCYTIC_2	79	82	PF00928	0.468
TRG_ER_diArg_1	182	184	PF00400	0.592
TRG_NES_CRM1_1	118	134	PF08389	0.494
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1U4	Leptomonas seymouri	64%	96%
A0A0S4J983	Bodo saltans	31%	77%
A0A0S4JCU4	Bodo saltans	26%	100%
A0A1X0NIG1	Trypanosomatidae	39%	100%
A0A3S7WQT5	Leishmania donovani	90%	100%
A0A422NZK1	Trypanosoma rangeli	39%	100%
A4HU39	Leishmania infantum	90%	100%
D0A9L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AMW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QHQ8	Leishmania major	91%	99%
V5BDJ1	Trypanosoma cruzi	40%	100%