Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H5U3_LEIBR

TriTrypDb:

LbrM.09.1200 , LBRM2903_090018500

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H5U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H5U3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	181	187	PF00089	0.657
CLV_NRD_NRD_1	173	175	PF00675	0.459
CLV_NRD_NRD_1	177	179	PF00675	0.460
CLV_NRD_NRD_1	183	185	PF00675	0.518
CLV_NRD_NRD_1	227	229	PF00675	0.577
CLV_NRD_NRD_1	230	232	PF00675	0.617
CLV_NRD_NRD_1	265	267	PF00675	0.615
CLV_NRD_NRD_1	272	274	PF00675	0.539
CLV_NRD_NRD_1	45	47	PF00675	0.487
CLV_PCSK_FUR_1	228	232	PF00082	0.639
CLV_PCSK_FUR_1	46	50	PF00082	0.449
CLV_PCSK_KEX2_1	100	102	PF00082	0.509
CLV_PCSK_KEX2_1	166	168	PF00082	0.487
CLV_PCSK_KEX2_1	173	175	PF00082	0.456
CLV_PCSK_KEX2_1	177	179	PF00082	0.465
CLV_PCSK_KEX2_1	183	185	PF00082	0.526
CLV_PCSK_KEX2_1	229	231	PF00082	0.542
CLV_PCSK_KEX2_1	265	267	PF00082	0.585
CLV_PCSK_KEX2_1	272	274	PF00082	0.624
CLV_PCSK_KEX2_1	276	278	PF00082	0.691
CLV_PCSK_KEX2_1	48	50	PF00082	0.552
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.525
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.465
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.676
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.715
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.571
CLV_PCSK_PC7_1	173	179	PF00082	0.482
CLV_PCSK_PC7_1	272	278	PF00082	0.805
CLV_PCSK_PC7_1	96	102	PF00082	0.499
CLV_PCSK_SKI1_1	53	57	PF00082	0.525
DEG_SCF_SKP2-CKS1_1	185	192	PF00560	0.532
DOC_ANK_TNKS_1	15	22	PF00023	0.460
DOC_USP7_MATH_1	116	120	PF00917	0.607
DOC_USP7_MATH_1	128	132	PF00917	0.655
DOC_USP7_MATH_1	3	7	PF00917	0.541
DOC_USP7_MATH_1	75	79	PF00917	0.654
DOC_USP7_UBL2_3	14	18	PF12436	0.679
DOC_WW_Pin1_4	186	191	PF00397	0.530
LIG_14-3-3_CanoR_1	106	114	PF00244	0.502
LIG_14-3-3_CanoR_1	145	152	PF00244	0.579
LIG_CaM_IQ_9	39	55	PF13499	0.555
LIG_deltaCOP1_diTrp_1	88	94	PF00928	0.462
LIG_FHA_1	201	207	PF00498	0.486
LIG_FHA_1	7	13	PF00498	0.508
LIG_FHA_1	71	77	PF00498	0.510
LIG_FHA_2	145	151	PF00498	0.524
LIG_FHA_2	80	86	PF00498	0.519
LIG_LIR_Nem_3	88	94	PF02991	0.491
LIG_PDZ_Class_3	277	282	PF00595	0.706
LIG_SH2_STAP1	123	127	PF00017	0.637
LIG_SH2_STAP1	70	74	PF00017	0.508
LIG_SH3_3	16	22	PF00018	0.462
LIG_SH3_3	182	188	PF00018	0.670
LIG_SH3_3	243	249	PF00018	0.517
LIG_TRAF2_1	82	85	PF00917	0.500
MOD_CDK_SPxK_1	186	192	PF00069	0.532
MOD_CK1_1	155	161	PF00069	0.543
MOD_CK1_1	6	12	PF00069	0.517
MOD_CK2_1	144	150	PF00069	0.514
MOD_CK2_1	79	85	PF00069	0.524
MOD_Cter_Amidation	270	273	PF01082	0.717
MOD_Cter_Amidation	98	101	PF01082	0.503
MOD_GlcNHglycan	157	160	PF01048	0.502
MOD_GlcNHglycan	193	196	PF01048	0.512
MOD_GlcNHglycan	200	203	PF01048	0.483
MOD_GlcNHglycan	77	80	PF01048	0.453
MOD_GSK3_1	75	82	PF00069	0.653
MOD_N-GLC_1	116	121	PF02516	0.550
MOD_N-GLC_1	207	212	PF02516	0.466
MOD_NEK2_1	191	196	PF00069	0.514
MOD_NEK2_1	207	212	PF00069	0.466
MOD_NEK2_1	42	47	PF00069	0.545
MOD_PIKK_1	106	112	PF00454	0.602
MOD_PIKK_1	128	134	PF00454	0.542
MOD_PIKK_1	152	158	PF00454	0.569
MOD_PIKK_1	233	239	PF00454	0.614
MOD_PKA_1	231	237	PF00069	0.580
MOD_PKA_2	144	150	PF00069	0.509
MOD_PKA_2	254	260	PF00069	0.607
MOD_PKA_2	6	12	PF00069	0.531
MOD_Plk_1	116	122	PF00069	0.650
MOD_Plk_1	207	213	PF00069	0.467
MOD_Plk_1	79	85	PF00069	0.498
MOD_Plk_4	37	43	PF00069	0.659
MOD_ProDKin_1	186	192	PF00069	0.532
TRG_ER_diArg_1	105	108	PF00400	0.712
TRG_ER_diArg_1	176	178	PF00400	0.479
TRG_ER_diArg_1	182	184	PF00400	0.500
TRG_ER_diArg_1	227	230	PF00400	0.612
TRG_ER_diArg_1	264	266	PF00400	0.578
TRG_ER_KDEL_1	279	282	PF00810	0.707
TRG_NLS_MonoCore_2	227	232	PF00514	0.563
TRG_NLS_MonoCore_2	45	50	PF00514	0.673
TRG_NLS_MonoExtC_3	227	232	PF00514	0.684
TRG_NLS_MonoExtC_3	45	51	PF00514	0.672
TRG_NLS_MonoExtN_4	228	233	PF00514	0.707
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W8	Leptomonas seymouri	86%	97%
A0A0S4JUY7	Bodo saltans	53%	100%
A0A1X0NHZ1	Trypanosomatidae	59%	92%
A0A3S7WQW2	Leishmania donovani	93%	99%
A0A422NZP9	Trypanosoma rangeli	65%	98%
A4HU37	Leishmania infantum	93%	99%
D0A9L6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	93%
E9AMW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
Q4QHR0	Leishmania major	91%	100%
V5BMM5	Trypanosoma cruzi	63%	98%