Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5U4_LEIBR

TriTrypDb:

LbrM.09.1210 , LBRM2903_090018600

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H5U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5U4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.647
CLV_NRD_NRD_1	287	289	PF00675	0.467
CLV_NRD_NRD_1	482	484	PF00675	0.527
CLV_NRD_NRD_1	52	54	PF00675	0.454
CLV_NRD_NRD_1	678	680	PF00675	0.676
CLV_NRD_NRD_1	721	723	PF00675	0.662
CLV_NRD_NRD_1	73	75	PF00675	0.476
CLV_NRD_NRD_1	731	733	PF00675	0.700
CLV_PCSK_FUR_1	288	292	PF00082	0.446
CLV_PCSK_KEX2_1	287	289	PF00082	0.468
CLV_PCSK_KEX2_1	290	292	PF00082	0.468
CLV_PCSK_KEX2_1	482	484	PF00082	0.518
CLV_PCSK_KEX2_1	538	540	PF00082	0.453
CLV_PCSK_KEX2_1	721	723	PF00082	0.622
CLV_PCSK_KEX2_1	73	75	PF00082	0.476
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.474
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.490
CLV_PCSK_PC7_1	69	75	PF00082	0.374
CLV_PCSK_SKI1_1	214	218	PF00082	0.435
CLV_PCSK_SKI1_1	287	291	PF00082	0.582
CLV_PCSK_SKI1_1	325	329	PF00082	0.402
CLV_PCSK_SKI1_1	485	489	PF00082	0.454
CLV_PCSK_SKI1_1	59	63	PF00082	0.358
CLV_PCSK_SKI1_1	620	624	PF00082	0.512
CLV_PCSK_SKI1_1	696	700	PF00082	0.590
CLV_PCSK_SKI1_1	710	714	PF00082	0.493
CLV_PCSK_SKI1_1	98	102	PF00082	0.365
DEG_APCC_DBOX_1	219	227	PF00400	0.567
DEG_APCC_DBOX_1	552	560	PF00400	0.697
DEG_SCF_FBW7_2	278	285	PF00400	0.588
DEG_SPOP_SBC_1	469	473	PF00917	0.724
DOC_CKS1_1	254	259	PF01111	0.577
DOC_CKS1_1	279	284	PF01111	0.589
DOC_MAPK_gen_1	585	593	PF00069	0.523
DOC_MAPK_gen_1	729	738	PF00069	0.455
DOC_MAPK_MEF2A_6	585	593	PF00069	0.562
DOC_PP1_RVXF_1	57	64	PF00149	0.566
DOC_PP4_FxxP_1	186	189	PF00568	0.637
DOC_USP7_MATH_1	240	244	PF00917	0.736
DOC_USP7_MATH_1	280	284	PF00917	0.599
DOC_USP7_MATH_1	320	324	PF00917	0.654
DOC_USP7_MATH_1	446	450	PF00917	0.630
DOC_USP7_MATH_1	469	473	PF00917	0.741
DOC_USP7_MATH_1	475	479	PF00917	0.737
DOC_USP7_MATH_1	578	582	PF00917	0.756
DOC_USP7_MATH_1	80	84	PF00917	0.663
DOC_USP7_UBL2_3	410	414	PF12436	0.661
DOC_USP7_UBL2_3	729	733	PF12436	0.403
DOC_WW_Pin1_4	253	258	PF00397	0.652
DOC_WW_Pin1_4	274	279	PF00397	0.726
DOC_WW_Pin1_4	551	556	PF00397	0.726
DOC_WW_Pin1_4	557	562	PF00397	0.738
DOC_WW_Pin1_4	82	87	PF00397	0.741
LIG_14-3-3_CanoR_1	17	26	PF00244	0.752
LIG_14-3-3_CanoR_1	248	257	PF00244	0.587
LIG_14-3-3_CanoR_1	325	330	PF00244	0.638
LIG_14-3-3_CanoR_1	513	519	PF00244	0.664
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BRCT_BRCA1_1	119	123	PF00533	0.551
LIG_BRCT_BRCA1_1	2	6	PF00533	0.589
LIG_BRCT_BRCA1_1	92	96	PF00533	0.646
LIG_Clathr_ClatBox_1	175	179	PF01394	0.575
LIG_CSL_BTD_1	645	648	PF09270	0.372
LIG_FHA_1	249	255	PF00498	0.570
LIG_FHA_1	259	265	PF00498	0.599
LIG_FHA_1	279	285	PF00498	0.729
LIG_FHA_1	364	370	PF00498	0.518
LIG_FHA_1	426	432	PF00498	0.694
LIG_FHA_1	474	480	PF00498	0.667
LIG_FHA_1	509	515	PF00498	0.737
LIG_FHA_1	657	663	PF00498	0.383
LIG_FHA_2	326	332	PF00498	0.627
LIG_FHA_2	498	504	PF00498	0.731
LIG_FHA_2	603	609	PF00498	0.648
LIG_LIR_Apic_2	202	208	PF02991	0.682
LIG_LIR_Gen_1	130	141	PF02991	0.618
LIG_LIR_Gen_1	308	319	PF02991	0.639
LIG_LIR_Gen_1	416	427	PF02991	0.707
LIG_LIR_Gen_1	587	597	PF02991	0.619
LIG_LIR_Gen_1	683	692	PF02991	0.299
LIG_LIR_Nem_3	130	136	PF02991	0.622
LIG_LIR_Nem_3	308	314	PF02991	0.603
LIG_LIR_Nem_3	331	337	PF02991	0.608
LIG_LIR_Nem_3	416	422	PF02991	0.701
LIG_LIR_Nem_3	587	593	PF02991	0.618
LIG_LIR_Nem_3	60	66	PF02991	0.561
LIG_LIR_Nem_3	636	641	PF02991	0.651
LIG_LIR_Nem_3	683	688	PF02991	0.302
LIG_LYPXL_yS_3	577	580	PF13949	0.702
LIG_MYND_1	557	561	PF01753	0.701
LIG_PCNA_yPIPBox_3	615	623	PF02747	0.537
LIG_Pex14_1	333	337	PF04695	0.571
LIG_Pex14_2	186	190	PF04695	0.602
LIG_Pex14_2	62	66	PF04695	0.601
LIG_Pex14_2	96	100	PF04695	0.635
LIG_PTAP_UEV_1	76	81	PF05743	0.601
LIG_RPA_C_Fungi	478	490	PF08784	0.440
LIG_SH2_GRB2like	336	339	PF00017	0.588
LIG_SH2_GRB2like	641	644	PF00017	0.393
LIG_SH2_NCK_1	271	275	PF00017	0.490
LIG_SH2_NCK_1	92	96	PF00017	0.383
LIG_SH2_PTP2	406	409	PF00017	0.392
LIG_SH2_SRC	112	115	PF00017	0.405
LIG_SH2_SRC	379	382	PF00017	0.718
LIG_SH2_SRC	406	409	PF00017	0.559
LIG_SH2_SRC	628	631	PF00017	0.585
LIG_SH2_SRC	641	644	PF00017	0.393
LIG_SH2_STAP1	271	275	PF00017	0.490
LIG_SH2_STAP1	359	363	PF00017	0.518
LIG_SH2_STAP1	427	431	PF00017	0.403
LIG_SH2_STAP1	672	676	PF00017	0.352
LIG_SH2_STAP1	92	96	PF00017	0.525
LIG_SH2_STAT3	359	362	PF00017	0.578
LIG_SH2_STAT3	408	411	PF00017	0.415
LIG_SH2_STAT3	495	498	PF00017	0.611
LIG_SH2_STAT3	72	75	PF00017	0.621
LIG_SH2_STAT5	133	136	PF00017	0.494
LIG_SH2_STAT5	406	409	PF00017	0.470
LIG_SH2_STAT5	427	430	PF00017	0.408
LIG_SH2_STAT5	590	593	PF00017	0.603
LIG_SH2_STAT5	600	603	PF00017	0.614
LIG_SH2_STAT5	621	624	PF00017	0.548
LIG_SH2_STAT5	641	644	PF00017	0.389
LIG_SH2_STAT5	661	664	PF00017	0.282
LIG_SH3_1	291	297	PF00018	0.609
LIG_SH3_1	74	80	PF00018	0.496
LIG_SH3_2	294	299	PF14604	0.657
LIG_SH3_3	234	240	PF00018	0.690
LIG_SH3_3	276	282	PF00018	0.701
LIG_SH3_3	291	297	PF00018	0.517
LIG_SH3_3	5	11	PF00018	0.483
LIG_SH3_3	74	80	PF00018	0.647
LIG_SUMO_SIM_par_1	222	230	PF11976	0.590
LIG_SUMO_SIM_par_1	607	614	PF11976	0.428
LIG_TRAF2_1	163	166	PF00917	0.447
LIG_TRAF2_1	305	308	PF00917	0.408
LIG_TRAF2_1	500	503	PF00917	0.606
LIG_TRAF2_1	605	608	PF00917	0.485
LIG_TYR_ITIM	404	409	PF00017	0.628
LIG_UBA3_1	533	538	PF00899	0.671
LIG_UBA3_1	609	617	PF00899	0.390
MOD_CK1_1	230	236	PF00069	0.667
MOD_CK1_1	28	34	PF00069	0.748
MOD_CK1_1	283	289	PF00069	0.745
MOD_CK1_1	468	474	PF00069	0.682
MOD_CK1_1	478	484	PF00069	0.504
MOD_CK1_1	560	566	PF00069	0.620
MOD_CK2_1	230	236	PF00069	0.718
MOD_CK2_1	452	458	PF00069	0.671
MOD_CK2_1	497	503	PF00069	0.601
MOD_CK2_1	602	608	PF00069	0.614
MOD_Cter_Amidation	51	54	PF01082	0.597
MOD_Cter_Amidation	730	733	PF01082	0.572
MOD_GlcNHglycan	2	5	PF01048	0.604
MOD_GlcNHglycan	232	235	PF01048	0.625
MOD_GlcNHglycan	27	30	PF01048	0.719
MOD_GlcNHglycan	322	325	PF01048	0.585
MOD_GlcNHglycan	347	350	PF01048	0.729
MOD_GlcNHglycan	401	404	PF01048	0.527
MOD_GlcNHglycan	467	470	PF01048	0.782
MOD_GlcNHglycan	574	577	PF01048	0.574
MOD_GlcNHglycan	580	583	PF01048	0.519
MOD_GlcNHglycan	602	605	PF01048	0.545
MOD_GlcNHglycan	77	80	PF01048	0.634
MOD_GSK3_1	24	31	PF00069	0.798
MOD_GSK3_1	274	281	PF00069	0.610
MOD_GSK3_1	442	449	PF00069	0.538
MOD_GSK3_1	463	470	PF00069	0.625
MOD_GSK3_1	471	478	PF00069	0.553
MOD_GSK3_1	514	521	PF00069	0.634
MOD_GSK3_1	572	579	PF00069	0.691
MOD_GSK3_1	716	723	PF00069	0.518
MOD_GSK3_1	81	88	PF00069	0.760
MOD_LATS_1	547	553	PF00433	0.601
MOD_N-GLC_1	716	721	PF02516	0.661
MOD_NEK2_1	342	347	PF00069	0.649
MOD_NEK2_1	399	404	PF00069	0.556
MOD_NEK2_1	418	423	PF00069	0.674
MOD_NEK2_1	514	519	PF00069	0.679
MOD_NEK2_1	589	594	PF00069	0.514
MOD_NEK2_1	716	721	PF00069	0.464
MOD_NEK2_2	12	17	PF00069	0.648
MOD_NEK2_2	353	358	PF00069	0.448
MOD_PIKK_1	18	24	PF00454	0.661
MOD_PIKK_1	342	348	PF00454	0.590
MOD_PIKK_1	363	369	PF00454	0.608
MOD_PIKK_1	563	569	PF00454	0.484
MOD_PKA_1	721	727	PF00069	0.579
MOD_PKA_2	230	236	PF00069	0.762
MOD_PKA_2	373	379	PF00069	0.690
MOD_PKA_2	39	45	PF00069	0.624
MOD_PKA_2	508	514	PF00069	0.612
MOD_PKA_2	681	687	PF00069	0.549
MOD_PKA_2	720	726	PF00069	0.526
MOD_Plk_1	353	359	PF00069	0.638
MOD_Plk_1	446	452	PF00069	0.584
MOD_Plk_1	716	722	PF00069	0.670
MOD_Plk_2-3	608	614	PF00069	0.423
MOD_Plk_4	117	123	PF00069	0.525
MOD_Plk_4	136	142	PF00069	0.344
MOD_Plk_4	325	331	PF00069	0.512
MOD_Plk_4	418	424	PF00069	0.529
MOD_Plk_4	589	595	PF00069	0.493
MOD_Plk_4	633	639	PF00069	0.509
MOD_ProDKin_1	253	259	PF00069	0.575
MOD_ProDKin_1	274	280	PF00069	0.676
MOD_ProDKin_1	551	557	PF00069	0.677
MOD_ProDKin_1	82	88	PF00069	0.693
MOD_SUMO_rev_2	503	508	PF00179	0.527
MOD_SUMO_rev_2	581	589	PF00179	0.404
TRG_DiLeu_BaEn_1	529	534	PF01217	0.523
TRG_DiLeu_BaEn_4	607	613	PF01217	0.393
TRG_DiLeu_BaEn_4	629	635	PF01217	0.522
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.446
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.454
TRG_DiLeu_BaLyEn_6	645	650	PF01217	0.393
TRG_DiLeu_LyEn_5	529	534	PF01217	0.381
TRG_ENDOCYTIC_2	104	107	PF00928	0.446
TRG_ENDOCYTIC_2	133	136	PF00928	0.494
TRG_ENDOCYTIC_2	336	339	PF00928	0.550
TRG_ENDOCYTIC_2	406	409	PF00928	0.491
TRG_ENDOCYTIC_2	415	418	PF00928	0.538
TRG_ENDOCYTIC_2	577	580	PF00928	0.616
TRG_ENDOCYTIC_2	590	593	PF00928	0.460
TRG_ENDOCYTIC_2	685	688	PF00928	0.365
TRG_ER_diArg_1	287	289	PF00400	0.592
TRG_ER_diArg_1	482	485	PF00400	0.668
TRG_ER_diArg_1	72	74	PF00400	0.591
TRG_ER_diArg_1	720	722	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.732

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTV6	Leptomonas seymouri	52%	100%
A0A0S4JUS6	Bodo saltans	24%	100%
A0A3Q8IH12	Leishmania donovani	77%	100%
A0A422NZM2	Trypanosoma rangeli	31%	100%
A4HU38	Leishmania infantum	76%	100%
E9AMW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QHQ9	Leishmania major	75%	99%
V5DEB6	Trypanosoma cruzi	33%	100%